Clinical trials: Immune System Function
Sjogren's Syndrome
Functional Analysis of Salivary Glands and Correlation With Sialoscintigraphy in Sjogren's Syndrome
Sjögren's syndrome is a complex autoimmune disorder. The investigators hypothesize that striated ductal cells may function as non-professional antigen-presenting cells in Sjögren's syndrome.
- Trial name
- NCT06536075
- Testing
- Sialoscintigraphy
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HIV/AIDS
The Effects of Exercise Training in Vascular Function of Patients Living With HIV
Introduction: It is well known that the infection caused by the Human Immunodeficiency Virus (HIV) is associated to a higher cardiovascular event risk.
- Trial name
- NCT03343522
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
Adjuvant Chemotherapy, Colon Cancer
Modulation of Immune Response by Oral Zinc Supplementation in Chemotherapy for Colon Cancer
In leukocytes of patients undergoing adjuvant chemotherapy for colon cancer treatment: a)identify genes modulated by oral supplementation of zinc; b) evaluate the effects of oral zinc supplementation on humoral immunity and…
- Conditions
- Adjuvant Chemotherapy, Colon Cancer, Immunity
- Trial name
- NCT01261962
- Testing
- zinc
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
TYPE 1 DIABETES
β-cell Function in Type 1 Diabetes May Not Be As Low As Presumed
Enhancing endogenous insulin production in type 1 diabetic patients (T1DP) can improve glycemic control and decrease complications and rates of mortality.
- Trial name
- NCT02199470
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Gonca Incemehmet Tamer
Brain-damaged Patients
IRM Cognition in Patients With Head Trauma
Longitudinal descriptive study of a cohort of twenty brain-damaged patients for a two years period.
- Trial name
- NCT03181373
- Testing
- Cognitive rehabilitation program
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Clermont-Ferrand
Asthma, Chronic Obstructive Pulmonary Disease (COPD), or Chronic Lung Disease (E.G., Chronic Bronchitis and Restrictive Lung Diseases Such as Asbestosis), The Effect of Yoga, Paranayama Yoga Practice on Respiratory Diseases
EFFECT OF PRANAYAMA YOGA ON COPD
The aim of the study In this study, pranayama yoga practices are the sub-dimensions of respiratory parameters, symptom and disease affection level, psychosocial adjustment and psychosocial adjustment in individuals with COPD.
- Trial name
- COPD (NCT06022627)
- Testing
- Pranayama Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Asthma Management, Time Restricted Eating
Investigating the Impact of Early Time-Restricted Eating on Health Outcomes and Quality of Life in Adults With Mild Controlled Asthma Compared to Healthy Adults
This study aims to explore how early time-restricted eating (eTRE) - where all daily meals are eaten within a specific time window - affects health and quality of life in adults.
- Trial name
- eTRE (NCT07345572)
- Testing
- Early Time-Restricted Eating (eTRE) and Habitual Diet (HD), Habitual Diet (HD) and Early Time-Restricted Eating (eTRE)
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- De Montfort University
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Colorectal Cancer (MSI-H), Anxiety
Impact of Anxiety-Sleep Symptom Cluster on Immune Function and Quality of Life in Colorectal Cancer
This prospective observational study investigates the impact of the anxiety-sleep disturbance symptom cluster on cellular immune function and quality of life in colorectal cancer (CRC) patients undergoing chemotherapy.
- Trial name
- NCT07234682
- Testing
- standard-of-care chemotherapy
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Hebei Provincial Hospital of Traditional Chinese Medicine
Multiple Sclerosis
Relıabılıty and valıdıty of the supıne-to-stand Test wıth Multiple Sclerosis
Background: Supine-to-Stand Test (SST) requires muscle strength, flexibility, and dynamic balance and can be used as a marker of functional motor competence in patients with Multiple Sclerosis (pwMS).
- Trial name
- NCT06790992
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Sanko University
Multiple Sclerosis
Active and Mindful - A Mind-Body Programme for People With Multiple Sclerosis: a Feasibility Study Protocol
The purpose of this exploratory study is to evaluate the feasibility and acceptability of the "Active and Mindful" home-based mind-body exercise program for individuals diagnosed with Multiple Sclerosis (MS) in Portugal and…
- Trial name
- NCT07654699
- Testing
- Active and Mindful Program
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Catarina Alexandra Nunes Martins
HIV Infections
A Study of the Pharmacokinetics and Safety of BMS-663068 Administered in Subjects With Normal Renal Function and With Mild, Moderate, Severe and End Stage Renal Dysfunction (ESRD)
An oral dose in healthy and renally impaired subjects to determine the drug effect for BMS-663068.
- Trial name
- NCT02674581
- Testing
- Oral BMS-663068 (pro-drug)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Relapsed Graves' Disease, Thyroid; Functional Disturbance
A Prospective Evaluation of Radiofrequency Ablation in the Treatment of Relapsed Graves' Disease.
There have been previous reports of using High-intensity focused ultrasound (HIFU) as a feasible thermal ablative treatment for relapsed Graves' disease.
- Conditions
- Relapsed Graves' Disease, Thyroid; Functional Disturbance, Radiofrequency Ablation Treatment
- Trial name
- NCT06418919
- Testing
- Radiofrequency ablation treatment
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Irritable Bowel Syndrome (IBS)
The Diagnostic Predictability of Food Allergy Testing
Irritable bowel syndrome (IBS) sufferers often find that specific foods can exacerbate their symptoms; identifying which foods involves a long and arduous process.
- Trial name
- FAST (NCT01791621)
- Testing
- Elimination/Challenge Diet
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Atopic Eczema
Effect of Moisturizing Creams on Skin Barrier Function
This study is a randomized, double-blind, placebo-controlled bilateral study on the effect of moisturizing creams on skin barrier function.
- Trial name
- NCT00771121
- Testing
- urea/lactic acid
- Where
- 2 sites in Sweden
- Sponsor
- ACO Hud Nordic AB
Primary Immune Deficiency, Exercise Capacity
Evaluation of Adult Patients With Immunodeficiency Within the Scope of the ICF
Primary immunodeficiency is a clinically, immunologically, and genetically heterogeneous group of diseases that occur as a result of quantitative and/or qualitative deficiency of one or more cellular and molecular components…
- Conditions
- Primary Immune Deficiency, Exercise Capacity, Physical Activity, Quality of Life
- Trial name
- NCT06014463
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Asthma, Allergy
Effects of Plant Stanols on Immune Function in Asthma Patients
Rationale: Plant stanols are well known for their effects on lowering intestinal cholesterol absorption ultimately resulting in 10-15% reduced serum LDL cholesterol concentrations in humans.
- Trial name
- NCT01715675
- Testing
- Plant stanol enriched soy-based yoghurt, Soy-based yoghurt without added plant stanols
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- Maastricht University Medical Center
Type 1 Diabetes Mellitus, New-onset Type 1 Diabetes Mellitus
Tocilizumab (TCZ) in New-onset Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Based on previous research, study doctors think that giving medicines to affect the immune system soon after diabetes is diagnosed may stop, delay or decrease the…
- Conditions
- Type 1 Diabetes Mellitus, New-onset Type 1 Diabetes Mellitus, T1DM, T1D
- Trial name
- EXTEND (NCT02293837)
- Testing
- Tocilizumab (TCZ), Standard of Care
- Where
- 19 sites in United States, Australia
- Volunteers
- 136 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis, Swelling Joint
Characterization of Regulatory T Lymphocytes in the Synovial Fluid of Patients Affected by Rheumatoid Arthritis.
In rheumatoid arthritis (RA) the clinical response to anti-TNFα is related to an increase in the number or in the function of Treg lymphocytes in the peripheral blood of patients.
- Conditions
- Rheumatoid Arthritis, Swelling Joint, Joint Fluid, Characterization of Regulatory T Lymphocytes
- Trial name
- CATERLIS (NCT03293667)
- Testing
- Exploratory synovial fluid analysis
- Where
- France
- Volunteers
- 19 people
- Sponsor
- University Hospital, Montpellier
Multiple Sclerosis
LUNA-EMG to Enhance Motor Functions in Multiple Sclerosis
The aim of the present study is to evaluate the effects of training performed with the LUNA-EMG system to enhance motor functions of the lower limb in multiple sclerosis. This is a randomized open-label trial.
- Trial name
- LUNA-MS (NCT04720898)
- Testing
- LUNA-EMG
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- University of Liege
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