Clinical trials: Impairment
Mild Cognitive Impairment
Phase II Trial of Tesamorelin for Cognition in Aging HIV-Infected Persons
The aim of this study is to test whether tesamorelin, in combination with a text-messaging application to help with motivation and adherence, will significantly improve memory and thinking in HIV.
- Trial name
- NCT02572323
- Testing
- Tesamorelin
- Where
- 4 sites in United States
- Volunteers
- 73 people
- Sponsor
- University of California, San Diego
Retinitis Pigmentosa, Visual Impairment
Environmental Localization Mapping and Guidance for Visual Prosthesis Users
This study is driven by the hypothesis that independent navigation by blind users of visual prosthetic devices can be greatly aided by use of an autonomous navigational aid that provides information about the environment and…
- Conditions
- Retinitis Pigmentosa, Visual Impairment, Visual Prosthesis
- Trial name
- SLAM (NCT04359108)
- Testing
- Navigation system mode: Argus Vision, Navigation system mode: Depth Vision, Navigation system mode: Depth Vision with Haptic / Audio
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment, Dementia
Remote Game-based Exercise Program for Cognitive and Motor Function Improvement
As our population ages, more older adults face motor-cognitive declines, increasing their risk of falls and fear of falling. Exercise is an effective way to maintain cognitive function, as supported by recent studies.
- Conditions
- Mild Cognitive Impairment, Dementia, Cognitive Impairment, Memory Loss
- Trial name
- NCT05235113
- Testing
- Tele-Exergame Platform, No Tele-Exergame Platform
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
Renal Insufficiency
A Pharmacokinetic Study of Abiraterone Acetate in Male Participants With Impaired Renal Function Compared to Individuals With Normal Renal Function
The purpose of this study is to determine the pharmacokinetic (how the drug concentrations change over time) profile of abiraterone acetate 1000 mg when administered as a single dose in male participants with impaired renal…
- Trial name
- NCT01715259
- Testing
- Abiraterone acetate: participants with end-stage renal disease, Abiraterone acetate: matched control participants with normal renal function
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cougar Biotechnology, Inc.
Cognitive Impairment, Physical Functioning
REducing SEDENTary Behaviour May Slow Cognitive Decline in Older Adults With Mild Cognitive Impairment: A Pilot Study
With the nation's fastest growing demographic being adults over 65, one in every three seniors is estimated to die from Alzheimer's Disease (AD).
- Conditions
- Cognitive Impairment, Physical Functioning, Quality of Life
- Trial name
- RESEDENT (NCT03439059)
- Testing
- Reducing Sedentary Behaviour Group
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Western University, Canada
Alzheimer Dementia, Alzheimer Disease
Treating Hyperexcitability in AD With Levetiracetam
The aim of this study is to explore the relationship between cortical hyperexcitability, abnormalities of brain network function, and cognitive dysfunction in human patients with AD and whether administration of the antiepileptic…
- Conditions
- Alzheimer Dementia, Alzheimer Disease, Dementia of Alzheimer Type, Mild Cognitive Impairment
- Trial name
- LeAD (NCT03875638)
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Brain Diseases, Epilepsy
Amygdala Memory Enhancement
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories.
- Conditions
- Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury
- Trial name
- NCT05065450
- Testing
- Intracranial Stimulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD)
Digital Solutions for Predicting the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors
Population ageing is one of the main factors responsible for the global increase in the prevalence of dementia. Recent evidence suggests that modifiable risk factors, such as cardiovascular disease and lifestyle, may increase the…
- Trial name
- PrevAl (NCT07731191)
- Testing
- Digital solution for the prediction of the biological mechanisms of Alzheimer's disease through the analysis of risk factors
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Gait Disorders, Neurologic, Gait Disorders in Old Age
ExerG: Video Game-based Physical Cognitive Training for Patients: a Usability Study
Video game-based training programs, in the following referred to as "exergames" are an innovative digital training approach to simultaneously train physical and cognitive functions and increase training motivation for various…
- Conditions
- Gait Disorders, Neurologic, Gait Disorders in Old Age, Gait Disorder, Sensorimotor, Balance; Distorted
- Trial name
- ExerGetic (NCT05967078)
- Testing
- ExerG
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Frank Behrendt
Frail Elderly Syndrome, Cognitive Impairment
Impact of a Multicomponent Exercise Program on Functional Capacity in Frail Aged Participants With Cognitive Decline
Randomized Controlled trial of 370 aged participants over 75 years old coming from clinics of Geriatric Departments in three University Hospitals in Spain (Pamplona, Getafe y San Sebastián).
- Trial name
- NCT03657940
- Testing
- VIVIFRAIL multicomponent exercise training program
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Fundacion Miguel Servet
Mild Cognitive Impairment, Probable Alzheimer's Disease
Dietary Treatments for Cognitive Impairment in Older Adults
This trial seeks to establish the feasibility of implementing a ketogenic, modified Atkins diet (MAD) to older adults with mild cognitive impairment (MCI) or early Alzheimer's disease (AD) living in the community.
- Trial name
- NCT02521818
- Testing
- Modified Atkins Diet, NIA Diet for Seniors
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment
Effects of Single and Dual Task Training in Individuals With Mild Cognitive Impairment
The aim of this study is to compare the effects of single and dual-task training on processing speed, cognitive functions, walking speed, dual-task performance and balance functions in individuals with mild cognitive impairment.
- Trial name
- NCT04301960
- Testing
- Single task training, Dual task training
- Where
- Cyprus
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
End Stage Renal Disease
Neuroimaging and End Stage Renal Disease
Brain impairment is one of the common complications of end-stage renal disease (ESRD). The patients always present with various cerebrovascular diseases, cognitive impairment and sensorimotor abnormalities, with morbidity over…
- Trial name
- NESRD (NCT03961724)
- Testing
- magnetic resonance image (MRI)
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hypertension, Elderly
Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population
Introduction: High blood pressure especially systolic hypertension is a common condition in the elderly and is considered as a major determinant not only of cardiovascular (CV) morbidity and mortality, but also of several other…
- Conditions
- Hypertension, Elderly, Cardiovascular Mortality, Cognitive Impairment
- Trial name
- PARTAGE (NCT00901355)
- Where
- 6 sites in France, Italy
- Volunteers
- 1,130 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Mild Cognitive Impairment (MCI)
Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment
This study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment to reduce their NPS, and to investigate the feasibility and effectiveness of the intervention.
- Trial name
- IMPACT (NCT07420426)
- Testing
- automated instant message-guided neuropsychiatric symptoms management, general mental health management
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Obesity, Impaired Glucose Tolerance
The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women
This study will look at the effect of exenatide, a drug which has been approved for the treatment of type 2 diabetes, on body weight, appetite and energy expenditure among moderately obese women without diabetes.
- Trial name
- NCT00456885
- Testing
- exenatide
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Advanced Solid Tumors
A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Renal Impairment
Study to evaluate the safety, tolerability, and pharmacokinetics of TAS-102 in patients with advanced solid tumors and varying degrees of renal impairment.
- Trial name
- NCT02301117
- Testing
- TAS-102
- Where
- 14 sites in United States, Czechia and 1 more
- Volunteers
- 43 people
- Sponsor
- Taiho Oncology, Inc.
Depression
Cognitive Correlates of Antidepressant Treatment Response in Elders
Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants".
- Trial name
- NCT01477268
- Testing
- Zoloft (antidepressant)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Language Disorders
A Comparison of Language Intervention Programs
Brief Summary: Nearly 7% of elementary school children present with difficulties learning and using language. Unfortunately, language impairments are often long lasting and may have serious social, academic, and vocational…
- Trial name
- NCT00033150
- Testing
- Fast ForWord, Computer Assisted Language Intervention, Individual Language Intervention
- Where
- 2 sites in United States
- Volunteers
- 216 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
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