Clinical trials: Immune System Function
Type 1 Diabetes, Type 2 Diabetes
The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
The investigators recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1.
- Trial name
- NCT06976619
- Testing
- Liraglutide Pen Injector, Saline Injections
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Asthma, Allergic Rhinitis
Longitudinal Observational Study in Prematurely Born Preschool Children: Assessment of Lung Function Parameters
The PRE-AR project is a longitudinal observational study. The primary objective is the assessment of lung function parameters in late preterm preschool children.
- Trial name
- NCT02636933
- Testing
- Lung Function Assessment
- Where
- Italy
- Volunteers
- 152 people
- Sponsor
- Stefania La Grutta, MD
Type 1 Diabetes
Artificial Pancreas - Adolescent Physiology & Psychology Longitudinal Evaluation
This study designed to assess changes in control of Type 1 Diabetes in pubertal adolescents over a two year period. There are two arms/substudies, the first being a longitudinal randomized controlled trial and the second an…
- Trial name
- AP APPLE (NCT04510506)
- Testing
- Artificial Pancreas (AP)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Virginia
Erectile Dysfunction, Type 1 Diabetes Mellitus
Collagen Scaffolds Loaded With HUCMSCs for the Improvement of Erectile Function in Men With Diabetes
The intent of this clinical study is to answer the questions: 1) is the proposed treatment feasible; 2) is treatment effective in improving the disease pathology of patients with diagnosed diabetic erectile dysfunction.
- Conditions
- Erectile Dysfunction, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
- Trial name
- NCT02579148
- Testing
- HUCMSC injection, collagen scaffolds/HUCMSC injection
- Where
- China
- Sponsor
- Leilei Zhu
Multiple Sclerosis
An Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocrelizumab Treatment
The study will evaluate the physical impact of MS from participant's perspective, provide continued access to ocrelizumab and assess the safety and tolerability of ocrelizumab.
- Trial name
- OleroMAX (NCT06675955)
- Testing
- Ocrelizumab
- Where
- 56 sites in Bulgaria, France and 4 more
- Volunteers
- 500 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Study of the Functional Status Neutrophils in Rheumatoid Arthritis Patients to Identify New Biomarkers of Response to Anti-TNFalpha Therapy
The goal of this interventional pathophysiological exploratory, cohort, prospective, with a 6-month follow-up study is to characterize phenotypic and functional alterations of PolyMorphonuclear Neutrophils as well as…
- Trial name
- NeutroARTherap (NCT05802719)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Healthy, Cystic Fibrosis (CF)
MRI for Non-Invasive Imaging in Neonates and Children
The purpose of this study is to develop rapid MRI techniques for imaging the lung with hyperpolarized helium-3 gas as an inhaled contrast agent.
- Conditions
- Healthy, Cystic Fibrosis (CF), Asthma, Bronchopulmonary Dysplasia (BPD)
- Trial name
- NCT02163681
- Testing
- Hyperpolarized Helium-3 MRI of the chest
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes
Combination Therapy With Sitagliptin and Lansoprazole to Restore Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes
Sanford Research/USD proposes to study the combination therapy of oral administration of sitagliptin and lansoprazole versus placebo for the preservation of pancreatic beta cells still present in patients with recent-onset…
- Trial name
- REPAIR-T1D (NCT01155284)
- Testing
- Sitagliptin and Lansoprazole
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Lymphoma, B-Cell
The Clinical Implications of Immune Checkpoint Pathways in PCNSL
Central nervous system lymphoma (CNSL) is a rare brain tumor constituting 3% of all newly diagnosed brain tumors, and 2% to 3% of all cases of non-Hodgkin lymphoma. There are two subtypes of CNSL.
- Trial name
- NCT04158128
- Testing
- non-intervention
- Where
- Taiwan
- Volunteers
- 46 people
- Sponsor
- National Taiwan University Hospital
Multiple Sclerosis
Study of Exercise on Impact of Cognitive Functioning in Multiple Sclerosis Patients
Cognitive impairment affects roughly 50% of people with multiple sclerosis (MS). There are currently no satisfactory medical treatments for cognitive impairments related to MS and alternative forms of treatment are needed.
- Trial name
- NCT02106052
- Testing
- Aerobic exercise, Stretching and toning exercise
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Washington
Multiple Sclerosis
Modulation of Plasmacytoid Dendritic Cell Function in Multiple Sclerosis
The purpose of this study is to determine whether interferon-beta impairs the ability of plasmacytoid dendritic cells to promote pathogenic immune responses in patients with multiple sclerosis.
- Trial name
- NCT00468182
- Testing
- Interferon-beta 1b (Betaseron)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Rutgers, The State University of New Jersey
Arthroplasty, Replacement, Knee, Recovery of Function
The Influence of Rapid Recovery on Sleep Quality Following Total Knee Replacement Surgery
The purpose of this study is to evaluate the influence of rapid recovery on sleep quality following total knee replacement surgery.
- Conditions
- Arthroplasty, Replacement, Knee, Recovery of Function, Arthritis, Rheumatoid
- Trial name
- NCT02845960
- Testing
- rapid recovery
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Southwest Hospital, China
Dementia, Dementia, Vascular
Feasibility of the SmartPrompt for Improving Everyday Function in Dementia
Difficulty completing everyday tasks is a primary reason for the high cost of care, loss of caregiver paid hours, and general caregiver burden associated with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia Alzheimers, Dementia, Mixed
- Trial name
- SmartPrompt (NCT04313582)
- Testing
- SmartPrompt smartphone application
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Temple University
Relapsing-Remitting Multiple Sclerosis
A Proof of Concept Study to Evaluate the Effectiveness of Tysabri in Relapsing Remitting Multiple Sclerosis (RRMS) Patient Bladder Function
The primary objective of the study was to measure the change in bladder function as measured by Urogenital Distress Inventory (UDI)-6 compared to baseline over 6 months of Tysabri treatment.
- Trial name
- TRUST (NCT00818038)
- Testing
- BG0002 (natalizumab)
- Volunteers
- 30 people
- Sponsor
- Biogen
Asthma
A Study to Evaluate the Onset of Effect and Time Course of Change in Lung Function With Benralizumab in Severe, Uncontrolled Asthma Patients With Eosinophilic Inflammation
The purpose of this study is to investigate the onset and maintenance of effect of benralizumab on lung function, blood eosinophils, asthma control metrics and quality of life during 12-week treatment in patients with…
- Trial name
- SOLANA (NCT02869438)
- Testing
- Benralizumab
- Where
- 54 sites in United States, Chile and 4 more
- Volunteers
- 233 people
- Sponsor
- AstraZeneca
Spondylarthritis, Spondylarthropathies
Core Stabilization Training in Juvenile Spondyloarthropathy
Core stabilization exercises developed by McGill have been shown to be one of the physiotherapy techniques aimed at reducing pain, increasing aerobic capacity, enhancing muscle strength, and thereby improving bone health in…
- Conditions
- Spondylarthritis, Spondylarthropathies, Juvenile Idiopathic Arthritis
- Trial name
- NCT06546293
- Testing
- core stabilization exercises, daily physical activity program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis
Investigation of Factors Affecting Functional Capasity in Multiple Sclerosis
Functional exercise capacities of Multiple Sclerosis (MS) patients decrease with the effect of symptoms and sedentary lifestyle.
- Trial name
- NCT06090084
- Testing
- Evaluation
- Volunteers
- 140 people
- Sponsor
- Izmir Bakircay University
Asthma, Rhinitis
Evaluation of Different Disease Control Indices in Children With Asthma and Rhinitis
In this study will be consecutive enrolled children with asthma (classified according to GINA guidelines) and rhinitis (classified by ARIA guidelines); the investigators will research clinical personal and parental history…
- Trial name
- NCT00952835
- Testing
- regular treatment
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Universita di Verona
Exercise Induced Bronchoconstriction, Asthma
Exercise Induced Bronchoconstriction and Field Tests
Asthma and exercise induced bronchoconstriction (EIB) represent an important challenge for the athlete, and correct diagnosis is important as it affects health as well as performance with strict regulations concerning asthma…
- Trial name
- EXCIT (NCT04275648)
- Testing
- AsthmaTuner exercise field test
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Multiple Sclerosis
Functions, Physical Activity and Employment for Individuals With MS: A Pilot Feasibility Study
Multiple Sclerosis (MS) is a chronic disease affecting young adults. Impaired balance, walking, reduced physical activity and participation in employment are common, however, less integrated in the health care.
- Trial name
- CoreDISTp (NCT05057338)
- Testing
- CoreDISTparticipation, Standard care
- Where
- 2 sites in Norway
- Volunteers
- 30 people
- Sponsor
- Nordlandssykehuset HF
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.