Clinical trials: Immune System Disease
Lymphoma, Non-Hodgkin Lymphoma, B-Cell
Phase 1 Study of BAFF CAR-T Cells (LMY-920) for Non-Hodgkin Lymphoma
Therapy with chimeric antigen receptor T (CAR-T) cells has demonstrated activity against refractory lymphoma, however not all tumors respond or remain in response to CD19 targeted CAR-T cells.
- Trial name
- NCT05312801
- Testing
- BAFF CAR-T
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Luminary Therapeutics
Pemphigus
Effect of Anti CD20 in Pemphigus Desease
to treat in an open non comparative clinical study patients presenting pemphigus with corticodependance, corticoresistance and contre-indication to systemic steroids.
- Trial name
- NCT00213512
- Testing
- Mabthera
- Where
- France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Rouen
Asthma
The Development of a Clinical Test to Assess the Inflammatory Phenotype of Asthma
The purpose of this study is to determine the type and degree of inflammatory parameters in peripheral blood of asthma patients compared to analysis of induced sputum.
- Trial name
- AIR (NCT01611012)
- Where
- Netherlands
- Volunteers
- 115 people
- Sponsor
- Prof. Jan-Willem Lammers MD PhD
Asthma, Lung Diseases
Center for Reducing Asthma Disparities - Howard/Hopkins Centers
To evaluate asthma morbidity in low-income, African-American children and adults with asthma.
- Trial name
- NCT00281112
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Immune Thrombocytopenia
A Multicentre Investigation of 2 Cycles Rituximab Compared With Standard Regimen in Management of Steroid-Resistant/Relapsed Immune Thrombocytopenia （ITP）
The project was undertaking by Qilu Hospital, Shandong University and other several well-known hospitals in China. In order to report the efficacy and safety of Rituximab in different frequencies for the treatment of adults with…
- Trial name
- NCT02137681
- Testing
- Rituximab
- Where
- China
- Sponsor
- Shandong University
Arthritis, Rheumatoid
Single Dose Study Of GW856553 On A Protein That Is An Indicator For Rheumatoid Arthritis (RA)
This study is designed to compare a range of doses of GW856553 versus placebo on the biomarkers associated with rheumatoid arthritis
- Trial name
- NCT00256919
- Testing
- GW856553
- Where
- 17 sites in Bulgaria, Germany and 3 more
- Volunteers
- 51 people
- Sponsor
- GlaxoSmithKline
Asthma
A Case-control Study on the Differentiation Between Cough Variant Asthma and Chronic Cough
this study aimed to compare characters in pulmonary function of patients with cough variant asthma and chronic cough and establish a diagnostic model.
- Trial name
- NCT06199830
- Testing
- positive bronchial provocation test
- Where
- China
- Volunteers
- 645 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Multiple Sclerosis, Self Efficacy
Unidimensional Self-Efficacy Scale for Multiple Sclerosis (USE-MS) Turkish Adaptation
Multiple Sclerosis (MS) is a chronic, inflammatory, demyelinating, autoimmune disease of the central nervous system. Despite functional limitations and unpredictable disease course, individuals with MS are aimed to maintain…
- Trial name
- NCT06231030
- Testing
- Validity, Reliability and Adaptation
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 176 people
- Sponsor
- Nigde Omer Halisdemir University
B-Cell Non-Hodgkin Lymphoma (NHL)
Non-Interventional Study of Ranicabtagene Autoleucel Injection for Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
Establishing real-world data of patients with relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL) treated with Ranicabtagene Autoleucel Injection to evaluate its efficacy and safety.
- Trial name
- NCT07888530
- Testing
- Ranicabtagene Autoleucel Injection
- Volunteers
- 200 people
- Sponsor
- Hrain Biotechnology Co., Ltd.
Graft vs Host Disease
Chimeric Natural Killer Receptor-Universal T Cells for Refractory GVHD
This is a single arm, open-label, multi-center, pilot studies (Investigator Initiated Trial, IIT) to evaluate the safety, tolerability, efficacy, pharmacokinetics and pharmacodynamics of universal T-cells engineered with chimeric…
- Trial name
- NCT06568328
- Testing
- Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Fujian Medical University
Graft Versus Host Disease
Early Detection of Mucosal Abnormalities in Graft-versus-host Disease
Gastro-intestinal graft versus host disease (GVHD) is a major source of morbidity and mortality amongst allogenic hematopoietic stem cell transplantation (Allo-HSCT).
- Trial name
- E-mage (NCT02707354)
- Testing
- Probe based confocal laser endomicroscopy (Cellvizio)
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Nantes University Hospital
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia
Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorders
This phase I trial is studying the side effects and best dose of vorinostat when given together with cytarabine and etoposide in treating patients with relapsed or refractory acute leukemia or myelodysplastic syndromes or…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7)
- Trial name
- NCT00357305
- Testing
- vorinostat, cytarabine, etoposide
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- National Cancer Institute (NCI)
Leukemia, Relapsed Adult Acute Lymphocytic Leukemia
Single Agent Lenalidomide in Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia
Time-to-Progression (TTP)
- Trial name
- NCT01401322
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Cancer of the Digestive System, Thoracic Diseases
Assessment of Postoperative Lymphopenia as Risk Factor for Postoperative Infections
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia.
- Trial name
- EVALYMPH (NCT02799251)
- Testing
- Collection of plasma cell rate
- Where
- 20 sites in France
- Volunteers
- 1,125 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Rheumatoid Arthritis
Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)
The goal of this clinical trial is to compare therapeutic drug monitoring (TDM) versus Standard of care in patients with rheumatoid arthritis treated with a subcutaneous tumor necrosis factor inhibitor (adalimumab).
- Trial name
- RA-DRUM (NCT06440629)
- Testing
- Therapeutic drug monitoring (TDM) of adalimumab
- Where
- 22 sites in Austria, Italy and 4 more
- Volunteers
- 387 people
- Sponsor
- Diakonhjemmet Hospital
HIV Infections
A Simplified Kaletra® (Lopinavir/Ritonavir)-Based Therapy Versus a Sustiva® (Efavirenz)-Based Standard of Care in Previously Non-Treated HIV-Infected Subjects
The purpose of this study is to determine whether a simplified lopinavir-ritonavir based therapy will continue to keep the viral load to very low levels after initial treatment with a combination of Kaletra® (lopinavir/ritonavir)…
- Trial name
- NCT00075231
- Testing
- Kaletra® (lopinavir/ritonavir), Combivir® (lamivudine, zidovudine), Sustiva® (efavirenz)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Abbott
Rheumatoid Arthritis
A Study Assessing the Safety and Efficacy of Sarilumab Added to Non-MTX DMARDs or as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis (SARIL-RA-HARUKA)
Primary Objective: To document the long-term safety of sarilumab added to non-methotrexate (non-MTX) disease-modifying antirheumatic drugs (DMARDs) or as monotherapy.
- Trial name
- NCT02373202
- Testing
- Sarilumab, Sulfasalazine, Leflunomide
- Where
- 40 sites in Japan
- Volunteers
- 91 people
- Sponsor
- Sanofi
Hepatocellular Carcinoma (HCC)
Regional Lymph Node Metastasis and Survival Outcomes in Advanced HCC
Tumor-draining lymph nodes play an important role in anti-tumor immune responses. In patients with hepatocellular carcinoma (HCC), however, the relationship between regional lymph node metastasis (LNM) and immunotherapy-based…
- Trial name
- CHANCE2421 (NCT06876753)
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Zhongda Hospital
Folliculotropic Mycosis Fungoides, Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
Extracorporeal Photopheresis and Mogamulizumab for the Treatment of Erythrodermic Cutaneous T Cell Lymphoma
This phase II trial studies the effect of extracorporeal photopheresis (ECP) and mogamulizumab in treating patients with erythrodermic cutaneous T cell lymphoma (CTCL), a type of skin lymphoma.
- Conditions
- Folliculotropic Mycosis Fungoides, Primary Cutaneous T-Cell Non-Hodgkin Lymphoma, Sezary Syndrome, Stage IB Mycosis Fungoides and Sezary Syndrome AJCC v8
- Trial name
- NCT04930653
- Testing
- Extracorporeal Photopheresis, Mogamulizumab, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- City of Hope Medical Center
Asthma, COPD
Bronchoprotection of Salbutamol in Asthma and Chronic Obstructive Pulmonary Disease
This study will investigate potential differences in how two puffs of salbutamol protects airway smooth muscle from contracting in people with asthma and chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00440245
- Testing
- salbutamol
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Saskatchewan
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