Clinical trials: Improvement the Treatment of the Patient
Compensated Chronic Hepatitis B
Efficacy of Telbivudine Treatment at Long Term on the Absence of Liver Inflammation in Patients With Compensated Chronic Hepatitis B
The purpose of this trial is to provide data of absence of inflammation in patient liver histology after long-term telbivudine treatment and thus help investigators to make a comprehensive judgment on treatment discontinuation in…
- Trial name
- NCT00877149
- Testing
- telbivudine/LDT600
- Where
- 4 sites in China
- Volunteers
- 80 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes Mellitus, Type 2, Overweight
A Diabetes Improvement in Medical Therapy Versus SADJB Study
The incidence of diabetes mellitus is increasing annually in Asia. It is the leading cause of blindness, chronic renal insufficiency, and amputations, multiplying the risks of heart disease and stroke.
- Trial name
- DIMS (NCT03165812)
- Testing
- SADJB-SG group, IMT group
- Where
- 2 sites in Malaysia
- Volunteers
- 84 people
- Sponsor
- Universiti Putra Malaysia
Generalised Anxiety Disorder
A Non-randomized Controlled Trial Was Conducted to Observe the Improvement in the Level of HAMA in Patients With Generalized Anxiety Disorder During the 6-week Period of Oral Treatment With Chaihu Jia Longgu Muli Tang (Bupleurum Plus Dragon Bone and Oyster Shell Decoction) Combined With Sertraline.
The purpose of this study is to clinically observe the efficacy of Bupleurum Plus Dragon Bone and Oyster Shell Decoction in the treatment of Generalized Anxiety Disorder to improve the scores of HAMA
- Trial name
- NCT06725771
- Testing
- Bupleurum Plus Dragon Bone and Oyster Shell Decoction Combined with Sertraline, Sertraline Hydrochloride Tablets
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Lin Xiaoqian
IVF, Infertility
Improvement of Fertilization Rate and Embryo Quality by Treating Calcium Ionophore in IVF Patients: a Sibling Oocyte Control Study
GM508 CultActive is a bicarbonate buffered reagent and ready-to-use designed to investigate oocytes of patients with failed fertilization after previous Intracytoplasmatic Sperm Injection cycles.
- Conditions
- IVF, Infertility, Artificial Oocyte Activation
- Trial name
- GM508 in IVF (NCT05722067)
- Testing
- calcium ionophore
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Chang Gung Memorial Hospital
Alzheimer Disease
Transcranial Magnetic Stimulation (TMS) Treatment for Alzheimer Patients
Transcranial Magnetic Stimulation (TMS) for treatment of Alzheimer disease.
- Trial name
- NCT01334450
- Testing
- TMS , H2-coil
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Periodontal Diseases
Treatment of Periodontal Disease With Two Different Bioactive Gels for Home Oral Care
This study is an open-label split-mouth study in which periodontal patients will be treated in order to obtain periodontal health.
- Trial name
- NCT04781478
- Testing
- Application of Biorepair Gel, Irrigation of Chlorhexidine 1.00% gel
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Heart Failure With Reduced Ejection Fraction (HFrEF)
Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)
The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy.
- Trial name
- ECHO-LBBp (NCT06689111)
- Testing
- Left bundle branch pacing lead, CRT with the standard method through cs
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital of Patras
Decompensated Heartfailure, Cardio-renal Syndrom
Nasal High Flow at Acute Hart Failure
The pilot study aims to compare the results of using a new respirator (OPTIFLOW TM-High-Flow-Machine) with those from Standard-Oxygen-Therapy during the stabilization of patients who have been hospitalized due to acute heart…
- Trial name
- NCT02058810
- Testing
- Nasal high flow, Conventional nasal oxygen
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Regensburg
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Cannabis Gummy for the Improvement of Sleep and Quality of Life in Patients With Cancer, Pillow Trial
This clinical trial tests how well a cannabis gummy works in improving sleep and quality of life in patients with cancer. Many people with cancer (about 60%) have trouble sleeping, which can lower their quality of life.
- Trial name
- NCT07658677
- Testing
- Actigraphy, Best Practice, Biospecimen Collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Theodore Brasky PhD
Kidney Transplant; Complications, Liver Transplant; Complications
Medicine Adherence and Effects on Transplants With Pilloxa's Electronic Pillbox
Poor adherence to medication among patients with chronic diseases is a major problem. A patient group where the adherence to prescribed medications is extremely important are organ transplanted patients.
- Trial name
- NCT03848585
- Testing
- Pilloxa Pillbox, Non active Pilloxa Pillbox
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Pilloxa
Spinal Cord Injury
Hunova® Randomized Controlled Trial for Trunk Control Improvement in Spinal Cord Injured Patients
In patients with Spinal Cord Injury (SCI), trunk and therefore postural control (both in statics and dynamics) are impaired, often with strong consequences on daily life activities.
- Trial name
- NCT05887752
- Testing
- Standard rehabilitation, Hunova® rehabilitation
- Where
- Italy
- Volunteers
- 74 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Gingival Recessions, Generalized
Surgical Treatment for Gingival Recessions After Orthodontic Treatment
Modification of the periodontal soft tissue phenotype and coverage of exposed root surfaces in patients who have undergone orthodontic treatment.
- Trial name
- NCT07763808
- Testing
- Coronally advanced flap and a de-epithelialized soft tissue graft, Coronally advanced flap and a subepithelial connective tissue graft, Coronally advanced flap and Mucoderm soft tissue collagen graft
- Where
- Azerbaijan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aziz Aliyev Azerbaijan State Advanced Training Institute for Doctors
Metastatic Malignant Female Reproductive System Neoplasm
Single Fraction or Multi-fraction Palliative Radiation Therapy for the Improvement of Quality of Life in Patients With Metastatic Gynecologic Cancers
This phase II trial studies if a single session of palliative radiation therapy can help improve symptoms of gynecologic cancers that have spread to other places in the body (metastatic) and that affect quality of life as well or…
- Trial name
- NCT04516135
- Testing
- 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Cough
The Real-world Treatment Satisfaction by Gefapixiant in RCC
Chronic cough has a high global prevalence and it is refractory to such treatments by approximately 20% of patients. Gafapixant is a P2X3 receptor antagonist that has demonstrated the reduction of cough in patients with…
- Trial name
- NCT06542484
- Testing
- Gefapixant Citrate
- Where
- 2 sites in Japan
- Volunteers
- 63 people
- Sponsor
- Nagoya City University
Breast Cancer, Gynecologic Cancer
CAncer, NUtrition and Taste 2
Although it has been established that the perception of food and eating and cooking habits change during cancer and its treatment, quality of life related to meals, which is an indicator of the psychobiological and physiological…
- Conditions
- Breast Cancer, Gynecologic Cancer, Bronchial Cancer, Breast, Gynecological or Bronchial Cancer Treated With Intravenous Chemotherapy
- Trial name
- CANUT-2 (NCT05027490)
- Testing
- CANUT support, Anthropometric measures, Prehension strength measurement
- Where
- 10 sites in France
- Volunteers
- 209 people
- Sponsor
- Hospices Civils de Lyon
Heart Failure, Sleep Disordered Breathing
Sleep Apnea Treatment During Cardiac Rehabilitation of Congestive Heart Failure Patients
Sleep disordered breathing (SDB) is a frequent comorbidity for heart failure patients. Its prevalence varies according to the seriousness of the condition of the patients, but it is present in approximately 50% of patients.
- Trial name
- SATELIT-HF (NCT01120548)
- Testing
- ventilation therapy
- Where
- 19 sites in France
- Volunteers
- 300 people
- Sponsor
- French Cardiology Society
Gastric Adenocarcinoma, Pancreatic Adenocarcinoma
An Exercise and Nutrition Monitoring Intervention (Pt Pal) for the Improvement of Strength in Patients With Pancreatic or Stomach Cancer Receiving Chemoradiation Therapy Before Surgery, SurgeryStrong Study
This clinical trial studies the effectiveness of a home-based exercise and nutrition monitoring program called Pt Pal in improving strength in patients with pancreatic or stomach cancer receiving chemoradiation therapy before…
- Trial name
- NCT05056805
- Testing
- Aerobic Exercise, Dietary Intervention, Nutritional Intervention
- Sponsor
- M.D. Anderson Cancer Center
Dry Eye Syndrome
Observational Study on the Improvement of Dry Eye Syndrome, Treatment Satisfaction, and Intraocular Tolerance With Diquasol Eye Drops
This study is to verify the efficacy and safety in the treatment of dry eye syndrome in patients prescribed with Diquasol eye drops as a monotherapy, or in combination with Hyaluron eye drops, or in combination with Hyaluronmax…
- Trial name
- NCT06172530
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Type 1 Diabetes
Obtain a Good Blood Glucose Control With the Paradigm Real Time System
In this study, subjects with insufficient metabolic control despite optimized basal-bolus injection regimens were randomily assigned to either the Mini- Med Paradigm REAL-Time insulin pump (PRT), an insulin pump that can receive…
- Trial name
- RTD (NCT00441129)
- Testing
- Minimed paradigm Real Time Sytem, Minimed Paradigm 512/712 Insulin pump
- Where
- 8 sites in France
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Medtronic MiniMed, Inc.
Heart Failure
The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission.
Heart failure (HF) is a chronic condition that is characterized by a weakened and enlarged heart. It typically causes symptoms such as breathlessness and swelling of the legs, and it is a serious illness that shortens life…
- Trial name
- TAPERED-HF (NCT07513883)
- Testing
- Down-titration, Continuation of guideline-directed heart failure therapy
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Ziekenhuis Oost-Limburg