Clinical trials: Implementation, open to volunteers
Rare Diseases, Albinism
Implementation of Long-read Sequencing for the Diagnosis of Rare Diseases.
Following on from the third national plan for rare diseases (PNMR3), the main objectives of the PNMR4 are to reduce diagnostic uncertainty and dead ends and to strengthen translational research to promote diagnosis and the…
- Conditions
- Rare Diseases, Albinism, Intellectual Disability
- Trial name
- LongEpi (NCT07400913)
- Testing
- Long-read sequencing
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Information Seeking Behavior
Implementation of Point-of-Care Pharmacogenomic Decision Support Accounting for Minority Disparities
(a) To explore the feasibility and utility of implementing broad preemptive pharmacogenomic result delivery in the inpatient setting across multiple institutions specifically with the goal of incorporating minority-specific…
- Trial name
- NCT03225820
- Where
- 2 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Chicago
Tuberculosis, HIV
Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda
This cluster-randomized trial in Uganda will evaluate the effectiveness and implementation of a novel, peer-led TB education and counseling strategy to improve outcomes among persons with tuberculosis (TB) with and without…
- Trial name
- TEACH (NCT05917210)
- Testing
- Peer-Navigaton TB-EC Strategy, Usual TB-EC Strategy
- Where
- Uganda
- Volunteers
- 1,920 people
- Sponsor
- Yale University
Hip Fractures, Femoral Neck Fractures
Evaluating a Strategy to Improve Pre-Anesthesia Care Discussions (My Anesthesia Choice-Hip Fracture)
The objective of this study is to assess the implementation process for and the effectiveness of a quality improvement (QI) strategy to increase shared decision-making around anesthesia options for hip fracture surgery at 6 US…
- Conditions
- Hip Fractures, Femoral Neck Fractures, Intertrochanteric Fractures, Subtrochanteric Fractures
- Trial name
- NCT06438640
- Testing
- My Anesthesia Choice-HF Model
- Where
- 6 sites in United States
- Volunteers
- 1,881 people
- Sponsor
- University of Pennsylvania
Opioid Use Disorder
Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD
The researchers will study the KIOS app, a digital health tool made to help people recovering from opioid addiction take better care of themselves.
- Trial name
- NCT07348796
- Testing
- KIOS App
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Asthma in Children
Implementation of Asthma Community Home and School Management Program (Asthma CHAMPS)
The long-term goal is to implement an evidence-based asthma intervention based on the Center for Disease Control's recommended framework (EXHALE) within Baltimore City Public Schools (BCPS).
- Trial name
- NCT05814510
- Testing
- Asthma CHAMPS full program, Asthma CHAMPS Wait List Control
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Breast Cancer
Developing a Comprehensive Exercise Service for Breast Cancer Process
"Moving Together" (Juntas en Movimiento) is a hospital-based, comprehensive, and personalized exercise service designed for women diagnosed with breast cancer.
- Trial name
- NCT07380971
- Testing
- Supervised in-person exercise training, Supervised Online Exercise Training, Home-Based Autonomous Exercise Program
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- GO fit Lab- Ingesport
Cardiovascular-kidney-metabolic Syndrome, Diabete Type 2
SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome
SWAP-CKM (SWitching to Appropriate Prescription in Cardiovascular-Kidney-Metabolic Syndrome) is a pragmatic, cluster-randomized clinical trial designed to evaluate whether electronic health record (EHR)-based alerts can improve…
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Diabete Type 2, Chronic Kidney Disease, Heart Failure
- Trial name
- SWAP-CKM (NCT07910968)
- Testing
- Real-Time EHR Prompts and Audit-and-Feedback Reports
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Kaiser Permanente
HIV - Human Immunodeficiency Virus
HIV Prevention With PrEP Among People on Opioid Replacement Therapy
The purpose of this study is to assess the feasibility and acceptability of providing oral pre-exposure prophylaxis (PrEP) and opioid agonist therapy (OAT) simultaneously in existing pharmacy-based programs operating in Alberta…
- Trial name
- OAT-PrEP (NCT07160075)
- Testing
- Simultaneous administration of OAT and oral PrEP at existing pharmacy-based programs
- Where
- 6 sites in Canada
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Cara Spence
Lung Cancer Screening
LUNG-07: Advancing Precision-Based Lung Cancer Screening: Implementation, AI-Guided Risk Stratification, and Biomarker Integration (CREST AI)
This research study aims to investigate methods for enhancing lung cancer screening. The study will investigate whether an artificial intelligence (AI) tool, known as Sybil, can aid in predicting the risk of lung cancer.
- Trial name
- NCT07408531
- Testing
- Sybil Artificial Intelligence (AI) screening
- Where
- 2 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Allogenic Bone Marrow Transplantation
Rehab Study for alloBMT Patients
The goals of this phase III clinical trial is to determine effectiveness in the setting where it will be implemented as well as to gain an understanding of the context for implementation.
- Trial name
- CaRE-4-alloBMT (NCT07457866)
- Testing
- CaRE-4-alloBMT
- Where
- Canada
- Volunteers
- 208 people
- Sponsor
- Jennifer Jones
Families With Infants
HealthySteps + PlayReadVIP
This study aims to investigate the effectiveness and implementation outcomes for the integration of two evidence-based practices and interventions (EBPIs) within pediatric primary care settings: HealthySteps (HS), which provides…
- Trial name
- NCT06941337
- Testing
- HealthySteps (HS), PlayReadVIP
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Obesity, Bariatric Surgery Patients
Digital Preparation for Bariatric Surgery: Feasability Pilot Trial
Metabolic and bariatric surgery (MBS) is in increasing demand due to the growing prevalence of severe obesity and the cumulating evidence of long-term benefits on weight loss, cardiometabolic and functional health outcomes, and…
- Conditions
- Obesity, Bariatric Surgery Patients, Online Education, eHealth Literacy
- Trial name
- Pilot Be-Ready (NCT07201870)
- Testing
- Acces to Precare online platform
- Where
- Canada
- Volunteers
- 1,050 people
- Sponsor
- Laval University
Insomnia
A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care
The overall objective of this study is to conduct a randomized effectiveness-implementation trial to test the non-inferiority of tele-Brief Behavioral Treatment for Insomnia vs.
- Trial name
- NCT05759065
- Testing
- Tele-Brief Behavioral Treatment for Insomnia, Tele-Cognitive-Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Brigham and Women's Hospital
Chronic Disease
Impact of Mulstidisciplinary Medication Assessment Review in Surgery Departments
The presence of a clinical pharmacist (for their pharmacological expertise) and a general practitioner (for their somatic expertise) in surgery departments would contribute to improve the management of medications in elderly…
- Trial name
- CHIROPMEV (NCT03827031)
- Testing
- Mutlidisciplinary medication Review (MMR), Mutlidisciplinary medication Review (MMR) with community pharmacist follow-up
- Where
- 4 sites in France
- Volunteers
- 297 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cerebral Palsy, Prematurity
Best Practices Fo Early Diagnosis of Cerebral Palsy
In this research, the investigators are using an implementation science approach to enhance the uptake of a clinical practice guideline for earlier diagnosis of cerebral palsy (i.e.
- Trial name
- CP (NCT06537622)
- Testing
- Implementation group, Standard of care
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Myocardial Infarction, Risk Reduction
The Perfect-CR Implementation Study
The goal of this open-label cluster-randomized effectiveness-implementation hybrid trial is to study whether a) audit and feedback of cardiac rehabilitation service delivery within a national quality registry and b) structured…
- Trial name
- NCT05889416
- Testing
- Audit and feedback through a quality registry, Implementation support
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Skane University Hospital
Opioid Use Disorder, Opioid Misuse
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/opioid use disorder in three American Indian and Alaska Native (AI/AN)…
- Conditions
- Opioid Use Disorder, Opioid Misuse, Chronic Pain
- Trial name
- OPTIC (NCT06565416)
- Testing
- Implementation Strategies
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- University of New Mexico
Prostate Cancer, Sexual Dysfunction, Physiological
Canada-wide Implementation of a Virtual Sexual Health and Rehabilitation eClinic (SHAReClinic) for Prostate Cancer Patients and Their Partners
The goal of this observational study is to evaluate the effectiveness of SHAReClinic, a national, virtual Sexual Health and Rehabilitation eClinic designed to support prostate cancer patients and their partners.
- Conditions
- Prostate Cancer, Sexual Dysfunction, Physiological, Sexual Dysfunction, Psychological, Sexual Dysfunction
- Trial name
- NCT06877598
- Where
- 10 sites in Canada
- Volunteers
- 575 people
- Sponsor
- University Health Network, Toronto
Suicidal Ideation and Behavior
Adapting Youth Nominated Support Team (YST) to Prevent Suicide
The goal of this study is to conduct a pilot test of a mental health support program called the Youth-Nominated Support Team - Probation (YST-P) for young people ages 12-17 on probation, experiencing suicidal ideation and…
- Trial name
- NCT07559955
- Testing
- Youth-Nominated Support Team for Probation
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Columbia University
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