Clinical trials: Immune System Disorder
Cardiopulmonary Arrest, Pediatric ALL
Impact of 2 Resuscitation Sequences on Management of Simulated Pediatric Cardiac Arrest
The International Liaison Committee on Resuscitation regularly publishes a Consensus on Science with Treatment Recommendations but guidelines can nevertheless differ when knowledge gaps persist.
- Conditions
- Cardiopulmonary Arrest, Pediatric ALL, Resuscitation
- Trial name
- NCT05474170
- Testing
- AHA resuscitation sequence, ERC resuscitation sequence
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Geneve TEAM Ambulances
HIV Infections
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of the Therion Recombinant Vaccinia-HIV-1 IIIB ENV/GAG/POL Vaccine (TCB-3B) and MN RGP 120/HIV-1 In Alum.
To evaluate the safety of administering Therion Recombinant Vaccinia-HIV-1 IIIB env/gag/pol Vaccine (TBC-3B) vaccinations to vaccinia-naive individuals.
- Trial name
- NCT00000866
- Testing
- MN rgp120/HIV-1, TBC-3B Vaccine
- Where
- 4 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dermatophagoides Farinae Allergy, Asthma
Evaluation of a Nasal Allergen Challenge Procedure Using Dust Mite Extract
The purpose of this study is to serve as a pilot safety study for nasal allergen challenges.
- Conditions
- Dermatophagoides Farinae Allergy, Asthma, Healthy
- Trial name
- Dusty (NCT00927329)
- Testing
- dust mite inhalation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 1, Hyperlipidemias
Efficacy of Colesevelam in Subjects With Type 1 Diabetes Mellitus
This is a prospective, randomized, double blind, parallel, placebo controlled clinical trial evaluating the efficacy of colesevelam HCl in reducing LDL in subjects with type 1 diabetes mellitus over a 12 week treatment period.
- Trial name
- NCT00938405
- Testing
- Colesevelam HCl
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
HIV/AIDS
HIV Self-Testing to Empower Prevention Choices in Sex Workers
Transgender, male, and female sex workers are 49, 21 and 14 times as likely to be HIV-infected as other adults in the general population.
- Trial name
- NCT03426670
- Testing
- OraQuick HIV Self-Test
- Where
- Uganda
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Makerere University
HIV Infections
HIV Prevention With the Mentally Ill
The purpose of this study is to determine whether motivational interviewing and skills building interventions reduce HIV risk behavior for adults with serious and persistent mental illness.
- Trial name
- NCT00643305
- Testing
- Skills Building with Motivational Interviewing, Skills Building
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Primary Immune Deficiency Diseases
Evaluate Bacteriophage as a Useful Immunogen in Patients With Primary Immune Deficiency Diseases (PIDD)
This protocol is designed to ascertain whether the bacteriophage 0X174 neoantigen is safe and effective as an antigen used in the evaluation of primary and secondary immune responses.
- Trial name
- Bacteriophage (NCT01617122)
- Testing
- Bacteriophage OX174
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Anaphylaxis
Study to Explore the Pharmacokinetics and Pharmacodynamics of Epinephrine in Healthy Male and Female Subjects With Different Skin to Muscle Depth (STMD)
A single dose, open label, randomized cross-over study to explore the pharmacokinetics and pharmacodynamics of epinephrine in healthy male and female subjects
- Trial name
- NCT03282929
- Testing
- Part 1, Part 2 Group 1, Part 2 group 2
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Multiple Sclerosis, Relapsing-Remitting, Healthy Controls
The Relationships Between Personal Identity, Autobiographical Memory and Future Thinking in People With Multiple Sclerosis
Personal identity is composed of multiple facets of the self that are constructed and nourished through memories of past experiences (i.e., autobiographical memory) and the imagination of events that may occur in the future…
- Trial name
- SELFSEP (NCT05648292)
- Testing
- Neuropsychological tests and psychological questionnaires
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
HIV Infections, Hepatitis B
Project UNITY - HIV Risk Reduction and Vaccine Education Interventions
To determine the efficacy of an enhanced HIV risk reduction intervention delivered concurrently with a vaccination schedule to reduce the number of unprotected vaginal and anal sex acts among HIV-negative, high-risk non-injection…
- Trial name
- NCT00150098
- Testing
- Enhanced HIV risk reduction and HIV vaccine education
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- New York Blood Center
Adult Onset Still Disease
Multi-center Registration Study of Adult Onset Still's Disease in Chinese Population
This multi-center registration study will investigate the clinical characteristics of AOSD population in China , identify possible factors inducing the onset and active condition of AOSD in Chinese population , and identify the…
- Trial name
- MAOSDC (NCT03651193)
- Testing
- Exon sequencing and Methylated sequencing
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
HIV, Seroconversion, HIV
Accurate Staging of Immuno-virological Dynamics During Acute HIV Infection
In this prospective longitudinal study we aim to assess how immunologic and viral aspects of the human immunodeficiency virus (HIV) viral reservoir, established during early HIV infection and responsible for viral rebound at…
- Trial name
- ACS (NCT03449706)
- Testing
- Early combination anti-retroviral treatment
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Multiple Sclerosis, Gait Disorders, Neurologic
Measurement and Training of Dual-Task of Gait in Persons With Multiple Sclerosis
The purpose of this study is to determine the utility of a performance measure for the dual-task of gait and considering people with multiple sclerosis have both cognitive and motor problems, the secondary aim of this study is to…
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Cognitive Impairment
- Trial name
- MS (NCT03536299)
- Testing
- Dual-task gait, Single-task gait
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Asthma
Evaluation of Metabolic Profile of OC000459
An open label study in 9 male and 9 female healthy subjects to determine the pharmacokinetics of parent compound and metabolite after eight days of dosing.
- Trial name
- NCT02341521
- Testing
- OC000459
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Atopix Therapeutics, Ltd.
Meningococcal Infections
Safety and Immune Response of Novartis of MenACWY Conjugate Vaccine When Given to Healthy Children
To evaluate the safety and immune response of Novartis MenACWY conjugate vaccine when given to healthy children compared to a licensed Meningococcal ACWY polysaccharide-protein conjugate vaccine.
- Trial name
- NCT00616421
- Testing
- MenACWY-CRM, Licensed meningococcal ACWY vaccine
- Where
- 68 sites in United States, Canada
- Volunteers
- 2,907 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Anaphylaxis
Use of Dexamethasone in Prevention of the Second Phase or a Biphasic Reaction of Anaphylaxis
Anaphylaxis is an acute serious allergic reaction, with multi-organ system manifestations caused by the release of chemical mediators and it is potentially fatal .
- Trial name
- NCT03523221
- Testing
- Dexamethasone Oral
- Where
- Qatar
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Graft-Versus-Host Disease
Experience of Having Chronic Graft-Versus-Host Disease
Primary Objectives: 1. To explore the experience of chronic graft-versus-host disease (cGVHD) following allogeneic blood or marrow transplantation from the perspective of the patient and the patient's primary family caregiver. 2.
- Trial name
- NCT00353106
- Testing
- Interview, Questionnaire
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Parkinson Disease, Diabetes Mellitus, Type 1
Biological Sample Collection for Research and Biobanking
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells).
- Conditions
- Parkinson Disease, Diabetes Mellitus, Type 1, Macular Degeneration, ALS
- Trial name
- NCT04270604
- Testing
- Biological sample collection
- Where
- United States
- Volunteers
- 1,279 people, healthy volunteers welcome
- Sponsor
- New York Stem Cell Foundation Research Institute
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Decoy Receptor 3 (DcR3) Polymorphisms in Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE)
Although SLE and RA are correlated with genetic predisposing factors such as human leukocyte antigen (HLA) class II, both diseases and other genetic factors might have contributed to the development of dysregulated lymphocyte…
- Trial name
- NCT00172666
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HIV Infections
CASI-Plus mHealth for Ukraine's APS Program (Aim 2)
The CASI-Plus mHealth intervention seeks to improve partner elicitation and testing as part of assisted partner services (APS) in Ukraine, through a mHealth client engagement tool using computer-assisted self-interview (CASI).
- Trial name
- NCT05826977
- Testing
- CASI-Plus
- Where
- 2 sites in Ukraine
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of Washington
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