Clinical trials: Impairment
Renal Impairment
A Study Investigating the Safety of RO7795081 and How the Body Processes RO7795081 in People With Normal or Decreased Kidney Functions
The purpose of this study is to assess the effect of renal impairment on the pharmacokinetics (PK) and safety of RO7795081, following a single oral dose in participants with renal impairment compared with participants with normal…
- Trial name
- NCT07741604
- Testing
- RO7795081
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Healthy, Mild Cognitive Impairment
Does Acoustic Stimulation During Sleep Boost Slow Wave Sleep and Memory Performance?
With aging the amount of slow wave sleep decreases drastically and this disruption is markedly exaggerated in older adults suffering from mild cognitive impairment and Alzheimer's disease.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT04277104
- Testing
- Closed loop acoustic stimulation
- Where
- Switzerland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Bern
Advanced Cancer
Hepatic Impairment Study For Crizotinib In Advanced Cancer Patients
This study is designed to evaluate the potential effect of hepatic impairment on the pharmacokinetics and safety of crizotinib in advanced cancer patients.
- Trial name
- NCT01576406
- Testing
- crizotinib
- Where
- 20 sites in United States
- Volunteers
- 88 people
- Sponsor
- Pfizer
Schizophrenia, Bipolar Disorder
Neurofilament Light Chains and Cognitive Impairment in Chronic Psychiatric Disease
The validation of biomarkers allowing the discrimination of cognitive and behavioral disorders of psychiatric origin from those of neurodegenerative origin would facilitate diagnosis and improve patient management.
- Conditions
- Schizophrenia, Bipolar Disorder, Alzheimer Disease, FTD
- Trial name
- Nfl_COG (NCT04946916)
- Testing
- blood sample taken
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- Hôpital le Vinatier
Mild Cognitive Impairment
TMS Treatment of Social Cognition Skills in Mild Cognitive Impairment
Social cognitive abilities are impaired in around 17% of subjects with mild cognitive impairment (MCI), and might not reflect upon functional status.
- Trial name
- NCT04490616
- Testing
- rTMS treatment
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- Ospedale Regionale di Lugano
Diabetes, Diabetes Mellitus, Type 2
Safety and Tolerability of Liraglutide in Subjects With Impaired Kidney Function and in Subjects With Normal Kidney Function
This trial is conducted in Oceania. The aim of this trial is to assess whether dose adjustment is required for patients with renal impairment by investigating the pharmacokinetics of liraglutide in subjects with various degrees…
- Trial name
- NCT01508806
- Testing
- liraglutide
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Novo Nordisk A/S
Older Adults (60 - 85 Years Old), Mild Cognitive Impairment (MCI)
Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory
A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities.
- Trial name
- DEEPBRAIN (NCT07560904)
- Testing
- Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz), Control striatal stimulation, Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)
- Where
- Czechia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Mild Cognitive Impairment, Alzheimer Disease
Alzheimer's Disease Neuroimaging Initiative 4
The Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4) is a non-randomized, longitudinal, natural history study designed to validate biomarkers, improve clinical trial design, and advance understanding of Alzheimer's disease…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- ADNI4 (NCT05617014)
- Testing
- Neuraceq, Amyvid, Tauvid
- Where
- 65 sites in United States, Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Neuromuscular Diseases in Children, Respiratory Function Impaired
Respiratory Functions, Thoracoabdominal Movements and Exercise Capacity in Neuromuscular Diseases
The clinical trial titled "Investigation of Respiratory Functions, Thoracoabdominal Movements, and Exercise Capacity in Neuromuscular Diseases" aims to evaluate the respiratory functions, thoracoabdominal movements, and exercise…
- Conditions
- Neuromuscular Diseases in Children, Respiratory Function Impaired, Respiratory Insufficiency, Duchenne Muscular Dystrophy
- Trial name
- NCT06756633
- Testing
- Respiratory Function Test, Structured light plethysmography, 6 Minute Walking Test
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Moderate Hepatic Impairment, Severe Hepatic Impairment
A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called Lorlatinib) in health participants.
- Conditions
- Moderate Hepatic Impairment, Severe Hepatic Impairment, Healthy Volunteers
- Trial name
- NCT05224609
- Testing
- Lorlatinib
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Pfizer
Alzheimer's Disease (AD) and Related Disorders
A Cohort of Outpatients From French Research Memory Centers in Order to Improve Knowledge on Alzheimer's Disease and Related Disorders
A Multicenter national prospective cohort study including at least 2300 individuals consecutively recruited from French Research Memory Centers and followed-up over 5 years.
- Trial name
- MEMENTO (NCT01926249)
- Where
- 29 sites in France
- Volunteers
- 2,325 people
- Sponsor
- University Hospital, Bordeaux
Physical Fitness
Methods of Assessing Fitness and Physical Capacity
Aerobic fitness is an important part of sport training preparation for wheelchair rugby players. Currently, there are some test protocols on arm crank ergometer for spinal cord injury people.
- Trial name
- NCT05106348
- Testing
- Aerobic Fitness Test
- Where
- Poland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Jolanta Marszałek
Mild Cognitive Impairment
Effects of Tai Chi Chuan With Different Doses on Cognitive Function in Elderly Patients With Mild Cognitive Impairment
To determine the impact of Tai Chi Chuan with different exercise volume on cognitive function in elderly patients with mild cognitive impairment.
- Trial name
- NCT06372535
- Testing
- Tai Chi Chuan （dose 1）, Tai Chi Chuan （dose 2）, Tai Chi Chuan （dose 3）
- Volunteers
- 540 people
- Sponsor
- Lidian Chen
Alzheimer Disease, Dementia
Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers
This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers.
- Conditions
- Alzheimer Disease, Dementia, Mild Cognitive Impairment, Peer-bonded Caregiver
- Trial name
- NCT06940687
- Testing
- Pre-recorded Music Session, Live Music Session
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Advanced Solid Tumors, Hematologic Malignancies
Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment
This purpose of this study is to help to evaluate the pharmacokinetic (PK) profile of pralatrexate when administered to patients with various degrees of hepatic impairment and to evaluate the safety and establish the dosing…
- Trial name
- SPI-FOL-102 (NCT07036133)
- Testing
- Pralatrexate Injection
- Where
- 4 sites in United States
- Volunteers
- 24 people
- Sponsor
- Acrotech Biopharma Inc.
Memory Disorders, Mild Cognitive Impairment
Effectiveness of Home-based Electronic Cognitive Therapy in Alzheimer's Disease
The current study will examine the use of a mobile electronic application used to deliver cognitive rehabilitation to patients with mild cognitive impairment due (MCI) due to Alzheimer's disease (AD), and patients with mild AD.
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Alzheimer's Disease
- Trial name
- CTAD (NCT02521558)
- Testing
- Intervention Group, Control Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston University
Lung Diseases, Obstructive, Pulmonary Rehabilitation
Respiratory Function in Patients With Post-tuberculosis Lung Impairment
Pulmonary tuberculosis (TB) is an important risk factor for chronic respiratory disease due to residual lung damage. A recent review of the literature on TB sequelae and rehabilitation has provided clear evidence that TB is…
- Conditions
- Lung Diseases, Obstructive, Pulmonary Rehabilitation, Lung TB
- Trial name
- NCT03821285
- Testing
- Pulmonary Rehabilitation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Università degli Studi dell'Insubria
Post-Acute COVID-19 Syndrome
REVERSE-Long COVID-19 With Baricitinib Study
REVERSE-LC is a phase 3 trial of baricitinib versus placebo in adults with neurocognitive impairment (a form of Alzheimer's Disease and Related Dementias or ADRD) or cardiopulmonary symptoms due to Long COVID.
- Trial name
- REVERSE-LC (NCT05858515)
- Testing
- Baricitinib 4 MG
- Where
- 6 sites in United States
- Sponsor
- Vanderbilt University Medical Center
Vestibular Hypofunction, Ataxia - Other
Vibrotactile Balance Belt Effect on Improving Gait
This study will examine the effect of using a vibrotactile feedback implemented into a belt, at improving gait in those with gait disorders.
- Conditions
- Vestibular Hypofunction, Ataxia - Other, Gait Impairment
- Trial name
- BalanceBelt (NCT07253532)
- Testing
- BalanceBelt
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Airway Clearance Impairment
Outcome Comparisons of Vibratory Airway Clearance Devices
This pilot study aims to compare the ability of a higher oscillatory index device versus a lower oscillatory index device on airway secretion clearance and other clinically significant outcomes.
- Trial name
- NCT05873504
- Testing
- High Oscillatory Index Device, Low Oscillatory Index Device
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Rush University Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.