Clinical trials: Immunity, Cellular
HIV Infections
A Study to Monitor Patients With Primary or Early HIV Infection
The purpose of this study is to monitor patients who recently have been infected with HIV in order to learn how their immune systems respond to HIV infection and to study how the virus acts in their bodies.
- Trial name
- NCT00000911
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Primary Graft Dysfunction, Lung Transplantation
This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction
Lung transplant recipient survival lags other solid organ recipients, with the main early cause of death being primary graft dysfunction (PGD).
- Conditions
- Primary Graft Dysfunction, Lung Transplantation, Acute Lung Injury(ALI), Natural Killer Cell Mediated Immunity
- Trial name
- MARAVIROC (NCT06853223)
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cholera
Evaluation of a Boosting Regimen With Oral Cholera Vaccine
Data demonstrates that Shanchol™ (killed bivalent oral cholera vaccine) provides protection over 3 years and data regarding the protective efficacy over five years is anticipated for 2012.
- Trial name
- Boost (NCT01579448)
- Testing
- Shanchol™, oral cholera vaccine, Shanchol™, killed, whole cell, bivalent, oral cholera vaccine, no intervention
- Where
- India
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Sachin Desai
Influenza
Comparison of the Safety and Immune Response of an Influenza Vaccine Made by a New Manufacturing Process With a Vaccine Made by the Traditional Manufacturing Process for Season 2003/2004
The objectives of the study are to assess the immunogenicity and safety of the inactivated influenza vaccine (whole virion, Vero cell-derived) at Day 21 and Day 180 after vaccination.
- Trial name
- NCT00161837
- Testing
- Vero Cell-derived Influenza Vaccine, Egg-derived Influenza Vaccine
- Where
- Poland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Virus Diseases
A Study to Evaluate Persistence of Immune Responses After Post-exposure Prophylaxis of Rabipur® (Purified Chicken-embryo Cell Rabies Vaccine) in Chinese Children
The purpose of this study is to evaluate the long-term persistence of immune responses approximately 5 years or more after simulated rabies post-exposure prophylaxis provided in 2012 according to Essen (1-1-1-1-1) or Zagreb…
- Trial name
- NCT02991872
- Testing
- Blood draw
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Non-small Cell Lung Cancer (NSCLC)
Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer
All subjects will receive the vaccine subcutaneously every 3 weeks x 3 with optional yearly booster vaccines up to and including 10 years post last vaccine for those patients who are confirmed responders to the vaccine .
- Trial name
- NCT01720836
- Testing
- Vaccine + PolyICLC
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Olivera Finn
Newly Diagnosed Glioblastoma
The Assessment of Immune Response in Newly Diagnosed Glioblastoma Patients Treated With Pembrolizumab
To evaluate the short-term and longer-term safety, tolerability, and effectiveness of neoadjuvant and adjuvant Pembrolizumab on top of standard therapy (Stupp protocol) in patients with Glioblastoma Multiforme (GBM).
- Trial name
- PIRG (NCT05235737)
- Testing
- Pembrolizumab
- Where
- Poland
- Volunteers
- 36 people
- Sponsor
- Medical University of Silesia
Staphylococcus Aureus
Ex Vivo Evaluation of Immunity Activation Face to S. Aureus Antigens and Adjuvants of a Vaccine Candidate in Cells From Haemodialysis Patients
S. aureus is a leading cause of severe infections notably in haemodialysis patients. These patients have a high risk of S. aureus nasal carriage, with a rate of persistent carriage near 30%.
- Trial name
- ANTISTAPH (NCT03643328)
- Testing
- blood samples, nasal swabs
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy
Towards a Food Ingredient Clinically Proven to Benefit Gut Health: Novel RG-I Variants
The aim of this study is to determine, quantify and understand the potential prebiotic effects of RG-I variants via microbiota modulation. The anti-inflammatory potential effects of these variants will also be investigated.
- Trial name
- NUTRIGUT (NCT06081972)
- Testing
- Maltodextrin, Chicory RG-I, Carrot RG-I
- Where
- Sweden
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Melanoma
Characterisation of T Lymphocytes, NK Cells and Macrophages in Melanoma Patients
Melanoma tumor tissue ( in particular regressive areas) present a lymphocytic infiltrate with an anti-tumoral specificity. The aim of the study is to analyse at different stages of the disease, tumor samples and to characterise…
- Trial name
- IMMUMELA (NCT01336270)
- Testing
- biological collection
- Where
- France
- Volunteers
- 217 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Herpes Zoster
Month 30 & 42 Extension Studies of CRD-004 Primary Study
The safety and immunogenicity of the GSK324332A vaccine has been evaluated up to Month 12 post-vaccination in the primary study.
- Trial name
- NCT00492648
- Testing
- Blood sampling for assay of persistence of immunogenicity
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
Evaluating the Immune Response to a rAd5 HIV Vaccine Administered in Three Different Ways in Healthy, HIV-Uninfected Adults
The purpose of this study is to evaluate the immune response to the Vaccine Research Center (VRC) rAd5 HIV vaccine when the vaccine components are administered in three different ways, in healthy, HIV-uninfected adults.
- Trial name
- NCT01479296
- Testing
- VRC rAd5 vaccine (rAd5 gag-pol/env A/B/C), rAd5 env A, rAd5 env B
- Where
- 8 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphocytes, Weight Loss
Effect of Weight Reduction on Immunity
This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group…
- Conditions
- Lymphocytes, Weight Loss, Viral Diseases, Immunity
- Trial name
- NCT03336086
- Testing
- weight loss program
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
Influenza
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 3, 2011
This study will investigate markers, mechanisms and define general predictors for immunological health by comparing influenza vaccine responses in monozygotic and dizygotic twins.
- Trial name
- NCT03022422
- Testing
- TIV, High-Dose TIV
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Stanford University
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Immune Response to SARS-CoV-2 (COVID-19) Vaccines in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
This study evaluates the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
- Trial name
- NCT04852822
- Testing
- Biospecimen Collection, Electronic Health Record Review
- Where
- 11 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Washington
Adenocarcinoma, Circulating Tumor Cells
CTC Pancreatic Adenocarcinoma
Proportion of circulating tumor cells (CTC) in the postoperative phase after curative tumor removal of pancreatic cancer will be determined and correlated to the accordance of anesthesia (desflurane versus propofol)
- Conditions
- Adenocarcinoma, Circulating Tumor Cells, Pancreatic Neoplasms
- Trial name
- NCT02335151
- Testing
- Desflurane
- Where
- 4 sites in Switzerland
- Volunteers
- 86 people
- Sponsor
- University of Zurich
HIV Infections
Candidate HIV Vaccine
This study will evaluate whether an experimental vaccine intended to prevent HIV infection is safe and whether it causes any side effects.
- Trial name
- NCT00089531
- Testing
- VRC-HIVDNA016-00-VP
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HPV
HPV Vaccine Reduced Dose
This study aims to answer the question: does 1-dose HPV vaccination generate the same immune responses compared to 2- or 3-dose HPV vaccination? This will be done by studying the immune response in blood, lymph nodes, and bone…
- Trial name
- NCT06799494
- Testing
- Gardasil-9, Lidocaine injection, Lorazepam
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University
Pancreatic Cancer
Immune Response After Pancreatic Cancer Treatment
The aim of this project is to describe the differential immunologic responses of patients who undergo in situ IRE, margin accentuation IRE with surgical resection of the primary tumor, and surgical resection of the primary tumor…
- Trial name
- IRE Immuno (NCT03069599)
- Testing
- irreversible electroporation (IRE)
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Tuberculosis
Study Evaluating Aerosol and Intradermal Administration of a Candidate Tuberculosis (TB) Vaccine, MVA85A, as a Way to Increase Immune Response and Avoid Anti-vector Immunity
Boost vaccinations sometimes have no effect because the body has got used to the vaccine and no longer reacts to it. We are therefore investigating whether vaccinating with aerosolised MVA85A (a candidate tuberculosis vaccine)…
- Trial name
- NCT01954563
- Testing
- MVA85A
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Oxford