Clinical trials: Implants
Chronic Heart Failure
Symphony: The Implantable Counter Pulsation Device (CPD) Safety and Feasibility Trial
The Counter Pulsation Device (CPD) System 'Symphony' is intended to provide counter pulsation therapy for up to thirty (30) days to patients with chronic heart failure who have persistent worsening of their condition despite…
- Trial name
- Symphony (NCT01543022)
- Testing
- Symphony, The operative approach is limited to an infraclavicular incision similar to that used for placement of a pacemaker
- Where
- 3 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Abiomed Inc.
Implant Site Pocket Infection
Regenerative Surgical Treatment of Peri-implant Defects
Does submerged healing of implants improve clinical and radiologic outcomes for the treatment of peri-implantitis? A number of recent systematic reviews have shown that the prevalence of periimplantitisin the population is high.
- Trial name
- NCT04440241
- Testing
- regenerative treatment periimplantitis
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Hallux Valgus, Hallux Limitus
The Hyalex MTP Study
The HYALEX SLALOM MTP Hemiarthroplasty System consists of a synthetic implant designed to replace the distal metatarsal surface of the great toe for treatment of arthritis .
- Conditions
- Hallux Valgus, Hallux Limitus, Hallux Rigidus
- Trial name
- NCT07538141
- Testing
- MTP Hemiarthroplasty
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Hyalex Orthopaedics, Inc.
Peri-implant Mucositis
Efficacy of Adjunctive At-Home Photodynamic Therapy (aPDT) in the Treatment of Peri-Implant Mucositis
The study aims to establish a validated protocol enabling an alternative approach for bacterial biofilm control through the application of a novel at-home photodynamic/antibacterial blue light therapy in addition to non-surgical…
- Trial name
- NCT06859866
- Testing
- Standard oral hygiene, The addition of home-based dual-light photodynamic therapy (Lumorinse® + Lumoral®)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Koite Health Oy
Lock Solution, Catheter Related Blood Stream Infections
Randomized, Multicenter, Double-blind, Vancomycin-controlled Study to Evaluate the Efficacy of Ethanol Lock Solution for the Curative Treatment of Implantable Venous Access Port Infection Due to Coagulase-negative Staphylococci
Implantable venous access port infections are mainly due to coagulase negative staphylococci and may be managed by antibiotic lock therapy with retention of the port. Most of the time a vancomycin lock is used.
- Conditions
- Lock Solution, Catheter Related Blood Stream Infections, Central Venous Catheter Infection, Intravenous Drug Delivery Systems
- Trial name
- Etha-LOCK (NCT02411331)
- Testing
- Ethanol 40% + Enoxaparine 400UI/ml, Vancomycine 5 mg/ml + Héparine 2500UI/ml
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Clermont-Ferrand
Mucositis Oral
Effect of Probiotic Use Bifidobacterium Animalis Subsp. Lactis in Peri-implant Mucositis
Peri-implant disease is an inflammatory process of bacterial etiology that can affect the tissues around the implants and can be classified as peri-implant mucositis or peri-implantitis.
- Trial name
- Mucosite prob (NCT04187222)
- Testing
- Mechanical debridements, Bifidobacterium animalis subsp. lactis
- Where
- Brazil
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Badly Decayed Teeth
Immediate Implant Placement in the Esthetic Zone With and Without Using Autogenous Mixed With Xenograft
Xenografts are graft materials derived from the inorganic portion of animal bones; the most common source is bovine the removal of the organic component are processed to remove their antigenicity, while the remaining inorganic…
- Trial name
- NCT04096209
- Testing
- autograft mixed with xenograft bone
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
HIV, Contraception
Pharmacologic Strategies to Use the Levonorgestrel Implant in HIV-infected Women
The purpose of this study is to determine whether increasing the dose of the levonorgestrel subdermal contraceptive implant will overcome a detrimental drug-drug interaction with efavirenz based antiretroviral therapy.
- Trial name
- NCT02722421
- Testing
- Levonorgestrel, Efavirenz
- Where
- Uganda
- Volunteers
- 28 people
- Sponsor
- University of Nebraska
Skin Aging
Tolerance and Efficacy Evaluation of 3 Face Creams
The study will evaluate the tolerance and the efficacy on skin comfort of F#1048-082 soothing cream used just after injection procedure and also the tolerance and the efficacy of the F#841-020 anti-age cream on aging parameters…
- Trial name
- FILLER (NCT02063971)
- Testing
- Soothing (formulation number: F#1048-082) and antiaging creams (F#841-020 and F#1374-002)
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Adele Sparavigna
Ventricular Tachycardia, Coronary Artery Disease
Coronary Flow During Rapid Heart Rates
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1.
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction
- Trial name
- VT flow (NCT05841199)
- Testing
- Pressure and flow measurement during simulated VT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Periimplantitis, Periodontal Disease
Preventive Maintenance Therapy on Peri-implant Diseases
In the field of periodontics, periodontal support therapy has proven to be essential in preventing the incidence or recurrence of periodontal diseases. The protocol is designed according to the risk profile of a patient.
- Trial name
- PIMT (NCT02789306)
- Testing
- Epidemiological study on the incidence of peri-implantitis
- Where
- Spain
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Center of Implantology, Oral and Maxillofacial Surgery, Badajoz, Spain
Myocardial Function After LVAD Implant, Ischemic Cardiomyopathy
Recovery of Hibernating Myocardium in End Stage Heart Failure
This study will collect clinical, echocardiographic, nuclear imaging and hemodynamic data in a group of patients with end stage ischemic cardiomyopathy undergoing left ventricular assist device (LVAD) implantation to investigate…
- Trial name
- RHIMES-HF (NCT02573207)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Intermountain Health Care, Inc.
Upper Central Incisor Edentulism
Central Incisors Narrow Implants in Alternative to Bone Augmentation With 4.2 mm Implants .
Horizontal bone augmentation procedures are commonly used to increase bone width to allow the placement of dental implants or to improve aesthetics in deficient areas.
- Trial name
- NCT02897193
- Testing
- ICE dental implant 4.2 mm, NICE dental implant 3.2 mm, Alpha Bio's Graft Bovine bone
- Where
- 2 sites in Chile
- Volunteers
- 42 people
- Sponsor
- Alpha - Bio Tec Ltd.
Peri-implant Mucositis
Domiciliary Use of Hyaluronic Acid Gel Solutions vs Domiciliary Use of Chlorhexidine Mouthwash 0,20% for the Management of Peri-implant Mucositis Sites
This is a randomized controlled clinical trial (RCT). After signing the informed consent, patients satisfying the inclusion criteria will undergo supragingival and subgingival professional oral hygiene of both arches performed…
- Trial name
- NCT05312593
- Testing
- Aftoral Oral Gel, Unidea Chlorhexidine mouthwash
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Pavia
Hemifacial Microsomia, Mucormycosis
Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction.
This clinical study aims to evaluate the effectiveness of patient-specific 3D-printed titanium facial implants in the reconstruction and aesthetic correction of facial defects.
- Conditions
- Hemifacial Microsomia, Mucormycosis, Oral Squamous Cell Carcinoma, Microgenia
- Trial name
- 3DFACE (NCT07654647)
- Testing
- Patient-specific titanium implants for facial reconstruction
- Where
- Syria
- Volunteers
- 30 people
- Sponsor
- Latakia University
Cataract
Prospective Evaluation and Comparison of Bilateral Synergy Implants and Bilateral PanOptix Implants
The purpose of this study is to evaluate the AcrySof PanOptix Intraocular Lens (IOL) for binocular distance corrected near visual acuity (DCNVA) compared to TECNIS Synergy IOL.
- Trial name
- NCT05186298
- Testing
- AcrySof® IQ PanOptix®, Synergy®, Cataract Surgery
- Where
- 5 sites in United States
- Volunteers
- 320 people
- Sponsor
- Alterman, Modi, & Wolter Ophthalmic Physicians & Surgeons
Periodontal Diseases, Periimplant Diseases
Markers of Bone Destruction and Oxidative Stress in Peri-implantitis
The aim of this study is to evaluate and compare the levels of bone resorption (RANKL, OPG) and oxidative stress (Nitrotyrosine, NQO1) markers, along with pro-inflammatory cytokines (IL-1β), in the saliva and peri-implant…
- Trial name
- NCT07397884
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Hearing Impaired Children
Hearing Impairment in Children: Pupillometry and Hearing Thresholds Assessment
The results of the previous study on auditory effort in young children with cochlear implants show that pupils respond to the presence or the absence of the perceived stimuli.
- Trial name
- NCT06317493
- Testing
- Stimuli
- Where
- 5 sites in Italy, Slovenia
- Volunteers
- 180 people
- Sponsor
- IRCCS Burlo Garofolo
Tachycardia, Ventricular
SMS: Substrate Modification Study in Patients Getting an Implantable Cardioverter Defibrillator (ICD)
The present standard of care for the management of unstable ventricular tachycardia (VT) in the setting of chronic coronary artery disease is the placement of an implantable cardioverter defibrillator (ICD) after the initial…
- Trial name
- SMS (NCT00170287)
- Testing
- ICD Ablation plus VT-ablation, ICD Therapy
- Where
- 7 sites in Denmark, Germany
- Volunteers
- 116 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Immediate Dental Implants
Evaluation of Immediate Implant Placement Using Dual Zone Approach Versus Connective Tissue Graft
Tooth extraction is followed by ridge alteration and soft tissue collapse and recession. Different strategies were proposed to limit this collapse however, the ability of these techniques to mimic the original soft tissue level…
- Trial name
- NCT05776498
- Testing
- immediate implant placement with particulate bone graft using the dual zone technique., immediate implant placement with connective tissue grafting
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
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