Clinical trials: Implants
Disorder of Soft Tissue
Safety Evaluation of Aline HA, an Implanted Cross-Linked HA Device
The protocol hypothesis is that treatment with Aline HA™ will be safe through 6 months as determined by clinical assessment of treatment sites and routine tracking of adverse events.
- Trial name
- NCT01708213
- Testing
- Aline HA
- Where
- 2 sites in Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TauTona Group
Non-Proliferative Diabetic Retinopathy
A Study to Evaluate the Efficacy and Safety of OTX-TKI (Axitinib Implant) in Participants With Non-Proliferative Diabetic Retinopathy
The purpose of this trial is to study the safety and effectiveness of OTX-TKI (axitinib intravitreal hydrogel) for the treatment of Non-Proliferative Diabetic Retinopathy.
- Trial name
- HELIOS-3 (NCT07235085)
- Testing
- Intravitreal injection of axitinib hydrogel implant followed by a second intravitreal injection of the axitinib implant at Week 24
- Where
- United States
- Volunteers
- 930 people
- Sponsor
- Ocular Therapeutix, Inc.
Edentulism, Implant Dentistry
Marginal Bone Remodeling at Monolithic Zirconia Full-Arch Prostheses in the Maxilla and Mandible
This prospective observational clinical study aims to compare 12-month clinical, radiographic, and patient-reported outcomes of monolithic zirconia full-arch implant-supported prostheses placed in the maxilla versus the mandible.
- Trial name
- NCT07323290
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Dental Implant Failure Nos, Wound Heal
Soft Peri-implant Tissue Around Different Abutment Materials
Soft tissue attachment to the implant surface serves as a biological seal preventing the development of inflammatory periimplant diseases (i.e.
- Trial name
- NCT03459547
- Testing
- dental implant
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Dental Implants
Anterior Mandibular Region for Immediate Implant Placement
Immediate implant placement has been proven to be a successful treatment modality, it is however considered a technique sensitive procedure, which mandates careful planning on basis of the recommended guidelines and thorough site…
- Trial name
- NCT06527950
- Testing
- no intervention
- Where
- Egypt
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Bone Resorption, Wound Heal
Alveolar Socket Healing With and Without PRGF
A single-centre randomised controlled pilot study involving 12-24 healthy adult patients for investigating dental extraction socket healing with and without plasma rich in growth factors (PRGF) taking place during early days of…
- Trial name
- NCT04383158
- Testing
- PRGF ENDORET® obtained from ENDORET® POST-EXTRACTION ALVEOLUS DENTAL KIT (KMU16)
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Alveolar Bone Loss, Bone Resorption
Outcome of Implant-supported Overdentures
The aim of this pilot study was to assess survival rates and peri-implant bone loss of two narrow-diameter titanium-zirconium implants supporting maxillary and mandibular overdentures during an observation time of 3 years.
- Conditions
- Alveolar Bone Loss, Bone Resorption, Dental Implants, Edentulous Maxilla
- Trial name
- NCT03777748
- Testing
- dental implants and stud attachments
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Arrythmias
Air Pollution and Implantable Cardioverter Defibrillators
Community based studies have shown increased cardiovascular mortality associated with acute exposures to particulate air pollution.
- Trial name
- NCT00015574
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Teeth Absent, Tooth-loss
Peri-implant Tissues on the Galimplant Anti-rotational Slim Abutment.
A dental implant is an alloplastic material surgically inserted in a residual bone ridge, mainly with a prosthetic foundation. Nowadays the most widely used implants and with a higher degree of scientific evidence are the…
- Conditions
- Teeth Absent, Tooth-loss, Tooth Extraction, Dental Implant
- Trial name
- NCT05118815
- Testing
- Slim abutment, Standard abutment
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Degenerative Disc Disease (DDD), Spinal Stenosis
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials
This is a prospective, multi-center, observational Post-Market Clinical Follow-Up (PMCF) study designed to collect additional safety and clinical performance data on CE-marked Titania® spinal instrumentation and fusion systems…
- Conditions
- Degenerative Disc Disease (DDD), Spinal Stenosis, Spondylolisthesis, Spinal Deformities
- Trial name
- INFO SPINE (NCT07615491)
- Testing
- Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 561 people
- Sponsor
- Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.
Cancers, Chronic Pain
The Clinical Evaluation of Implantable Pump System For Safety And Delivery Accuracy In Patients Requiring Intrathecal Administration Of Morphine Sulfate For Chronic Pain
The objectives of this study are to confirm the medication delivery accuracy of the Infusion System, LLC Implantable Drug Delivery System (IDDS) with Patient Controlled Analgesia for intrathecal delivery of morphine sulfate for…
- Trial name
- NCT01185470
- Testing
- Implantation of Morphine Sulfate delivering programmable pump
- Where
- 9 sites in United States
- Volunteers
- 75 people
- Sponsor
- Medallion Therapeutics, Inc.
Skull Fixation After Craniotomy for Neurosurgical Procedures
Implant System for Fixation of Cranial Bone Flaps After Craniotomy for Brain Surgery
Bone flaps after craniotomy are typically fixed with suture material, mini plates and others devices. In some cases, fixation with suture material is not secure as it may result in shifting of the bone flap with its dislocation.
- Trial name
- CRANIOSG (NCT00797979)
- Testing
- Skull Grip bone fixation, sutures
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dental Implants
PEEK Versus Titanium Customized Healing Abutments
The study suggests that if the investigators used customized healing abutments synthesized from PEEK may have a favorable effect on peri-implant soft tissues regarding decreased plaque accumulation and healing stimulation…
- Trial name
- NCT05989061
- Testing
- PEEK customized healing abutment, Titanium customized healing abutment
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Prostate Cancer
Rectal Spacer Hydrogel Before Radiation Therapy in Reducing Radiation Dose to the Rectum in Patients With Prostate Cancer
This phase II trial studies the effect of rectal spacer hydrogel before radiation therapy in reducing radiation dose to the rectum in patients with prostate cancer.
- Trial name
- NCT05224869
- Testing
- Medical Device Usage and Evaluation, CT simulation, Stereotactic body radiation therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prostate Cancer (Diagnosis), Prostate Cancer Patients Who Have Brachytherapy Seed Implant
Immune Biomarkers in Prostate Cancer Patients Treated With Brachytherapy
Analysis of peripheral immune cells before, during, and after brachytherapy treatment. Corresponding analysis of tissue samples collected during brachytherapy treatment.
- Conditions
- Prostate Cancer (Diagnosis), Prostate Cancer Patients Who Have Brachytherapy Seed Implant, Prostate Cancer Patients Treated by Radiotherapy, Prostate Cancer Recurrent
- Trial name
- NCT07131956
- Where
- 3 sites in Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Immediate Dental Implant
Modified Periosteal Inhibition With Simultaneous Implant Placement in Aesthetic Zone
A randomized controlled clinical and radiographic trial. Twenty sites with remaining roots or non-restorable teeth in the maxillary anterior region that fulfill the inclusion criteria will be selected from the Periodontology…
- Trial name
- NCT06519773
- Testing
- Modified periosteal inhibition
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Breast Augmentation, Breast Reconstruction
Evaluation of the Safety and Performance of ESTYME® MATRIX Round and Anatomical Breast Implants - EMMIE Study
The study will evaluate the safety and performance of the ESTYME® MATRIX Round and Anatomical Silicone Gel-Filled Breast Implants in the breast augmentation and reconstruction.
- Trial name
- EMMIE (NCT03386682)
- Testing
- ESTYME® MATRIX Breast Implants
- Where
- 8 sites in France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Symatese Aesthetics
Implantable Defibrillator User, Distress
A Personalized and Interactive Web-based Health Care Innovation to Advance the Quality of Care
This study evaluates the clinical efficacy and cost-effectiveness of the ACQUIRE-ICD care innovation as add-on to usual care as compared to usual care alone in patients with an implantable cardioverter defibrillator.
- Trial name
- ACQUIRE-ICD (NCT02976961)
- Testing
- Supportive care
- Where
- 5 sites in Denmark
- Volunteers
- 478 people
- Sponsor
- Susanne Schmidt Pedersen
Cancer
Assessment of Complications, Quality of Life and Easiness of Use of Implantable Central Venous Access Ports
This is a prospective, descriptive and observational study of the anticancer center practice
- Trial name
- CCI (NCT00921141)
- Where
- France
- Volunteers
- 815 people
- Sponsor
- Centre Oscar Lambret
Peri-Implantitis and Peri-implant Mucositis
The Use of Adjunct Oxygen High-Level Laser Therapy on the Clinical and Microbiological Outcomes of Peri-implant Disease
The goal of this clinical trial is to learn whether using a special light-activated treatment called photodynamic therapy, or more specifically, its modified version called oxygen high-level laser therapy, using a high-powered…
- Trial name
- NCT07287956
- Testing
- Oxygen high-level laser therapy (Diode laser and hydrogen peroxide), Diode laser therapy
- Where
- Jordan
- Volunteers
- 16 people
- Sponsor
- King Abdullah University Hospital
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