Clinical trials: Immune System Function
Multiple Sclerosis
Feasibility and Acceptability of Orthotic Shorts for People With Multiple Sclerosis
Walking can be slow and unsteady in people with multiple sclerosis (MS). This study will investigate whether orthotic shorts might help.
- Trial name
- NCT03164031
- Testing
- Close-fitting orthotic shorts, Looser fitting shorts
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Sheffield Hallam University
Cocaine Use, Cocaine Dependence
rTMS and Cognitive-behavioral Therapy for Cocaine Use Disorder
The goal of the study is to investigate the feasibility, safety, and effect of rTMS on mPFC/dACC activity using a combination of fMRI and clinical outcome measures, when used as an augmentation to CBT.
- Conditions
- Cocaine Use, Cocaine Dependence, Cocaine Use Disorder, Cocaine Use Disorder, Moderate
- Trial name
- COAST (NCT05974202)
- Testing
- Active H7-coil repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Herpes Zoster, HIV Infections
Live Zoster Vaccine in HIV-Infected Adults on Antiretroviral Therapy
Herpes zoster, or shingles, is the result of a viral infection that causes a painful skin rash, usually in older people or people with suppressed immune systems like those infected with HIV.
- Trial name
- NCT00851786
- Testing
- ZOSTAVAX
- Where
- 43 sites in United States
- Volunteers
- 395 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections, Dyslipidemia
Study of Niacin on Endothelial Function in HIV-infected Subjects With Low High Density Lipoprotein Cholesterol Levels
This study is a pilot study examining the effect of extended-release niacin (Niaspan ®) on flow-mediated vasodilation (FMD) of the brachial artery, among human immunodeficiency virus (HIV)-1 infected individuals with low high…
- Conditions
- HIV Infections, Dyslipidemia, Endothelial Dysfunction
- Trial name
- NCT00986986
- Testing
- extended release niacin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Type 1 Diabetes
Immune Intervention With Rituximab to Preserve Beta Cell Function in Early Onset Type 1 Diabetes
Transient elimination of B lymphocytes with anti-CD20 monoclonal antibody would decrease immune-mediated destruction of beta cells and result in preserved beta-cell function in patients with type 1 diabetes of recent onset.
- Trial name
- NCT01280682
- Testing
- rituximab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Yang Tao
Upper Respiratory Tract Infections
Vitamin D Supplementation and Upper Respiratory Tract Infections in Adolescent Swimmers
Background: The medical and economic burden of upper respiratory tract infections (URTIs) is extremely high, while prevention and treatment options are limited.
- Trial name
- NCT01215682
- Testing
- vitamin D
- Where
- 4 sites in Israel
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Type 1 Diabetes (T1D)
Effect of Melatonin Supplementation on Excecutive Functions, Sleep Quality and Glycemic Metrics Among Adolescents With Type 1 Diabetes Mellitus
Cognitive impairment, poor sleep quality, Alzheimer's disease and dementia are complications of uncontrolled type 1 diabetes (T1D).
- Trial name
- MS642/2024 (NCT07592442)
- Testing
- Melatonin tablet 3 mg once daily
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Non Hodgkin Lymphoma
Long-term Cognitive, Neuropsychiatric and Functional Outcomes in Adults Who Have Received Chimeric Antigen-Receptor T-Cell (CAR-T) Therapy for Aggressive Lymphoma at Stanford
This study aims to assess the feasibility of performing neuropsychological testing to measure the cognitive performance of individuals following Axicabtagene ciloleucel CAR-T therapy at Stanford.
- Trial name
- NCT05416554
- Testing
- Neuropsychological testing
- Where
- United States
- Sponsor
- Stanford University
HIV Infections
Treatment of Acute HIV Infection to Preserve Immune Function
While most people with HIV experience significant destruction of their immune systems, some people appear to have preserved immune function and can control the virus without drugs.
- Trial name
- NCT00055094
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Allergic Rhinitis
Pilates Training in Patients With Allergic Rhinitis
The purpose of this study was to determine the effects of pilates training on symptoms in patients with allergic rhinitis.
- Trial name
- NCT05693883
- Testing
- Pilates training
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Chulalongkorn University
Cirrhosis, Liver, Splenectomy; Status
The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on the Immune Function for Cirrhosis Patients
In this study, the investigators compared the improvement of immune function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection.
- Trial name
- ELSDI (NCT05338294)
- Testing
- Laparoscopic splenectomy and azygoportal disconnection
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Northern Jiangsu People's Hospital
Intestinal and Lmmune Function Lmproved
Investigating the Efficacy of Probiotics in Enhancing Gastrointestinal and Immunological Health
Evaluate the effectiveness and safety of Ligilactobacillus salivarius LS97 as a food supplement compared to a placebo in improving intestinal and immune functions in healthy adults.
- Trial name
- NCT06886724
- Testing
- Probiotic
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Multiple Sclerosis, Hearing Disorders
Auditory Functions in Patients With Multiple Sclerosis
The study will analyze the auditory functions of patients with Multiple Sclerosis using auditory tests like pure tone auditory test, speech perception test, Auditory Brain Response (ABR) and Distortion Product Otoacustic Emission…
- Trial name
- NCT06164483
- Testing
- Auditory test, CSF sampling
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Catania
HIV Infections
A Phase IV Study of BMS-232632 in HIV+ Patients With Metabolic Syndrome
The purpose of this clinical research study is to learn if BMS-232632 administered as Atazanavir/ritonavir (ATV/RTV) is superior to an anti-retroviral regimen including Lopinavir/ritonavir (LPV/RTV), as assessed by an increased…
- Trial name
- NCT00312754
- Testing
- Atazanavir
- Where
- 6 sites in France
- Volunteers
- 70 people
- Sponsor
- Bristol-Myers Squibb
Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies
RATIONALE: Deferasirox may remove excess iron from the body caused by blood transfusions. PURPOSE: This clinical trial studies deferasirox in treating iron overload caused by blood transfusions in patients with hematologic…
- Conditions
- Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01273766
- Testing
- deferasirox, laboratory biomarker analysis, enzyme-linked immunosorbent assay
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University Health Sciences
Asthma
Lung Function of Asthmatic Children by Nebulized MgSO4
Asthma is a common chronic respiratory illness which results in frequent wheezing, cough,reduced quality of life. Standard treatment for asthma attack includes oxygen therapy, β2-agonists (e.g.
- Trial name
- NCT01799109
- Testing
- Magnesium Sulfate & albuterol, albuterol, magnesium
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Multiple Sclerosis
EFFECTS OF AEROBIC AND RESISTANCE TRAINING ON IMMUNE FUNCTION IN MULTIPLE SCLEROSIS
Background: Multiple Sclerosis (MS) is a chronic immune-mediated, inflammatory, and neurodegenerative central nervous system disorder characterized by axonal damage.
- Trial name
- ABIF-MS (NCT07640100)
- Testing
- Aerobic and Progressive Resistance Exercise Program, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Seda Saka
Multiple Myeloma
Prospective Evaluation of Taste Function In Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation
The purpose of this study is to study taste disturbances on patients with myeloma who received high dose melphalan.
- Trial name
- NCT03276481
- Testing
- Oral microbiota assessment, Comprehensive chemical gustometry, Measurement of salivary flow
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Plasma Cell Myeloma
Telehealth Exercise Intervention to Improve Physical Function and Frailty in Multiple Myeloma Survivors
This clinical trial examines a telehealth exercise intervention in improving physical function and frailty in multiple myeloma survivors.
- Trial name
- NCT05142371
- Testing
- Best Practice, Exercise Intervention, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- City of Hope Medical Center
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