Clinical trials: Immune System Disease
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi
This phase II trial tests how well pirtobrutinib (LOXO-305) and venetoclax works in treating patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that remains despite treatment (resistant) with…
- Trial name
- NCT06466122
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kerry Rogers
HIV/AIDS, Sexual Behavior
Reducing HIV Risk in Urban Women: Soap Opera Videos on Video-Capable Cell Phones
Background: Love, Sex, and Choices (LSC) is a soap opera video series created to reduce HIV sex risk in women. Methods: LSC was compared to text messages in a randomized trial in 238 high-risk mostly Black young urban women.
- Conditions
- HIV/AIDS, Sexual Behavior, Woman's Role, Risk Behavior
- Trial name
- NCT03330522
- Testing
- Love, Sex, & Choices video series, Messages in text
- Where
- United States
- Volunteers
- 295 people
- Sponsor
- Northeastern University
Type 1 Diabetes, Type 2 Diabetes
Establishment of the Human Intestinal and Salivary Microbiota Biobank- Diabetes
This is a prospective, clinical, monocentric study aimed to collect biological samples and study microbiota from subjects suffering from type 1 diabetes mellitus, subjects suffering from type 2 diabetes mellitus and from healthy…
- Trial name
- BIOMIS-Diab (NCT04698122)
- Testing
- Biological sample collection, Questionnaire, Medical examination
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Asthma.
Effect of Aerobic Training in Moderate or Severe Asthmatic Patients
Exercise training has been proposed as adjunctive therapy in asthma to improve many clinical outcomes; however its effects on bronchial hyperresponsiveness (BHR) and inflammation, characteristic features in asthma, remains poorly…
- Trial name
- ETA1 (NCT02033122)
- Testing
- Aerobic training, Breathing exercise
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Instituto de Investigação em Imunologia
NSCLC, ALCL
Crizotinib Continuation Clinical Study
The purpose of this continuation study is to provide continued access to crizotinib treatment for eligible participants from a current Pfizer sponsored crizotinib clinical study that is planned to close.
- Conditions
- NSCLC, ALCL, IMT
- Trial name
- NCT05160922
- Testing
- crizotinib
- Where
- 13 sites in China, Italy and 3 more
- Volunteers
- 27 people
- Sponsor
- Pfizer
Moderate or Severe Submental Fullness
Phase 1-2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat
To evaluate the safety and potential efficacy of deoxycholic acid injection compared to placebo for the reduction of submental fat (fat below the chin).
- Trial name
- ATX-101 (NCT00618722)
- Testing
- Deoxycholic Acid Injection
- Where
- 6 sites in Australia, Canada and 1 more
- Volunteers
- 85 people
- Sponsor
- Kythera Biopharmaceuticals
Choroidal Neovascularization
Intravitreal Bevacizumab for the Treatment of CNV in VKH Disease - A Prospective Study
Efficacy of monthly intravitreal anti-vascular endothelial growth factor (VEGF) associated to systemic immunosuppression in patients with Vogt-Koyanagi-Harada Disease and choroidal neovascularization. Minimum follow-up 12 months.
- Trial name
- NCT02015351
- Testing
- bevacizumab
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- University of Sao Paulo
Primary Amyloidosis of Light Chain Type
High Cut-off Hemodialysis in Patients With Advanced Cardiac AL Amyloidosis and End Stage Renal Disease
The aim of the study is to assess survival of patients with advanced cardiac AL amyloidosis treated with high cut-off hemodialysis (HCO-HD) combined with chemotherapy.
- Trial name
- DIACAL (NCT01531751)
- Testing
- High Cut-off Hemodialysis, Chemotherapy
- Where
- Italy
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Food Allergy in Infants, Proctocolitis
Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive...
- Conditions
- Food Allergy in Infants, Proctocolitis, Atopic Dermatitis, Reflux, Gastroesophageal
- Trial name
- NCT04651829
- Testing
- oral food challenge 1, oral food challenge 2
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Armand Trousseau
Cachexia, Lymphoma
Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer
RATIONALE: Nutritional supplements may help prevent loss of appetite, weight loss, and fatigue in patients with advanced cancer.
- Conditions
- Cachexia, Lymphoma, Lymphoproliferative Disorder, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00053053
- Testing
- Juven, Non-Juven Supplement
- Where
- 250 sites in United States, Canada
- Volunteers
- 472 people
- Sponsor
- Radiation Therapy Oncology Group
Systemic Lupus Erythematosus
Anti-infection of Low-does IL-2 in SLE
The objective of this clinical study is to evaluate the potential effect of anti-infection of low-does IL-2 in patients with SLE.
- Trial name
- NCT02932137
- Testing
- Interleukin-2
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Postprandial Lipid Metabolism, Type 1 Diabetes (T1D)
The TiMeD-T1D Project
The aim of the proposed study is to investigate the metabolic consequences of varying the timing of meal insulin boluses and skipping boluses altogether in individuals with type 1 diabetes.
- Trial name
- NCT07172672
- Testing
- 400 mL Fresubin Energy Drink and 100 mL heavy cream with the addition of the 18F-FTHA radiotracer
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Lymphoblastic Leukemia, Acute, Childhood
N-Acetylcysteine vs Placebo as Adjunctive Treatment in Pediatric Leukemia
The goal of this clinical trial is to analyze the effect of N-Acetylcysteine administration towards blood oxidant level, transaminase enzyme, and bilirubin level in ALL children who undergo induction phase of chemotherapy.
- Trial name
- NCT05611086
- Testing
- N-Acetylcysteine
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Teny Tjitra Sari
Rheumatoid Arthritis
ALX-0061 Phase I Bioavailability Study in Healthy Volunteers
The overall aims of the study are: To assess the bioavailability of single doses of ALX-0061, administered s.c. at three dose levels, using 2 corresponding single i.v. dose levels as reference.
- Trial name
- NCT02101073
- Testing
- ALX-0061
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ablynx, a Sanofi company
Asthma
Comparison of Flutter and PEP Mask on Chest Clearance, Dyspnea in Elderly Asthmatic Patients
This study will be a Randomized controlled and will be conducted in Allied Hospital, Faisalabad. The study will be completed within the duration of 10 months. Convenience sampling study technique will be used to collect the data.
- Trial name
- NCT05618873
- Testing
- Flutter device, positive expiratory pressure mask
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Glioblastoma, Medulloblastoma
Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG
Indoximod was developed to inhibit the IDO (indoleamine 2,3-dioxygenase) enzymatic pathway, which is important in the natural regulation of immune responses.
- Conditions
- Glioblastoma, Medulloblastoma, Ependymoma, Diffuse Intrinsic Pontine Glioma
- Trial name
- NCT04049669
- Testing
- Indoximod, Partial Radiation, Full-dose Radiation
- Where
- 5 sites in United States
- Volunteers
- 130 people
- Sponsor
- Theodore S. Johnson
Multiple Myeloma, Lymphoma
A Study of Peripheral Blood Progenitor Cells Mobilisation (PBPC) With VTP195183 Plus Granulocyte-Colony Stimulating Factor (G-CSF) Compared to Mobilisation With G-CSF Alone
Hematopoietic stem cells (HSC) are used to support the administration of high dose chemotherapy for a range of human cancers. For a safe HSC transplantation, a minimum of 5 million HSC per kilogram are required.
- Trial name
- NCT00234169
- Testing
- VTP195183
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Type 1 Diabetes Mellitus
Study of IMCY-0098 in Patients With Recent Onset Type 1 Diabetes
This clinical study will evaluate the safety of an innovative approach expected to be disease-modifying by stopping the auto-immune-mediated destruction of islet β-cells in the pancreas.
- Trial name
- NCT03272269
- Testing
- IMCY-0098
- Where
- 17 sites in Belgium, Denmark and 5 more
- Volunteers
- 41 people
- Sponsor
- Imcyse SA
Systemic Lupus Erythematosus
Comparison Between Early-onset and Late-onset Patients With Systemic Lupus Erythematosus.
The present study aims to: Compare clinical features, hematological indices and disease activity between the early-onset and late-onset patients with systemic lupus erythematosus.
- Trial name
- NCT06294483
- Testing
- CBC, Antinuclear Antibody tests (ANA), Rest of ANA profile
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Multiple Sclerosis
Tecfidera and MRI for Brain Energy in MS
The primary objective of this study is to test the hypothesis that DMF can improve mitochondrial function in the brain of people with MS.
- Trial name
- NCT02644083
- Testing
- Dimethyl fumarate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Oregon Health and Science University
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