Clinical trials: Immune System Tolerance
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Acute Glycemic Effects of Crackers Made by Different Flours
This study investigated the acute effects of cracker consumption made by different flours on glycemic responses.
- Trial name
- NCT05702372
- Testing
- Glucose as reference food, Cracker made by wheat flour, Cracker made by rye flour
- Where
- Greece
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Type 2 Diabetes Mellitus
A Diabetes Prevention Study Targeting High Risk Individuals With Education and Ongoing Support
The study aims to identify people at high diabetes risk within the local population and then implement and evaluate a pragmatic and low-cost diabetes prevention programme containing structured education on lifestyle, physical…
- Trial name
- PREVENTION (NCT00677937)
- Testing
- Modified DESMOND education and ongoing support
- Where
- United Kingdom
- Volunteers
- 748 people
- Sponsor
- University Hospitals, Leicester
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Iron Deficiency
A Pilot Study Comparing Tolerance of Oral Heme Iron Polypeptide With Oral Ionic Iron
This is a pilot study designed to compare the tolerance of ionic iron (ferrous sulphate) with heme iron polypeptide. Subjects will take one week of one product followed by a week with no product followed by a week with the other…
- Trial name
- NCT01865175
- Testing
- ionic iron, heme iron polypeptide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Percutaneous Coronary Intervention
Effects of Yangxinshi Pills on the Exercise Tolerance Compared With Trimetazidine in Patients After PCI
This study compared the effect of Yangxinshi on exercise tolerance of patients with percutaneous coronary intervention (PCI) for the first time with Trimetazidine.Half of participants will receive Yangxinshi and Trimetazidine…
- Trial name
- HEARTRIP (NCT03809273)
- Testing
- Yangxinshi, Trimetazidine, Yangxinshi mimic
- Where
- 15 sites in China
- Volunteers
- 681 people
- Sponsor
- Shenyang Northern Hospital
Healthy
Oxytocin Effects on the Tolerance of Infidelity
To investigate whether intranasal oxytocin (40 IU) treatment can influence the tolerance of infidelity in males and females.
- Trial name
- NCT02733237
- Testing
- oxytocin treatment
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
COPD, Oxygen Therapy
Closed-loop System for Oxygen Delivery and Exercise in Chronic Obstructive Pulmonary Disease
The purpose of this study is to investigate the benefit of Closed-loop System for Oxygen Delivery (FreeO2) as compared with fixed oxygen flow during endurance shuttle walking test in patients with Chronic obstructive pulmonary…
- Conditions
- COPD, Oxygen Therapy, Hypercapnia
- Trial name
- FreeO2-rehab (NCT01575327)
- Testing
- Automated settings on the oxygen delivery device, Manual settings with FreeO2 system in collection mode
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- AGIR à Dom
Insulin Resistance
Cardiovascular and Metabolic Responses to a Mixed Meal
The purpose is to determine whether regular endurance exercise and/or body weight influence the way our nervous and vascular systems respond during the metabolism of meals.
- Trial name
- NCT00882986
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- John Thyfault
Diabetes Mellitus
Effect of Smoking on Postprandial Gastric Emptying, Glucose Tolerance and Secretion of Gut and Pancreatic Hormones
The study aims to evaluate the effect of smoking on postprandial responses such as plasma glucose, secretion of gut - and pancreatic hormones and gastric emptying in healthy, heavy smoking men.
- Trial name
- SmokinGLP-1 (NCT02497651)
- Testing
- Liquid mixed meal, Skin Biopsy
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Cow's Milk Allergy
Parmigiano-Reggiano Cheese as a Possible Strategy to Acquire Oral Tolerance in Children With Cow's Milk Allergy
Cow's milk allergy is the most common food allergy in children. The scenery clinical and epidemiological of cow's milk allergy is significantly changed in the last decade.
- Trial name
- NCT02081651
- Testing
- Parmigiano Reggiano cheese
- Volunteers
- 90 people
- Sponsor
- Federico II University
Tuberculosis
Safety and Immunogenicity of Nyaditum Resae® Probiotic to Protect From Tuberculosis
This is a double-blind, masked, compared with placebo clinical trial in healthy volunteers with or without tuberculosis infection.
- Trial name
- NCT02076139
- Testing
- Nyaditum resae® 10e4, Nyaditum resae® 10e5, Distilled water
- Where
- Spain
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Manresana de Micobacteriologia, SL
Healthy
Single Dose Safety, Tolerance and Pharmacokinetic Study in Healthy Volunteers Undergoing Contrast-enhanced Abdominal Computed Tomography (CT)
This is a non-randomized dose-escalating study that will evaluate the safety and tolerability of GE-145 at four different dose levels through the assessment of clinical laboratories, vital signs, physical examinations…
- Trial name
- NCT01004770
- Testing
- GE-145 (AN113111) Injection, Visipaque (iodixanol) Injection
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Yellow Fever Vaccine
VAC-SIP-YF (Vaccination- Safety & Immunogenicity During Pregnancy- Yellow Fever)
The aim of this study is to compare the immunogenicity induced by yellow fever vaccination administered during pregnancy with that induced by vaccination outside pregnancy, and to assess the maternal and fetal tolerance of this…
- Trial name
- VAC-SIP-YF (NCT06694766)
- Testing
- Blood sample collection
- Where
- France
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Tolerance, Capsaicin
Intranasal Capsaicinoid Spray
Rhinitis is inflammation of the inside of the nose. Symptoms of rhinitis include itchiness, sneezing, and a "runny" nose (rhinorrhea).
- Conditions
- Tolerance, Capsaicin, Rhinitis
- Trial name
- NCT03952845
- Testing
- Capsaicinoid
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Tolerance, Safety Issues
Buck Institute Ketone Ester RCT
This study is to investigate the tolerability and safety of a ketone promoting ingredient, called a ketone ester (KE), in healthy older adults.
- Conditions
- Tolerance, Safety Issues, Aging
- Trial name
- BIKE (NCT05585762)
- Testing
- Ketone ester
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Buck Institute for Research on Aging
Kidney Failure, Chronic, Renal Insufficiency
Renal Allograft Tolerance Through Mixed Chimerism (Belatacept)
This study will examine the safety and effectiveness of a combination kidney and bone marrow transplant from a haplo-identical related donor.
- Trial name
- NCT02314403
- Testing
- Belatacept, ATG, Rituximab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Effects of Bran Size on Glycemic Responses
This study investigated the effects of bran's particle size on glycemic responses
- Trial name
- NCT03314142
- Testing
- Glucose as reference food, White bread as reference food, Bread enriched with coarse wheat bran
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
NSCLC
IN10018 Combination Therapy in Advanced EGFR Mutation-positive NSCLC
This is a multicenter, open-label, phase Ib/II clinical study to evaluate the safety, tolerability, pharmacokinetics and antitumor efficacy of IN10018 in combination with third-generation EGFR-TKI (Furmonertinib is the proposed)…
- Trial name
- NCT05994131
- Testing
- IN10018, Furmonertinib
- Where
- China
- Volunteers
- 110 people
- Sponsor
- InxMed (Shanghai) Co., Ltd.
COPD (Chronic Obstructive Pulmonary Disease)
Inhaled Treprostinil for Dyspnea and Exercise Intolerance in Mild COPD
The goal of this clinical trial is to evaluate the impact of inhaled Treprostinil on breathlessness and low exercise capacity in patients living with mild chronic obstructive pulmonary disease.
- Trial name
- NCT06969573
- Testing
- Treprostinil Inhalation Solution 36 mcg, Treprostinil Inhalation Solution 78 mcg
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Advanced Malignant Neoplasm
A Clinical Trial of TQB3006 Tablets in Patients With Advanced Malignant Cancer
This study includes two stage: dose escalation and dose extension, with a single dose and a multiple dose study. This is a single-center, open, non-randomized, single arm, study to evaluate the safety, tolerability and…
- Trial name
- NCT06344351
- Testing
- TQB3006 tablets
- Where
- 5 sites in China
- Volunteers
- 27 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
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