Clinical trials: Implants
Enucleated; Eye, Eye Cancer
Use of an Allograft Set-up (SclerFIX) as Replacement of Sclera Graft for Support of Enucleation Implant
The purpose of this open, monocenter pilot trial is to evaluate the tolerance of the SclerFIX product, an allograft of umbilical cord lining membrane, in the reinforcement of ocular implants in patients who underwent enucleation…
- Trial name
- NCT05236049
- Testing
- SclerFIX
- Where
- France
- Volunteers
- 12 people
- Sponsor
- TBF Genie Tissulaire
Edentulous Alveolar Ridge Atrophy
Immediate Implants With Customized Abutments
Tooth extraction is followed by marked alterations of the tissue volume. The resorption process of at least the surrounding mucosa can be altered by using immediate implant placement and additional features such as immediate…
- Trial name
- NCT05638958
- Testing
- Immediate post-extractive Implant placement
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Geneva
Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes
Real World Evidence of Xen45 Gel Implant in Pseudoexfoliation Glaucoma
The Xen implant is an ab interno device that has been shown to be effective in reducing intraocular pressure in several types of glaucoma, although the evidence in pseudoexfoliative glaucoma is limited.
- Conditions
- Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma in Both Eyes, Open Angle Glaucoma
- Trial name
- NCT06993311
- Testing
- Xen Gel Stent implantation
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Xerencia de Xestión Integrada de Ferrol
Alveolar Bone Loss, Dental Implant
Evaluation of the Effect of Periimplant Soft Tissue Phenotype on Marginal Bone Loss
The goal of this clinical trial to test the effect of periimplant soft tissue phenotype in the participants with implant placed and at least 1 year after implant loading. The main questions it aims to answer are: 1.
- Conditions
- Alveolar Bone Loss, Dental Implant, Periimplantitis
- Trial name
- NCT05640284
- Testing
- Nuclear Factor-Kappa B Ligand (RANKL) analysis, Osteoprotegerin (OPG) analysis, Tumor Necrosis Factor Alpha (TNF-α) analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people
- Sponsor
- Necmettin Erbakan University
Edentulous Mandible
"Comparative Study of Supra-Structure Materials in Full-Arch Implant Prosthetics: a Randomized Clinical Trial"
after the implants' osseointegration period (4 months), digital scans will be taken for the implant positions and the STL files will be stored and sent for the CAD software to design a full arch restoration.
- Trial name
- CSDSMDA (NCT06673355)
- Testing
- dental implant prosthesis
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Dental Implant, Bone Healing
Diode Laser 940 Nm Versus Electrosurgical Device During Second Stage Implant Surgery on Bone and Soft Tissue Healing
Background: Dental lasers and electrosurgical devices have been introduced a long time ago. However, limited studies are available concerning their use in the second stage of implant surgery, with the conventional surgical…
- Conditions
- Dental Implant, Bone Healing, Soft Tissue Healing
- Trial name
- NCT06231134
- Testing
- Conventional surgery, Diode laser 940 nm, Electrosurgical
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Hams Hamed Abdelrahman
Osteoarthritis Of Knee
Evaluation Protocol of the Installation of Knee Unicompartmental Prosthesis (Journey (Smith & Nephew)) With Mechanical Ancillary Versus Robotic Assisted (Navio System).
Unicompartmental knee arthroplasty by unicompartmental prosthesis (PUC) is a treatment for isolated internal femoro-tibial osteoarthritis.
- Trial name
- PUC NAVIO (NCT03469193)
- Testing
- internal PUC implanted with mechanical ancillary, Internal PUC implanted with robotic assistance
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Hospices Civils de Lyon
Arthropathy of Hip
The Relationship Between Component Position and RoM
The aim of the study is to determine the influence of the combined anteversion of acetabular cup and the femoral stem used in total hip arthroplasty on the theoretical and actual range of motion of the hip in three dimensional…
- Trial name
- NCT02884349
- Testing
- RoM assessment
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Golden Jubilee National Hospital
Congenital Hearing Loss, Bilateral Cochlear Implants
Investigating the Neural Oscillatory Features for Limited Access to Oral Language in Deaf Children With Early Bilateral Cochlear Implantation
Children with severe-to-profound congenital hearing loss often experience significant language development challenges. While cochlear implants (CIs) can restore auditory input, outcomes vary widely, even among those who receive…
- Trial name
- ICO (NCT07739433)
- Volunteers
- 150 people
- Sponsor
- Institut Pasteur
Mastectomy, Breast Cancer
Pre-pectoral Versus Sub-pectoral Implant Placement in Immediate Breast Reconstruction
Despite the popularity and proved safety of prepectoral implant-based reconstruction, there is little evidence on long-term results and variables which could influence surgical outcome.
- Trial name
- NCT03959709
- Testing
- immediate acellular dermal matrix-assisted implant-based breast reconstruction with prepectoral implant placement., Immediate acellular dermal matrix-assisted implant-based breast reconstruction with subpectoral implant placement
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Ottawa Hospital Research Institute
Ventricular Arrythmia, Ischemic Cardiomyopathy
Multicentre Investigation of Novel Electrocardiogram Risk Markers in Ventricular Arrhythmia Prediction
This is a prospective open label single blinded multi-centre observational study involving a study group of patients already undergoing implantable cardioverter-defibrillator (ICD)(including Cardiac resynchronisation therapy…
- Trial name
- MINERVA (NCT03022487)
- Where
- 8 sites in United Kingdom
- Volunteers
- 395 people
- Sponsor
- University of Leicester
Neurologic Disorder, Paralysis
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT05041114
- Testing
- Motor Neuroprosthesis
- Where
- 3 sites in Australia
- Sponsor
- Synchron Medical, Inc.
Dental Implant, Edentulism
Long-Term Clinical and Radiographic Outcomes Following Freehand and Guided Dental Implant Placement: A Randomized Controlled Trial Follow-Up
This study is a long-term clinical follow-up of a previously conducted randomized trial comparing different levels of surgical guidance in dental implant placement.
- Conditions
- Dental Implant, Edentulism, Navigation
- Trial name
- SMART-ACCURACY (NCT07373548)
- Testing
- dental implant placement
- Where
- Hungary
- Volunteers
- 96 people
- Sponsor
- SmileDent Kft.
Orthopedic Disorder, Retained Metal Implant
Metallosis on Tissues and Serum Metal Levels in Children
Slightly elevated blood metal levels have been found in adults undergoing hip and knee replacement. It is unknown whether pediatric patients with metal implant(plates/screws/rods) have elevated blood metal levels.
- Trial name
- NCT03359109
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Jaw, Edentulous, Dental Implant
An Implant With an Acid-etched Fixture Surface and Internal-hex Collar May Achieve Greater Osseointegration.
Brånemark System® dental implant osseointegration was introduced clinically in 1965 as a novel approach to the replacement of missing teeth.
- Trial name
- NCT01641198
- Testing
- Configuration 1, Configuration 2, Configuration 3
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Université de Montréal
Dental Implants
Clinical and Radiographic Outcomes of Implant-supported Prostheses With Cantilever Extensions After 10 Years of Function
A retrospective examination was performed on patients who had received treatment with dental implants supporting a prosthesis with a cantilever extension for at least 10 years of function.
- Trial name
- Cantilevers (NCT06534398)
- Testing
- Dental implant prosthesis with cantilever extension
- Where
- Greece
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Glaucoma
A Study of Yutiq Steroid Insert During Glaucoma Tube Implant Surgery
This is a pilot study, which will include approximately five eyes of 5 patients. This study proposes that a sustained release steroid insert (Yutiq)1 be implanted along with a glaucoma drainage device (Ahmed Glaucoma Valve (AGV)…
- Trial name
- NCT04918121
- Testing
- Yutiq 0.18 MG Drug Implant
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sanjay Asrani
Peri-implant Crevicular Fluid
An Exploratory Clinical Investigation Evaluating Two Abutment Surfaces
A total of 22 subjects will be included in the study. The subjects who were treated with NobelActive TiUnite and On1 machined abutment will be enrolled in the control group and subjects who were treated with NobelActive TiUltra…
- Trial name
- Exploratory (NCT06557447)
- Testing
- Immunological and microbiological sample of peri-implant crevicular fluid; clinical evaluation
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Studio Ban Mancini Fabbri
Jaw, Edentulous, Partially
Straumann Roxolid Multi-Center Study
The primary objective of this study is to demonstrate non-inferiority of the Straumann Bone Level Ø 3.3 mm NC SLActive Roxolid Implants compared to Straumann Bone Level Ø 4.1 mm RC SLActive Roxolid Implants based on mean crestal…
- Trial name
- NCT01842958
- Testing
- Straumann Bone Level Implants, 4.1 mm implant diameter, Straumann Bone Level Implants, 3.3 mm implant diameter
- Where
- 5 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block
LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI
Patients with new-onset complete LBBB (QRS > 120 ms, persisting > 24 h after TAVI) and moderately reduced LVEF (35-50%) will be screened in participating centers.
- Conditions
- TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block, Reduced Left Ventricular Ejection Fraction
- Trial name
- LBB(AP)TAVI (NCT07909239)
- Testing
- Left bundle branch area pacing with pacemaker, Implantation loop recorder
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Clermont-Ferrand
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