Clinical trials: Impaired Cognition
Healthy
Carbon Dioxide (CO2) and Cognitive Impairment
The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.
- Trial name
- NCT05292378
- Testing
- 2500 ppm Carbon Dioxide, 600 ppm Carbon Dioxide
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cancer, Insomnia
Online Treatment of Cognitive Impairment and Insomnia in Cancer Survivors
The investigators will answer the question of whether treating insomnia using Cognitive Behavior Therapy for Insomnia (CBT-I) can improve perceived cognitive impairment (PCI) in cancer survivors compared to a waitlist control…
- Conditions
- Cancer, Insomnia, Cognitive Impairment
- Trial name
- NCT04026048
- Testing
- Cognitive Behaviour Therapy for Insomnia (CBT-I)
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- Memorial University of Newfoundland
Parkinson's Disease, Cognitive Impairment
Memantine for Treatment of Cognitive Impairment in Patients With Parkinson's Disease and Dementia
The purpose of this research is to evaluate the usefulness of memantine, compared to placebo (sugar pill), for the treatment of cognitive impairment in patients with idiopathic Parkinson's disease (PD) and dementia.
- Conditions
- Parkinson's Disease, Cognitive Impairment, Dementia
- Trial name
- NCT00294554
- Testing
- Memantine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Dementia
Combining Acupuncture and Acupressure for Dementia Elderly
This is an assessor-blinded, randomized controlled trial. A total of 248 (anticipated) elderly people aged ≥65 years with a mild to moderate dementia will be recruited from local nursing and care homes.
- Trial name
- NCT04305951
- Testing
- Comprehensive acupuncture therapy (CAT), Comfy Acupressure for the Elderly (CAE)
- Where
- Hong Kong
- Volunteers
- 236 people
- Sponsor
- The University of Hong Kong
Cognitive Ability, General, High Blood Pressure
Assessing the Impact of Calcium Channel Blockers on COGnitive Function in the Very Elderly (AI-COG)
Older adults are at increased risk of high blood pressure and cognitive decline. High blood pressure itself also increases risk of cognitive decline.
- Trial name
- NCT01868165
- Where
- 7 sites in United Kingdom
- Volunteers
- 337 people
- Sponsor
- Imperial College London
HIV Infections
Clinical Trial of CNS-targeted HAART (CIT2)
CIT2 is a strategy for targeting HAART (Highly Active Antiretroviral Therapy) to the CNS (Central Nervous System) in patients with HIV associated neurocognitive impairment (HNCI).
- Trial name
- NCT00624195
- Testing
- FDA Approved Antiretroviral Therapy (see list below)
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of California, San Diego
Substance Abuse, Substance Dependence
Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment
The initial phase of substance abuse treatment is a vulnerable period for relapse. Cognitive impairments are common during this phase and may reduce the ability to benefit from other forms of substance abuse and rehabilitation…
- Conditions
- Substance Abuse, Substance Dependence, Cognitive Impairment
- Trial name
- NCT01410110
- Testing
- Cognitive Training + Work Therapy, Work Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Yale University
Traumatic Brain Injury, Fatigue
Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy
This study aims to evaluate the efficacy of 4 weeks of daily light exposure in reducing Post-Traumatic Brain Injury (TBI) Fatigue immediately post-treatment and at a one-month follow up.
- Trial name
- NCT01725750
- Testing
- Bright White Light (BWL), Dim Red Light (DRL)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Cognitive Impairment, Lewy Body Dementia, Parkinson's Disease Rapid Eye Movement Sleep Behavior Disorder, Parkinson's Disease Dementia
A Study of Clenbuterol (CST-103) Co-administered With Nadolol (CST-107) in Subjects With Neurodegenerative Disorders
This is a Phase II, randomized, placebo-controlled, double-blind, crossover study on the CNS and pharmacodynamic effects of clenbuterol (CST-103) co-administered with nadolol (CST-107) in 4 subject populations with…
- Trial name
- CLIN-011 (NCT04739423)
- Where
- 7 sites in Australia, New Zealand and 1 more
- Volunteers
- 41 people
- Sponsor
- CuraSen Therapeutics, Inc.
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain
We aim to conduct a pilot randomized controlled trial comparing 2 symptom management programs for older adults with self-reported memory problems and chronic pain, Active Brains 1 and Active Brains 2.
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT04044183
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Obstructive Sleep Apnea, Mild Cognitive Impairment
Mild Cognitive Impairment and Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) has been linked to increased risk for Alzheimer's disease (AD), but little prospective evidence exists on the effects of OSA treatment in preclinical AD.
- Trial name
- MEMORIES (NCT01482351)
- Testing
- CPAP adherence intervention, Attention control intervention
- Where
- 3 sites in United States
- Volunteers
- 54 people
- Sponsor
- George Mason University
Cognitive Impairment
GAME Veterans With PTSD Using Computer-Based Cognitive Training
The investigators hypothesis are as follows: H1a: OEF/OIF veterans with PTSD who perform cognitive training (CT) will demonstrate greater objective improvements on standard (untrained) neurocognitive measures, with the largest…
- Trial name
- NCT01087775
- Testing
- Cognitive Training
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Karen Seal
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Breast Cancer Female
Metacognitive Strategy Training in Cancer-related Cognitive Impairment
The first aim of this study is to determine the feasibility of delivering CO-OP remotely to breast cancer survivors, who self-report cancer-related cognitive impairment (CRCI), in preparation for a future R01 trial.
- Trial name
- NCT05505045
- Testing
- CO-OP Procedures, Attention Control Procedures
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Missouri-Columbia
Alzheimer Disease, Dementia
A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)
The main goals of this study are to further determine whether the study drug donanemab is safe and effective in participants with Alzheimer's disease and to validate neuropsychological assessments administered over…
- Conditions
- Alzheimer Disease, Dementia, Brain Diseases, Central Nervous System Diseases
- Trial name
- NCT04640077
- Testing
- No Intervention, donanemab
- Where
- 27 sites in United States, Canada
- Volunteers
- 95 people
- Sponsor
- Eli Lilly and Company
Cognitive Impairment, End Stage Renal Disease
A Study to Assess the Tolerability and Efficacy of AKST1210 in Patients on Hemodialysis With Cognitive Impairment
This study will evaluate the tolerability, feasibility, and efficacy of the AKST1210 column in subjects with end-stage renal disease with cognitive impairment (ESRD-CI) undergoing hemodialysis 3 times per week.
- Trial name
- NCT04527328
- Testing
- AKST1210, Hemodialysis
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Alkahest, Inc.
Mild Cognitive Impairment
Plasticity Using Stimulation and Habit: A Pilot Open-label rTMS Study for MCI
The goal of this pilot study is to determine whether a high-dose form of non-invasive brain stimulation is a promising and safe treatment for Mild Cognitive Impairment (MCI).
- Trial name
- PUSH-Pilot (NCT04503096)
- Testing
- High-dose accelerated rTMS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Alzheimer Disease
BI 425809 in Patients With Cognitive Impairment Due to Alzheimer's Disease.
The study is designed to compare the effects of BI 425809 compared to placebo in patients with cognitive impairment due to Alzheimer's Disease.
- Trial name
- NCT02788513
- Testing
- BI 425809 dose 1, BI 425809 dose 2, BI 425809 dose 3
- Where
- 95 sites in United States, Austria and 12 more
- Volunteers
- 611 people
- Sponsor
- Boehringer Ingelheim
Alzheimer's Disease
Resveratrol for Alzheimer's Disease
Resveratrol is derived from plants and is found in highest levels in red wine and the skin of red grapes. A recent study reported that monthly and weekly consumption of red wine is associated with a lower risk of dementia.
- Trial name
- NCT01504854
- Testing
- Resveratrol
- Where
- 26 sites in United States
- Volunteers
- 119 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Schizophrenia
The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia
The primary objectives of this application are to determine if the selective ERβ agonist LY500307, when added to antipsychotic medications, improves negative and/or cognitive symptoms in patients with schizophrenia.
- Trial name
- Beta (NCT01874756)
- Testing
- LY500307 150mg, LY500307 75mg, LY500307 25mg
- Where
- 4 sites in United States
- Volunteers
- 95 people
- Sponsor
- Indiana University