Clinical trials: Immune System Tolerance
Solid Tumors, Malignant Hemopathy
Nivestim® (Filgrastim) Tolerance in Patients Treated by Toxic Chemotherapeutic Agents
The main aim of the study is to assess the safety of Nivestim® treatment in patients treated with neutropenia-inducing chemotherapy for a malignant disease, solid tumor or a malignant hemopathy.
- Conditions
- Solid Tumors, Malignant Hemopathy, Chemotherapy-induced Febrile Neutropenia (FN)
- Trial name
- NCT01574235
- Testing
- Nivestim®
- Where
- 87 sites in France
- Volunteers
- 2,114 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Neonatal Respiratory Distress
Tolerance of nHFPV Versus nCPAP in Neonatal Respiratory Distress
Respiratory distress is the main cause of morbimortality in preterm and term neonates. In most of the case, these babies required the use of positive end expiratory pressure (PEEP) delivered by a non invasive device.
- Trial name
- TONIPEP (NCT02030691)
- Testing
- Nasal continuous airway positive pressure (nCPAP), Nasal high frequency percussive ventilation (nHFPV)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Bordeaux
Diabetes, Gestational
Challenging the Gold Standard: Pilot Study Comparing Continuous Glucose Monitoring System (CGMS), Capillary Glucose Monitors and 3 Hour Glucose Tolerance Test (GTT) to Diagnose Gestational Diabetes Mellitus (GDM)
The purpose of this research study is to compare 3 methods of measuring blood glucose (blood sugar) levels to see if the finger-stick method or the continuous glucose monitoring system is better than or as good as the 3 hour…
- Trial name
- NCT01074489
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Cincinnati
Disease Related Malnutrition
Tolerance and Acceptability of an Oral Nutrition Supplement
The goal of this study is to learn whether a new oral nutritional supplement is acceptable to adults who are malnourished, or at risk of malnutrition, and need nutritional support.
- Trial name
- NCT07904715
- Testing
- Oral nutritional supplementation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Aymes International Limited
Topical Penile Exposures
Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures
The purpose of this study is to determine the safety of male genitalia when exposed to dapivirine gel following seven once daily applications.
- Trial name
- NCT01277640
- Testing
- dapivirine
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- International Partnership for Microbicides, Inc.
Type 1 Diabetes
Study of the Acute Metabolic Effect of Exenatide in Type 1 Diabetes
The study is designed as an open labeled pilot trial to analyze the acute responses of glucose, GLP-1, GIP, insulin secretory,and glucagon to a mixed meal tolerance test (MMTT) or intravenous glucose tolerance tests (IVGTT) with…
- Trial name
- NCT01855490
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Spinal Cord Injuries, Pressure Ulcer
Alternating Pressure Overlay on Weight Bearing Tissue Tolerance in People With Spinal Cord Injury
The purpose of this study is to test if the newly-developed Dabir alternating pressure (AP) overlay could be beneficial to preventing skin damage during daily activities, such as lying in bed.
- Trial name
- NCT03317288
- Testing
- Dabir Air overlay
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Illinois Chicago
Muscle Stretching Exercises, Pain Threshold
Muscle Stretching - the Potential Role of Endogenous Pain Inhibitory Modulation on Stretch Tolerance
This study investigates the influence of a remote, painful stimulus on stretch tolerance. Half of the participants will receive a conditioning painful stimulus following static stretching while the other half will rest quietly.
- Trial name
- NCT03713788
- Testing
- Cold pressor test
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Kidney Transplantation, Renal Transplantation
Tolerance by Engaging Antigen During Cellular Homeostasis
Anti-rejection medicines, also known as immunosuppressive drugs, are prescribed to organ transplant recipients to prevent rejection of the new organ.
- Conditions
- Kidney Transplantation, Renal Transplantation, Renal Transplant Recipient
- Trial name
- TEACH (NCT03504241)
- Testing
- Donor-derived Mesenchymal Stromal Cells, alemtuzumab, belatacept
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gestational Diabetes Mellitus (GDM), Pregnancy Complications
Glycemic Markers for Predicting Gestational Diabetes in Pregnant Women With Previous Bariatric Surgery
Gestational diabetes mellitus (GDM) is associated with significant maternal and fetal complications. The standard diagnostic test for GDM is the 75-gram oral glucose tolerance test (OGTT).
- Conditions
- Gestational Diabetes Mellitus (GDM), Pregnancy Complications, History of Bariatric Surgery
- Trial name
- BARI-GDM (NCT07517406)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Burak Deniz Aydoğdu
Diabetes During Pregnancy, Pregnancy Complications
Effects of Leg Ergometer Versus Arm Ergometer on Blood Glucose, Exercise Tolerance, Weight, and Psychological Stress Among Gestational Diabetic Patients
The current study is a single-blind, parallel-group randomized controlled trial involving 108 participants with diabetes during pregnancy. The trial will compare leg ergometer with arm ergometer.
- Conditions
- Diabetes During Pregnancy, Pregnancy Complications, Pregnancy in Diabetes, Gestational Diabetes Mellitus (GDM)
- Trial name
- GDM (NCT07554287)
- Testing
- Leg Ergometer, Arm Ergometer
- Where
- Pakistan
- Volunteers
- 108 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Stroke Rehabilitation, Neurorehabilitation
Movement-activated Auricular Vagus Nerve Stimulation in Rehabilitation
Rehabilitation engineering laboratory (RELab) at the ETH Zurich is recruiting participants with a motor function deficit for studying a novel non-invasive brain stimulation method that may be a promising approach for benefiting…
- Trial name
- sVNS-rehab (NCT06623721)
- Testing
- Movement-evoked transcutaneous auricular Vagus nerve stimulation
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Olivier Lambercy
Coronary Heart Disease
Effects of Yangxinshi Pills on the Exercise Tolerance of the Patients With Coronary Heart Disease
Compared with conventional treatment of the coronary heart disease,the aim of the research is to find out if the addition of Yangxinshi pills on the basis of conventional treatment can improve exercise tolerance of patients with…
- Trial name
- NCT03478332
- Testing
- Yangxinshi pill, conventional coronary heart disease medicine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Affiliated Hospital of Changchun University of Chinese Medicine
Gastric Cancer
Chemotherapy Options for the First Line Chemotherapy in Elderly Patient With Advanced Gastric Cancer
The investigators compare the overall survival between combination chemotherapy and monochemotherapy as a first-line chemotherapy in elderly patients with metastatic or recurrent gastric cancer.
- Trial name
- NCT02114359
- Testing
- Capecitabine/cisplatin, S-1/cisplatin, Capecitabine/oxaliplatin
- Where
- 14 sites in South Korea
- Volunteers
- 111 people
- Sponsor
- Seoul National University Hospital
Tuberculosis
Study to Evaluate the Tolerability and Immunogenicity of Nyaditum Resae ® Probiotic Administered to Pediatric Population in Contact With Tuberculosis With or Without Latent Tuberculosis Infection
This is a doble-blind, masked, compared with placebo clinical trial in pediatric population in contact with tuberculosis with or without tuberculosis infection.
- Trial name
- NCT02581579
- Testing
- Nyaditum resae ® 10e5 of heat-killed Mycobacterium manresensis
- Where
- 3 sites in Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Manresana de Micobacteriologia, SL
TCR-T Cells, Refractory Solid Tumors
KSX01-TCRT Injection Project in Solid Tumors
1) Safety and efficacy of TCR-T cells in subjects with refractory/relapsed solid tumors. 2) The activation and proliferation of TCR-T cells in the subject, and the survival time.
- Conditions
- TCR-T Cells, Refractory Solid Tumors, Relapsed Solid Tumors
- Trial name
- NCT05811975
- Testing
- KSX01-TCRT injection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- TCRx Therapeutics Co.Ltd
Impaired Glucose Tolerance, Obesity
Enhancing Fitness in Older Pre-diabetic Veterans
This study targets older adults (ages 60 and over) who are overweight (body mass index 25-40) with impaired fasting glucose (100 - 125).
- Conditions
- Impaired Glucose Tolerance, Obesity, Diabetes
- Trial name
- NCT00594399
- Testing
- Physical Activity Counseling
- Where
- United States
- Volunteers
- 302 people
- Sponsor
- US Department of Veterans Affairs
Face Skin Photoaging
Face Photoaging: Efficacy and Tolerance Evaluation of an Intradermal Injective Treatment
Efficacy and tolerance evaluation of an intradermal injective treatment
- Trial name
- NCT03274232
- Testing
- SUNEKOS ® 200
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Nutrition Disorders
Acceptability and Tolerance Study of a Plant-based Tube Feed
This is a single arm, prospective, multi-centre study to evaluate the gastrointestinal tolerance and compliance over a 7-day period with a plant based tube feed.
- Trial name
- NCT06209593
- Testing
- Compleat plant protein tube feed
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Société des Produits Nestlé (SPN)
Acne Vulgaris
Evaluation of Quality of Life, Efficacy, and Tolerance of Duac® Gel Compared to Differin® Gel in the Treatment of Acne
The objectives of this clinical trial are to compare the quality of life of the subjects, the efficacy and the tolerance of Duac® Gel (gel formulation with a combination of clindamycin phosphate [equivalent to 1% clindamycin] and…
- Trial name
- NCT00807014
- Testing
- Duac Gel, Differin gel
- Where
- 8 sites in Spain
- Volunteers
- 169 people
- Sponsor
- Stiefel, a GSK Company
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