Clinical trials: Impairment
Mild Cognitive Impairment, Alzheimer Disease
Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia
The purpose of this study is to investigate whether a blood pressure medication, spironolactone, can be tolerated by older African American adults that have memory and thinking problems, also called mild cognitive impairment…
- Trial name
- STAND (NCT04522739)
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Central Visual Impairment
Peripheral Reading
The purpose of this study is to evaluate reading performance in the visual periphery by simulating central vision loss using a computer-controlled gaze-contingent display with an eye tracker.
- Trial name
- NCT03640130
- Testing
- Gaze-contingent text enhancement
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Houston
Amnestic Mild Cognitive Impairment, Alzheimer's Disease
The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF)
An urgent need exists to find effective treatments for Alzheimer's disease (AD) that can arrest or reverse the disease at its earliest stages.
- Trial name
- NCT01767909
- Testing
- Insulin (Humulin® R U-100)
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Southern California
Aging, Cognitive Ability, General
Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study
The purpose of this study is to examine the effects of modifiable lifestyle factors including exercise and healthy living on brain health. The investigators will compare 2 types of interventions, moderate aerobic walking vs.
- Trial name
- NCT02726906
- Testing
- Moderate-aerobic walking, Positron Emission Tomography (PET) scan, Healthy living education
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Cognitive Dysfunction, Cognition Disorders
Multiple Interventions to Prevent Cognitive Decline
The investigators aim to test the feasibility of a pragmatic non-pharmacological strategy, that may prevent cognitive decline in patients with mild cognitive impairment.
- Conditions
- Cognitive Dysfunction, Cognition Disorders, Memory Disorders
- Trial name
- MIND (NCT04079075)
- Testing
- Cognitive training, Physical activity, Nutrition education
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- Universidade do Porto
Memory Disorders
Anti-Inflammatory Treatment for Age-Associated Memory Impairment: A Double-Blind Placebo-Controlled Trial
This project is designed to study whether anti-inflammatory drugs, such as celecoxib, may delay age-related mental decline. We are also looking at genetic risk and brain structure as potential predictors of mental decline.
- Trial name
- NCT00009230
- Testing
- Celecoxib
- Where
- United States
- Sponsor
- University of California, Los Angeles
Congenital CMV Infection
Evaluation of Long-term Efficacy of 4 to 6-month Course Antiviral Therapy for Neurodevelopmental Impairments Caused by Congenital Cytomegalovirus Infection
Title: Evaluation of Long-term Efficacy of 4-month versus 6-month Course Antiviral Therapy for Neurodevelopmental Impairment Caused by Congenital CMV Infection: A Multicenter, Randomized, Controlled, Non-inferiority Clinical…
- Trial name
- NCT07450365
- Testing
- Intravenous ganciclovir (6 mg/kg, twice daily) or oral valganciclovir (16 mg/kg, twice daily) was administered for a treatment course of 4 months., Patients received a 6-month course of anti-CMV therapy. The treatment regimen consisted of either intravenous ganciclovir (6 mg/kg, twice daily) or oral valganciclovir (16 mg/kg, twice daily).
- Volunteers
- 150 people
- Sponsor
- Hu Bofei
Cognitive Impairment, Mild
Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects With Cognitive Impairment
A randomized, double-blind, placebo-controlled, two arm cross-over study to determine whether a specific combination of Andrographis paniculata and Withania somnifera can be regarded as a safe and effective treatment for…
- Trial name
- NCT03780621
- Testing
- Andrographis and Withania
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- EuroPharma, Inc.
Brain Injuries, Respiratory Function Impaired
Effects of rTMS on Respiratory Function and Gut Microbiota in Patients With Brain Injury
Impaired respiratory function may occur after brain injury, and will progress to restricted respiratory dysfunction without early intervention.
- Conditions
- Brain Injuries, Respiratory Function Impaired, Gut Microbiota
- Trial name
- NCT06288984
- Testing
- active rTMS
- Volunteers
- 74 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Neuromotor Impairments
Physical Therapy for Montana Children With NMD Using Hippotherapy and the Equine Environment
The goal of this pilot clinical trial is to determine if physical therapy incorporating horses can improve the motor skills of the arms in children 6-17 years old with neuromotor disorders (such as cerebral palsy, spinal muscular…
- Trial name
- NCT06887647
- Testing
- Physical Therapy Using Hippotherapy and the Equine Environment, Standard Play-Based Physical Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Montana
Cognitive Dysfunction
Stem Cell Therapy for Early Alzheimer's Disease
The goal of this clinical trial is to learn if stem cell therapy works to treat brain inflammation in adults. Inflammation in the brain may be involved in adults who have memory or thinking problems.
- Trial name
- NCT06775964
- Testing
- adMSC
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Paul E Schulz
Critical Illness, COVID-19
Neurocognitive Impairment in Patients With COVID-19
Delirium and acute neurocognitive impairment are increasingly observed in adult and pediatric patients with COVID-19. Prospective clinical studies combining clinical and laboratory examinations including specific biomarkers of…
- Conditions
- Critical Illness, COVID-19, Central Nervous System Injury, Delirium
- Trial name
- NCoV (NCT04359914)
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- University of Rostock
Dementia of Alzheimer Type
Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI)
The RAATE-MCI proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults.
- Trial name
- RAATE-MCI (NCT04956549)
- Testing
- Physical activity program, Successful Aging
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Pennington Biomedical Research Center
Alzheimer Disease, Mild Cognitive Impairment (MCI)
Communication Regarding Preclinical Dementia Diagnostic and Diagnostic Disclosure Among Patients with MCI and SCD
The study investigate what information individuals with SCD or MCI and their co-participant would like to receive during pre-diagnostic counseling and diagnostic disclosure, and how this information should be conveyed.
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
- Trial name
- NCT06621758
- Testing
- questionnaire
- Volunteers
- 120 people
- Sponsor
- Danish Dementia Research Centre
Frailty, Aging
Multicomponent Exercise and Virtual Reality for Older Adults
Population aging is associated with an increased risk of frailty, falls, and loss of autonomy. This pilot study aims to evaluate the effects of a program that combines multicomponent exercise and non-immersive virtual reality…
- Conditions
- Frailty, Aging, Functional Impairment
- Trial name
- MOVE ON (NCT07529743)
- Testing
- Multicomponent Exercise plus Non-Immersive Virtual Reality, Non-Immersive Virtual Reality
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- European University Miguel de Cervantes
Dementia, Delirium
Assessing the Effects of Robotic Pets on Patients With Dementia in the Acute Care Hospital Setting
Robotic pets can provide a source of affection and companionship for patients. This is especially important as individuals with dementia may receive infrequent visitation from family members if their families struggle with how to…
- Trial name
- NCT06683443
- Testing
- Robotic Joy for All™ pet
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Sarasota Memorial Health Care System
Sleep Deprivation, Sleepiness
Metabolomics-based Sleepiness Markers
Estimating that people sleep on average up to two hours less over the last decades, sleepiness and fatigue need to be considered as significant societal problems of the modern world.
- Conditions
- Sleep Deprivation, Sleepiness, Insufficient Sleep Syndrome
- Trial name
- ME-SMART (NCT05585515)
- Testing
- Sleep deprivation, Sleep restriction
- Where
- Switzerland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Frailty, Mild Cognitive Impairment
E-health Enhanced Motor-cognitive Training for AED Discharged Older Adults With Cognitive Frailty
The goal of this pilot randomized controlled trial is to explore the feasibility of e-health enhanced motor-cognitive interventions for discharged community-dwelling older adults with cognitive frailty in the emergency department…
- Trial name
- NCT05750121
- Testing
- E-health enhanced motor-cognitive training
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Subarachnoid Hemorrhage, Aneurysmal
Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
- Trial name
- NCT04938414
- Testing
- Lumbar puncture
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetic Macular Edema
A 12 Month Core Study to Assess the Efficacy and Safety of Ranibizumab (Intravitreal Injections) in Patients With Visual Impairment Due to Diabetic Macular Edema and a 24 Month Open-label Extension Study
CRFB002D2301: The core study was designed to confirm the efficacy and safety of ranibizumab (0.5 mg) as adjunctive therapy when added to laser photocoagulation and/or mono-therapy in patients with visual impairment due to…
- Trial name
- RESTORE (NCT00687804)
- Testing
- Ranibizumab, Laser
- Where
- 13 sites in Australia, Belgium and 11 more
- Volunteers
- 345 people
- Sponsor
- Novartis
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