Clinical trials: Impaired Glucose Tolerance (Prediabetes)
Prediabetic State, Diabetes Mellitus, Type 2
Cardiorespiratory Fitness in Prediabetic,Type 2 Diabetic and Healthy Individuals
The aim of this study to investigate and compare cardiorespiratory fitness (CRF) parameters of prediabetic, type 2 diabetic and healthy individuals.
- Conditions
- Prediabetic State, Diabetes Mellitus, Type 2, Cardiorespiratory Fitness, Inflammation
- Trial name
- NCT03823664
- Testing
- Cardiorespiratory Fitness
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Gestational Diabetes, Glucose Intolerance
Postpartum Weight Loss and Exercise (PRIDE)
The overall objective of this pilot project is to test in 50 women with a history of gestational diabetes mellitus (GDM), the effectiveness and feasibility of an 8 month intensive lifestyle intervention to reduce the rate of…
- Trial name
- PRIDE (NCT01296516)
- Testing
- Non-intervention group, Face to face, Telehelath Group
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Pennington Biomedical Research Center
Cystic Fibrosis
Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance
This study will investigate the link between glucose abnormalities and elements critical to muscle function including mass, composition and energy metabolism.
- Trial name
- NCT02776098
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Obesity, Prediabetes
The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal Rhythm
Time-restricted eating (TRE) is a dietary manipulation that involves restricting food intake to 6-12 h/day with no food intake during the rest of the day. In animals, TRE improves metabolic function without caloric restriction.
- Trial name
- Rhythm (NCT07820384)
- Testing
- Time restricted eating, Healthy Eating, Extended eating window
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Lactose Intolerance, Lactose Intolerant
Milk for Diabetes Prevention
Individuals with lactase non-persistence (LNP; determined by a functional variant in the LCT gene [rs4988235, GG genotype]) are susceptible to lactose intolerance in adulthood due to deficiency of lactase, the enzyme which…
- Conditions
- Lactose Intolerance, Lactose Intolerant, Lactase Persistence, Pre-Diabetes
- Trial name
- NCT06513026
- Testing
- Lactose-Containing Milk, Lactose-Free Milk
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Albert Einstein College of Medicine
Glucose Intolerance
A Low Glycemic Index Diet for Prevention of Glucose Intolerance During Bed Rest
Recovery from surgery, injury or illness might require periods of bed rest in-hospital or at home. Bed rest may be needed for recovery but also has negative consequences.
- Trial name
- NCT03595943
- Testing
- Low glycemic index, pulse-based diet, Moderate glycemic index hospital diet
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Apical Periodontitis, Insulin Resistance
Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.
Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin…
- Conditions
- Apical Periodontitis, Insulin Resistance, PreDiabetes, Diabetes; Stable
- Trial name
- NCT04824209
- Where
- 2 sites in Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Type2 Diabetes Mellitus
Study of Association of Salivary Adipokines With Prediabetes and Type 2 Diabetes Mellitus
India has more than 65 million adults with Type 2 Diabetes Mellitus (T2DM) and also has a large number with subclinical stages of glycaemia including impaired fasting glucose (IFG) and impaired glucose tolerance (IGT).
- Trial name
- NCT03901248
- Testing
- No Intervention
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
Overweight and Obesity, Prediabetes
Effects of Biofunctional Orange Juice on Cardiometabolic Risk Markers
The effects of orange juice enriched with vitamin D3 and encapsulated probiotics (Lacticaseibacillus casei Shirota and Lacticaseibacillus rhamnosus GG) compared to conventional orange juice on several cardiometabolic and…
- Conditions
- Overweight and Obesity, Prediabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114576
- Testing
- Orange juice enriched with vitamin D3 and encapsulated probiotics, Conventional orange juice
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Agricultural University of Athens
PreDiabetes
Whole Prediabetes: A Family-Centered Whole Foods Diet in Adults With Prediabetes and Their Offspring
This study will address the following aims: Aim 1: Design a family-centered whole foods diet adapted from the 2020-2025 DGA framework for 8-12 families that include an index parent (25-59 years) with medically managed prediabetes…
- Trial name
- NCT05483972
- Testing
- Whole Prediabetes Diet Intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Diabetes, Pre-diabetes
Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)
The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α…
- Conditions
- Diabetes, Pre-diabetes, Obesity
- Trial name
- NCT01876992
- Testing
- Metformin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cardiovascular Disease
Prevention of Cardiac and Vascular Events in Patients With NGT/IGT.
Impaired glucose tolerance or mild glucose elevations in the non-diabetic range are associated with increased cardiovascular disease and recent studies suggested the need to detect these glucose abnormalities early in the…
- Trial name
- NCT00408577
- Testing
- L-arginine
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Insulin Resistance, Obesity
Efficacy of Lyophilized Dried Cornus Mas L. on Anthropometric and Biochemical Parameters in Insulin Resistance
The aim of this study is to determine the effect of 3 months supplementation of lyophilize dried cornelian cherry (Cornus mas L.) on women diagnosed with insulin resistance.
- Conditions
- Insulin Resistance, Obesity, PreDiabetes
- Trial name
- NCT05292300
- Testing
- Cornelian Cherry (Cornus mas L.), Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Marmara University
Type 2 Diabetes Mellitus
The Study of Exenatide Action on Vessel Function in Type 2 Diabetes and Prediabetes
The purpose of this investigation is to evaluate whether exenatide, a type 2 diabetes medication, will improve the function of the innermost part of the arterial wall called the endothelium after a fat-enriched meal and to…
- Trial name
- NCT01181986
- Testing
- Exenatide SC, Exenatide IV, Exendin-9
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Carl T. Hayden VA Medical Center
Metabolic Syndrome, Prediabetes
Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome
This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes.
- Trial name
- BITE (NCT07620886)
- Testing
- Postprandial walking, Brief resistance exercise snacks
- Volunteers
- 25 people
- Sponsor
- Seoul National University
Impaired Glucose Tolerance
Effects of Artificial Sweeteners on Gut Microbiota and Glucose Metabolism
The Objectives of this study is to determine the effect(s) of daily non-caloric artificial sweetener (NAS) consumption (sucralose or aspartame) on the composition of the bacteria and also to determine the changes in glucose…
- Trial name
- NCT02569762
- Testing
- Sucralose-Aspartame, Aspartame-Sucralose
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Pre-diabetes
Continuous Glucose Monitoring in Prediabetes
The objective of this project is to develop a behavioral intervention that combines wearable continuous glucose monitoring (CGM) with smartphone feedback and educational video clips generated by artificial intelligence (AI)…
- Trial name
- G1 (NCT06472297)
- Testing
- The continuous glucose monitoring system
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Prediabetes, Newly Diagnosed Type 2 Diabetes
The Effects of Jerusalem Artichoke and Fermented Soybean Powder Mixture Supplementation on Glucose Control
The purpose of this randomized, double-blind, placebo-controlled study was to determine whether jerusalem artichoke and fermented soybeans powder mixture is effective in the control of blood glucose level in subjects with…
- Trial name
- NCT02506582
- Testing
- jerusalem artichoke and fermented soybeans powder mixture
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Food Insecurities, Cardiometabolic Comorbidities
Human Immunodeficiency Virus (HIV) Food Insecurities
The objectives of this study are to better understand how FI (food insecurities) contributes to the development of cardiometabolic comorbidities among PWH (People with HIV) and to test a novel bilingual FI intervention designed…
- Conditions
- Food Insecurities, Cardiometabolic Comorbidities, HIV, PreDiabetes
- Trial name
- NCT04943861
- Testing
- weCare/Secure, Usual Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Wake Forest University Health Sciences
Alzheimer Disease
Study of Azeliragon in Patients With Mild Alzheimer's Disease and Impaired Glucose Tolerance
This is a study to evaluate the efficacy and safety of azeliragon in patients with mild Alzheimer's disease and impaired glucose tolerance.
- Trial name
- Elevage (NCT03980730)
- Testing
- Azeliragon
- Where
- 33 sites in United States, Canada
- Volunteers
- 43 people
- Sponsor
- vTv Therapeutics
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