Clinical trials: Immune System Tolerance
Gastroschisis
Oral Care in Infants With Gastroschisis
Gastroschisis is a rare abdominal wall defect. Though survival rate is high, there are significant complications related to feeding intolerance and infections.
- Trial name
- NCT03393832
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Baylor College of Medicine
Phenylketonurias
Study of Phenoptin to Increase Phenylalanine Tolerance in Phenylketonuric Children on a Phenylalanine-restricted Diet
The primary objective of this trial is to evaluate the ability of Phenoptin to increase phenylalanine (phe) tolerance in children with phenylketonuria who are following a phe-restricted diet.
- Trial name
- NCT00272792
- Testing
- Sapropterin Dihydrochloride
- Where
- 9 sites in United States
- Volunteers
- 45 people
- Sponsor
- BioMarin Pharmaceutical
Allergic Conjunctivitis, Allergic Rhinitis
Study Evaluating Safety of Ragweed Mix Given by Intralymphatic Node Injections
A safety study conducted on subjects ≥16 years old evaluating the safety of 4 intralymphatic injections of 2 different dose levels of the investigational short and tall ragweed product.
- Trial name
- NCT03038971
- Testing
- Dose Level 1, Dose Level 2
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Woodmont Pharmaceuticals, Inc.
Healthy
Pharmacokinetic Study of CXB909 in Healthy Male Subjects
The primary objective of this dose escalation study is to examine the safety, tolerability, and pharmacokinetic properties of single-doses of CXB909, compared to placebo, in healthy male volunteers.
- Trial name
- NCT01505907
- Testing
- CXB909
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CeNeRx BioPharma Inc.
Childhood Obesity
Leipzig Childhood Obesity Study
The aim of this study is to identify polymorphisms that make children and adolescents more prone to obesity and metabolic dysfunction, as well as to identify biomarkers that are linked to causes and consequences of obesity.
- Trial name
- NCT04491344
- Where
- Germany
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Metastatic Colorectal Cancer
Toxicity/Benefit Ratio Optimization of Chemotherapy in Colorectal Cancer (CRC) Patients by Determination of Individual Genotypic Determinants
This study intends to optimize a fluorouracil/irinotecan chemotherapy regimen by the identification of individual thymidylate synthase (TS) and UDP-glucuronosyltransferase 1 (UGT1A1) polymorphisms before the first administration.
- Trial name
- NCT00138060
- Testing
- irinotecan, 5 fluorouracil
- Where
- 6 sites in France
- Volunteers
- 71 people
- Sponsor
- Institut de Recherche Clinique sur les Cancers et le Sang
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Trial name
- NCT02436213
- Testing
- Cardiopulmonary exercise test, Blood test
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Feeding Intolerance, Necrotizing Enterocolitis
Enteral Granulocyte Colony Stimulating Factor and Erythropoietin Early in Life Increases Feeding Tolerance in Preterm Infants: A Randomized Controlled Trial
With preterm birth, the ingestion of amniotic fluid containing enterocyte trophic factors ceases abruptly. This likely predisposes them to villous atrophy feeding intolerance and necrotizing enterocolitis(NEC) once feedings are…
- Trial name
- NCT01441427
- Testing
- recombinant human G-CSF, and rhEPO, rh G-CSF, rh EPO
- Volunteers
- 93 people
- Sponsor
- Ain Shams University
Chronic Obstructive Pulmonary Disease
Effect of Inspiratory Muscle Training During PR on Dyspnoea and Exercise Tolerance in COPD Patients
Chronic obstructive pulmonary disease is a respiratory disease that results in progressive airflow limitation and respiratory distress.
- Trial name
- NCT04120142
- Testing
- Pulmonary rehabilitation+IMT, Pulmonary rehabilitation
- Where
- Tunisia
- Volunteers
- 34 people
- Sponsor
- Faculty of Medicine, Sousse
Renal Transplant Rejection, Tolerance
Study of Combined Kidney and Blood Stem Cell Transplant From a Brother or Sister Donor
The purpose of this study is to find out if an investigational treatment will allow kidney transplant recipients to better accept their new kidney and stop immunosuppressive medicines.
- Conditions
- Renal Transplant Rejection, Tolerance, Kidney Transplant
- Trial name
- NCT03707262
- Testing
- Donor CD34+ and CD3+ cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jeffrey Veale, MD
Impaired Glucose Tolerance, Type2 Diabetes
Influence of Preprandial Metformin Administration on Carbohydrate Absorption
Type 2 diabetes is spreading worldwide as well as obesity. Metformin is the most prescribed antidiabetic medication. One suggested mechanism of action is by decreasing carbohydrate absorption.
- Trial name
- METTIME (NCT04018105)
- Testing
- Oral glucose tolerance test (OGTT) with or without metformin
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Metastatic Breast Cancer
Liposomal Doxorubicin and Docetaxel in Metastatic Breast Cancer
Evaluation of safety and efficacy of a treatment associating Pegylated Liposomal Doxorubicin + Docetaxel in patients with metastatic breast cancer
- Trial name
- NCT00524810
- Testing
- Pegylated liposomal doxorubicin, Docetaxel
- Where
- France
- Volunteers
- 67 people
- Sponsor
- ARCAGY/ GINECO GROUP
ARDS, Mechanical Ventilation
Role of Pulmonary Perfusion on Tolerance to Supine Position in Patients With ARDS
The relationship between the presence or absence of endothelial dysfunction and changes in pulmonary perfusion will be evaluated, to then determine if there is any association between changes in the V / Q ratio and tolerance to…
- Conditions
- ARDS, Mechanical Ventilation, Prone Position
- Trial name
- NCT05408442
- Testing
- No intervention
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Influenza, Acute Respiratory Distress Syndrome
The Role of Cxcr4Hi neutrOPhils in InflueNza
Influenza is still responsible for more than 650,000 deaths per year worldwide and no major improvements in patients' care has been made despite 50 years of research.
- Trial name
- CHOPIN (NCT06254313)
- Testing
- Additional tubes and LBA
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Bordeaux
Glucose Tolerance Impaired
Dose Response Relationship Between Fat Ingestion and Metabolism
The goal of this clinical trial is to compare features of metabolism in healthy, young adults after they consume four meals of differing fat quantity.
- Trial name
- AFDR (NCT05906342)
- Testing
- 20% fat meal, 40% fat meal, 60% fat meal
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity & Overweight, Insulin Resistance Syndrome
SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level
This single-center, randomized, single-blind, 2-period crossover interventional study will evaluate whether exposure to a pleasant food odor 10 minutes before a 75 g oral glucose tolerance test (OGTT) modifies glucose homeostasis…
- Trial name
- SENSILNS (NCT07638111)
- Testing
- Pleasant Food Odor Stimulation, Control Environmental Condition
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Rheumatoid Arthritis
Study Evaluating the Tolerance and Safety of Enbrel (Etanercept) in Adults and Children
This postmarketing surveillance study will evaluate the safety profile of Enbrel (etanercept) in an Indian population. It will provide surveillance on a currently approved indication for Enbrel of reducing symptoms and inhibiting…
- Trial name
- NCT00484809
- Testing
- Enbrel (Etanercept)
- Volunteers
- 100 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Urinary Incontinence, Medical Device Discomfort
Tolerance, Use and Performance of the PEASY Urine Collection Device in Hospitalized Patients
At present, 3 types of urine collection device can be distinguished: absorbent devices (diaper-type), penile clamps and penile collection sheaths.
- Trial name
- TUPELO (NCT07028996)
- Testing
- Daily use of the PEASY urine collection device for 5 days, Daily collection of patient feedback using a visual analog scale (0-100)
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Nicotine Dependence
Human Laboratory Study Of Varenicline in Smokers
The purpose of this study is to test the ways that a drug called varenicline helps smokers to quit smoking. Varenicline is also called Chantix® and is approved by the United States Food and Drug Administration (FDA) to help…
- Trial name
- NCT00709696
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity
A Tolerance and Pharmacokinetic Study of Trodusquemine in Healthy Volunteers
The purpose of this study is to evaluate the safety and tolerance of single intravenous (through a vein) doses of trodusquemine. Different amounts of trodusquemine will be given to each volunteer group throughout the study.
- Trial name
- NCT00509132
- Testing
- trodusquemine
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Genaera Corporation