Clinical trials: Immune System Disease
Dental Caries
Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial
Postoperative hypersensitivity (POH) is a problem for many patients as determined by the recent Practitioners Engaged in Applied Research and Learning (PEARL) study of POH following occlusal caries restoration.
- Trial name
- POH RCERT (NCT01268605)
- Testing
- Restoration with a dentin bonding agent (DBA), Restoration with a resin modified glass ionomer liner (RMGI)
- Where
- 41 sites in United States
- Volunteers
- 341 people
- Sponsor
- Pearl Network
IgA Nephropathy (IgAN)
SLN12140 in Adult Participants With IgA Nephropathy in China
This study is a randomized, parallel, double-blind, placebo-controlled, subcutaneous administration Phase II dose-exploration clinical trial aimed at evaluating the efficacy, safety, PK, PD, and immunogenicity characteristics of…
- Trial name
- NCT07553494
- Testing
- SLN12140
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Linno Pharmaceuticals, Inc.
Diabetes Mellitus, Type 1
Mindfulness-based Arabic Guided Self-help for Parents of Children With Type 1 Diabetes
Kuwait ranks as the third country worldwide for the incidence of type 1 diabetes (T1D) with an incidence of 37.10 per 100,000 children.
- Trial name
- NCT03358394
- Testing
- A human-interventional study
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- SHAHAH ALTAMMAR
Systemic Mastocytosis
New Italian Mastocytosis Registry
This study will involve 27 centers in Italy. Since this is a multidisciplinary disease, participating centers may be from various medical areas (hematology, dermatology, allergy, etc.). The study will last 10 years.
- Trial name
- NIMR (NCT07917156)
- Testing
- CLINICAL AND BIOLOGICAL DATA COLLECTION
- Where
- 10 sites in Italy
- Volunteers
- 1,500 people
- Sponsor
- Associazione Rete Italiana Mastocitosi
Neurological Disease
Development, Reliability and Validity of the Telerehabilitation Usability Questionnaire- TrUQ
Neurological diseases are central nervous system diseases that cause an increase in the level of disability and limitations in daily life.
- Trial name
- NCT05970939
- Testing
- Development of the Telerehabilitation Usability Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Gazi University
Exercised Induced Asthma, Asthma
The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.
The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB).
- Trial name
- NCT02872675
- Testing
- HOST-DM059, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Type 1 Diabetes Mellitus
Do Sulphonylureas Preserve Cortical Function During Hypoglycaemia?
To see if using medication called sulphonylureas can help improve symptoms which patients rely on to recognise low blood glucose levels ( hypoglycaemia) and also to see if they can reduce the slowing down in brain function which…
- Trial name
- NCT00472875
- Testing
- Glibenclamide
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College Hospital NHS Trust
HIV Infections
ETE Interventions in the Dental Setting
The purpose of this study is to use information technology (IT) to support the delivery of HIV prevention and care best practices in the dental care setting to meet the Department of Health and Human Services (DHHS) Ending the…
- Trial name
- NCT05584501
- Testing
- Care Navigator, Health Information Supported Ending the HIV Epidemic (ETE) Activities in Dental Setting
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Columbia University
Marginal Zone Lymphoma, Nodal Marginal Zone Lymphoma
MALIBU Trial - Combination of Ibrutinib and Rituximab in Untreated Marginal Zone Lymphomas
Single-arm, phase II clinical trial of patients with Extranodal Marginal Zone Lymphoma (EMZL). It is planned to recruit 130 patients.
- Conditions
- Marginal Zone Lymphoma, Nodal Marginal Zone Lymphoma, Splenic Marginal Zone Lymphoma
- Trial name
- MALIBU (NCT03697512)
- Testing
- Ibrutinib, Rituximab
- Where
- 36 sites in Belgium, France and 3 more
- Volunteers
- 175 people
- Sponsor
- International Extranodal Lymphoma Study Group (IELSG)
Rheumatoid Arthritis
A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid Arthritis
This multicenter, open-label study will evaluate the efficacy and safety of subcutaneously administered RoActemra/Actemra (tocilizumab) as monotherapy or in combination with methotrexate or other non-biologic DMARDs in patients…
- Trial name
- NCT01995201
- Testing
- DMARD, methotrexate, tocilizumab [RoActemra/Actemra]
- Where
- 53 sites in Ireland, Portugal and 1 more
- Volunteers
- 401 people
- Sponsor
- Hoffmann-La Roche
Pressure Ulcer, Foot Ulcer, Diabetic
Use of Santyl Within an Accountable Care Organization
This study is designed to assess the comparative effectiveness of SANTYL® versus standard of care in the treatment of pressure ulcers and diabetic foot ulcers within the continuum of care of an ACO.
- Trial name
- NCT02716519
- Testing
- Santyl, Standard Care
- Where
- United States
- Sponsor
- Smith & Nephew, Inc.
Multiple Myeloma
A Phase 1 Study of CNTO 328 (Siltuximab) in Relapsed or Refractory Multiple Myeloma
The purpose of this study is to assess the safety and the tolerability of siltuximab up to 11.0 mg/kg in combination with bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma.
- Trial name
- NCT01309412
- Testing
- Siltuximab
- Where
- 5 sites in Japan
- Volunteers
- 9 people
- Sponsor
- Janssen Pharmaceutical K.K.
HIV/AIDS
Packaging PrEP to Prevent HIV Among WWID
Evidence suggests women who inject drugs (WWID) are disproportionately vulnerable to HIV. If HIV incidence continues unchecked, 1 in 23 WWID in the United States will acquire HIV.
- Trial name
- NCT03304912
- Testing
- PrEP Education and option to accept a PrEP prescription
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Drexel University
Staphylococcal Aureus Infection, Recurrent Staphylococcal Infection
Host Factors in Invasive and Recurrent Staphylococcus Aureus Infection
The incidence of community-associated (CA) staphylococcal infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA), has increased dramatically in recent years.
- Conditions
- Staphylococcal Aureus Infection, Recurrent Staphylococcal Infection, Invasive Staphylococcal Infection
- Trial name
- NCT00911430
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Graft-Versus-Host Disease, GVHD
A Study of Photobiomodulation (PBM) Therapy in People With Oral Graft-Versus-Host Disease (GVHD) After Stem Cell Transplant
The purpose of this study is to find out whether photobiomodulation/PBM therapy using the Thor LX2.3 therapy system is a safe and effective treatment for oral Graft-Versus-Host Disease/GVHD.
- Conditions
- Graft-Versus-Host Disease, GVHD, Undefined
- Trial name
- NCT05675930
- Testing
- Photobiomodulation Therapy
- Where
- 9 sites in United States
- Volunteers
- 44 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Peripheral T Cell Lymphoma
The Efficacy and Safety of F520 in Patients With Relapsed/Refractory Peripheral T Cell Lymphoma (PTCL).
It is a multi-center, prospective, open-label, two-stage optimized design, single-arm, phase II clinical study to evaluate the efficacy and safety of F520 for the treatment of relapsed and refractory peripheral T cell lymphoma…
- Trial name
- NCT04457830
- Testing
- F520
- Volunteers
- 105 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Multiple Myeloma
Study of Oral IXAZOMIB in Combination With Lenalidomide and Dexamethasone in Participants With Newly Diagnosed Multiple Myeloma
The purpose of this study is to determine the safety, tolerability, maximum tolerated dose (MTD), and recommended phase 2 dose (RP2D) in phase 1 and to determine the combined response rate of clinical response CR and very good…
- Trial name
- NCT01383928
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 20 sites in United States
- Volunteers
- 64 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Diffuse Large B Cell Lymphoma, Refractory Diffuse Large B-Cell Lymphoma
Secondary Prognostic Index in RefrActory Lymphoma
60% of patients with diffuse large B cell lymphoma are healed after first-line treatment which whatever the age. For the remaining 40% of patients (relapses and primary refractories): 38% of patients will be cured with a 2nd line…
- Trial name
- SPiRAL (NCT04804865)
- Testing
- prognostic assessment
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- Weprom
Diabetes, Diabetes Mellitus, Type 1
First Research Study to Compare a Possible New Medicine NNC9204-1513 to the Medicine Glucagon, in Healthy People.
The study is comparing the new medicine NNC9204-1513 with a standard therapy of glucagon (GlucaGen®). This is the first time NNC9204-1513 is given to humans.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT03444467
- Testing
- NNC9204-1513, Glucagon
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Methadone, HIV Infections
Recovery Management Intervention in China
The purpose of the study is to develop and pilot-test a Recovery Management Intervention (RMI) program for heroin addicts released from compulsory rehabilitation in China.
- Trial name
- NCT01270100
- Testing
- Recovery management
- Where
- China
- Sponsor
- University of California, Los Angeles
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