Clinical trials: Implementation, open to volunteers
Healthy
Implementation of Job Rotation for the Development of Nursing Competencies and the Improvement of Organizational Health in a Department of Cardiovascular Sciences: A Research Protocol
This prospective, monocentric observational study aims to evaluate the implementation of a Job Rotation (JR) program in the Department of Cardiovascular Sciences at Fondazione Policlinico Universitario A. Gemelli IRCCS.
- Trial name
- JR_01 (NCT06987487)
- Testing
- Job Rotation Program, No Job Rotation (Standard Care)
- Where
- Italy
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ovarian Cancer
Implementation of New Models of Ovarian Carcinoma Resistant to Therapy
The project focuses on developing new experimental models of ovarian cancer that accurately reflect patients who do not respond to first-line platinum-based treatments and who are resistant to PARP inhibitors (PARPi).
- Trial name
- NCT07757711
- Testing
- Platinum drugs and PARPi
- Volunteers
- 50 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Post Partum Haemorrhage
Outcomes and Perceptions of the Implementation of the JADA Device in a Stage II Postpartum Hemorrhage Management Protocol in Referral Hospitals of the Colombian Pacific Region
This study focuses on postpartum hemorrhage (PPH), a condition that stands out as the leading cause of global maternal mortality. Annually, about 14 million women experience PPH, resulting in approximately 70,000 deaths.
- Trial name
- JADAValle (NCT06843265)
- Testing
- Vacuum- Induce Hemorrhage Control
- Volunteers
- 24 people
- Sponsor
- Fundacion Clinica Valle del Lili
Ovarian Neoplasms, BRCA 1 Gene Mutation
Ovarian Cancer Liquid Biopsy for Early Assessment & Detection in Individuals With BRCA1/2 Pathogenic Variants
The goal of this clinical study is to evaluate the feasibility and acceptability of the Galleri multi-cancer early detection blood test in people with BRCA1 or BRCA2 gene changes who are at high risk for ovarian cancer.
- Conditions
- Ovarian Neoplasms, BRCA 1 Gene Mutation, BRCA 2 Gene Mutation, Serous Tubal Intraepithelial Carcinoma
- Trial name
- OC-LEAD (NCT07764744)
- Testing
- Galleri Multi-Cancer Early Detection (MCED) Blood Test
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Weill Medical College of Cornell University
Suicide Prevention
Practice Facilitation to Enhance Implementation of a Pediatric Suicide Prevention Pathway
Suicide in youth is rapidly growing to where it is the second leading cause of death across the United States. Use of available tools have shown the potential to boost primary care providers' (PCPs) detection of suicide risk and…
- Trial name
- NCT06619782
- Testing
- Practice Facilitation, Training in National Institute of Mental Health Youth Suicide Prevention Pathway
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Colorado, Denver
Cardiovascular Diseases
Proactive Population Health Management of Cardiovascular Disease in Primary Care Using the PROSPERA-program.
The PROSPERA-program is a complex multilevel approach that includes training for healthcare providers, a risk assessment process, and decision support tools to help match patients with the appropriate treatment based on their…
- Trial name
- PROSPERA (NCT06593704)
- Testing
- PROSPERA-program
- Where
- Netherlands
- Volunteers
- 848 people
- Sponsor
- Leiden University Medical Center
Trauma, Psychological, Psychosis
A Comprehensive Third-generation Intervention for People With Psychosis and Post-traumatic Stress Symptoms
Existing data suggest that both trauma and Post-Traumatic Stress Disorder (PTSD) are very common among individuals with psychosis.
- Trial name
- IITG-PPT (NCT05619822)
- Testing
- TAU + A comprehensive third-generation intervention, TAU
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Complutense de Madrid
Dietary Intakes, Physical Activity
Implementing Modified Practices to Leverage Evidence for Movement, Engagement, and Nutrition Topics in Early Childcare and Education
The goal of this cluster-randomized, controlled trial is to learn if a professional development program for childcare educators, called the Boston Healthy Child Care Initiative, can help improve the nutritional quality of…
- Conditions
- Dietary Intakes, Physical Activity, Child Care, Early Education
- Trial name
- IMPLEMENT (NCT07874295)
- Testing
- Boston Healthy Child Care Initiative
- Where
- United States
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Metastatic Prostate Cancer (mPC)
Implementation of a New Algorithm for HRR Gene Mutation Testing in Patients With mPC Through Liquid Biopsy Integration
Implementation of a new algorithm for HRR gene mutation testing in patients with mPC through liquid biopsy integration
- Trial name
- L2-267 (NCT06762379)
- Where
- Italy
- Volunteers
- 125 people
- Sponsor
- European Institute of Oncology
Mental Wellbeing
Evaluating Practices That Foster Care Partnerships and Wellbeing Among Informal Carers and Long-term Care Workers
WELL CARE aims to strengthen the supports available to informal carers and long-term care (LTC) workers for improving their resilience and mental wellbeing through care partnerships. The project consortium, lead by prof.
- Trial name
- WELLCARE (NCT07708649)
- Testing
- Solution Prototype in Germany, Solution Prototype in Italy, Solution Prototype in Slovenia
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Low Back Pain
Implementation of P3C-LBP in Swedish Primary Care
The goal of this observational study is to evaluate the implementation of a patient centered coordination care (P3C) pathway for the management of patients with low back pain (LBP) in primary care, in Östergötland health care…
- Trial name
- P3C-LBP (NCT06240533)
- Where
- Sweden
- Volunteers
- 300,000 people
- Sponsor
- Linkoeping University
Pulmonary Hypertension Due to Left Heart Disease, Heart Failure With Preserved Ejection Fraction
Training in HFpEF-PH
Exercise interventions alone or as a component of a comprehensive cardiac rehabilitation program for patients with heart failure (HFrEF and HFpEF) have already shown to reduce the risk of hospitalisations due to HF and improved…
- Trial name
- TRAIN HFpEF (NCT05464238)
- Testing
- Exercise rehabilitation, Standard treatment
- Where
- 2 sites in Germany, Lithuania
- Volunteers
- 90 people
- Sponsor
- Heidelberg University
Breast Cancer
Design and Pilot Implementation of a Chatbot to Support Breast Cancer Screening Among Black Women
Black women are more likely than White women to be diagnosed at later stages and to die from breast cancer. Increasing breast cancer screening rates could help improve early detection of and survival from breast cancer.
- Trial name
- NCT07858825
- Testing
- Chatbot
- Volunteers
- 873 people, healthy volunteers welcome
- Sponsor
- University of Washington
Social Determinants of Health (SDOH)
The Development, Implementation, and Evaluation of a Social Engagement Support System
The goal of this clinical trial is to determine if artificial intelligence and machine learning (AI/ML) models can help address social needs in Medicaid enrollees.
- Trial name
- NCT06913049
- Testing
- Social Engagement Support System
- Where
- United States
- Volunteers
- 249,660 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore County
Concussion, Mild, Traumatic Brain Injury
Improving In-hospital and Post-discharge Patient Education for Mild Traumatic Brain Injury
The purpose of this study is to develop and validate ways to provide better patient education and clinical management for individuals who go to the emergency department (ED) with concussion or mild traumatic brain injury (mTBI).
- Trial name
- EDucate (NCT06595914)
- Testing
- Clinical implementation strategies
- Where
- United States
- Volunteers
- 5,831 people
- Sponsor
- Medical College of Wisconsin
Cancer Related Cognitive Impairment, Breast Cancer Survivor
The Computerized Retraining and Functional Treatment - Group Intervention
The goal of this clinical trial is to examine the efficacy of a novel, remotely-applied group intervention, Cognitive Retraining and Functional Treatment Group (CRAFT-G), designed to improve cognitive function, mental health and…
- Trial name
- CRAFT-G (NCT07591857)
- Testing
- CRAFT-G, CCT
- Where
- Israel
- Volunteers
- 48 people
- Sponsor
- Hadassah Medical Organization
Sedentary Behavior
Stand & Move at Work II: Effectiveness and Implementation of a Worksite Wellness Program
This is a 2-arm group-randomized hybrid effectiveness-implementation (HEI type 2) study to test an evidence-based intervention (EBI) known as Stand \& Move at Work(SMW) to reduce sedentary time in the workplace, and to test the…
- Trial name
- SMWII (NCT05485675)
- Testing
- Stand & Move at Work, Stand & Move at Work+
- Where
- United States
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Colorectal Carcinoma (CRC)
Patient-led Follow-up from Home After Surgery for Colorectal Carcinoma
The primary goal of the patient-led follow-up from home, is the improvement of quality of life and the reduction of stress in patients, while obtaining a more complete picture of their health status.
- Trial name
- PROMISE (NCT06613581)
- Testing
- Home-based follow-up
- Where
- 5 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Smoking Cessation
Phone Enabled Implementation of Cessation Support
The tobacco use burden in Lebanon is exceptionally high: 35% of adults are current cigarette smokers and 39% are current waterpipe smokers.
- Trial name
- PHOENICS (NCT05628389)
- Testing
- Educational materials, Phone counseling, Nicotine Replacement Therapy
- Where
- Lebanon
- Volunteers
- 1,500 people
- Sponsor
- University of Florida
Knee Osteoarthritis (Knee OA)
An Implementation Science Approach to Evaluating Self-Administered Acupressure for Knee Osteoarthritis in Older-Aged Adults in the Community
This study aims to evaluate the implementation and effectiveness of a self-administered acupressure (SAA) program for knee osteoarthritis (OA) among older adults in Hong Kong community centers.
- Trial name
- NCT07329023
- Testing
- Experimental Group: Self-Administered Acupressure (SAA), Control Group: General Health Education
- Where
- Hong Kong
- Volunteers
- 368 people
- Sponsor
- The Hong Kong Polytechnic University
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