Clinical trials: Immune System Function
Type 1 Diabetes
Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes
Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk in type 1 diabetes (T1D). The purpose of this study is to measure the effect of metformin on insulin sensitivity, vascular function and…
- Trial name
- MeT1 (NCT01813929)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Asthma
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
This is an interventional, randomized, parallel group, treatment, Phase 3b/4, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function…
- Trial name
- ATLAS (NCT05097287)
- Testing
- Dupilumab
- Where
- 249 sites in United States, Belgium and 21 more
- Volunteers
- 1,339 people
- Sponsor
- Sanofi
HIV Infection, Cardiovascular Disease
Effect of Maraviroc on Endothelial Function in HIV-Infected Patients
The purpose of this study is to determine the potentially beneficial aspects of CCR5 inhibition on inflammation and endothelial function as measured by brachial artery reactivity in antiretroviral treated HIV patients with an…
- Conditions
- HIV Infection, Cardiovascular Disease, Inflammation, HIV Infections
- Trial name
- NCT00844519
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Francisco
Severe Asthma
Effect of Biologicals on Alternative Functions of Eosinophils in Severe Asthma
The investigators will measure different cytokines in the sputum (interleukin ((IL))-3, granulocyte-macrophage colony-stimulating factor ((GM-CSF)), IL5, IL-13, IL-33, IL-4, IL-25 thymic stromal lymphopoietin ((TSLP)) and…
- Trial name
- NCT04520165
- Where
- Belgium
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Liege
Endothelial Function
Peripheral Endothelial Function in Asthmatic Patients
The aim of the study is to assess the peripheral endothelial function in adult asthmatic patients and the relationship between the peripheral endothelial function and the pulmonary function.
- Trial name
- Endothasthm (NCT02593344)
- Testing
- Endopat
- Where
- 2 sites in France
- Volunteers
- 113 people
- Sponsor
- Hopital Foch
Asthma, Regulatory T Cell Function
Oral Contraceptives and Asthma Control
Asthma is a chronic inflammatory disorder of the airways affecting approximately 15 million individuals in the U.S. The rate of asthma exacerbations among women is twice that of men after adolescence, and a large proportion of…
- Trial name
- NCT00662051
- Where
- United States
- Sponsor
- University of Kentucky
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Assessment of the Effects of a DPP-4 Inhibitor (Sitagliptin) Januvia on Immune Function in Healthy Individuals
Patients with diabetes have high blood sugar levels (hyperglycemia) because pancreatic beta-cells no longer produce sufficient insulin.
- Trial name
- NCT00813228
- Testing
- Sitagliptin (Januvia)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Optic Neuritis
Fampridine-SR and Optic Neuritis Recovery
Optic Neuritis (ON) is a condition that occurs in approximately 50% of individuals with relapse remitting MS, and is the presenting event in 15-20% of patients who go on to develop MS.
- Trial name
- FAMP-ON (NCT04148781)
- Testing
- Fampridine SR
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Courtney Casserly
HIV Infections
Aging & HIV/AIDS Neurocognitive Sequelae and Functional Consequences
While the numbers of HIV infected veterans under the age of 50 are declining, the percentage of HIV infected veterans over the age of 50 is increasing with the largest percentage increases in the 50-59 age group and the 70+ age…
- Trial name
- NCT00675766
- Where
- United States
- Volunteers
- 223 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Gastric Cancer, Enteral Immunonutrition
Effect of Enteral Immunonutrition on Immune, Inflammatory Markers and Nutritional Status in Patients Undergoing Gastrectomy for Gastric Cancer
Enteral immunonutrition (EIN) has been gaining increasing attention, but data of its immune and anti-inflammatory function in patients undergoing gastrectomy for gastric cancer are poorly investigated.
- Trial name
- NCT03730545
- Testing
- enteral immunonutrition
- Volunteers
- 124 people
- Sponsor
- West China Hospital
Mitral Valve Regurgitation
CardiAQ-Edwards™ Transcatheter Mitral Valve Replacement (TMVR) Study
Clinical study to evaluate the safety and performance of the CardiAQ-Edwards™ Transcatheter Mitral Valve
- Trial name
- RELIEF (NCT02722551)
- Testing
- Transcatheter Mitral Valve Re-placement (TMVR) with the CardiAQ-Edwards™ Transcatheter Mitral Valve
- Where
- 15 sites in Canada, Denmark and 5 more
- Sponsor
- Edwards Lifesciences
Colorectal Cancer
The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection
Systemic inflammation caused by surgery may aggravate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity.
- Trial name
- NCT03273231
- Testing
- Ketamine, Saline
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Diabetes Mellitus, Type 1
Effect of Medium Chain Fatty Acids on Cognitive Function During Acute Hypoglycemia in Patients With Type 1 Diabetes
At present, there are no therapeutic agents that can minimize severe hypoglycemia (low blood sugar) and its effects on long-term brain function.
- Trial name
- NCT00592072
- Testing
- Medium chain fatty acid (Octanoic and Decanoic acid)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Yale University
Obesity, Asthma
The Effect of Obesity on Lung Functioning
This research study is looking at the effects of weight loss, due to surgery or structured weight-loss program on lung function, inflammation in your body and lungs, asthma and asthma symptoms.
- Trial name
- NCT00284895
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Jewish Health
Asthma, Asthma in Children
Comparison of Mesh Nebulizer and Compressor Nebulizer With Pulmonary Function Test in Pediatric Asthma Attacks
Asthma is a worldwide health problem and is one of the most common chronic diseases of childhood in most countries. Symptoms begin before the age of 5 years in 80% of children with asthma, but the diagnosis is not always easy.
- Trial name
- NCT06211998
- Testing
- Group 1, Group 2
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Berker Okay
Juvenile Idiopathic Arthritis
PEAK Study (Physical Exercise and Activity in Kids)
The objectives of this study are to study the effect of formal exercise training on motor function and overall physical fitness in children with arthritis. A 12-week comprehensive exercise program will be used.
- Trial name
- NCT00213187
- Testing
- Aerobic and Qi gong Exercise
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- The Hospital for Sick Children
Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
Investigation and Classification of Treatable Traits in Patients With Chronic Airway Diseases
This research study focuses on chronic airway diseases, such as Chronic Obstructive Pulmonary Disease (COPD) and asthma. These conditions make it difficult for patients to breathe, but breathing difficulty (dyspnea) is often…
- Conditions
- Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD), Chronic Airway Diseases
- Trial name
- NCT07472738
- Testing
- Comprehensive Clinical Assessment
- Where
- China
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Asthma
The Ohio State University Asthma Registry
The purpose of this study is to collect information in order to identify people who have asthma and who may be good candidates to participate in one of the future asthma studies to be conducted at The Ohio State University Asthma…
- Trial name
- NCT00839748
- Where
- United States
- Sponsor
- Ohio State University
Toxic Epidermal Necrolysis
Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions (ACDEs): A Pilot Study
The purpose of this study is to determine whether isotretinoin is helpful in treating patients with an adverse cutaneous drug eruption known as toxic epidermal necrolysis (TEN).
- Trial name
- NCT02795143
- Testing
- Isotretinoin
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Respiratory System Abnormalities
Manual Diaphragm Release in Cleaning Laborer
This study intended to examine the effect of manual diaphragm release on pulmonary function, chest wall mobility, and functional ability in female occupational cleaners with respiratory hazards.
- Trial name
- NCT05802355
- Testing
- Manual Diaphragm Release, control group
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- Maged Basha
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