Clinical trials: Impairment Upper Limb
Hemiplegic Cerebral Palsy, Mirror Movement Therapy
Effectiveness of the Mirror Therapy for Improving Bimanual Performance, Somatosensory Function of the Impaired Upper Limb and Quality of Life in Children With Unilateral Spastic Cerebral Palsy
Background: Unilateral Spastic Cerebral Palsy (USPC) is caused by an injury in one brain hemisphere in the immature brain, and affects the contralateral side of the body, especially on the upper limb.
- Trial name
- NCT05244083
- Testing
- Mirror Therapy, Program without Mirror Therapy
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Universitat Internacional de Catalunya
Chronic Stroke
Intensive Neurorehabilitation and Stimulation in Chronic Stroke Patients
Chronic stroke patients (> 6 months) with severe motor impairment of the upper extremity will be enrolled in this single-centre, randomized controlled clinical trial (RCT).
- Trial name
- NCT03947645
- Testing
- Ipsilesional stimulation, Contralesional stimulation
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Tuebingen
Breast Cancer, FIT-HaNSA
The Validity and Reliability of FIT-HaNSA in Breast Cancer Patients
Breast cancer is the most common type of cancer among women and covers 25% of all cancers. After mastectomy and reconstruction, many patients develop various upper extremity complications such as joint movement limitation, pain…
- Conditions
- Breast Cancer, FIT-HaNSA, Upper Extremity Dysfunction
- Trial name
- NCT04795778
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Parkinson Disease
Modulation of GABA-A Receptors in Parkinson Disease-Flumazenil Arm
This arm is a positron emission tomography (PET) biomechanistic GABA-A receptor target engagement study that includes detailed clinical and motor assessments before and after the i.v.
- Trial name
- NCT03462641
- Testing
- Flumazenil
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Michigan
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Upper Limb Injury, Virtual Reality
Using Virtual Reality for Rehabilitation of Upper Limbs at Home Trial
The IVR games have been enhanced to include more levels. The new aspects to be tested in this study are new IVR exercises that would be made upper limb rehab designed for children for home use, as repeated sessions with…
- Conditions
- Upper Limb Injury, Virtual Reality, Rehabilitation, Paediatric
- Trial name
- NCT05272436
- Testing
- Virtual Reality Upper Limb Motor Impairment Rehabilitation
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Sheffield Hallam University
Stroke, Upper Limb Motor Impairment
Beyond Observation: Validating the Ecological Relevance of the Ad-AHA Stroke Using Sensor-Based Measures
After a stroke, many people experience difficulty using both hands together in daily life. Most rehabilitation assessments, however, only measure how the affected arm performs in one-handed tasks.
- Conditions
- Stroke, Upper Limb Motor Impairment, Bimanual Function
- Trial name
- NCT07366697
- Testing
- Sensor-based monitoring and clinical assessment
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- KU Leuven
Macular Edema, Central Retinal Vein Occlusion
Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The present study provided additional efficacy and safety data for 0.5-mg ranibizumab using as needed (PRN) dosing over 24 months in patients with visual impairment due to macular edema secondary to Central Retinal Vein Occlusion…
- Trial name
- CRYSTAL (NCT01535261)
- Testing
- Ranibizumab 0.5 mg/0.05 ml
- Where
- 78 sites in Australia, Austria and 16 more
- Volunteers
- 357 people
- Sponsor
- Novartis Pharmaceuticals
Stroke
Unilateral Versus Bilateral Task-specific Training on Motor Impairment, Upper Extremity Function, and Hand Dexterity in Post-Stroke Rehabilitation
This randomized clinical trial will examine upper limb rehabilitation in individuals recovering from stroke. The study will compare unilateral and bilateral task-oriented training approaches to determine their relative…
- Trial name
- NCT07523503
- Testing
- Unilateral task oriented training (UTOT) with baseline EMS, Bilateral task oriented training (BTOT) with baseline EMS
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- University of Faisalabad
Obesity
Rimonabant in Abdominally Obese Patients With Impaired Fasting Blood Glucose
Primary objective: To determine the effect of Rimonabant 20mg on the co-primary endpoint including Fasting Plasma Glucose (FPG), HDL-Cholesterol (HDL-C) and triglyceride (TG) levels over a period of 12 months when prescribed with…
- Trial name
- PRADO (NCT00405808)
- Testing
- Rimonabant
- Where
- 27 sites in Austria, Belgium and 25 more
- Volunteers
- 2,666 people
- Sponsor
- Sanofi
Stroke, Hemiplegia
Virtual Reality-Based Mirror Therapy and FES-Cycling in Stroke Rehabilitation
This randomized controlled, assessor-blinded study aimed to compare the effects of virtual reality-based mirror therapy (VRBMT) and functional electrical stimulation-assisted cycling (FES-cycling) when combined with conventional…
- Conditions
- Stroke, Hemiplegia, Upper Extremity Impairments
- Trial name
- NCT07666308
- Testing
- Conventional Rehabilitation, Virtual Reality-Based Mirror Therapy, Functional Electrical Stimulation-Assisted Cycling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara City Hospital Bilkent
Alzheimer s Disease
Deep Cervical Lymphovenous Anastomosis for Severe Alzheimer's Disease
Alzheimer's disease (AD) is a severe neurodegenerative disease with heavy social burden. Current drugs cannot reverse disease progression.
- Trial name
- DCLVA-AD (NCT07669272)
- Testing
- Deep Cervical Lymphovenous Anastomosis, Routine Treatment
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Southwest Hospital, China
Stroke Rehabilitation
Digital Interactive Technologies in Rehabilitation of Post-sroke Patients With Impaired Fine Function of the Hand
The aim of the study is to investigate the efficacy and safety of digital interactive technology with artificial intelligence and biofeedback Smart glove "SensoRehab" for restoration of in-hand manipulation in patients with…
- Trial name
- NCT05214521
- Testing
- digital interactive technology Smart glove "SensoRehab"
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
Stroke
The Impact of App-based Cognitive Training on Post-stroke Upper Extremity Rehabilitation
To find out the impact of app-based cognitive training on upper extremity function in patients with sub-acute stroke.
- Trial name
- NCT05951530
- Testing
- traditional physical therapy, mobile app-based cognitive training
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Hemiparesis
Robotic Brace Incorporating Electromyography for Moderate Affected Arm Impairment After Stroke
Of the 5.7 million stroke survivors in the United States, up to 80% exhibit significant weakness in one arm (called "hemiparesis"). This devastating impairment undermines performance of valued activities and quality of life.
- Trial name
- NCT01654315
- Testing
- Myomo Robotic Arm, RTP Standard Therapy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Ohio State University
Tetraplegia, Spinal Cord Injury
Cortical Recording and Stimulating Array Brain-Machine Interface
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
- Conditions
- Tetraplegia, Spinal Cord Injury, Brainstem Stroke, Brachial Plexus Injury
- Trial name
- CRS-BMI (NCT01894802)
- Testing
- Implantation of CRS Arrays
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Michael Boninger
Hearing Loss, Cognitive Impairment
Auditory-Cognitive Optimization Care Program for Older Adults With Hearing Loss and Cognitive Impairment
Hearing loss and cognitive impairment are common and interrelated health problems that may affect communication, information processing, attention, psychological well-being, daily functioning, and quality of life.
- Trial name
- A-COP (NCT07869745)
- Testing
- Auditory-Cognitive Optimization Care Program (A-COP), Hearing Management and Newspaper-Reading Activities
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Taipei Medical University
Solid Tumors, Hematologic Malignancies
Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment
The purpose of this study is to compare the safety and efficacy of carfilzomib, including measuring the amount of the study drug in the blood at certain times following dosing.
- Conditions
- Solid Tumors, Hematologic Malignancies, Hepatic Impairment
- Trial name
- NCT01949545
- Testing
- Carfilzomib
- Where
- 11 sites in United States, France and 2 more
- Volunteers
- 46 people
- Sponsor
- Amgen
Diabetes Mellitus, Type 2, Kidney Function Tests
The Study Will Evaluate Average 24-hr Sodium Excretion During Dapagliflozin Treatment in Patients With Type 2 Diabetes Mellitus With Preserved or Impaired Renal Function or Non-diabetics With Impaired Renal Function.
The purpose of this study is to evaluate how dapagliflozin mechanism of action is impacted by Type 2 Diabetes Mellitus status and kidney function
- Trial name
- DAPASALT (NCT03152084)
- Testing
- Dapagliflozin
- Where
- 4 sites in Netherlands, Sweden
- Volunteers
- 24 people
- Sponsor
- AstraZeneca
Stroke, Stroke, Acute
Associative Peripheral Stimulation for Reduction of Motor Impairment During Acute Period of Stroke Recovery
Associative Peripheral Stimulation (APS) is a non-invasive therapy intended for stroke rehabilitation involving transcutaneous electrical muscle stimulation paired with voluntary movement.
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Stroke, Hemorrhagic
- Trial name
- APS-PILOT (NCT06575140)
- Testing
- Associative Peripheral Stimulation (APS) 1.0, Peripheral Neuromuscular Stimulation
- Where
- 3 sites in Mexico
- Volunteers
- 20 people
- Sponsor
- Ahmed A. Rahim