Clinical trials: Impairment
HIV Associated Neurocognitive Disorder
Study of Paroxetine and Fluconazole for the Treatment of HIV Associated Neurocognitive Disorder
The purpose of this study is to see if paroxetine and fluconazole are safe and effective as a treatment for problems with memory, concentration, thinking, and judgment in people who are infected with HIV.
- Trial name
- ParaFlu (NCT01354314)
- Testing
- Fluconazole, Paroxetine, Paroxetine and Fluconazole
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins University
Memory Problems, Aging
What Are my Options to Stay Safe at Home: Technology For Aging at Home
Most older people want to stay at home as long as possible. Effective self-management for people losing autonomy depends on reliable monitoring of their mobility, health and safety and active implication in decision-making.
- Conditions
- Memory Problems, Aging, Mild Cognitive Impairment, Shared Decision Making
- Trial name
- COORDINATEs (NCT04267484)
- Testing
- GPS and travel diary, e-decision support platform
- Where
- 4 sites in Canada, Netherlands and 1 more
- Volunteers
- 294 people
- Sponsor
- CHU de Quebec-Universite Laval
Mild Cognitive Impairment, Anxiety State
Efficacy of Sublingual 5-MeO-DMT for Reducing Anxiety and Depression in MCI
This Phase I/II clinical trial aims to test the effectiveness of a new sublingual formulation of 5-MeO-DMT in reducing symptoms of anxiety, depression, and cognitive decline in individuals with mild to moderate Alzheimer's…
- Conditions
- Mild Cognitive Impairment, Anxiety State, Depression Anxiety Disorder
- Trial name
- 5-MeO-DMT (NCT06812221)
- Testing
- Sublingual administration, Electroencephalography, Biochemical mesurements
- Where
- Argentina
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Biomind Labs Inc.
Hearing Impaired Children
Hearing Impairment in Children: Pupillometry and Hearing Thresholds Assessment
The results of the previous study on auditory effort in young children with cochlear implants show that pupils respond to the presence or the absence of the perceived stimuli.
- Trial name
- NCT06317493
- Testing
- Stimuli
- Where
- 5 sites in Italy, Slovenia
- Volunteers
- 180 people
- Sponsor
- IRCCS Burlo Garofolo
Cystic Fibrosis-related Diabetes, Cystic Fibrosis
Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cystic Fibrosis
Cystic Fibrosis (CF) related diabetes (CFRD) is a unique form of diabetes mellitus, different from type 1 diabetes and type 2 diabetes.
- Trial name
- NCT06560463
- Testing
- Access to Dexcom G7 CGM Data
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Visual Impairment
Quality of Life in Italian Visually Impaired Patients
Clinical register of visual rehabilitation activity and observational study on the validation of the VA LV VFQ questionnaire in the Italian context
- Trial name
- SOPIITA (NCT05752214)
- Testing
- WEB Register
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Amore Filippo
Alzheimer Disease, Dementia
Movement Intervention for Memory Enhancement
Dancing is a complex sensorimotor rhythmic activity that integrates cognitive, physical, and social components and is applicable to seniors with various fitness levels.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Decline, Cognitive Impairment
- Trial name
- MIME (NCT03475316)
- Testing
- Social Dancing, Treadmill Walking
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Stroke, Post-stroke Cognitive Impairment (PSCI)
Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)
Post-stroke cognitive impairment (PSCI) refers to a clinical syndrome characterized by cognitive impairment that occurs after a stroke event and persists for at least 24 weeks.
- Trial name
- Be-CLEVER (NCT05976152)
- Testing
- dl-3-butylphthalide
- Where
- China
- Volunteers
- 3,200 people
- Sponsor
- Fudan University
Renal Insufficiency
A Study of LY3473329 in Participants With Impaired and Normal Renal Function
The main purpose of this study is to assess the amount of study drug (LY3473329) that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment compared…
- Trial name
- NCT05778864
- Testing
- LY3473329
- Where
- 4 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Cognitive Impairment
Evaluation of the Effect of Cooled Haemodialysis on Cognitive Function in Patients Suffering With End-stage KD
The Investigators aim to perform a feasibility study that will inform the development of a definitive, fully powered, randomised, controlled clinical trial in the future.
- Trial name
- E-CHECKED (NCT03645733)
- Testing
- Lower Temperature Group
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Heart of England NHS Trust
Visual Impairment, Healthy
Touching the World With a Cane: Cognitive and Neural Processes
The use of tools is ubiquitous in our lives and allows us to expand the sensorimotor capacities of our body. Much research has been done on the subject in sighted people over the past decades.
- Trial name
- TOOL_TOUCH (NCT05199896)
- Testing
- Behavioral protocol, EEG protocol, fMRI protocol
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Memory Impairment
The Effect of tES on a Cognitive Training
The aim of this study is to investigate the effect of a transcranial electrical stimulation (tES) on a cognitive training in healthy elderly and memory impaired participants.
- Trial name
- NCT03475446
- Testing
- real anodal tDCS healthy elderly, real tACS healthy elderly, real anodal tDCS MCI
- Where
- Switzerland
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Bern
Alzheimer Disease, Mild Cognitive Impairment
Dementia Signal Development Study of Nautilus NeuroWave TM for the Detection of Dementia
This study is being performed to generate data regarding brain vibration /oscillation differences between individuals with dementia and normal controls.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Frontotemporal Lobar Degeneration, Memory Disorders
- Trial name
- NCT02333942
- Testing
- Nautilus NeuroWaveTM System
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Sepsis, Cognitive Impairment
HMGB1 in ICU-survivors
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer…
- Trial name
- NCT02914756
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Mild Cognitive Impairment, Alzheimer Disease
Senicapoc in Alzheimer's Disease
Development of novel disease-modifying therapies for Alzheimer's disease (AD) remains of paramount importance. This study will be a Phase II randomized clinical trial testing Senicapoc in patients with mild or prodromal AD.
- Trial name
- Senicapoc (NCT04804241)
- Testing
- Senicapoc
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Driving Impaired
Validation of Alcohol Level Identification Using DRIVESC
This pilot study will evaluate the feasibility and acceptability of using a commercially available DRIVESC fitness-to-drive measurement tool to detect alcohol-induced impairment in healthy adult participants.
- Trial name
- NCT07282405
- Testing
- DRIVESC, Alcohol
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Mild Cognitive Impairment (MCI)
Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment
Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults.
- Trial name
- NCT07097051
- Testing
- real tACS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- High Point University
Cerebrovascular Disorder, Stroke
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
Background: A stroke occurs when not enough blood reaches the brain. Sometimes stroke causes changes in certain brain matter. This is called white matter hyperintensity (WMH) and can lead to mental decline.
- Conditions
- Cerebrovascular Disorder, Stroke, Aging
- Trial name
- NCT03366129
- Where
- 3 sites in United States
- Volunteers
- 81 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Mild Cognitive Impairment, Alzheimer Disease
Retinal Neuro-vascular Coupling in Patients With Neurodegenerative Disease
Alzheimer´s disease (AD) in one of the most important causes of dementia and poses a considerable challenge in health care. Today, criteria for the diagnosis and the follow up of patients with AD mainly rely either on subjective…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Healthy
- Trial name
- NCT02663531
- Testing
- DVA, FDOCT, Pattern ERG
- Where
- Austria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
COVID-19
Portable Oxygen Concentrator (POC) Versus Standard of Care in Long-COVID: Randomized Crossover Exploratory Pilot Study.
A prospective, open label, randomized, crossover, pilot, exploratory study to describe the effect of the Inogen One® G4 POC on brain hypoxia, peripheral oxygen saturation and cognitive function in adults with longterm- COVID.
- Trial name
- RESTORE (NCT05212831)
- Testing
- Inogen One® G4
- Where
- 2 sites in Canada
- Volunteers
- 21 people
- Sponsor
- Inogen Inc.
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