Clinical trials: Immune System Tolerance
Allergy Milk
Step Down Approach in Children With Cow Milk Allergy
Cow's milk allergy (CMA) affects up to 3% of European children. In the absence of an alternative to cow's milk, the management of CMA is based on the use of safe, affordable and nutritionally adequate formulas.
- Trial name
- SDACMA (NCT03449537)
- Testing
- extensively hydrolyzed casein formula + LGG, Hypoallergenic formula based on amino-acid based formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Federico II University
Energy Intake, Gastrointestinal Hormones
Effects of Oral Pre-loads on Subsequent Energy Intake
The aim of this project is to investigate the effect of erythritol (given as pre-load), compared to sucrose, sucralose, and water on energy intake during a subsequent ad libitum test meal in healthy participants.
- Conditions
- Energy Intake, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT04713137
- Testing
- Erythritol, Sucrose, Sucralose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Acute Myeloid Leukemia, Acute Lymphocytic Leukemia
Study Evaluating the Tolerance and Biological Activity of Oral Clioquinol in Patients With Relapsed or Refractory Hematological Malignancy
This is an open-label, single arm phase 1 study to evaluate the dose-limiting toxicity, maximum tolerated dose, and recommended phase II dose of Clioquinol in patients with relapsed or refractory hematologic malignancies.
- Conditions
- Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Chronic Lymphocytic Leukemia, Myelodysplasia
- Trial name
- NCT00963495
- Testing
- Clioquinol
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Healthy
The Effect of Nonverbal Vocalisations on Pain Tolerance
Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions. and important social issues.
- Trial name
- VOCPAIN (NCT04425395)
- Testing
- Cold pressor task (CPT), Acoustic Recordings, Index measurement NOL™
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy Infants
Efficacy of Two HMOs in Chinese Infants
This is a randomized, controlled, double-blind, intervention trial of healthy male and female term infants to evaluate the efficacy of the 2 HMOs on beneficially modulating the gut microbiota, gut maturation, gut barrier…
- Trial name
- NCT06361719
- Testing
- Experimental Group (EG), Control Group (CG)
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Iron Deficiency
A Pilot Study Comparing Tolerance of Oral Heme Iron Polypeptide With Oral Ionic Iron
This is a pilot study designed to compare the tolerance of ionic iron (ferrous sulphate) with heme iron polypeptide. Subjects will take one week of one product followed by a week with no product followed by a week with the other…
- Trial name
- NCT01865175
- Testing
- ionic iron, heme iron polypeptide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Determination of Glycemic Index of Six Greek Honey Grades
This study determined the glycemic index and glycemic load of six Greek honey varieties
- Trial name
- NCT03331757
- Testing
- Glucose as reference food, Fir honey, Heather honey
- Where
- Greece
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Postmenopausal Osteoporosis, Multiple Sites
Safety Study of an Oral Vitamin D Analog in Postmenopausal Women
Determine the safety of 2MD, a vitamin D analog, when administered orally once daily for 28 days in healthy normal postmenopausal women.
- Trial name
- NCT01969656
- Testing
- 2MD, Calcitriol
- Sponsor
- Deltanoid Pharmaceuticals
Food Allergy, Early Allergen Introduction
Food Introduction for Risk Reduction, Support Tolerance: Behavioral Intervention for Toddler Eating Success
The goal of this clinical trial is to evaluate the feasibility, acceptability, perceived safety, and adherence outcomes of FIRST BITES (Food Introduction for Risk Reduction, Support Tolerance: Behavioral Intervention for Toddler…
- Trial name
- FIRST BITES (NCT07857057)
- Testing
- Education and Reminders/Supportive Communication, Education
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Heart Failure, Atrial Fibrillation
The Influence of Heart Rate Limitation on Exercise Tolerance in Pacemaker Patients.
To examine the effects of heart rate reduction on exercise capacity in control subjects and patients with chronic heart failure.
- Conditions
- Chronic Heart Failure, Atrial Fibrillation, Arrhythmia, Sinus
- Trial name
- TREPPE (NCT02247245)
- Testing
- Ivabradine, Atrial fibrillation
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Leeds
Dystrophic Epidermolysis Bullosa
Pilot Study Evaluating the Efficiency and the Tolerance of the PDT in the Treatment of Epidermal Dysplasia for Patients Affected by Hereditary DEB
The hereditary dystrophic epidermolysis bullosa are genodermatosis responsible of a poor adhesion of the epidermis to the dermis pulling a large mucocutaneous fragility and recurrent spontaneous or posttraumatic bullous…
- Trial name
- NCT02004600
- Testing
- Photodynamic therapy (PDT)
- Where
- 2 sites in France
- Sponsor
- Centre Hospitalier Universitaire de Nice
Wound
HEAL Study: Healing Results, Efficacy and Acceptability of a New Contact Layer
Assessment of efficacy, tolerance and acceptability for the wound dressing URGO AWC_019 in the treatment of acute wounds, chronic wounds and epidermolysis bullosa skin lesions
- Trial name
- HEAL (NCT03640871)
- Testing
- URGO AWC_019 dressing (AWC=Advanced Wound Care)
- Volunteers
- 80 people
- Sponsor
- Laboratoires URGO
Congestive Heart Failure
Cardiac Resynchronization Therapy, Dyspnea and Exercise Tolerance in Patients With Congestive Heart Failure (CHF)
A new therapy for patients with advanced heart failure (HF) involves the implantation of a specialized pacemaker device (Cardiac Resynchronization Therapy, CRT) that attempts to restore the synchronized contraction of the…
- Trial name
- NCT00700700
- Testing
- Active Cardiac Resynchronization Therapy (CRT)
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Queen's University
Coronary Artery Bypass Graft Surgery, Spine Surgery
Does Pre-operative Carbohydrate Loading Reduce Insulin Resistance and Improve Outcomes in Elective Surgical Patients?
The recent development of an oral carbohydrate drink for consumption prior to elective surgical procedures has been shown to improve insulin sensitivity.
- Trial name
- Preop (NCT00618592)
- Testing
- PreOp carbohydrate drink
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
TOLerogenic Potential of Hematopoietic Stem and Progenitor Cells and Inflammatory Bowel Disease
Pediatric refractory Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, not responsive to current treatments.
- Trial name
- TOL-IBD (NCT07740499)
- Testing
- biological sample collection: an additional volume of peripheral blood (3-10 ml), biological sample collection: small fragment (1-5 mm) of intestinal tissue - residual or leftover material, biological sample collection: leftover peripheral blood samples from healthy subjects
- Where
- 2 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diabetes After Total Pancreatectomy
The Impact of Lixisenatide on Postprandial Glucose Tolerance in Pancreatectomised Subjects
Postprandial glucose (PPG) excursions are not only determined by insulin-mediated glucose disposal and endogenous glucose production (regulated by insulin and glucagon); also the rate of gastric emptying constitutes an important…
- Trial name
- Px-Lixi (NCT02640118)
- Testing
- Lixisenatide, Standardized liquid meal
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Sleep Apnea, Obstructive
Trazodone Dose Tolerance and APAP Adherence
Trazodone may help obstructive sleep apnea patients to stick to their therapy, but optimal dosing is unknown. This study looks at what dose of trazodone has the best balance of potential benefits to side-effects in people with…
- Trial name
- TrazoDose (NCT02945644)
- Testing
- Trazodone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Louis Stokes VA Medical Center
Pregnancy, Obesity
Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn
The purpose of the study is to investigate if the probiotics Vivomixx® can affect gestational weight gain, microbiota and pregnancy complications in pregnant obese women and birth weight body composition of their infants.
- Conditions
- Pregnancy, Obesity, Gestational Diabetes Mellitus
- Trial name
- POP (NCT02508844)
- Testing
- Vivomixx®
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Adiposity, Insulin Sensitivity
Metabolic Adaptations to High-fat Diet
The purpose of this study is to understand how the body's response after a meal is influenced by insulin and sugar in the blood.
- Conditions
- Adiposity, Insulin Sensitivity, Impaired Glucose Tolerance, Metabolic Disturbance
- Trial name
- MetFlexHFD (NCT06537401)
- Testing
- Hypercaloric, High Fat Diet
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- George Washington University
Healthy
Single Dose Study Of PF-04171327 And Prednisone On Carbohydrate Metabolism
This study will investigate the effect of a single dose of PF-04171327 or prednisone on calculated measures of glucose tolerance and insulin resistance by using a modified oral glucose tolerance test
- Trial name
- NCT01199900
- Testing
- PF-04171327, Prednisone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
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