Clinical trials: Impairment Upper Limb
Stroke, Cardiovascular, Cognitive Impairment
OptiCogs: A Multicomponent Intervention to Rehabilitate Cognitive Impairment in People Post-stroke
OptiCogs Online is a complex multicomponent intervention comprising of cognitive, physical activity and educational components.
- Trial name
- NCT05414539
- Testing
- OptiCogs Online
- Where
- Ireland
- Volunteers
- 9 people
- Sponsor
- University of Limerick
Chonic Stroke Patients With Motor Impairment of Upper Limb
Impact of rTMS on BCI Control in Upper Limb Motor Rehabilitation of Patients With Chronic Stroke
Cerebrovascular accidents (strokes) are a major public health issue. Stroke is the 3rd leading cause of death and the leading cause of disability and loss of autonomy.
- Trial name
- BCINET (NCT06951035)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke, Spinal Cord Injury
ArmeoSenso - Home Therapy and Assessment for Patients With Arm Impairments Based on Wearable Movement Sensors
stroke, spinal cord injury, rehabilitation, home therapy, upper limb, arm, virtual reality, interia sensor, Trial with medical device
- Trial name
- NCT02098135
- Testing
- ArmeoSenso
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- University of Zurich
Adrenomyeloneuropathy Without Cerebral Involvement
Epidural Spinal Cord Stimulation for Lower-limb Impairment in Adrenomyeloneuropathy
Adrenal spinal neuropathy (AMN) is a rare X-linked genetic disease caused by mutations in the ABCD1 gene, and belongs to a special type of adrenal leukodystrophy.
- Trial name
- EPIC-AMN (NCT06796920)
- Testing
- Spinal cord stimulation
- Where
- 4 sites in China
- Volunteers
- 10 people
- Sponsor
- Third Military Medical University
Cholestatic Liver Disease
Evaluate PK & Safety of Saroglitazar in Subjects With Moderate Hepatic Impairment Due to Cholestatic Liver Disease
Evaluating Pharmacokinetic and safety of Saroglitazar Magnesium 1 mg when dosed on alternate days in subjects having moderate hepatic impairment with cirrhosis due to cholestatic liver disease
- Trial name
- NCT06825559
- Testing
- Saroglitazar Magnesium 1 mg
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Zydus Therapeutics Inc.
Spinal Cord Injury, Tetraplegia/Tetraparesis
MEP Up-conditioning to Target Corticospinal Plasticity
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist…
- Trial name
- uMEP2 (NCT06989905)
- Testing
- Up-conditioning of the wrist extensor motor evoked potential
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Medical University of South Carolina
Hemiplegic Cerebral Palsy
Feasibility of Pediatric CIMT by Televideo
The study will test a remotely delivered, intensive, therapist-led, pediatric CIMT intervention, to improve the quality and frequency of upper limb movement during functional activity.
- Trial name
- CHAMP-T (NCT05303883)
- Testing
- Pediatric Constrained Induced Movement Therapy
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Ohio State University
Cognitive Impairment, Schizophrenia
Safety, Biomarker Study of RL-007 in Subjects With Schizophrenia
The purpose of this study is to assess the safety and effects on electrical activity in the brain of an investigational drug (RL-007) for improving cognition in patients with schizophrenia
- Trial name
- NCT04822883
- Testing
- RL-007
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Recognify Life Sciences
CVA (Cerebrovascular Accident), Stroke
Constraint-Induced Movement Therapy for Adults Post-Stroke With Mild Upper Extremity Impairment
Constraint-Induced Therapy (CI Therapy) is a behavioral approach to neurorehabilitation and consists of multi-components that have been applied in a systematic method to improve the use of the limb or function addressed in the…
- Conditions
- CVA (Cerebrovascular Accident), Stroke, Upper Extremity Paresis
- Trial name
- NCT05492513
- Testing
- Grade 1 CI Therapy +Sensory Components
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Depressive Symptoms, Quality of Life
Non-pharmacological Care for Depression in Cancer Patients Using VR and TMS
Despite its significant impact on individuals and healthcare systems, substantial gaps remain in the clinical and rehabilitative management of depression in oncology patients.
- Conditions
- Depressive Symptoms, Quality of Life, Cognitive Impairment
- Trial name
- INCEPT (NCT06589544)
- Testing
- Virtual Reality-based Cognitive Remediation (VR-COG) + Treatment as Usual (TAU), Repetitive transcranial magnetic stimulation (rTMS) + Treatment as usual (TAU), Treatment as Usual (TAU)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University Hospital of Ferrara
Stroke, Amyotrophic Lateral Sclerosis
Auto-calibrating System for Upper Limb Disability Assessment, Neurological and Occupational Rehabilitation
This interventional, multicenter, low-intervention clinical trial aims to evaluate the usability, feasibility, safety, and preliminary clinical impact of a robotic rehabilitation system designed for upper limb rehabilitation in…
- Conditions
- Stroke, Amyotrophic Lateral Sclerosis, PARKINSON DISEASE (Disorder), Mild Cognitive Impairment (MCI)
- Trial name
- ASULDAR (NCT07636538)
- Testing
- Auto-calibrating System for Upper Limb disability Assessment, neurological and occupational Rehabilitation, conventional therapy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Diabetic Macular Edema
Study of Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients With Visual Impairment Due to Diabetic Macular Edema
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with visual impairment due to diabetic macular edema (DME).
- Trial name
- KESTREL (NCT03481634)
- Testing
- Brolucizumab, Aflibercept
- Where
- 116 sites in United States, Argentina and 12 more
- Volunteers
- 566 people
- Sponsor
- Novartis Pharmaceuticals
Dystonia
Brain Function in Focal Dystonia
Objectives The main objectives of this proposal are (1) to characterize motor learning abnormalities in patients with focal dystonia; (2) to show, using transcranial magnetic stimulation, that this abnormal motor learning went…
- Trial name
- NCT00102999
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Diabetic Macular Edema
A Trial to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Participants With Diabetic Macular Edema (DME)
This Phase 3 study will evaluate the efficacy, durability, and safety of KSI-301 compared to aflibercept in participants with treatment-naïve DME.
- Trial name
- GLEAM (NCT04611152)
- Testing
- KSI-301, Aflibercept
- Where
- 75 sites in United States, Germany and 6 more
- Volunteers
- 460 people
- Sponsor
- Kodiak Sciences Inc
Stroke
Physiotherapy and Action-Observation Therapy: An Integrated Approach for Upper Limb Impairment in Subacute Stroke
Motor impairment is one of the most common result of a stroke, which causes disability and difficulties in activities of daily living. This motor impairment can concern the upper limb or the lower limb, or both.
- Trial name
- PHOENICS (NCT04560764)
- Testing
- Virtual Reality, Action Observation Therapy, Landscape video
- Where
- Italy
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Intensive Upper Limb Training in Chronic Stroke
The evidence supporting routine provision of high-dose, high-intensity upper limb neurorehabilitation treatment for stroke survivors beyond the first few months after stroke is limited.
- Trial name
- INTENSIVE (NCT05527262)
- Testing
- Queen Square Upper Limb Neurorehabilitation Programme, Immersive gaming therapy
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University College, London
Incomplete Spinal Cord Injury
The Use of Electromagnetic Field (EMF) Treatment in Chronic Spinal Cord Injury (SCI) Patients
The purpose of this study is to further establish safety and efficacy of the BQ EMF treatment of chronic SCI subjects who demonstrate stability in The Graded and Redefined Assessment of Strength, Sensibility and Prehension…
- Trial name
- NCT04050696
- Testing
- BQ 1.2
- Where
- 3 sites in United States, Israel
- Volunteers
- 8 people
- Sponsor
- BrainQ Technologies Ltd.
Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
Comparative Effects of Integrated Versus Sequential Approaches to Dual-Task Training in Elderly With Mild to Moderate Cognitive Impairment
Mild and Moderate cognitive impairment is a condition characterized by a noticeable decline in cognitive abilities, including memory and thinking skills, which is greater than expected for an individual's age but does not…
- Trial name
- nill (NCT07775079)
- Testing
- Integrated Dual-Task Training, Sequential Dual-Task Training
- Where
- Pakistan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Shifa Tameer-e-Millat University
Stroke Sequelae
Effect of Air Splints on Sensoriomotor Disturbances of the Affected Upper Extremity and Trunk Control in the Adult Post-stroke Patient
Objective: Sensory impairment in the affected upper limb occurs in approximately 50% of post-stroke patients and negatively impacts functional capacity and quality of life.
- Trial name
- NCT07029061
- Testing
- Air splints
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Alfonso X El Sabio University
Cerebral Palsy, Hemiplegic
Sensory-Motor Relationship in Unilateral CP
Cerebral palsy (CP) is characterized by many problems related to brain damage. One of these is sensory impairment. Sensory impairments in CP patients can also occur together with motor functions.
- Trial name
- NCT07429175
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ankara University