Clinical trials: Immunomodulation
COVID-19
Extracorporeal Photopheresis as a Possible Therapeutic Approach to Adults With Severe and Critical COVID-19
Optimal approach for adult patients hospitalized with severe and critical COVID-19 non-responsive to antiviral and immunomodulatory drugs is not well established.
- Trial name
- COVID-ECP (NCT05882331)
- Testing
- Extracorporeal photopheresis
- Where
- Hungary
- Volunteers
- 7 people
- Sponsor
- Del-Pest Central Hospital - National Institute of Hematology and Infectious Diseases
Primary Immune Thrombocytopenia (ITP)
Immunomodulation With Eltrombopag in ITP
The study aims to investigate immunomodulatory effects of eltrombopag combined with dexamethasone in young and midlife adult patients with newly diagnosed primary Immune thrombocytopenia (ITP).
- Trial name
- iROM2 (NCT04812483)
- Testing
- Eltrombopag (Revolade®), standard therapy (without eltrombopag): HD-DXM
- Where
- 6 sites in Switzerland
- Volunteers
- 2 people
- Sponsor
- University Children's Hospital Basel
Non Small Cell Lung Cancer
Immuno-effect of Tα1 for Stage I NSCLC
To explore the effect of thymosin alpha 1 (Tα1) on postoperative peripheral blood circulating tumor cells and immunosenescence in patients with early-stage non-small cell lung cancer (NSCLC).
- Trial name
- NCT06598839
- Testing
- Thymosin Alpha1
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Yousheng Mao
Immune Thrombocytopenia
Immunomodulation With Romiplostim in Young Adults With ITP
The study aims to investigate immunomodulatory effects of thrombopoietin-receptor Agonist (TPO-RA) in patients with primary ITP, who failed first-line therapy or who became intolerant to it.
- Trial name
- iROM (NCT02760251)
- Testing
- romiplostim
- Where
- 5 sites in Switzerland
- Volunteers
- 15 people
- Sponsor
- University Hospital, Basel, Switzerland
Knee Osteoarthritis
Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells
Articular cartilage can be the seat of many diseases including osteoarthritis and traumatic defaults. The cartilage has no intrinsic ability to repair resulting at long term in function loss in the joints.
- Trial name
- ARTHROSTEM (NCT01879046)
- Testing
- arthroplasty
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Nantes University Hospital
Perennial Allergic Rhinoconjunctivitis, House Dust Mite Allergy
A Study to Investigate an Immunomodulatory Therapy in Adult Patients With Perennial Allergic Rhinoconjunctivitis
The purpose of the study is to test the efficacy of the combination treatment AllQbG10 in patients with perennial allergic rhinoconjunctivitis due to house dust mite allergy in a double-blind, placebo-controlled setting
- Trial name
- NCT00574704
- Testing
- CYT005-AllQbG10 (combination of house dust mite allergen extract with CYT003-QbG10)
- Volunteers
- 40 people
- Sponsor
- Cytos Biotechnology AG
Organ Transplantation, Intestine
Leuven Tolerogenic Protocol for Intestinal Transplantation
An immunomodulatory protocol, experimentally-proven to promote T-regulatory dependent graft protective mechanisms was applied in a clinical cohort of 13 intestinal transplant recipients to activate - in a protolerogenic…
- Trial name
- LP (NCT02314949)
- Testing
- intestinal transplantation
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Colorectal Cancer, Non-small Cell Lung Carcinoma (Adenocarcinoma), Triple Negative Breast Cancer, Renal Cell Carcinoma
A Study of PDR001 in Combination With LCL161, Everolimus or Panobinostat
The purpose of this study was to combine the PDR001 checkpoint inhibitor with several agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety…
- Trial name
- NCT02890069
- Testing
- PDR001, LCL161, Everolimus
- Where
- 25 sites in United States, Germany and 5 more
- Volunteers
- 298 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, Relapsing Remitting Multiple Sclerosis
Investigation of Subclinical Markers of Multiple Sclerosis
Transcranial magnetic stimulation (TMS) studies reported consistent and substantial impairments in the central nervous system (CNS) in multiple sclerosis (MS).
- Trial name
- SUBCLIN-MS (NCT04604041)
- Testing
- 1. Clinical testing; 2. Neurophysiological examination (TMS, EMNG); 3. Psychomotor examination; 4. Neuropsychological evaluation; 5. Flow cytometry; 6. ELISA
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University of Split, School of Medicine
Kidney Transplantation, Renal Transplant Recipients
Selective CD28 Blockade in Renal Transplant Recipients
The aim of this study is to evaluate the safety and efficacy of lulizumab, a CD28-specific domain antibody (CD28 dAb), compared to tacrolimus, as the primary immunosuppressant in first-time renal transplant recipients.
- Trial name
- NCT04903054
- Testing
- Lulizumab, Tacrolimus, Thymoglobulin®
- Where
- United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infection, Atherosclerosis
Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients
This study is a substudy of the MAN2 -study (Mycophenol mofetil in Antiretroviral Naïve patients 2, see elsewhere in the ClinicalTrials.gov database).
- Trial name
- NCT00247494
- Testing
- mycophenol mofetil (MMF, Cellcept®) 500 mg BID
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Bladder Cancer
Oral Lenalidomide and Intravesical BCG for Therapy of Bladder Cancer
The purposes of this study are to: find out whether participants' cancer returns or gets worse while they are taking lenalidomide and Bacille Calmette-Guerrin (BCG); evaluate the safety and tolerability of the combination of…
- Trial name
- NCT01373294
- Testing
- Bacille Calmette-Guerrin (BCG), Lenalidomide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Ischemia Reperfusion Injury, Ischaemia Reperfusion Injury
Immune Modulation by Ischemic Pre-conditioning in Healthy Individuals: Intracellular Signalling in Regulatory Cells
The aim of the study is to investigate how phosphorylation of STAT3, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) reacts to remote ischemic conditioning (rIC)…
- Trial name
- KONDI-immun (NCT03541239)
- Testing
- Single Cuff Tourniquet 8000
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Crohn's Disease
Vitamin D Supplementation in Adult Crohn's Disease
The purpose of this study is to determine whether vitamin D supplementation is effective in the prevention of relapse in Crohn's disease.
- Trial name
- VITD-CD (NCT01369667)
- Testing
- Vitamin D3
- Where
- Ireland
- Volunteers
- 117 people
- Sponsor
- University of Dublin, Trinity College
Dry Eye Syndrome (DES), Sjogren's Syndrome
Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome
By analyzing the differential proteins in exosomes, this study aims to understand the pathological mechanisms of SJS and DES, identify potential diagnostic and therapeutic methods, and advance the diagnosis and treatment of these…
- Conditions
- Dry Eye Syndrome (DES), Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT06771427
- Testing
- acupuncture GB20 or GB20 plus BL2, Chinese herbal tea TBDESJS
- Where
- Taiwan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Multiple Sclerosis, MS, Clinically Isolated Syndrome
Cohort Study of Clinically Isolated Syndrome and Early Multiple Sclerosis
A majority of patients with multiple sclerosis initially presents with a single demyelinating event, e.g. in the optic nerves, brain, brainstem or spinal cord, referred to as a clinically isolated syndrome (CIS).
- Trial name
- CIS-COHORT (NCT01371071)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Charite University, Berlin, Germany
Hepatocellular Cancer, Gastrointestinal Cancer
Investigation of Immune Modulation by Modern Acupuncture in Gastroenterologic Cancers
According to the total population of cancer patients, hepatocellular carcinoma (HCC) and colorectal cancer (CRC), two of gastroenterological cancers are involved in the most acquired five cancers.
- Conditions
- Hepatocellular Cancer, Gastrointestinal Cancer, Immunosuppression
- Trial name
- NCT04692454
- Testing
- Modern acupuncture
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- Taipei Medical University WanFang Hospital
Obesity
The Symbiont-Restore Study
Within the framework of the Science Foundation Ireland funded Microbe Restore Project, the Symbiont Restore Study is an Investigator-initiated trial which explores the prospective health advantages associated with a particular…
- Trial name
- NCT05942586
- Testing
- Probiotic capsule (L. reuteri PB-W1™), Prebiotic sachet (Prebiotic Blend)
- Where
- Ireland
- Volunteers
- 137 people
- Sponsor
- University College Cork
Heart Failure, Congestive
ACCLAIM - Advanced Chronic Heart Failure CLinical Assessment of Immune Modulation Therapy
The purpose of this study is to test the safety and efficacy of the Celacade™ system in reducing the risk of mortality and cardiovascular hospitalizations in patients with chronic systolic heart failure.
- Trial name
- NCT00111969
- Testing
- Celacade™ system
- Volunteers
- 2,016 people
- Sponsor
- Vasogen
Human Papillomavirus Infection
Efficacy and Immunomodulation Study of Simultaneous Human Papillomavirus/ Hepatitis B (HPV/HBV) Vaccination
Rationale: In march 2009 the Dutch Health Council advised to introduce general infant hepatitis B (HBV) vaccination in the Dutch national immunization program (NIP) {Gezondheidsraad 2009 #16914}.
- Trial name
- TANGO (NCT01082861)
- Testing
- Cervarix, Engerix-B
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute for Public Health and the Environment (RIVM)