Clinical trials: Immune System
Multiple Sclerosis
Physical Activity in Multiple Sclerosis (MS): A Novel Approach to Study Outcomes
Physical activity and exercise interventions in multiple sclerosis (MS) have received great attention most recently and there exists several randomized clinical trials (RCTs) addressing the outcomes associated with such…
- Trial name
- PHYSACTINMS (NCT02297932)
- Testing
- Strength training, Stretching
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kessler Foundation
Multiple Sclerosis
Endurance and Walking Training by Nordic Walking in Multiple Sclerosis
Walking capacity is one of the most valuable body functions among persons with multiple sclerosis (MS) and it is one of the most frequently affected, even in early stages of the disease.
- Trial name
- NCT03976128
- Testing
- Nordic Walking Training, Conventional endurance training
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Multiple Sclerosis Center of Catalonia
Multiple Myeloma
Safety and Efficacy of Pomalidomide, Bortezomib and Low-dose Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to compare the efficacy of the combination of pomalidomide, bortezomib and low dose dexamethasone to the combination of bortezomib and low dose dexamethasone in participants with relapsed/refractory…
- Trial name
- OPTIMISMM (NCT01734928)
- Testing
- Pomalidomide, Bortezomib, Dexamethasone
- Where
- 321 sites in United States, Austria and 20 more
- Volunteers
- 559 people
- Sponsor
- Celgene
Multiple Myeloma, Lymphoma
Busulfan Plus Melphalan Conditioning Regimen for Lymphoid Malignancies or Multiple Myeloma
Primary Objectives: 1. To determine the efficacy of administering multiple doses of intravenous (i.v.) busulfan at a dose of 130 mg/m2, to yield a systemic plasma drug exposure represented by a daily area under the plasma…
- Trial name
- NCT00427765
- Testing
- Busulfan, Melphalan
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections
Sexual Health Advocacy for Guys - a Text Messaging-based HIV Prevention Program for Guys Who Are Into Guys
SHAG is a text messaging-based HIV prevention program designed for cisgender sexual minority boys and men 13-20 years of age across the United States.
- Trial name
- SHAG (NCT06230367)
- Testing
- Sexual health advocacy for guys, Healthy lifestyle control
- Where
- 2 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Center for Innovative Public Health Research
Lymphoma, Non-Hodgkin, Lymphoma, Follicular
A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab
A study of PF-05082566, a 4-1BB agonist monoclonal antibody (mAb), in patients with solid tumors or b-cell lymphomas, and in combination with rituximab in patients with CD20 positive Non-Hodgkin's Lymphoma (NHL).
- Conditions
- Lymphoma, Non-Hodgkin, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT01307267
- Testing
- PF-05082566, rituximab
- Where
- 42 sites in United States, Australia and 3 more
- Volunteers
- 190 people
- Sponsor
- Pfizer
HIV Infections, HIV-1-infection
HIV Drug Resistance Pattern Due to Migration in Poland
According to the Polish governmental statistics migration of people from Ukraine to Poland is growing and only in year 2020 have come to Poland about a quarter of a million of Ukrainian migrants.
- Conditions
- HIV Infections, HIV-1-infection, Resistant Infection
- Trial name
- NCT04636736
- Testing
- HIV drug resistance testing
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Relapsing Multiple Sclerosis
A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)
This study aims to examine the efficacy and safety of obexelimab in participants with relapsing multiple sclerosis
- Trial name
- NCT06564311
- Testing
- Obexelimab
- Where
- 47 sites in United States, Austria and 10 more
- Volunteers
- 93 people
- Sponsor
- Zenas BioPharma (USA), LLC
Mantle Cell Lymphoma
Acalabrutinib and Rituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma
This phase II trial studies the side effects of acalabrutinib and rituximab and its effect in treating patients with previously untreated mantle cell lymphoma.
- Trial name
- NCT04765111
- Testing
- Acalabrutinib, Rituximab
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- M.D. Anderson Cancer Center
ARDS (Moderate or Severe)
FAPI PET/CT to Detect Fibroblast Activity in Non-resolving ARDS
Of patients requiring mechanical ventilation in the ICU 23% meet criteria of the Acute Respiratory Distress Syndrome (ARDS). Mortality of this syndrome remains high (35-46%) in moderate and severe ARDS.
- Trial name
- FAPI ARDS (NCT06691464)
- Testing
- PET
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Primary Gougerot-Sjögren Syndrome, Systemic Sclerosis, Diffuse
Quantification and Characterization of Circulating Epithelial and Endothelial Cells in Gougerot-Sjögren Syndrome, Compared to Systemic Sclerosis
Primary Gougerot-Sjögren's syndrome is a systemic autoimmune disease belonging to the group of connectivities, whose physiopathology remains largely unknown.
- Trial name
- CIRCEE (NCT05528809)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Follicular Lymphoma
R2 in the Treatment of Follicular Lymphoma
Lenalidomide Based Immunotherapy in the Treatment of FL
- Trial name
- NCT03715309
- Testing
- Revlimid
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Ruijin Hospital
Relapsing Remitting Multiple Sclerosis
Atorvastatin in Relapsing-Remitting Multiple Sclerosis
A phase II open-label baseline-to-treatment trial was designed to evaluate the safety, tolerability and efficacy of orally administered atorvastatin in patients with relapsing-remitting multiple sclerosis (RRMS).
- Trial name
- NCT00616187
- Testing
- interferon beta treatment to add-on atorvastatin treatment, untreated to atorvastatin treatment
- Volunteers
- 41 people
- Sponsor
- Charite University, Berlin, Germany
Asthma
Efficacy of a Smart add-on Device in Combination With a Triple Treatment in Asthma Patients on Inhaler Technique and Adherence
The goal of this observational study is to determine if using the SiA® (Systematic Intervention Agent) system can improve inhaler technique and medication adherence in adults with asthma who are already using Trimbow pMDI…
- Trial name
- SiASMARTer (NCT06908421)
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Chiesi Pharma AB, Nordic
Rheumatoid Arthritis
Efficacy Confirmation Trial of CDP870 Without Coadministration of Methotrexate (MTX) in Japanese Rheumatoid Arthritis (RA)
The objectives of this study are to verify the superiority in efficacy (American College of Rheumatology 20%: ACR20) and investigate the pharmacokinetics and safety of CDP870 versus placebo without coadministration of MTX in…
- Trial name
- NCT00791921
- Testing
- CDP870
- Where
- 7 sites in Japan
- Volunteers
- 230 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Mantle Cell Lymphoma, B Cell Lymphoma
Phase II Palbociclib +Ibrutinib in Mantle Cell Lymphoma
The proposed study is a single-arm, multi-center, open-label phase II study of the combination of palbociclib and ibrutinib in patients with previously treated mantle cell lymphoma to evaluate the efficacy of this combination…
- Trial name
- NCT03478514
- Testing
- Palbociclib, Ibrutinib
- Where
- 9 sites in United States
- Volunteers
- 39 people
- Sponsor
- Alliance Foundation Trials, LLC.
Waldenstrom Macroglobulinemia
DT PACE, Tandem Autologous Transplant, Maintenance Therapy for Waldenstrom's Macroglobulinemia Patients
The purpose of this study is to find out what the response is and the side effects are with chemotherapy using a combination of drugs called D.T.
- Trial name
- NCT00107614
- Testing
- DT PACE + Rituxan
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Arkansas
Refractory Multiple Myeloma, Stage I Multiple Myeloma
Randomized Trial of Cryotherapy Duration Prior to High Dose Melphalan in Myeloma Patients
The purpose of this study is to compare the effect of short-term (2 hours/120 minutes) and long-term (6 hours/360 minutes) schedules of crushed ice therapy (cryotherapy).
- Conditions
- Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT01653106
- Testing
- cryotherapy, questionnaire administration, pharmacological study
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission
Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies
This clinical trial studies the use of reduced intensity chemotherapy and radiation therapy before donor stem cell transplant in treating patients with hematologic malignancies.
- Conditions
- Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission, Aplastic Anemia, Chronic Myelomonocytic Leukemia
- Trial name
- NCT02566304
- Testing
- Fludarabine, Total-Body Irradiation, T Cell-Depleted Donor Lymphocyte Infusion
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Healthy
A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral Drugs
The study purpose is to evaluate the potential for a pharmacokinetic drug-drug interaction, safety and tolerability when Narlaprevir, Ritonavir (used as a metabolic inhibitor) and Tenofovir disoproxil fumarate (part 1) and…
- Trial name
- NCT03537404
- Testing
- Narlaprevir, Ritonavir, Tenofovir Disoproxil Fumarate
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- R-Pharm