Clinical trials: Impaired Health
Mild Cognitive Impairment (MCI), Depressive Symptoms
rTMS Combined With Aerobic Exercise for Older Adults With Mild Cognitive Impairment and Comorbid Depression
This study aims to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) and aerobic exercise on cognitive function and mental health in older adults with mild cognitive impairment (MCI) and comorbid…
- Trial name
- NCT07652775
- Testing
- Repetitive Transcranial Magnetic Stimulation, Aerobic Exercise
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Cheng-Hsin General Hospital
Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI)
CPAP Randomized Controlled Trial
The overall goal of this randomized controlled trial is to test the hypothesis that in older adults with mild cognitive impairment (MCI) and previously untreated obstructive sleep apnea (OSA), 4 months of web-based sleep…
- Conditions
- Obstructive Sleep Apnea (OSA), Mild Cognitive Impairment (MCI), Cognitive Decline Prevention in Pre-frail Older Adults
- Trial name
- NCT06773416
- Testing
- CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health, Delayed CPAP Therapy Combined with Web-Based Sleep Education for Cognitive and Sleep Health
- Where
- Canada
- Volunteers
- 206 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neurocognitive Disorders
Personalized Interventions Via Health Portraits in Mild Behavioral Impairment
The incidence of MBI and the probability of progression to dementia are high. Early detection and intervention have important clinical significance to reduce the occurrence of dementia, delay the progression of dementia and…
- Trial name
- NCT06416514
- Testing
- Personalized intervention
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Provincial Hospital
Dementia
Preventing Medication Mismanagement in People Living With Dementia
The purpose of this research is to learn whether the HiDO-ALZ device can improve medication compliance and health outcomes in participants with dementia that need to take daily medication.
- Trial name
- NCT07600684
- Testing
- HiDO HomeCareSystem
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- HiDO Technologies
Alcohol Dependence, Dependence
Screening for Alcohol-related Cognitive Impairments in Cirrhotic Patients
80% of patients with alcohol use disorders (AUD) present cognitive impairments, such as memory and executive functions. These disorders may have repercussions in addiction treatment by altering the patient's adherence to care.
- Conditions
- Alcohol Dependence, Dependence, Cognitive Impairments, Cirrhosis
- Trial name
- CirCo (NCT04490330)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Postpartum Pelvic Floor Dysfunction, Postpartum Urinary Incontinence
Exercise-Based Sensorimotor Physiotherapy for Postpartum Pelvic Health and Functional Recovery
This study evaluated whether a 12-week exercise-based sensorimotor physiotherapy program could improve pelvic health and functional recovery in postpartum women.
- Conditions
- Postpartum Pelvic Floor Dysfunction, Postpartum Urinary Incontinence, Postpartum Functional Recovery, Lumbopelvic Motor Control Impairment
- Trial name
- NCT07702565
- Testing
- Exercise-Based Sensorimotor Physiotherapy Program, Standard Postpartum Education and Home Advice
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Özge BAYKAN ÇOPUROĞLU
Stroke, Cognitive Decline
Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE)
This study is a phase III, prospective, placebo-controlled randomized clinical trial involving 8,518 subjects with low to moderate stroke risk, followed for 3 years in Brazil.
- Trial name
- PROMOTE (NCT05155137)
- Testing
- Drug Capsule (Valsartan + Amlodipine + Rosuvastatin), Stroke Riskometer
- Where
- 2 sites in Brazil
- Volunteers
- 8,518 people
- Sponsor
- Hospital Moinhos de Vento
Mild Cognitive Impairment, Cognitive Decline
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
The study will examine whether 5mg melatonin (over the counter, OTC) over a 9-month period improves Alzheimer's disease (AD) biomarkers and cognitive function in two groups of individuals: those with mild cognitive impairment…
- Conditions
- Mild Cognitive Impairment, Cognitive Decline, Healthy Aging
- Trial name
- NCT03954899
- Testing
- melatonin
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Natalie Denburg
Cochlear Implants, Sensory-Neural Hearing Loss
Balance in Children With Cochlear Implants
Cochlear implantation is performed in children with sensorineural hearing loss to restore hearing. Fifty percent of children with sensory neural hearing loss, who are candidates for cochlear implant, have vestibular (inner ear)…
- Conditions
- Cochlear Implants, Sensory-Neural Hearing Loss, Balance Disorder
- Trial name
- NCT03620500
- Testing
- Gross motor and developmental balance testing
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Mild Cognitive Impairment (MCI)
Unlock the Secrets of Ageing Brains Through P300 Brain-computer Interface Games
The study will investigate the use of Electroencephalography (EEG) in understanding mild cognitive impairment (MCI). EEG is commonly used in everyday clinical practice for the assessment of a wide range of neurological disorders.
- Trial name
- NCT06628427
- Testing
- MoCA Test, Random Dot Motion (RDM) task, P300-BCI task without feedback
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Sheffield
Hearing Loss, Tinnitus
Hearing Impairment, Cognitive Therapy and Coping
A randomized controlled study with hearing impaired workers, who have voluntarily signed up for an 8 session cognitive therapy (CBT) course The CBT intervention will be compared to a waiting list control group.
- Conditions
- Hearing Loss, Tinnitus, Stress, Psychological, Mental Fatigue
- Trial name
- NCT01206829
- Testing
- 8-session CBTcourse, 8 session cognitive behavioral therapy
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Aging, Mild Cognitive Impairment
My Healthy Brain: Preserving and Promoting Brain Health Through Evidence-based Practices
The objective of this trial is to demonstrate early proof-of-concept for My Healthy Brain, an 8-week group program that directly targets multiple lifestyle factors associated with brain health and prevention of cognitive decline.
- Conditions
- Aging, Mild Cognitive Impairment, Dementia, Old Age; Dementia
- Trial name
- NCT04537728
- Testing
- My Healthy Brain Version 2
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Mental Health Impairment, Mental Health Disorder
The MILESTONE Study: Improving Transition From Child to Adult Mental Health Care
This study evaluates the longitudinal health and social outcomes of adolescent mental health service users who are at the transition boundary of their child and adolescent mental health service, and whether the implementation of…
- Trial name
- MILESTONE (NCT03013595)
- Testing
- TRAM feedback
- Where
- 10 sites in Belgium, Croatia and 6 more
- Volunteers
- 1,000 people
- Sponsor
- University of Warwick
Cognitive Impairment
The Effect of Exercise on Cognition in Older Adults At-risk for Diabetes: A Feasibility Pilot Study
Older adults with type 2 diabetes experience cognitive decline and are at higher risk for developing dementia. Consequently, older adults at-risk for developing type 2 diabetes (based on body mass, glucose levels) are at higher…
- Trial name
- NCT03254381
- Testing
- Resistance Training, Balance and Tone Training
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Western University, Canada
Stem Cell Transplantation
Physical Impairments in Allogeneic-HSCT
Pulmonary functions, exercise capacity and muscle strength deteriorate in survived hematopoietic stem cell transplantation (HSCT) recipients due to toxic effects of chemotherapy, radiotherapy, conditioning regimens and/or…
- Trial name
- NCT03448627
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Gazi University
COVID-19, SARS-CoV-2 Infection
Physical and Cognitive Impairments in People Suffering From Long COVID
Of the 1,900,000 Canadians who have been infected by COVID-19, 8 to 15% will continue to experience COVID-19 related symptoms well after 12 weeks. The persistence of such symptoms is now defined as "long COVID" syndrome.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Corona Virus Infection, Physical Disability
- Trial name
- NCT05216536
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Laval University
Attention Impaired, Cognitive Change
The Influence of Mindfulness Meditation Retreat on Attention to Internal Experience
Although attention is thought to have a definitive functional role in mindfulness meditation training and its salutary mechanisms of action, extant empirical evidence is mixed and limited.
- Conditions
- Attention Impaired, Cognitive Change, Mental Health Issue
- Trial name
- NCT04749264
- Testing
- Mindfulness meditation retreat
- Where
- Israel
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Post-Intensive Care Syndrome (PICS), Critical Illness Recovery
Virtual Reality for Recovery After Intensive Care (PICS)
The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU).
- Conditions
- Post-Intensive Care Syndrome (PICS), Critical Illness Recovery, Rehabilitation After Critical Illness, Rehabilitation Exercise of ICU Patients
- Trial name
- VR4ICU (NCT07585500)
- Testing
- Immersive VR Multi-Domain Rehabilitation, Tablet-Based Multi-Domain Training
- Where
- Portugal
- Volunteers
- 51 people
- Sponsor
- University of Minho
Stroke Rehabilitation
Multimodal Correction of Post-stroke Motor and Cognitive Impairments
The aim of the study is the development and scientific substantiation of the effectiveness and safety of multimodal rehabilitation technology using innovative digital technologies, biofeedback (BFB), virtual reality (VR)…
- Trial name
- NCT05391919
- Testing
- Multimodal technology (MT), Conventional rehabilitation (CR)
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Renal Impairments, IgA Nephropathy (IgAN)
A Study of RG002C0106 Injection in Adult Participants With Normal Renal Function and Mild-to-Moderate Renal Impairment
This is a Phase I trial designed to evaluate the impact of renal impairment on the efficacy and safety of the drug by comparing pharmacokinetic (PK) parameters and pharmacodynamic (PD) markers after a single subcutaneous…
- Trial name
- NCT07445906
- Testing
- RG002C0106
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd.