Clinical trials: Immune System Processes
HCV Infection, HIV Infections
Addressing the Cascade of Care in Vulnerable Populations With Poor Access to Healthcare in Madrid
Data on the prevalence of hepatitis C virus (HCV) for other vulnerable groups in Madrid, such as homeless persons and migrants, are scarce, and it is now necessary to implement intervention and elimination plans.
- Conditions
- HCV Infection, HIV Infections, Drug Use, HBV (Hepatitis B Virus)
- Trial name
- (UMC) (NCT04062253)
- Testing
- HCV rapid test
- Where
- Spain
- Volunteers
- 2,001 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Infanta Leonor
Atopic Dermatitis
A Study to Learn If the Study Medicine Called PF-08049820 Changes How the Body Processes the Other Study Medicines Called Oral Contraceptives, Midazolam, and Dabigatran in Healthy Adult Female Participants
The purpose of this study is to see how a medicine called PF-08049820 affects how other medicines move through the body. This information will help plan future studies.
- Trial name
- NCT07190430
- Testing
- PF-08049820, Midazolam, Dabigatran Etexilate
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer
Ebola Virus Disease, Marburg Virus Disease
Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults
Primary Objective: To evaluate the safety and tolerability of cAd3-EBO-S and cAd3 Marburg vaccines when administered Intramuscular (IM) at a dose of 1 x 10^11 particle units (PU) to healthy adults.
- Trial name
- NCT04723602
- Testing
- cAd3-Marburg, cAd3-EBO-S
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Albert B. Sabin Vaccine Institute
Healthy Controls, Chronic Obstructive Pulmonary Disease
Number of Multiple Breath Washout Tests in Adults With Pulmonary Disease and Healthy Controls
The investigators aim to determine the optimal number of measurements required for multiple-breath-washout derived lung function parameters in adults with pulmonary disease as well as in healthy controls
- Conditions
- Healthy Controls, Chronic Obstructive Pulmonary Disease, Bronchial Asthma, Sarcoidosis
- Trial name
- NCT03176745
- Testing
- multiple breath washout
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia
Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)
The aim of this proposal is to identify immune biomarkers, genetic risk, and the clinical consequences of low count monoclonal B-cell lymphocytosis (LC MBL), a common premalignant condition affecting up to 17% of European adults…
- Conditions
- Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia, Infections, Cancers
- Trial name
- MBL RiskConseq (NCT06416267)
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Healthy
Maca in Healthy Subjects After Strenuous Endurance Exercise
The aim of this study is to investigate Lepidium meyenii (Maca) extract supplementation on exercise-induced responses of the biochemical, and physiological parameters.
- Trial name
- NCT05779488
- Testing
- maca
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Healthy Subjects, Purpura, Thrombocytopenic, Idiopathic
Eltrombopag Taste Testing in Healthy Adult Volunteers
Based on a need for a pediatric formulation of eltrombopag for the treatment of pediatric thrombocytopenia, this study will help determine the best tasting pediatric formulation of eltrombopag.
- Trial name
- NCT00487968
- Testing
- eltrombopag
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Periodontitis, Generalized, Moderate
Er:YAG Laser Treatment of Moderate Chronic Periodontitis
The Er:YAG laser possesses specific characteristics allowing to be used in non-surgical periodontal treatment. The aim of the resent study was to evaluate the long-term clinical effectiveness of Er:YAG laser monotherapy in the…
- Trial name
- NCT05217823
- Testing
- Er:YAG laser, hand instruments
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Inflammation, Rheumatoid Arthritis
Safety and Tolerability of Anti-IL-20 in Healthy Volunteers and Patients With Rheumatoid Arthritis
This trial is conducted in Europe. The aim of this clinical trial is to investigate the safety and tolerability of single doses of Anti-IL-20 in healthy volunteers (HV) and patients with rheumatoid arthritis (RA).
- Conditions
- Inflammation, Rheumatoid Arthritis, Healthy
- Trial name
- NCT00818064
- Testing
- anti-IL-20
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Asthma, Dietary Intervention
Vegan Diet and Immune-Inflammatory Outcomes in Asthma and Healthy Adults
This randomized controlled study evaluates the effects of a balanced vegan diet compared with a balanced omnivorous diet on inflammatory and immune response markers and clinical asthma parameters in healthy adults and individuals…
- Conditions
- Asthma, Dietary Intervention, Vegan Diet
- Trial name
- VEGASTHMA (NCT07480369)
- Testing
- Omnivorous diet, Vegan diet
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Cardiac Arrest, Inflammation
Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)
This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after…
- Conditions
- Cardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)
- Trial name
- PCAS (NCT02664831)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Asthma, COPD
Circulating Micro RNAs Expression in Egyptian Bronchial Asthma and COPD Patients
This cross sectional study will be carried out on 30 subjects who will be recruited from the outpatient clinic of Chest Department, Tanta University Hospital.
- Trial name
- NCT02719145
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Primary Immune Deficiency Diseases
Evaluate Bacteriophage as a Useful Immunogen in Patients With Primary Immune Deficiency Diseases (PIDD)
This protocol is designed to ascertain whether the bacteriophage 0X174 neoantigen is safe and effective as an antigen used in the evaluation of primary and secondary immune responses.
- Trial name
- Bacteriophage (NCT01617122)
- Testing
- Bacteriophage OX174
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Chronic Radiation Dermatitis
Pilot Study of the Effect of Laser on Reversing Chronic Radiation Injury
Radiotherapy, an essential modality in cancer treatment, frequently induces a fibrotic process in the skin which can lead to increased risk of malignancy, poor wound healing, pain and limitation of movement, and permanent loss of…
- Trial name
- NCT01910818
- Testing
- Fractional CO2 laser treatment, No treatment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV Infections, Chlamydia Trachomatis
Safety, Acceptability and Preliminary Effectiveness of Carraguard™ (PC-515) in Preventing HIV/STI Transmission
The primary aims of the study were to assess the safety and acceptability of Carraguard ™ (PC-515) when applied vaginally at least three times weekly for 6-12 months.
- Conditions
- HIV Infections, Chlamydia Trachomatis, Neisseria Gonorrhoeae, Trichomonas Vaginitis
- Trial name
- NCT00213018
- Testing
- Carraguard (PC-515)
- Where
- 2 sites in South Africa
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Population Council
Multiple Sclerosis, Remitting-Relapsing Multiple Sclerosis
Cognitive Performance, Sleep Disturbances and Fatigue in Multiple Sclerosis
Fatigue is a prevalent symptom in patients with multiple sclerosis (MS) and is associated with considerable impairment in quality of life as well as loss of occupational capacity.
- Conditions
- Multiple Sclerosis, Remitting-Relapsing Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Secondary Progress Multiple Sclerosis
- Trial name
- NCT07426991
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in Germany
- Volunteers
- 837 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Asthma, Chronic Obstructive Pulmonary Disease
EXhaled Hydrogen Peroxide As a Marker of Lung diseasE (EXHALE) Pilot Study.
This Pilot study evaluates the use of a new device called Inflammacheck and whether it can consistently measure hydrogen peroxide levels in exhaled breath condensate.
- Trial name
- EXHALE Pilot (NCT03055923)
- Testing
- The Inflammacheck Device
- Where
- United Kingdom
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Infectious Diseases, Immunosenescence
Research Project on the Interaction Between Immune Function and Infectious Diseases in Older Adults and the Development of Prevention and Control Strategies
As population aging accelerates, infectious diseases have become a major factor affecting the health, quality of life, and survival outcomes of older adults.
- Conditions
- Infectious Diseases, Immunosenescence, Aging
- Trial name
- NCT07644962
- Volunteers
- 23,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Punch Biopsy Wounds, Healing Times
Healing of Punch Graft Wounds. Comparative Study Between MariGen and Oasis: a Non-inferiority Study
The objective is to determine, if healing of punch biopsy wounds treated with the fish skin derived MariGen Wound dressing is non-inferior to healing with wounds treated with pig intestines derived Oasis Sheet wound dressing.
- Trial name
- NCT01917591
- Testing
- Punch biopsies treated with MariGen Wound ECM dressing, Punch biopsies treated with Oasis ECM dressing
- Where
- Iceland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Kerecis Ltd.
Multiple Sclerosis, Depressive Disorder, Major
Depression and Immune Function in Multiple Sclerosis (MS)
Depression is one of the most common symptoms of multiple sclerosis (MS) with a life-time prevalence of major depressive disorder (MDD) of up to 50%.
- Trial name
- DENIM (NCT02740296)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany