Clinical trials: Immunity to Influenza Vaccine
Healthy
WU 345: Immune Responses to Adjuvanted and Non-adjuvanted Seasonal Influenza Vaccines in the Lymphoid Tissues.
Healthy adults (18-49 years of age) with no previous influenza virus vaccination history for at least three years prior to enrollment will be recruited to participate in this study.
- Trial name
- WU 345 (NCT07386509)
- Testing
- Fluad® and Afluria® vaccination
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
H5N1 Influenza
Evaluating the Safety and Immune Response to an H5N1 Influenza Vaccine in People Who Have Previously Received an H5N1 or H7N3 Influenza Vaccine and in People Who Have Never Received a Live Attenuated Influenza Vaccine
H5N1 is an influenza virus that has the potential to cause an influenza pandemic. This study will evaluate the safety and immune response to an H5N1 influenza vaccine in people who have previously received one of two versions of…
- Trial name
- NCT01443663
- Testing
- H5N1 Vaccine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Normal Physiology
Studying Cell Immune Responses to a Live Flu Vaccine in Healthy Adults
Background: One form of the influenza vaccine is a nasal spray. It uses a live but weakened flu virus. Researchers want to better under how the live vaccine interacts with the body s immune system.
- Trial name
- NCT01730144
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dengue, Sepsis
Immune Responses to Dengue and Sepsis
The goal of this research study is to help the investigators better understand serious dengue disease. The investigators will collect clinical information and up to four blood samples from participants with dengue, influenza…
- Conditions
- Dengue, Sepsis, Influenza
- Trial name
- DEN-SEP (NCT07040202)
- Where
- 4 sites in Cambodia
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Influenza
Comparison of the Safety and Immune Response of Three Different Lots of an Influenza Vaccine Made by a New Manufacturing Process With a Vaccine Made by the Traditional Manufacturing Process for Season 2004/2005
The objectives of the study are to assess the immunogenicity and safety among three different lots of the inactivated influenza vaccine (whole virion, Vero cell-derived) at Day 21 and Day 180 after vaccination.
- Trial name
- NCT00161811
- Testing
- Vero Cell-derived Influenza Vaccine, Egg cell-derived Influenza Vaccine
- Where
- 4 sites in Austria, Germany
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
HIV-1 Infection, Cancer
Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients
The purpose of this study is to evaluate the immunogenicity and safety of an adjuvanted A(H1N1)v influenza vaccine in HIV-infected and immunosuppressed patients after one and two injections.
- Conditions
- HIV-1 Infection, Cancer, Immunosuppression
- Trial name
- NCT01017172
- Testing
- serologic testing
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Goethe University
Influenza, Virus Diseases
Safety of and Immune Response to a Bird Flu Virus Vaccine (H9N2) in Healthy Adults (Study A)
Avian influenza (AI), or bird flu, has recently become a major health concern in Asia and other parts of the world. The purpose of this study is to test the safety of and immune response to a new AI vaccine in healthy adults.
- Trial name
- NCT00110279
- Testing
- H9N2 (6-2) AA ca Reassortant (A/chicken/Hong Kong/G9/97 x A/Ann Arbor/6/60 ca)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Respiratory Syncytial Virus Infections
A Study on the Immune Response and Safety Elicited by a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a Vaccine Against Influenza in Adults Aged 65 Years and Above
The purpose of this study is to assess the immunogenicity, safety and reactogenicity of the RSVPreF3 OA investigational vaccine when co-administered with the high dose quadrivalent influenza (FLU HD) vaccine in adults aged 65…
- Trial name
- NCT05559476
- Testing
- RSVPreF3 OA investigational vaccine, FLU HD vaccine
- Where
- 46 sites in United States
- Volunteers
- 1,029 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza, Human, Immune Response
Immunologic Response to FluMist vs. Flucelvax
The purpose of this study is to evaluate immunologic response to different types of influenza vaccine among children/adolescents/young adults 4-21 years of age.
- Trial name
- NCT03982069
- Testing
- FluMist live attenuated influenza vaccine, Flucelvax inactivated influenza vaccine
- Where
- 2 sites in United States
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Richard Zimmerman MD
Influenza, Vaccine Virus Shedding
Nasal and Systemic Immune Responses to Nasal Influenza Vaccine
Intranasal live attenuated influenza vaccine (LAIV; trade name FluMist/Fluenz-Tetra, manufactured by AstraZeneca/Medimmune) is the standard influenza vaccine given to children aged 2-17 years of age in the UK.
- Trial name
- Flu-M3 (NCT04110366)
- Testing
- Live attenuated influenza vaccine, Vehicle control
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Influenza
Routes of Immunization and Flu Immune Responses
The project aims to evaluate the impact of skin routes of immunization (transcutaneous and intradermal vs intramuscular) on cellular and humoral responses to seasonal influenza vaccination in adults (18-45 years old).
- Trial name
- FLUWAY (NCT01707602)
- Testing
- INTANZA® 15, Vaxigrip®, INTANZA® 15 T
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Influenza, Influenza Immunisation
Evaluation of Human Immune Responses to Influenza Virus Vaccination in Healthy Volunteers
This was an open label, single arm, Phase IV study of longitudinal immunologic responses to influenza vaccine in healthy adult participants, with the aim of enrolling up to 70 participants.
- Trial name
- NCT02385123
- Testing
- Influenza Virus Vaccine Inactivated
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Smoking
Effects of Sulforaphane (SFN) on Immune Response to Live Attenuated Influenza Virus in Smokers and Nonsmokers
Vegetables such as broccoli, cauliflower, kale and cabbage are particularly rich in a plant chemical called sulforaphane (SFN) which boosts production of certain "defense" enzymes that increase the activity of antioxidants.
- Trial name
- NCT01269723
- Testing
- Broccoli sprout homogenate, Alfalfa sprout homogenate
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Influenza
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010
This study will investigate response to influenza vaccines in monozygotic and dizygotic twins of different ages.
- Trial name
- NCT03022396
- Testing
- High Dose Fluzone® (intramuscular), Fluzone® (intramuscular)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Stanford University
Influenza
Heterosubtypic Immune Responses to Influenza in Older People
Vaccination is the principal means of combating epidemic and pandemic influenza. As vaccines induce relatively strain-specific and short-lived antibody responses, annual immunisation with regularly updated vaccine is recommended…
- Trial name
- NCT00798343
- Testing
- Seasonal vaccine, H5 vaccine
- Where
- United Kingdom
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Cognitive Change, Inflammation
Effect of a Fermented Soy Product on Cognition, Immune Status and Vaccine
The research study will test the effects of Q CAN PLUS powder on the immune, inflammatory and cognitive functions.
- Conditions
- Cognitive Change, Inflammation, Immune Response
- Trial name
- IS (NCT04866576)
- Testing
- Q CAN PLUS
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Healthy
A Study to Evaluate the Immune Response to the ASP7373 and Its Safety in Healthy Adult Volunteers
This trial is to investigate the clinically recommended dosage for ASP7373 based on the comparison of the immunogenicity and safety among the three doses of ASP7373 in healthy adults.
- Trial name
- NCT01450579
- Testing
- ASP7373
- Where
- Japan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- UMN Pharma Inc.
Influenza
A Study to Evaluate the Immune Response and Safety of a Seasonal Virus-Like Particle Influenza Vaccine in Healthy Young Adults
The purpose of this study is to determine the immune response of three dose levels of the Novavax Quadrivalent vaccine in healthy young adults (18-64). The study is broken down into 5 treatment groups.
- Trial name
- NCT01561768
- Testing
- Novavax Quadrivalent vaccine, Novavax Trivalent vaccine, cTIV
- Where
- 4 sites in Australia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Novavax
Pregnancy
Immune Responses to the Flu Shot During Pregnancy
This study will examine effects of everyday life stress and obesity on immune responses to influenza virus vaccine (the flu shot) during pregnancy. Following vaccination, antibody levels against influenza (the flu) increase.
- Trial name
- NCT02148874
- Testing
- influenza virus vaccination
- Where
- United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- Lisa Christian
Influenza A Subtype H5N1 Infection
Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response
The study is a prospective single site exploratory study to examine the impact of Food and Drug Administration (FDA) approved seasonal flu vaccine on the immune responses of H5N1 vaccine previously received with or without the…
- Trial name
- HIPCVAX-010S (NCT03701061)
- Testing
- Seasonal Influenza Vaccine
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University