Clinical trials: Immunologic Disease
Atopic Dermatitis
Effects of Lactobacillus Reuteri Plus Vitamin D3 in Children With Atopic Dermatitis
The purpose of this study is to evaluate in a randomized, double-blinded, controlled trial, whether a new food supplement containing Lactobacillus reuteri DSM 17938 and vitamin D3 (Reuterin® D3) may improve the SCORAD in…
- Trial name
- NCT02945683
- Testing
- Reuterin D3
- Where
- Italy
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Noos S.r.l.
Ataxia Telangiectasia
Comparative Bioavailability of Betamethasone Oral Solution Metered Spray (GTX-102) in Healthy Subjects
A Randomized, Open-label, Crossover Study to Evaluate the Comparative Bioavailability, Pharmacokinetics, and Safety of GTX-102 Administered as an Oral Spray Compared to Intramuscular Injection - betamethasone and an Oral Solution…
- Trial name
- NCT05531890
- Testing
- GTX-102 medium dose fast Period 1 and Period 2, GTX-102 medium dose slow Period 1 and Period 2, GTX-102 high dose fast Period 1 and Period 2
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Grace Therapeutics Inc.
Eosinophilic Esophagitis
Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus
The goal of this study is to test the feasibility and the tolerability of a tethered spectrally encoded confocal microscopy (SECM) capsule and to use it to image the esophagus.
- Trial name
- NCT02202590
- Testing
- SECM Capsule
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Renal Impairment
Safinamide Renal Impairment Trial
The primary purpose of the trial is to investigate the pharmacokinetics (behaviour of the compound in the body) of safinamide in subjects with different degrees of renal impairment in comparison to matched subjects with normal…
- Trial name
- NCT01374113
- Testing
- 50mg safinamide
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Newron Pharmaceuticals SPA
Human Immunodeficiency Virus Infection, Hepatitis C
Comparison of Plasma & SMARTplasma for Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) Antibody Testing
The purpose of this study is to compare the results for HIV and/or Hepatitis C Virus antibody testing when using routine plasma versus SMARTplasma from the same blood sample.
- Trial name
- NCT01447680
- Where
- 7 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- G & W Laboratories Inc.
Allergy
Effect of Virtual Reality Headsets on Fear Anxiety and Physiological Parameter in Skin Prick Test
The goal of this clinical trial is determine the effect of virtual reality headsets on pain, anxiety, fear and physiological parameters in children aged 4-7 years who undergoing skin prick test.
- Trial name
- NCT06401408
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Retention in Care, Hiv
A Mobile Phone SMS Intervention to Increase Retention in HIV Care Among HIV-Positive MSM in Peru (WELTEL PERU)
We will use a web-based system in order to deliver a text messaging-based intervention and assess the efficacy to increase retention in HIV care among HIV+ gay men in Peru.
- Trial name
- NCT05227417
- Testing
- SMS
- Where
- Peru
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Universidad Peruana Cayetano Heredia
Egg Allergy
Clinical Tolerance to a Live Attenuated Vaccine Against Influenza (Flumist®) in a Population Allergic to Eggs
The objective of this study is to verify the clinical tolerance to the vaccine Flumist (intranasal live attenuated influenza vaccine) in a population of egg allergic children.
- Trial name
- NCT02142491
- Where
- Canada
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Healthy Subjects
Phase I Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of OSE-127 in Healthy Subjects
This study is a first-in-human phase I randomised, double-blind, placebo-controlled, evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single (IV and SC) and Multiple (IV only)…
- Trial name
- NCT03980080
- Testing
- OSE-127
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- OSE Immunotherapeutics
Sjögren's Disease
a Salivary Cell-free RNA Liquid Biopsy Model for Non-invasive Diagnosis in Sjögren's Disease
The goal of this observational study is to learn whether salivary cell-free RNA (cfRNA) can be used as a non-invasive liquid biopsy test to help diagnose Sjögren's disease (SjD) and understand disease-related changes in the…
- Trial name
- cell-free RNA (NCT07824440)
- Where
- China
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Other Preterm Infants, Vitamin D Deficiency
The Effect of Vitamin D Administration to Premature Infants on Vitamin D Status and Respiratory Morbidity
This trial objective is to assess whether doubling the daily intake of vitamin D improves serum vitamin D levels and serves as primary prevention of respiratory infections and asthma in premature infants.
- Conditions
- Other Preterm Infants, Vitamin D Deficiency, Bronchiolitis, Asthma
- Trial name
- NCT02404623
- Testing
- Vitamin D
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Healthy Volunteers, Children With HSP
Polymorphism of the IgH Locus Regulatory Region as a Prognostic Factor During Immune Pathologies.
The investigators previously showed that both antibody class switching (from IgM to IgG, IgA or IgE) and antibody secretion are controlled by a polymorphic "3' regulatory region" (3'RR) of the immunoglobulin heavy chain (IgH)…
- Conditions
- Healthy Volunteers, Children With HSP, Subject With Allergy, Lymphoma
- Trial name
- PRIERR (NCT01715623)
- Testing
- a blood sample
- Where
- 4 sites in France
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Systemic Lupus, Sjogren's Syndrome
Evaluation of Influenza A/H3N2 Vaccine in Patients With Rheumatologic Diseases
Studies in the literature have shown reduced effectiveness of influenza A (H3N2) virus vaccine (20-40%) when compared to A (H1N1) and influenza B.
- Trial name
- NCT03540823
- Testing
- Inactivated and fragmented influenza vaccine (A / Michigan / 45/2015 (H1N1) pdm09-like virus, A / Singapore / INFIMH-16-0019 / 2016 (H3N2) -like virus; B / Phuket / 3073/2013-like virus)
- Where
- Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
A Brief Negotiation Interview Chatbot to Improve Buprenorphine Engagement Among Justice-Involved Individuals
Primary Objective: Conduct pilot study to assess effects of brief negotiation interview (BNI) Chatbot among individuals involved in the Connecticut criminal justice system with opioid use disorder (OUD).
- Conditions
- Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe, Criminal Behavior
- Trial name
- BNICHAT (NCT04982627)
- Testing
- BNI Chatbot, OUD Education & Treatment Resources
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Center for Progressive Recovery, LLC
HIV Infections, Sexually Transmitted Diseases
MEMA Kwa Vijana Trial: Impact of an Adolescent Sexual and Reproductive Health Intervention in Mwanza, Tanzania
The MEMA kwa Vijana Project is a community randomised trial which aims to assess the impact of a targeted intervention on adolescent sexual and reproductive health in Mwanza Region, Tanzania.
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Pregnancy, Sexual Behavior
- Trial name
- NCT00248469
- Testing
- In-school Sexual Health Education, Youth-friendly health services, Youth condom promotion & distribution
- Where
- Tanzania
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Type 1 Diabetes, Type 2 Diabetes
Exercise and Diabetes - an Observational Study of Exercise and Blood Glucose Control
This proposal seeks to gather continuous blood glucose and physical activity data from individuals with and without diabetes.
- Trial name
- NCT02190669
- Testing
- exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
HIV Infections
Safety and Immune Response to a Clade C DNA HIV Vaccine
The purpose of this study is to evaluate the safety and immune response to an HIV clade C DNA vaccine and to an MF59-adjuvanted clade C Env protein in healthy, HIV-uninfected adults.
- Trial name
- HVTN111 (NCT02997969)
- Testing
- DNA-HIV-PT123 vaccine, Protein/MF59 vaccine
- Where
- 5 sites in South Africa, Tanzania and 1 more
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus Infection, Sexually Transmitted Diseases
Men Together Making a Difference: Reducing HIV/STD Risk Behavior Among South African Men
Sub-Saharan Africa has about 10% of the world's population, but was home to more than 60% of all people living with HIV in 2003.
- Trial name
- NCT01490359
- Testing
- Men Making a Difference HIV/STD Risk Reduction Intervention, Health Promotion Control
- Volunteers
- 1,181 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Beta-Lactams Allergy, Hypersensitivity
Genomic Study of Genetic Polymorphisms Involved in Immediate Allergic Reactions to Beta-lactam Antibiotics
Beta-lactam antibiotics include penicillin and cephalosporins and are among the most prescribed antibiotics. This category of drugs is the most involved in immediate allergic manifestations with 2% reactions in treated subjects…
- Trial name
- PANGENOMIC-BL (NCT02895646)
- Testing
- Collection of blood sample
- Volunteers
- 2,356 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Food Allergy
Influence of Persistent Food Allergy on Nutritional Status of Children With Food Allergy
The goal of this single center retrospective cohort study with observational longitudinal follow up is to compare food - allergic children (egg, milk and peanut allergy) with children in control group (children without any food…
- Trial name
- NCT05937061
- Testing
- Blood sample analysis, Anthropometrics measurement - at inclusion to the study (all groups)., Bone mineral density measurement (DXA)
- Where
- Slovenia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
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