Clinical trials: Immune System Function
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Health Beliefs and Health Behaviors Among Minorities With Rheumatic Diseases
This study will explore the diverse health beliefs and behaviors among minority patients with rheumatic diseases. These diseases may cause joint pain, stiffness or swelling. Some can involve bones, muscles, tendons or ligaments.
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Arthritis
- Trial name
- NCT00069342
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Multiple Sclerosis
The Effect of Task-Oriented Training in Patients With Multiple Sclerosis
It is reported that 85% of MS patients have gait disturbance, 87.9% balance, 35-90% fatigue and 45-60% cognitive problems. Rehabilitation approaches based on the motor control systems model, the plasticity concept, the motor…
- Trial name
- NCT03505294
- Testing
- Task-oriented training
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Gazi University
Asthma
A Study To Assess The Effect Of PF-03526299 On Lung Function Following An Allergen Challenge In Asthmatic Subjects
PF-03526299, a novel anti-inflammatory agent should attenuate the effect of a bronchial allergen challenge on lung function and hence provide proof of mechanism for this agent.
- Trial name
- NCT00877539
- Testing
- PF-03526299, Fluticasone propionate
- Where
- 2 sites in United Kingdom
- Volunteers
- 29 people
- Sponsor
- Pfizer
HIV Infections
The CogNaive Study: Assessing Changes in Neurocognitive Function in Treatment Naïve HIV-1 Positive Subjects
The purpose of this study is to investigate the possibility of an association between changes in neurocognitive function, as measured by a computerised test battery, and the use of two different highly active antiretroviral…
- Trial name
- NCT00540137
- Testing
- nevirapine, atazanavir/ritonavir
- Where
- 2 sites in United Kingdom
- Volunteers
- 21 people
- Sponsor
- Imperial College London
Rheumatoid Arthritis
Tai Chi for Patients With Rheumatoid Arthritis
The purpose of this study was to study the impact of Tai Chi group exercise on physical function, health and disease activity of patients with RA, and to examine the patients' experience and perception of Tai Chi.
- Trial name
- NCT00522054
- Testing
- Physical exercise
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Diakonhjemmet Hospital
Advanced Solid Tumors, Relapsed/Refractory Lymphoma
Pharmacokinetics of Alisertib in Adults With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Function
The purpose of this study is to evaluate the effect of moderate or severe hepatic impairment on the single-dose pharmacokinetics of alisertib in adult participants with cancer.
- Trial name
- NCT02214147
- Testing
- Alisertib
- Where
- 7 sites in United States
- Volunteers
- 36 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Mitigation of Immune Function Decrements in Response to Stress
Nutrition Interventions to Support the Immune System in Response to Stress
Physical and psychological stress on military personnel during training and operational missions can suppress immune function. Creating superficial skin wounds via suction blisters can be used to detect changes in immune…
- Trial name
- NCT02053506
- Testing
- Immune-enhancing nutritional beverage, Probiotics (BB-12)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Systemic Lupus Erythematosus, Arthralgia
The Impact of Exercise on Hand Function, Daily Activities Performance and Quality of Life of SLE' Patients
A total of 240 consecutive SLE patients fulfilling the SLICC classification criteria was evaluated. Sixty two patients who met the inclusion criteria were randomly assigned to the exercise group (n=32) or the control group…
- Trial name
- NCT03802578
- Testing
- HAND EXERCISE
- Where
- 2 sites in Greece
- Volunteers
- 62 people
- Sponsor
- National and Kapodistrian University of Athens
Chronic Pain, HIV
An Observational Study of Distress, Immune Function, and Pain in HIV.
This case-control study focuses on pain in HIV, which is common despite antiretroviral therapy and compromises quality of life, mental health and daily functioning.
- Conditions
- Chronic Pain, HIV, Distress, Emotional, Immune System and Related Disorders
- Trial name
- NCT04757987
- Testing
- Pain
- Where
- South Africa
- Volunteers
- 107 people
- Sponsor
- University of Cape Town
Liver Cancer, Hepatocellular Carcinoma
Effect of a Perioperative Oral Nutritional Supplementation on Patients Undergoing Hepatic Surgery for Liver Cancer
Cirrhotic patients undergoing hepatic resection have a mortality rate near 10%, and 30 to 70% of them develop severe complications. These failures are mainly due to hepatic insufficiency.
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Cirrhosis, Liver Fibrosis
- Trial name
- IMPACT (NCT00151671)
- Testing
- Oral Impact®
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Rennes University Hospital
Rheumatoid Arthritis
High-intensity Interval Exercise in Rheumatoid Arthritis
Cardiovascular performance and overall fitness can be improved by high-intensity aerobic activity, and these benefits may be achievable by persons with rheumatic diseases.
- Trial name
- RA-HIIT (NCT05768165)
- Testing
- High intensity exercise
- Where
- 2 sites in Sweden
- Volunteers
- 87 people
- Sponsor
- Vastra Gotaland Region
Rheumatoid Arthritis
The Effect of Distant Reiki Application on Pain, Functional Status and Sleep Quality
Rheumatoid Arthritis (RA) is a chronic, multisystemic, progressive autoimmune disease characterized by joint destruction in synovial tissue, causing joint swelling, pain and morning stiffness.
- Trial name
- NCT05861934
- Testing
- Distant reiki group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Aksaray University Training and Research Hospital
Frailty, Disability Physical
Functional Decline and QoL in People Aging with HIV in Asia
This is a multi-center prospective cross-sectional study to determine the burden of decline in intrinsic capacity and functional ability, and the prevalence of geriatric syndromes, such as frailty, and disability in adult people…
- Conditions
- Frailty, Disability Physical, HIV/AIDS
- Trial name
- NCT04212884
- Where
- 2 sites in Hong Kong
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Signaling Mechanisms and Vascular Function in Patients With Diabetes Mellitus
The purpose of the study is to learn how blood vessel function is altered by diabetes. We are studying an investigational drug, Ebselen, to see if it can improve the ability of blood vessels to relax (widen).
- Trial name
- NCT00762671
- Testing
- Ebselen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Immunosenescence, Sarcopenia
Nutritional Supplementation and Muscle Health: A Pilot Study on Immune Function
The ability of older adults to improve their muscle strength through exercise training appears related to how well their immune system functions.
- Trial name
- NCT01935271
- Testing
- Muscle Armor Supplement
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Central Arkansas Veterans Healthcare System
Multiple Sclerosis
Combined Exercise Training in Patients With Multiple Sclerosis
It is stated that the affected cognitive functions in Multiple Sclerosis are learning, memory, attention, speed of information processing, visuospatial skills, and executive functions.
- Trial name
- NCT03591809
- Testing
- combined exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Gazi University
Type 1 Diabetes
Efficacy and Safety Study of Autologous Hematopoietic Stem Cell Transplantation to Treat New Onset Type 1 Diabetes
Type 1 diabetes is an autoimmune disease and results from T cell autoimmunity mediated destruction of the majority of insulin-producing pancreatic β-cells.
- Trial name
- NCT01341899
- Testing
- immunosuppression and stem cell transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Seasonal Allergic Rhinitis
Seasonal Allergic Rhinitis and Driving Ability
On-the-road driving performance of untreated seasonal allergic rhinitis patients during the allergic season (exposed) is compared to driving performance outside the allergic season (in winter, not-exposed).
- Trial name
- NCT00223587
- Testing
- 1 week of treatment discontinuation
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Utrecht Institute for Pharmaceutical Sciences
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Effect of Acute Hypoglycaemia on Cognitive Function and Brain Activation Patterns in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of the trial is to compare cognitive function and associated brain activation patterns during an acute hypoglycaemic episode and during euglycaemia (normal blood glucose concentration).
- Trial name
- NCT01789593
- Testing
- glucose clamp
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- Novo Nordisk A/S
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission
Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Reducing CMV Related Complications in Patients With Blood Cancer Undergoing Donor Stem Cell Transplant
This randomized phase II trial studies how well multi-antigen cytomegalovirus (CMV)-modified vaccinia Ankara vaccine works in reducing CMV related complications in patients with blood cancer who are undergoing donor stem cell…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Bone Marrow Transplantation Recipient
- Trial name
- NCT03438344
- Testing
- Multi-antigen CMV-Modified Vaccinia Ankara Vaccine, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Sponsor
- City of Hope Medical Center
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