Clinical trials: Implants
Hernia, Postoperative Pain
Assess the Feasibility and Efficacy of the CollaRx® Bupivacaine Implant Laparoscopic Inguinal or Umbilical Herniorrhaphy
This study will assess pain intensity for the first 72 hrs after aggravated movement (cough) following Laparoscopic Inguinal or Umbilical Herniorrhaphy.
- Trial name
- NCT01224145
- Testing
- 5x5cm bupivacaine collagen sponges
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Innocoll
Healthy
Implant Pharmacokinetic and Pharmacodynamic Study
This is a single center, pharmacokinetic and pharmacodynamic study in healthy volunteers. Twenty four subjects will be enrolled in the study and will be assigned to receive either a 16 mg afamelanotide bioresorbable implant from…
- Trial name
- NCT03634137
- Testing
- Afamelanotide Group 1, Afamelanotide Group 2
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Clinuvel Pharmaceuticals Limited
Open-angle Glaucoma
A Study of PER-001 in Participants With Open-Angle Glaucoma
This clinical study has two phases: Phase 1 and Phase 2a. Phase 1 is an open-label, single ascending dose (SAD), while Phase 2a is a randomized, single-masked (participant) with a sham control.
- Trial name
- NCT05822245
- Testing
- PER-001 Intravitreal Implant - Low Dose, PER-001 Intravitreal Implant - High Dose
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Perfuse Therapeutics, Inc.
Will Laser Treated Dental Implants Improve Stability Early Healing
Laser Treated vs SLA Treated Short Implants in Terms of Stability.
Laser treated short dental implants will be placed in a posterior atrophic ridge with only 8-10 mm available bone height. Their stability will be measured through a period of 12 weeks.
- Trial name
- NCT04100382
- Testing
- Laser and SLA
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hearing Loss
Evaluation of Middle Ear Implantation
The middle ear implant are used for patients with mild to severe sensorineural hearing loss, who cannot benefit from conventional hearing aids because of medical reasons such as chronic external otitis or external skin…
- Trial name
- NCT00451503
- Testing
- Middle Ear Implant
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pain, Dental Implant
Laser Photobiomodulation After Dental Implant Surgery: A Comparison of 650 nm and 810 nm Diode Lasers
The goal of this clinical trial is to evaluate the effectiveness of laser light therapy, known as photobiomodulation (PBM), in reducing pain after dental implant surgery.
- Trial name
- NCT06988722
- Testing
- 650 nm Diode Laser PBM, 810 nm Diode Laser PBM
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Institute of Laser Enhanced Sciences
Transplants and Implants
B-Cell Targeted Carfilzomib Desensitization
The primary purpose of this study is to provide a preliminary evaluation of the safety and potential efficacy of carfilzomib in reducing HLA antibody levels in highly sensitized kidney transplant candidates.
- Trial name
- NCT02442648
- Testing
- Carfilzomib, Rituximab
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- E. Steve Woodle
Prosthesis Durability
Vallecular Bolus Aggregation During Swallowing for Implant Overdenture.
evaluate the effect of implant retained mandibular overdenture on vallecular bolus aggregation during chewing and subsequent swallowing of solid food consistency.
- Trial name
- NCT06958055
- Testing
- videofluroscopy evaluation of swallowing function
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Maxillary Augmentation in Horizontal Bone Defect
Radiographic and Histomorphometric Assessment of Anterior Horizontal Maxillary Bone Augmentation Using Autogenous and Bovine Sticky Bone Versus Autogenous and Bovine Bone Shell Technique (Khoury): A Randomized Comparative Clinical Trial
This clinical trial aims to compare two bone augmentation techniques for patients with anterior horizontal maxillary bone defects: Autogenous and Bovine Sticky Bone Technique using S1 Bovine Bone Graft Autogenous and Bovine Bone…
- Trial name
- RCT (NCT07210385)
- Testing
- anterior horizontal maxillary bone augmentation using autogenous and bovine sticky bone, anterior horizontal maxillary bone augmentation using autogenous and bovine bone shell technique (khoury)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Aortic Bioprosthesis Degeneration
Influence of Original Native Aortic Valve Lesion (Stenosis or Steno-insufficiency vs. Insufficiency) on Post-implant Structural Bioprosthetic Degeneration After Aortic Valve Replacement
All patients undergoing elective aortic valve replacement for stenotic aortic valve replacement or aortic valve regurgitation at our institution from 2012 to 2021 who met the inclusion criteria for the study (described in the…
- Trial name
- DURABLE-AORTIC (NCT06964035)
- Testing
- Aortic valve replacement
- Where
- Netherlands
- Volunteers
- 10,000 people
- Sponsor
- Maastricht University Medical Center
Heart Failure, Systolic
Paced Heart Rate Acceleration for Cardiac Conditioning
A clinical trial of exercise-similar heart rate acceleration delivered via cardiac pacing vs. sham intervention in subjects at rest will be performed.
- Trial name
- HeartExcel (NCT06332391)
- Testing
- Exercise-similar cardiac pacing
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Denice Hodgson-Zingman, MD
Tachycardia, Ventricular Arrythmia
ExtraVascular Implantable Cardiac Defibrillator Continued Access Study
This study is designed to provide continued access to the Extravascular Implantable Cardioverter Defibrillator (EV ICD) System.
- Trial name
- EV ICD CA (NCT05049720)
- Testing
- Defibrillation using the Extravascular ICD
- Sponsor
- Medtronic
Cochlear Implant
Trial of Image-Guided Cochlear Implant Programming Versus Standard of Care
Cochlear implants are surgically implanted devices which restore the ability to hear to the hearing impaired. While remarkably successful, even in the best of performers restoration of hearing to levels of normal listeners is…
- Trial name
- IGCIP vs SOC (NCT02815124)
- Testing
- Standard of Care, Image-Guided Cochlear Implant Programming
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Preparation of the Implant Site With Piezosurgery vs Drill
Observational Study on the Preparation of the Implant Site With Piezosurgery vs Drill: Comparison Between the Two Methods in Terms of Post-operative Pain, Surgical Times and Operational Advantages
Purpose: Recent advances showed that ultrasonic implant site osteotomy is related with a decreased trauma and a better post operative healing of the surgical site if compared to the traditional drilling techniques.
- Trial name
- NCT03978923
- Testing
- preparation of the implant site with Piezosurgery vs drill
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Jaw, Edentulous, Partially
Evaluation of the Prevalence and Risk Factors for Patients With Peri-implant Disease：a Retrospective Study
To investigate the patient-related risk factors for peri-implant disease in partially edentulous patients rehabilitated with implants supported crown or bridge so as to provide evidence for clinical prevention and control.
- Trial name
- NCT02662361
- Where
- China
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Guided Bone Regeneration
Contour Augmentation by Means of Connective Tissue Grafting Versus Guided Bone Regeneration
The most frequent aesthetic complication following single implant treatment seems to be a lack of buccal convexity. This 'alveolar process deficiency' is the result of buccal bone remodeling following tooth extraction.
- Trial name
- NCT05143242
- Testing
- Hard tissue augmentation at the buccal aspect of single implants., Soft tissue augmentation at the buccal aspect of single implants.
- Volunteers
- 42 people
- Sponsor
- University Ghent
Immediate Dental Implant Placement, Connective Tissue Graft
Immediate Implants in Front Teeth With Bone Loss: Regeneration and Temporary Crown in a Randomized Clinical Study
This clinical trial investigates the biological and clinical outcomes of immediate implant placement in aesthetic areas presenting with buccal bone dehiscence.
- Conditions
- Immediate Dental Implant Placement, Connective Tissue Graft, Connective Tissue Graft Harvesting, Soft Tissue Management in Subcrestal Dental Implants
- Trial name
- GBR / RCT (NCT07415486)
- Testing
- immediate implant placement with DBBM-C and connective tissue graft, immediate implant placement with DBBM-C with collagen membrane
- Volunteers
- 24 people
- Sponsor
- Universitat Internacional de Catalunya
Knee Disease, Knee Infection
F18-MHF: Implants-Associated Infection Detection
Following intravenous injection of [F-18]MHF as a bolus, dynamic PET imaging of the lower limbs will be acquired for approximately 90 minutes. The acquired images will be processed and viewed on a MIMVista or similar workstation.
- Trial name
- NCT05889286
- Testing
- [F-18]MHF
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Amputation
Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback?
The investigators will investigate the device feasibility of human peripheral nerves and muscles recording and stimulation using percutaneous Utah Slanted Electrode Arrays (pUSEAs) implanted into residual peripheral arm nerves…
- Trial name
- NCT05505513
- Testing
- percutaneous Utah Slanted Electrode Arrays (pUSEAs)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Heart Failure
Chronicle Offers Management to Patients With Advanced Signs and Symptoms of Heart Failure (COMPASS-HF)
COMPASS-HF was a prospective, two-arm, randomized (1:1), multi-center, parallel controlled study. The purpose of the randomized study was to test the safety of an implantable hemodynamic monitor (IHM) and pressure sensor lead.
- Trial name
- NCT00643279
- Testing
- Chronicle Implantable Hemodynamic Monitor, Standard of Care
- Where
- 28 sites in United States
- Volunteers
- 277 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
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