Clinical trials: Immunological Tolerance
Impaired Glucose Tolerance, Hyperinsulinism
Effect of Meal Frequency on Glycemic Control of People at High Risk or Diagnosed With Diabetes
This study investigated any potential associations between two isocaloric diets with different meal frequency (3 meals versus 6 meals) and glycemic control in people at high diabetes risk (lean and overweight/obese women with…
- Conditions
- Impaired Glucose Tolerance, Hyperinsulinism, Poor Glycemic Control, Hyperglycemia
- Trial name
- NCT02248272
- Testing
- Isocaloric diet with 3 meals, Isocaloric diet with 6 meals
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Meropi Kontogianni
Healthy, Adult
Understanding Effects of Calcium on the Gut-Bone Axis
The study team is inviting 13 healthy people to complete a study to explore how calcium affects hormones and bones after eating. Participants will be asked to complete two study visits within eight weeks.
- Conditions
- Healthy, Adult, Calcium, Bone Resorption
- Trial name
- NCT06383117
- Testing
- Calcium carbonate
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Georgia
PreDiabetes
Black Bean (Phaseolus Vulgaris L.) Protein Hydrolysates Reduce Acute Postprandial Glucose Levels
This work aimed to evaluate the acute effect of a black bean protein hydrolysate (BPH) on glucose levels in adults with normal glucose tolerance (NGT) and prediabetes.
- Trial name
- NCT05869344
- Testing
- Black bean protein hydrolysates (BPH), Commercial non-caloric beverage
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Claudia Luévano-Contreras
Healthy Participants
Tolerance of an Immersive Virtual Reality Task Evaluating the Spatial Memory of Elderly Subjects
Spatial navigation is a high-level cognitive function allowing animals and humans to orient and move in space by constructing a mental representation of the environment.
- Trial name
- REVIAGE (NCT05996250)
- Testing
- Immersive virtual reality task
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Sleep, Insomnia
Treatment of Insomnia and Glucose Metabolism
Available data suggest that obtaining adequate sleep is associated with a better ability of the body to use carbohydrates as a source of energy and a lower risk of developing diabetes.
- Conditions
- Sleep, Insomnia, Insulin Resistance
- Trial name
- NCT00724282
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Healthy
Food Effects of Single Oral Dose of 600mg TR-701
This is an evaluation of the safety, tolerance, and pharmacokinetics of single oral doses of TR-701 given to normal, healthy, adult volunteers in the fed and fasted state.
- Trial name
- NCT00671359
- Testing
- TR-701 600mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Trius Therapeutics LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Food Allergy, Peanut Allergy
Study to Assess Tolerance of Traces in Peanut/Tree Nut Allergic Children.
This protocol will help better define whether patients with peanut and/or tree nut food allergy can tolerate traces in products with precautionary allergen labelling.
- Conditions
- Food Allergy, Peanut Allergy, Tree Nut Allergy
- Trial name
- NCT03680066
- Testing
- Oral food challenge to foods with traces
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Type 2 Diabetic
Pilot Study of the Effect of Purple Rice on Glucose Tolerance, Serum Lipids and Inflammation
This is a pilot study to demonstrate the effect of purple rice on post-prandial glucose and insulin. The purple color is due, like red wine grapes, mainly to the anthocyanins.
- Trial name
- NCT01720511
- Testing
- Purple Rice, Brown Rice
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Medicated Intrauterine Devices, Contraception
Mirena Efficiency and Tolerability During the First Year of Use
In this trial the efficacy and safety of Mirena was investigated during the first year of use
- Trial name
- NCT00696202
- Testing
- Mirena (BAY86-5028)
- Where
- France
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
Oxytocin Effects on the Tolerance of Infidelity
To investigate whether intranasal oxytocin (40 IU) treatment can influence the tolerance of infidelity in males and females.
- Trial name
- NCT02733237
- Testing
- oxytocin treatment
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Healthy Volunteers
The Tolerance, Pharmacokinetics of Jaktinib in Healthy Volunteers
A randomized, double-blinding, dose-escalated phase 1 trial to evaluate the tolerance and fasting/postprandial pharmacokinetics of jaktinib.
- Trial name
- NCT03314402
- Testing
- Jaktinib Dihydrochloride Monohydrate
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Gastrointestinal Tolerance, Gastrointestinal Symptoms
Gastrointestinal Symptoms and Tolerance in Infants Fed Goat or Cow's Milk-based Infant Formula
This randomized controlled double-blind study will compare the effect of a commercially available goat milk formula to a cow's milk formula on gastrointestinal symptoms and tolerance, and infections in infants.
- Conditions
- Gastrointestinal Tolerance, Gastrointestinal Symptoms, Infections, Quality of Life
- Trial name
- MESK-2 (NCT07342972)
- Testing
- Goat milk-based infant formula, Cow's milk-based infant formula
- Where
- Saudi Arabia
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ausnutria Hyproca B.V.
Immune Tolerance, Liver Transplant; Complications
Immune Tolerance After Pediatric Liver Transplantation
Immunosuppressive (IS) agents are effective treatment to avoid acute or chronic rejection after pediatric liver transplantation.
- Trial name
- NCT05501301
- Testing
- IS weaning off
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy
Effects of a Non-nutritive Sweetener Reduction Intervention in Pregnancy and Lactation on Maternal and Infant Outcomes
The effects of consuming non-nutritive sweeteners (NNS) during pregnancy and lactation on infant obesity and cardiometabolic disease risk are not well understood.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, Non-nutritive Sweeteners Consumption in Pregnancy and/or Lactation
- Trial name
- NCT06548828
- Testing
- NNS Restriction Intervention, Control Intervention
- Where
- United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- George Washington University
Behavioral Measures of Tolerance
Nutritive Effects of Prebiotics on Early Postnatal Behavioral Measures of Tolerance
The study is intended to measure infant comfort, behavior, and sleep when consuming study formula with prebiotics compared to infants who consume a study formula without the prebiotics.
- Trial name
- NCT02118935
- Testing
- Previously marketed cow's mlik-based infant formula, Marketed cow's milk-based infant formula with prebiotics
- Where
- 7 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Orthostatic Hypotension, Syncope
The Effect of Water Carbonation on Orthostatic Tolerance
The primary purpose of this investigation is to determine whether water carbonation can improve orthostatic tolerance in healthy control volunteers.
- Conditions
- Orthostatic Hypotension, Syncope, Vasovagal Syncope
- Trial name
- NCT05621460
- Testing
- 500mL carbonated water, 500mL still water, 50mL still water
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Simon Fraser University
Depressive Disorder
Single Dose Study of Controlled-Release Paroxetine Tablets in Healthy Japanese Male Subjects
The primary purpose of this study is to to assess the pharmacokinetics of paroxetine after single doses of paroxetine CR at the dose levels of 12.5, 25 and 50mg in healthy Japanese male volunteers.
- Trial name
- NCT00938184
- Testing
- Paroxetine 12.5 milligrams tablet, Paroxetine 25 milligrams tablet, Paroxetine 50 milligrams tablet
- Where
- Japan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Skin Aging
Tolerance and Efficacy Evaluation of 3 Face Creams
The study will evaluate the tolerance and the efficacy on skin comfort of F#1048-082 soothing cream used just after injection procedure and also the tolerance and the efficacy of the F#841-020 anti-age cream on aging parameters…
- Trial name
- FILLER (NCT02063971)
- Testing
- Soothing (formulation number: F#1048-082) and antiaging creams (F#841-020 and F#1374-002)
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Adele Sparavigna
Impaired Glucose Tolerance
The Role of Pulsatile Insulin Secretion (A Study Investigating the Effects of Partial Pacreatectomy on Glucose Metabolism)
The purpose of this study is to examine changes in sugar metabolism that may occur in subjects who have previously had part of their pancreas removed due to a benign lesion.
- Trial name
- Pilot OGTT (NCT00841867)
- Testing
- All subjects will undergo a 120 minute Oral Glucose Tolerance Test at study visit 2.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Radiation Tolerance, Skin Aging
Skin Safety Profile of Different Exposure to the Light Emitting Diode (LED) in Healthy Subjects
Photomodulation is a process which manipulates or regulates cell activity using light sources without thermal effect. Different studies have investigated the use of non-thermal low dose light emitting diode (LED) array for…
- Conditions
- Radiation Tolerance, Skin Aging, Rhytids
- Trial name
- NCT00818311
- Testing
- LED GentleWaves®
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- L'Oreal
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