Clinical trials: Immunocompromised
Herpes Zoster
ZOSTAVAX® in Renal Transplant Patients
The purpose of this study is to test the safety of a licensed zoster vaccine, ZOSTAVAX® (Zoster Vaccine Live) in 40 subjects, age 18 years or older, with chronic kidney disease (CKD) who are scheduled to receive a living donor…
- Trial name
- NCT01137669
- Testing
- Live attenuated herpes zoster vaccine
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumocystis, Steroids
Effect of Steroids During Pneumocystis Infection Among Non HIV Immunocompromised Patients
Pneumocystis jiroveci pneumonia (PcP) increased in non HIV immunocompromised patients. Mortality remains high for those patients with comorbidities (50% for patients with the most severe Pneumocystis pneumonia).
- Conditions
- Pneumocystis, Steroids, Immunocompromised Patient, Hematologic Neoplasms
- Trial name
- PIC (NCT02944045)
- Testing
- Methylprednisolone
- Where
- France
- Volunteers
- 222 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Locally Recurrent Skin Squamous Cell Carcinoma, Metastatic Skin Squamous Cell Carcinoma
Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System
This phase II trial compares the effect of amivantamab and hyaluronidase to cetuximab for the treatment of skin (cutaneous) squamous cell carcinoma that has come back after a period of improvement and has not spread to other…
- Trial name
- NCT07042295
- Testing
- Amivantamab and Recombinant Human Hyaluronidase, Biospecimen Collection, Cetuximab
- Where
- 57 sites in United States
- Volunteers
- 86 people
- Sponsor
- National Cancer Institute (NCI)
Severely Immunocompromised HIV Patients
Impact of a Dolutegravir-based Regimen on Early Mortality of AIDS Patients
The current available antiretroviral (ARV) agents make possible a successful treatment of virtually all HIV-infected patients, but some problems related to early mortality are still of concern, mainly in resources-limited…
- Trial name
- IDEA (NCT01837277)
- Testing
- Dolutegravir 50 mg, Efavirenz-based regimens
- Where
- 3 sites in Brazil
- Volunteers
- 186 people
- Sponsor
- Fundação Bahiana de Infectologia
Infections, Coronavirus, Kidney Transplantation
COVID-19 in Immunosuppressed Children
Viral respiratory infections are common infectious complications after kidney transplantation, especially in the pediatric age group, and immunosuppressed patients may develop more severe disease.
- Conditions
- Infections, Coronavirus, Kidney Transplantation, Liver Transplantation, Cancer
- Trial name
- NCT04511429
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- D'Or Institute for Research and Education
Tuberculosis
Immunocompetent Versus Immunocompromised Tuberculosis (TB) Patients
Tuberculosis (TB) is caused by Mycobacterium tuberculosis and is one of the top 10 causes of mortality worldwide. It is estimated that in 2017, 10 million people were infected with TB, and 1.6 million died from the disease…
- Trial name
- NCT06709157
- Testing
- P24 antigens and antibody, zeihl - Nelsen stain, culture on Lowenstein jensen media
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Healthy, Immunosuppressed
Pathophysiological Study of Characteristics of the Changes in the Cutaneous Immune System After Intradermal Antigen Injections
The goal of the vaccination is to induce humoral (antibody) and intracellular (T lymphocyte) responses. Various data show that intradermal vaccination is more efficient than intramuscular vaccination: the humoral response is…
- Trial name
- LBP003 (NCT00716989)
- Testing
- Tuberculin antigen
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cerebral Toxoplasmosis
Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital
Toxoplasmosis in HIV-positive individuals is well-studied and has a codified management protocol, which is not the case for other immunodeficiencies, except for recent recommendations in the context of hematopoietic stem cell…
- Trial name
- TOXO (NCT07299500)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Pneumocystis, Pneumocystis Pneumonia
Low Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Jirovecii Pneumonia
Pneumocystis jirovecii pneumonia (PCP) is an opportunistic fungal infection of immunocompromised hosts which causes in significant morbidity and mortality.
- Conditions
- Pneumocystis, Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- LOW-DOSE (NCT04851015)
- Testing
- trimethoprim-sulfamethoxazole
- Where
- Canada
- Volunteers
- 416 people
- Sponsor
- Todd C. Lee MD MPH FIDSA
HIV, Organ Transplantation
Bringing Optimised COVID-19 Vaccine Schedules To ImmunoCompromised Populations (BOOST-IC): an Adaptive Randomised Controlled Clinical Trial
Despite the greater risk of adverse COVID-19 outcomes, antibody and cell-mediated immune responses to COVID-19 vaccines vary amongst immunocompromised (IC) people and are poorly defined.
- Conditions
- HIV, Organ Transplantation, Lymphoma, Non-Hodgkin, Chronic Lymphocytic Leukemia
- Trial name
- BOOST-IC (NCT05556720)
- Testing
- Pfizer Bivalent COVID-19 Vaccine, Moderna Bivalent mRNA vaccine
- Where
- 13 sites in Australia
- Volunteers
- 960 people
- Sponsor
- Monash University
Cytomegalovirus Infections, Cytomegalovirus Retinitis
Open Label Ganciclovir Therapy for Sight- or Life-Threatening Cytomegalovirus Disease in the Immunocompromised Patient
To make intravenous (IV) ganciclovir available to immunocompromised patients with life-threatening or sight-threatening Cytomegalovirus (CMV) infection, where the symptoms of the disease are too severe to allow admission to a…
- Conditions
- Cytomegalovirus Infections, Cytomegalovirus Retinitis, HIV Infections
- Trial name
- NCT00002025
- Testing
- Ganciclovir
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Mycoses
PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)
This phase II study will be conducted to: 1. evaluate the pharmacokinetics, safety, tolerance, and efficacy of different dosing schedules of Posaconazole in immunocompromised hosts with a variety of refractory invasive fungal…
- Trial name
- NCT00034671
- Testing
- Posaconazole oral suspension
- Volunteers
- 98 people
- Sponsor
- Merck Sharp & Dohme LLC
Actinic Keratoses
Effects of Topical Diclofenac on Tumor Metabolism
The rationale of this study is to investigate the effects of topical diclofenac on tumor metabolism in the treatment of actinic keratoses in immunocompetent and immunocompromised patients.
- Trial name
- NCT01935531
- Testing
- 3% diclofenac in 2.5% hyaluronic acid gel
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- University Hospital Regensburg
RSV Infection
RSV Vaccination in Immunocompromised Patients.
Respiratory syncytial Virus (RSV) causes respiratory infections worldwide and typically presents with a seasonal pattern peaking in autumn/winter in temperate climate zones.
- Trial name
- NCT06597916
- Testing
- Arexvy powder and suspension for injection
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Neutropenia
Safety and Pharmacokinetics of Intravenous and Oral Posaconazole in Immunocompromised Children (MK-5592-097)
This study aims to evaluate the pharmacokinetics of posaconazole (POS) administered intravenously (IV) or orally to immunocompromised pediatric participants.
- Trial name
- NCT02452034
- Testing
- Posaconazole IV solution, Posaconazole powder for oral suspension
- Volunteers
- 118 people
- Sponsor
- Merck Sharp & Dohme LLC
the Incidence of PICC-related Complications
Comparing the Safety and Effectiveness of Tunnel PICC Guided by EDUG and Conventional PICC
This study was designed as a prospective, multicenter, randomized controlled study, with the incidence of postoperative complications as the main observation end point.
- Trial name
- PICC (NCT05621473)
- Testing
- PICC
- Volunteers
- 420 people
- Sponsor
- Shandong Branden Med.Device Co.,Ltd
Respiratory Syncytial Virus Infections, Immunocompromised Host
RSV, Influenza, and SARS-CoV-2 Outcomes in Severely Immunosuppressed Adults
Respiratory syncytial virus (RSV), influenza, and SARS-CoV-2 are common respiratory viruses. In healthy adults they usually cause mild, cold-like illness, but in people whose immune system is severely weakened - such as people…
- Conditions
- Respiratory Syncytial Virus Infections, Immunocompromised Host, Influenza, COVID - 19
- Trial name
- NCT07816471
- Volunteers
- 350 people
- Sponsor
- Hospital Italiano de Buenos Aires
Immunosuppression, Neoplasm
EVER/TMC Mutation as Marker of the Risk of Cutaneous Carcinoma in Immunosuppressed Patients
Detection of mutation / specific polymorphism of the EVER/TMC6 and/or EVER/TMC8 gen.
- Trial name
- EBVER/TMC (NCT01942005)
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- Andreas Arnold
Hematological Malignancies, Cancer
Cologne Cohort of Neutropenic Patients (CoCoNut)
The Cologne Cohort of Neutropenic Patients (CoCoNut) is a non-interventional cohort study assessing risk factors, interventions, and outcome of immunosuppressed patients with or without opportunistic infections.
- Conditions
- Hematological Malignancies, Cancer, Chemotherapy, Neutropenia
- Trial name
- CoCoNut (NCT01821456)
- Testing
- Antiinfectives
- Where
- Germany
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- University Hospital of Cologne
Influenza Virus
Surveillance of Influenza Virus Shedding and Immunologic Response in Immunocompromised Children and Young Adults
Influenza virus infections are a major cause of morbidity and mortality. The limited existing knowledge about the impact of influenza in immunocompromised patients suggests that they are at increased risk of influenza virus…
- Trial name
- NCT00998803
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- St. Jude Children's Research Hospital