Clinical trials: Impairment
Healthy, Hepatic Impairment
Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib
The purposes of this study are to determine: The pharmacokinetics (the amount of study drug in your blood and how long it takes the body to get rid of it) of the study drug and its metabolites (substances produced as the body…
- Trial name
- NCT06997276
- Testing
- Mirdametinib (MEK Inhibitor)
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Congestive Heart Failure, Cognitive Impairment
Cognitive Training in Heart Failure Study (CogTrain-HF)
The daily routine in clinical settings often showed cognitive impairments in patients with congestive heart failure, particularly in terms of executive functions, episodic memory, perceptual speed and attention.
- Trial name
- CogTrain-HF (NCT02415517)
- Testing
- Cognitive training, Test of general knowledge
- Where
- 2 sites in Germany
- Volunteers
- 107 people
- Sponsor
- Universität des Saarlandes
Multiple Sclerosis
The Effects of Attention Retraining in MS
The purpose of this study is to determine whether neuropsychological rehabilitation focused on attention retraining and teaching compensatory strategies has positive effects on cognitive performance, quality of life (QoL)and…
- Trial name
- MSattention (NCT01492023)
- Testing
- neuropsychological rehabilitation
- Where
- 3 sites in Finland
- Volunteers
- 97 people
- Sponsor
- Finnish MS Society
Mild Cognitive Impairment
Effects of Cognitive-motor Training on Cognition, Depression and Daily Functioning in Patients With Mild Cognitive Impairment (MCI)
This randomized controlled trial evaluated the effectiveness of an immersive virtual reality (IVR) application (focused on a daily activity) to train cognitive functions and its impact on depression and the ability to perform…
- Trial name
- NCT06313931
- Testing
- cognitive training via immersive virtual reality, cognitive training via paper and pencil, motor stimulation
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Universidad de Zaragoza
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
Risk Model of Cognitive Impairment in Diabetes
Development and validation of a risk model for predicting the risk of mild cognitive impairment among individuals of type 2 diabetes.
- Trial name
- NCT05590442
- Testing
- Tests
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Overweight and Obesity
Early Detection of Myocardial Work Impairment in Obesity II(EARLY-MYO-OBESITY-II)
This prospective study intends to explore the change of cardiac structure and function in the cohort of overweight or obesity patients, and determine the impact of clinical characteristics on cardiac remodeling and mechanics.
- Trial name
- NCT04933188
- Testing
- Myocardial work was estimated from left ventricular pressure-strain loop derived from speckle tracking echocardiography and non-invasive brachial artery cuff pressure
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Diabetes Mellitus, Type 2, Obesity
A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function
Novo Nordisk is developing the study medicine NNC0487-0111 to treat people living with type 2 diabetes and/or people living with overweight or obesity.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Overweight
- Trial name
- NCT06559527
- Testing
- NNC0487-0111
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Novo Nordisk A/S
Parkinson Disease
A Prospective Longitudinal Assessment of PD Functional Impairment and Disability Via Mobile Health Technology
The purpose of this study is to compare data from a battery of novel mobile health technologies to standard-of-care validated patient questionnaires and clinician rating scales in Parkinson's disease patients.
- Trial name
- NCT05153356
- Testing
- Personal Kinetigraph, Kinesia 360
- Sponsor
- Rush University Medical Center
Physical Disability
Feasibility of An Active Video Gaming Intervention
Replacing sedentary behaviors during leisure time with active video gaming (AVG) has been shown to be an enjoyable option for increasing the amount of physical activity acquired each week.
- Trial name
- NCT05310279
- Testing
- GAIMplank
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury
Evaluation of Consciousness Impairment in Severe TBI and Full-cycle Neuroregulation Based on Multimodal Imaging
The goal of this observational study is to learn about in Evaluation of consciousness impairment in severe TBI and full-cycle neuroregulation based on multimodal imaging.
- Trial name
- NCT06469827
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Visual Impairment, Macular Edema
Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Central Retinal Vein Occlusion (CRVO)
This clinical trial is designed to compare ranibizumab in comparison with Dexamethasone implant® after 6 months of treatment. In the study arm Lucentis will be given monthly in a pro re nata scheme whereas the comparator…
- Conditions
- Visual Impairment, Macular Edema, Central Retinal Vein Occlusion
- Trial name
- COMRADE-C (NCT01396083)
- Testing
- Ranibizumab
- Where
- 64 sites in Germany, Hungary and 2 more
- Volunteers
- 243 people
- Sponsor
- Novartis Pharmaceuticals
Mild Cognitive Impairment Due to Alzheimer's Disease
Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset
The purpose of this study is to qualify the biomarker risk algorithm for prognosis of the risk of developing Mild Cognitive Impairment due to Alzheimer's Disease (MCI-AD), and also to evaluate the efficacy of pioglitazone…
- Trial name
- TOMMORROW (NCT01931566)
- Testing
- Pioglitazone
- Where
- 55 sites in United States, Australia and 3 more
- Volunteers
- 3,494 people, healthy volunteers welcome
- Sponsor
- Takeda
Mild Cognitive Impairment (MCI), Memory Disorders, Age Related
Music for the Mind Study
The goal of this pilot clinical trial is to learn if older adults with mild cognitive impairment (MCI) find two music programs equally acceptable.
- Conditions
- Mild Cognitive Impairment (MCI), Memory Disorders, Age Related, Memory Decline
- Trial name
- M4M (NCT06866327)
- Testing
- Piano lessons, Music Lessons
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Rochester
Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy
The Association Between Cognitive Function and Neuropathy in Individuals With Type 2 Diabetes
The goal of this observational study is to evaluate whether individuals with different types of diabetic neuropathy (peripheral and cardiovascular autonomic neuropathy) are at an increased risk of cognitive impairment and to…
- Conditions
- Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy, Cognitive Impairment, Diabetes Type 2
- Trial name
- ASCEND (NCT06857994)
- Where
- Denmark
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Advanced or Metastatic Solid Tumor, Liver Failure
Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment
The goals of this clinical study are to learn more about the safety and dosing of the study drug, sacituzumab govitecan-hziy, in participants with solid tumors and moderate liver problems.
- Trial name
- NCT04617522
- Testing
- Sacituzumab Govitecan-hziy
- Where
- 15 sites in United States, France and 2 more
- Volunteers
- 30 people
- Sponsor
- Gilead Sciences
Cognitive Decline, Cognitive Impairment, Mild
Evaluation of Pilot Community-based Multi-domain Program Older Adults at Risk of Cognitive Impairment
The multi-domain programme was adapted from a larger international multi-domain interventional study for the Singapore community of older adults at risk of cognitive impairment.
- Trial name
- NCT04440969
- Testing
- Multi-domain intervention
- Where
- Singapore
- Volunteers
- 199 people
- Sponsor
- Geriatric Education and Research Institute
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Subjective Cognitive Complaint, Mild Cognitive Impairment
Validation of the MBI-C Scale in French
This study aims to validate the French version of the Mild Behavioral Impairment-Checklist (MBI-C) scale, hypothetically effective for measuring behavioral symptoms in patients presenting with a subjective cognitive complaint or…
- Conditions
- Subjective Cognitive Complaint, Mild Cognitive Impairment, Neuropsychiatric Symptoms
- Trial name
- MBI-C (NCT06516159)
- Testing
- MBI-C Scale in French
- Where
- 5 sites in France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Toulouse
Mild Cognitive Impairment
The Effect of Nimodipine on the Postoperative Cognitive Dysfunction
The calcium channel blocker nimodipine dilates cerebral blood vessels and can pass through the blood-brain barrier, providing neuroprotective effects by selectively improving cerebral blood flow and inhibiting neuronal necrosis…
- Trial name
- NCT02537080
- Testing
- Nimodipine group, Control group
- Where
- Czechia
- Volunteers
- 15 people
- Sponsor
- University Hospital Hradec Kralove
Alzheimer Disease, Mild Cognitive Impairment Due to Alzheimer's Disease
Alzheimer's Disease Multinuclear Imaging Neuro-Enhanced Resolution (AD-MINER)
This single-center prospective cohort study will enroll 750 participants (250 cognitively Normal (CN) individuals, 250 with mild cognitive impairment (MCI), and 250 with Alzheimer's disease (AD)).
- Trial name
- AD-MINER (NCT07089303)
- Where
- China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.