Clinical trials: Immuno-modulation
Plaque-type Psoriasis, Obesity (Body Mass Index >30 kg/m2)
n-3 Polysaturated Fatty Acids-rich Diet in Psoriasis
Low-grade systemic inflammation associated with obesity may worsen the clinical course of psoriasis. Both a low-calorie diet and nutritional supplementation have been shown to have an impact on the clinical course of psoriasis…
- Trial name
- PSO (NCT01876875)
- Testing
- Energy-restricted, n-3 polysaturated fatty acids-rich diet, Usual diet
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Federico II University
Immuno-modulation, Immuno-suppression
Analysis of the Specificity and Persistence of Nasal Immune Responses to Respiratory Viral Antigens in Immunocompromised and Healthy Cohorts
The goal of this observational study is to characterize nasal mucosal immunity to respiratory viruses, such as SARS-CoV-2, in immunocompromised individuals and healthy volunteers.
- Conditions
- Immuno-modulation, Immuno-suppression, Immunocompromised Patients, Healthy Subjects
- Trial name
- NCT07295535
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Lung Cancer
Radio-Immuno-Modulation in Lung Cancer
This project will assess the feasibility of treating advanced cancer using the immune system, without any anti-cancer drug. In this pilot study, the investigators propose combining low-dose radiotherapy, in lung cancer patients…
- Trial name
- RIM (NCT02579005)
- Testing
- Patients with a living donor, Patients with a UCB donor
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
COPD
Immuno-inflammatory Response of Erdosteine in COPD
Chronic obstructive pulmonary disease (COPD) remains a major contributor to global morbidity and mortality, exposing healthcare systems to a significant economical and social load.
- Trial name
- NCT07329946
- Testing
- Erdosteine, Standard of Care (SOC)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Pierachille Santus, MD, PhD
Solid Tumor, Adult, Solid Tumor
Phase I Study to Evaluate Safety and Anti-tumor Activity of PB101, an Anti-angiogenic Immunomodulating Agent
This clinical trial is designed as a multi-center, open-label, dose-escalation, dose-expansion, phase 1 clinical trial and will be evaluating the safety and efficacy of PB101 in patients with advanced solid tumors who have…
- Conditions
- Solid Tumor, Adult, Solid Tumor, Gastric Cancer, Hepatocellular Carcinoma
- Trial name
- NCT06075849
- Testing
- PB101
- Where
- 3 sites in South Korea
- Volunteers
- 30 people
- Sponsor
- Panolos Bioscience
Malnutrition, Esophageal Cancer
INEC Study: Immuno-modulating Enteral Nutrition in Cancer
The aim of this study is to investigate if enteral immunonutrition of head and neck or esophageal cancer patients, using an arginine, omega 3 fatty acid, nucleotides-enhanced diet [Impact (R), Novartis] versus a standard enteral…
- Conditions
- Malnutrition, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00333099
- Testing
- Impact (R) Enteral Nutrition, impact
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand
Multiple Sclerosis
Autologous Bone Marrow Derived Stem Cells for the Treatment of Multiple Sclerosis.
Until now, there is no effective approach to stop the progression of multiple sclerosis and stimulate re-myelination. Autologous stem cell transplantation shows hope and is quickly developing as an alternative therapy.
- Trial name
- NCT03069170
- Testing
- Stem Cell Transplantation
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- Stem Cells Arabia
Hospitalism
Psychological, Neurological and Immunological Changes Following a Meeting With a Chaplain Coupled With Biblical Readings
The aim of the "HEALING" " (Hospital-based Ecumenical And Linguistic Immuno-NeuroloGic) Study was to examine immunological and neurological changes in hospitalized participants after meeting a chaplain and Biblical listenings, in…
- Trial name
- HEALING (NCT04112121)
- Testing
- Meeting with a Chaplain coupled with Biblical Readings
- Where
- Hungary
- Volunteers
- 57 people
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Amyotrophic Lateral Sclerosis
Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2
The primary objective is to evaluate in ALS patients the regulatory T cell early response to two low-doses of IL-2 at 1 and 2 MIU per day after one course of 5 consecutive days comparatively to placebo.
- Trial name
- IMODALS (NCT02059759)
- Testing
- 1.0 MIU IL-2 per day, 2.0 MIU IL-2 per day
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Dengue, Dengue With Warning Signs
Anakinra in Dengue With Hyperinflammation ( AnaDen )
This study aims to evaluate the effect of anakinra in dengue patients with hyperinflammation as compared to placebo Primary Objective: To evaluate the efficacy of Anakinra in moderate-severe dengue patients with…
- Conditions
- Dengue, Dengue With Warning Signs, Severe Dengue, Anakinra
- Trial name
- NCT05611710
- Testing
- Anakinra
- Where
- Vietnam
- Volunteers
- 160 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Gastrointestinal, Microbiota Balance
The Effects of a Postbiotic Supplement on Biomarkers of Gut Health
This study is a randomized, double-blind, two-arm, placebo-controlled trial of N=80 (40/arm) apparently healthy men and women between 18 and 65 years old to be recruited at a single investigational center in Northeast Ohio (i.e.…
- Conditions
- Gastrointestinal, Microbiota Balance, Microbiota, Cortisol
- Trial name
- NCT07527286
- Testing
- Postbiotic
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Verb Biotics LLC
Multiple Myeloma, Stem Cell Transplant
Novel Drugs After Allo-HSCT in Patients With Multiple Myeloma
This is a retrospective observational study of epidemiological surveillance, multicenter, non-profit, spontaneous, Italian on patients submitted to allo-HSCT among Italian Transplant Centers GITMO.
- Trial name
- NEW_ALL_MM (NCT04506320)
- Where
- 2 sites in Italy
- Volunteers
- 202 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Allogeneic Hematopoietic Stem Cell (HSC) Transplantation
Expansion of Invariant NKT Cells for a Cell Immunotherapeutic Approach Allowing the Control of Graft Versus Host-disease and Preserving the Graft Versus Leukemia Effect After Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic hematopoietic stem cell (HSC) transplantation remains the most efficient cellular immunotherapeutic approach for the treatment of myeloid hematological malignancies.
- Trial name
- ExpiNKT1 (NCT03605953)
- Volunteers
- 134 people
- Sponsor
- Central Hospital, Nancy, France
Respiratory Tract Infections (RTI), Meningitis
Immune-Mitochondrial Correction in Military Recruits
The goal of this clinical trial is to learn if a new immune-mitochondrial correction strategy works better than standard vitamins to prevent infections in young male military recruits during their first 6 months of service.
- Conditions
- Respiratory Tract Infections (RTI), Meningitis, Primary Prevention/Methods, Primary Prevention
- Trial name
- IMMU-MITO (NCT07622147)
- Testing
- Multivitamin/Mineral supplements, Sodium nucleinate combination
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- MIPO Clinic