Clinical trials: Immunity, Cellular
Chronic Granulomatous Disease
Effect of IFN-γ on Innate Immune Cells
The investigators hypothesize that neutrophils and monocytes developed under the influence of Interferon- gamma-1b (IFN-γ-1b, Actimmune*) in vivo will display enhanced function across a broad range of activities related in large…
- Trial name
- NCT02609932
- Testing
- Administration of drug (Interferon-gamma 1-b) subcutaneously
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
AIDS, AIDS Vaccines
Study to Optimize the Quality of Samples for Cell-mediated Immunity (CMI) in ART-naïve HIV-1-infected Subjects
The purpose of this study is to investigate a combined set of parameters deemed to impact the quality of CMI analyses in terms of the proportion of viable lymphocytes in antiretroviral therapy-naïve HIV-1 infected subjects.
- Trial name
- NCT01610427
- Testing
- Blood sample collection
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- GlaxoSmithKline
COVID-19, Pregnancy Related
Evaluation of Humoral Immunity Following COVID-19 in Pregnancy
The proposed study is designed to investigate if and how pregnant women infected with Coronavirus Disease-19 (COVID-19) infection go on to develop long-term immunity.
- Conditions
- COVID-19, Pregnancy Related, Influenza, Human
- Trial name
- ImmunoCOVID (NCT04568044)
- Testing
- Blood sample
- Where
- 2 sites in United Kingdom
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Imperial College London
HIV Infections
Evaluating Immune Function Tests in People With HIV
Some people's immune systems are able to control HIV infection without anti-HIV drugs. Other people with HIV must take drugs to prevent the virus from destroying their immune systems.
- Trial name
- NCT00067795
- Where
- 6 sites in United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infection
Trial of pDNA CMV Vaccine (VCL-CT02) Followed by Towne CMV Vaccine (Towne) Challenge
Objectives of this trial are to: Evaluate the kinetics and magnitude of the CMV-specific immune response post-Towne challenge (3000 pfu) in healthy CMV-seronegative volunteers who receive VCL CT02 administered (1 mg weekly x 3) 3…
- Trial name
- NCT00373412
- Testing
- VCL CT02 pDNA vaccine, Towne CMV vaccine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Metastatic Malignant Melanoma
Inducing Systemic Immunity and Regressions in Metastatic Melanoma
In patients with multiple metastatic nodules of melanoma, the investigators evaluated whether autologous cytokines injected into cutaneous metastases would induce a systemic immune response as evidenced by the accumulation of…
- Trial name
- NCT02350972
- Testing
- Autologous cytokines
- Volunteers
- 88 people
- Sponsor
- NYU Langone Health
Melanoma (Skin)
S9431: Studying Genes and Immune Response in Tumor Samples From Patients With Locally Advanced or Metastatic Melanoma
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00898183
- Testing
- gene expression analysis, polymorphism analysis
- Volunteers
- 91 people
- Sponsor
- SWOG Cancer Research Network
Non Small Cell Lung Cancer, Bladder Cancer
Prospective Study to Evaluate the Blood Kinetics of Immune Cells and Immunosuppressive Cytokines After Exposure to an Immunity Checkpoint Inhibitor (ICI): Study of the Impact of Chemotherapy
Non-small cell lung cancer (NSCLC) is the most common histological form, accounting for 85% of all bronchopulmonary cancers (PBC).
- Conditions
- Non Small Cell Lung Cancer, Bladder Cancer, ENT Cancer
- Trial name
- CINECI (NCT04487457)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Tours
Cardiovascular Diseases
Molecular Investigation of GENetic Factors in Cardiovascular and Immune-related Traits and Diseases Using a BIOresource of Healthy Volunteers (GENBIO)
The risk of cardiovascular disease is determined by the complex interplay between an individual's genetic make-up, lifestyle, and the environment.
- Trial name
- GENBIO (NCT04931498)
- Testing
- Questionnaire, Anthropometric measurements: height, weight, and body fat, Blood pressure and heart rate
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Sepsis
Monitoring of Septic Shock-induced Immunosuppression
Septic syndromes are a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units (ICU).
- Trial name
- IMMUNOSEPSIS 5 (NCT07698093)
- Testing
- Additional tubes during routine blood sample collection
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- Hospices Civils de Lyon
Flu Vaccine
Senescent Immunity in Elders and Vaccine Responses (SILVER)
To study the effects of age on the immune system's response to flu vaccine and to study the connection between the immune system and physical and cognitive changes associated with aging.
- Trial name
- NCT04077424
- Testing
- Fluzone-High Dose Quadrivalent, Fluad, Flublock
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Pertussis
Adacel® Booster Vaccination for CMI Assay Development
Recruitment of individuals primed during childhood with TdaP (tetanus, diphtheria , acellular pertussis) vaccine, and administration of an Adacel booster with blood sample collection at various time points before and after…
- Trial name
- NCT04543669
- Testing
- Adacel®
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Non-target Heterologous Effects of Vaccines, Vaccine Interactions
The Interaction Between Measles and DTP Vaccination
The purpose of this study is to investigate for the broad immunological effects of administering measles vaccine (MV) and diphtheria-tetanus-whole cell pertussis vaccine (DTP) to 9 month old Gambian infants, either alone or…
- Trial name
- NCT02710045
- Testing
- Measles Vaccine at 9 months of age, DTP Vaccine at 9 months of age, Measles Vaccine at 18 months of age
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Medical Research Council Unit, The Gambia
Single Cell Sequencing Technology, Gene Expression Profiling
Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis.
Febrile illness is a common condition and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment.
- Conditions
- Single Cell Sequencing Technology, Gene Expression Profiling, Gene Expression, Infection
- Trial name
- NCT06846645
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Dry Eye Disease
Ocular Surface Immune Response in Dry Eye Disease
In vivo confocal microscopy (IVCM) is a sensitive imaging tool for detecting dry eye-associated subclinical inflammation. Studies have previously shown that IVCM provides an in vivo metric to measure inflammatory changes in the…
- Trial name
- NCT02042820
- Testing
- In vivo confocal microscopy (IVCM)
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Diphtheria; Haemophilus Influenzae Type b; Hepatitis B; Tetanus; Whole Cell Pertussis
Assess the Immune Response Following Primary Vaccination With GSK Biologicals' Tritanrix™-HepB/Hib-MenAC vs Tritanrix™-HepB/Hiberix™ Given at 6,10 & 14 Wks of Age to Infants Who Received Hepatitis B Vaccine at Birth
This study will only include infants born to mothers who are tested as seronegative for human immunodeficiency virus (HIV) \& hepatitis B surface antigen (HBsAg).
- Trial name
- NCT00317122
- Testing
- DTPw-HBV/Hib-MenAC conjugate vaccine
- Where
- 4 sites in South Africa
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Covid19
Safety, Tolerability, and Immunogenicity of the COVID-19 Vaccine Candidates VBI-2902a and VBI-2905a
VBI-2902a and VBI-2905a are investigational vaccine candidates that use enveloped virus-like particle (eVLP) expression of a modified version of the SARS-CoV-2 spike (S) glycoprotein and are designed to induce neutralizing…
- Trial name
- NCT04773665
- Testing
- VBI-2902a, VBI-2905a
- Where
- 4 sites in Canada
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.
Acute Coronary Syndrome, Stress Hyperglycemia
Cellular Immunity, Neuroendocrine, and Inflammatory Factors for Clinical Prognosis in Acute Coronary Syndrome
In acute coronary syndrome (ACS), there is an increase in cortisol levels, as an expression of the stress response, and C-reactive protein, as an expression of the inflammatory response, which are in turn associated with changes…
- Conditions
- Acute Coronary Syndrome, Stress Hyperglycemia, Cortisol; Hypersecretion, Inflammatory Response
- Trial name
- NCT06513611
- Testing
- Serum cortisol.
- Where
- Argentina
- Volunteers
- 150 people
- Sponsor
- Hospital de Clinicas José de San Martín
Influenza
Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection (SLVP031)
The purpose of this study is provide a better understanding of the adaptive immune response to the licensed flu vaccines. The investigators hope the information learned from this study will help identify and describe important…
- Trial name
- NCT03028987
- Testing
- Fluzone®, FluMist®
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Colorectal Adenocarcinoma, Mucinous Adenocarcinoma
METIMMOX-2: Metastatic pMMR/MSS Colorectal Cancer - Shaping Anti-Tumor Immunity by Oxaliplatin
Hypothesis: Patients with metastatic colorectal cancer with DNA mismatch repair-proficient (pMMR) function / microsatellite-stable (MSS) phenotype harbor a non-immunogenic disease that can be transformed into an immunogenic…
- Conditions
- Colorectal Adenocarcinoma, Mucinous Adenocarcinoma, Signet Ring Cell Adenocarcinoma
- Trial name
- METIMMOX-2 (NCT05504252)
- Testing
- Nivolumab, Oxaliplatin
- Where
- 3 sites in Norway
- Volunteers
- 80 people
- Sponsor
- University Hospital, Akershus