Clinical trials: Implementation, open to volunteers
Multiple Myeloma Bone Lesions
Exercise Therapy for Multiple Myeloma Patients
Physical exercise is an important supportive therapy for cancer patients, as it improves quality of life in general and might mitigate the side effects of drug treatment.
- Trial name
- SAPPHIRE-MM (NCT07388147)
- Testing
- Orthopedic consultation and rehabilitation by excercise therapy
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- University Hospital Heidelberg
HIV Antiretroviral Therapy (ART) Adherence
Hybrid Type-1 Effectiveness-Implementation Trial of Motivation Matters!
The goal of this clinical trial is to learn if an interactive mHealth intervention will be effective in helping HIV-positive women in high-burden settings who are initiating antiretroviral therapy (ART) take their ART regularly…
- Trial name
- NCT06745050
- Testing
- Text message mHealth Evidence-based intervention
- Where
- Kenya
- Volunteers
- 350 people
- Sponsor
- University of Washington
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction: Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent…
- Conditions
- Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H), Colectomy Left/Right/Total Under Laparotomy, Hepatectomy
- Trial name
- NCT07901582
- Testing
- Epidural administered opioid
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- National and Kapodistrian University of Athens
Liver Steatoses, Liver Metastasis Colon Cancer
Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis
Non-alcoholic fatty liver disease is becoming increasingly common in Canada and throughout the world. Fatty liver can increase the risks of perioperative complications for those who need liver surgery.
- Conditions
- Liver Steatoses, Liver Metastasis Colon Cancer, NAFLD
- Trial name
- NCT05884723
- Testing
- Ketogenic Diet
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- Anton Skaro
Ischemic Stroke, CYP2C19 Polymorphism
Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke
The goal of this observational study is to use a genetic test to help doctors prescribe the most effective medications after a patient has a stroke. One type of stroke is caused by a blood clot in brain vessels.
- Trial name
- ORCA-AIS (NCT06292117)
- Testing
- CYP2C19 Genotype
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Virginia
Helicobacter Pylori Infection, Colorectal Cancer
European Implementation Study on Simultaneous Screening for Gastric and Colorectal Cancers
The EUGastScreen study is designed as a quality implementation study to explore gastric cancer screening strategies within organised cancer screening frameworks.
- Conditions
- Helicobacter Pylori Infection, Colorectal Cancer, Gastric Cancer
- Trial name
- EUGastScreen (NCT07873580)
- Testing
- Fecal sample acquisition for Helicobacter pylori stool antigen test, Upper endoscopy with biopsies, Colonoscopy with biopsies after bowel cleansing
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
This Study Evaluates Interventions to Increase Surveillance Mammography Uptake for Early Breast Cancer Detection Among Singaporean Women in Real World
Community Study to Increase Mammogram Screening Among Overdue Women
Breast cancer is the most common cancer among women in Singapore, and regular mammogram screening can detect breast cancer early when treatment is more effective.
- Trial name
- IMPLEMENT (NCT07832396)
- Testing
- Evidence-based behavioural intervention
- Where
- Singapore
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Exercise, Cancer
Implementation of the 3-steps Assess-Advise-Refer Exercise (FitARise) Protocol as a Standard Practice in Cancer Care
This study proposes to evaluate the process and outcome of an implementation program designed to implement the American College of Sports Medicine (ACMS)-recommended exercise assessment, advice, and referral instruction as…
- Trial name
- NCT07210905
- Testing
- 3-step Assess-Advice-Refer
- Where
- 8 sites in Hong Kong
- Volunteers
- 1,800 people
- Sponsor
- The University of Hong Kong
Post Traumatic Stress Disorder (PTSD), Depression
Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans
The VA wants to understand what type of integrative and whole health approaches are helpful for Veterans. The study is comparing two primary care based mental health treatments, a mindfulness class that teaches mindfulness…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Depression, Anxiety
- Trial name
- NCT06162741
- Testing
- Primary Care Brief Mindfulness Training (PCBMT), Moving Forward (MF)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Lung Cancer, Peripheral Vascular Diseases
Peripheral Vascular Disease as a Clinical Trigger for Opportunistic Lung Cancer Screening Referral: An Implementation Study
The study aims to determine whether patients with peripheral vascular disease who attend the vascular clinics are eligible for lung cancer screening.
- Conditions
- Lung Cancer, Peripheral Vascular Diseases, Ankle Brachial Index, Low Dose Computed Tomography
- Trial name
- PVD-Lungs (NCT07598279)
- Testing
- Observational - low dose computed tomography scan, Experimental - low dose computed tomography scan
- Where
- India
- Volunteers
- 355 people
- Sponsor
- International Agency for Research on Cancer
Eating Disorders
Guided Self Help for Eating Disorders Implementation Study
Eating disorders are amongst the most understudied illnesses affecting young women in Canada. Further, mortality rates are amongst the highest of all psychiatric illnesses.
- Trial name
- GSHimplement (NCT06851273)
- Testing
- Guided Self Help Family Based Therapy (GSH FBT)
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- McMaster University
Dementia (Diagnosis), Parkinson Disease Dementia (PDD)
Enhancing Utility of Neuropsychological Evaluation for Earlier and Effective Diagnosis of Dementia in Parkinson's Disease
Dementia is observed in 80% of people living with advanced stage Parkinson's disease, however, there are inadequate opportunities for early and effective diagnosis of dementia in current clinical practice.
- Conditions
- Dementia (Diagnosis), Parkinson Disease Dementia (PDD), Parkinson Disease (PD)
- Trial name
- PDCogniCare (NCT07114354)
- Testing
- PDCogniCare platform
- Volunteers
- 275 people
- Sponsor
- The University of Queensland
GLP - 1
Lifestyle Change Implementation Research Network at PRC at UMass Chan
The goal of this project is to study how well the Noom digital lifestyle program works for adults who are taking Glucagon-Like Peptide-1 receptor agonist (GLP-1) medications.
- Trial name
- LCIRN (NCT07481305)
- Testing
- Digital Lifestyle Coaching Program
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Massachusetts, Worcester
Spinal Cord Injuries (SCI)
High-intensity Walking Rehabilitation in Outpatient Subacute Spinal Cord Injury
People with incomplete spinal cord injury (SCI) often have some preserved movement and may regain walking ability, but recovery can be limited, and more effective rehabilitation approaches are needed.The goal of this clinical…
- Trial name
- NCT07553923
- Testing
- High-intensity Rehabilitation, Usual Care
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Alberta
Plaque-Induced Gingivitis
Individualized Management of Plaque-Related Gingival Inflammation in Routine Dental Practice
Gingival inflammation is common and can often be reversed with effective daily oral hygiene. However, preventive care is not always delivered consistently in dental practices, and patients may not receive sufficient…
- Trial name
- NCT07882459
- Testing
- Structured Preventive Care Workflow (iMGi)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Curaden AG
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
Digital Patient-Reported Assessment in Older Adults With Acute Leukemia
This pilot study will evaluate the feasibility of implementing a structured digital patient-reported assessment pathway in adults aged 65 years or older with acute leukemia at Hospital Universitario Central de Asturias, Oviedo…
- Trial name
- NCT07597590
- Testing
- Digital Patient-Reported Assessment Pathway
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Brain Injuries
Implementation Study on Hospital-to-home Advanced Rehabilitation Technologies (ART)
To study the feasibility of the various model of ART rental service for home use, prescribed and supervised by experienced rehabilitation professionals and supported by tech partners, and its efficacy in improving function in…
- Trial name
- R@H (NCT07904624)
- Testing
- ART
- Where
- 3 sites in Singapore
- Volunteers
- 1,000 people
- Sponsor
- National University Hospital, Singapore
Nicotine Use Disorder, Smoking Cessation
Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites
The goal of this study is to: partner with Respiratory Health Association and determine barriers and unmet smoking cessation treatment needs from leaders in behavioral health organizations, treatment programs and adults who smoke…
- Conditions
- Nicotine Use Disorder, Smoking Cessation, Smoking Cessation Intervention
- Trial name
- NCT06837220
- Testing
- Enhanced Courage to Quit
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago
Aedes-borne Diseases
Implementation and Evaluation of Vector Control Methods in Kinshasa: The Case of Aedes
Arboviral diseases are viral diseases transmitted by mosquitoes of the Aedes genus and are constantly spreading throughout the world, constituting a significant threat to public health.
- Trial name
- NCT06981442
- Testing
- Community-based environmental management, Vector control against immature stages of Aedes, Vector control against the mature stages of Aedes
- Where
- Democratic Republic of the Congo
- Volunteers
- 2,050 people, healthy volunteers welcome
- Sponsor
- Institute of Tropical Medicine, Belgium
Post-Traumatic Stress Disorder (PTSD), Depressive Symptoms
Trauma-Focused Cognitive Behavioral Therapy in Unaccompanied Refugee Minors With PTSD in Greece: An RCT
This single-blinded, multicentered, randomized controlled trial aims to evaluate the effectiveness of Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) compared to Treatment-as-Usual (TAU) in reducing post-traumatic stress…
- Conditions
- Post-Traumatic Stress Disorder (PTSD), Depressive Symptoms, Anxiety Symptoms, Somatic Symptoms
- Trial name
- TF-CBT (NCT06975280)
- Testing
- Trauma - Focused Cognitive Behavioral Therapy, Treatment as Usual (TAU)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Theodora Anastasiou
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