Clinical trials: In Vitro Fertilization
Supervision of Pregnancy Resulting From In-vitro Fertilization
Optimal Planning of a Day 3 Cryopreserved(Frozen)-Thawed Embryo Transfer in a Natural Cycle With hCG Administration or After Spontaneous LH Peak?
The aim of the study is to determine whether spontaneous LH peak is superior to human chorionic gonadotropin before a transfer of a day 3 frozen embryo.
- Trial name
- PLUS (NCT02145819)
- Testing
- hCG, LH peak
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Universitair Ziekenhuis Brussel
Polycystic Ovary Syndrome (PCOS), Female Infertility
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
- Trial name
- PPOS-PCOS-IVF (NCT07394530)
- Testing
- Progestin-Primed Ovarian Stimulation (PPOS), GnRH Antagonist Protocol
- Where
- Vietnam
- Volunteers
- 400 people
- Sponsor
- Hanoi General Hospital (Vietnam)
Infertility
Endometrial Curettage Before Embryo Transfer
Studies have shown that endometrial sampling in the month prior to embryo transfer may increase pregnancy rates. We wish to test this hypothesis by performing a hysteroscopy and curettage in the month proceeding embryo transfer…
- Trial name
- NCT00367367
- Testing
- Hysteroscopy and Curettage
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Infertility, Female
Assessment of Blood and Follicular Fluid Immune Cell Constitution in Patients Undergoing in Vitro Fertilization
The etiology of infertility in the majority of patients with poor response to ovarian stimulation remains unknown. This study will investigate the role of immune cells (T cells, B cells, dendritic cells and NK cells), that…
- Trial name
- NCT01083745
- Where
- Israel
- Sponsor
- Hillel Yaffe Medical Center
Luteal Hormone Supplementation in In-vitro Fertilization, Embryo Transfer
Phase 3 Trial to Evaluate the Efficacy and Safety of COL-1620 Vaginal Progesterone Gel
The primary objective of this trial is to demonstrate the non-inferiority of the clinical pregnancy rate per embryo transfer to the historical standard value in in-vitro fertilization (IVF)/embryo transfer (ET) cycles in Japan…
- Trial name
- NCT01863680
- Testing
- COL-1620, Gonadotropin-releasing hormone (GnRH) analogue, Follicle-stimulating hormone (FSH)
- Where
- 5 sites in Japan
- Volunteers
- 178 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Endometriosis, Rectum, Endometriosis of Colon
The (Cost-)Effectiveness of Surgical Excision of Colorectal Endometriosis Compared to ART Treatment Trajectory
To goal of this study is to determine whether laparoscopic resection of colorectal endometriosis results in an increased cumulative live birth rate (CLBR) both spontaneous and after ART (including in vitro fertilization (IVF) or…
- Conditions
- Endometriosis, Rectum, Endometriosis of Colon, Subfertility, Female
- Trial name
- TOSCA (NCT05677269)
- Testing
- Laparoscopic excision of endometriosis, including colorectal endometriosis, In vitro fertilisation or intracytoplasmic sperm injection
- Where
- 10 sites in Netherlands
- Volunteers
- 339 people
- Sponsor
- Leiden University Medical Center
Polycystic Ovary Syndrome, Obesity
Liraglutide and Metformin Combination on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With PCOS, Obesity and Infertility
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and one of the leading causes of infertility.
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT05952882
- Testing
- Liraglutide + Metformin, Metformin
- Volunteers
- 188 people
- Sponsor
- Mỹ Đức Hospital
IVF
Prolonged Protocol of Early Follicular or Mid Luteal Phase
Due to the injection of gonadotropin releasing hormone agonist (GnRH-a) before controlled ovarian hyperstimulation (COH), the scheme of prolonged early follicular period protocol has obvious advantages in achieving ideal egg…
- Trial name
- NCT04522479
- Testing
- Change the injection time of long acting GnRH-a
- Where
- China
- Volunteers
- 1,150 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
In Vitro Fertilization
A Trial of Single Dose Corifollitropin Alfa's Ability to Induce Multiple Follicular Growth During the First Week of Controlled Ovarian Stimulation for IVF or ICSI (38833)(P05788)
To evaluate the induction of multiple follicular growth after single dose administration of 100 μg or 150 μg Org 36286 in a long protocol of GnRH agonist.
- Trial name
- Realize (NCT00702351)
- Testing
- Org 36286 (corifollitropin alfa)
- Volunteers
- 50 people
- Sponsor
- Organon and Co
Quality of Life, IVF
CALM IVF (Creating Affiliations, Learning, and Mindfulness for In Vitro Fertilization Patients)
The investigators have designed a psychoeducational group curriculum specifically for new in vitro fertilization (IVF) patients (both male and female) to improve their treatment knowledge, to allow them to engage more in their…
- Conditions
- Quality of Life, IVF, Patient Satisfaction, Patient Engagement
- Trial name
- NCT04048772
- Testing
- CALM IVF, Standard of Care
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Sterility, Infertility
The Use of GnRH Agonist Trigger for Final Follicle Maturation in Women Undergoing Assisted Reproductive Technologies
This is a prospective comparative randomized controlled trial investigating the effect of two GnRH agonist trigger protocols on the ongoing pregnancy rate in hyper-responder women undergoing assisted reproductive technology.
- Trial name
- NCT03169166
- Testing
- Triptorelin
- Where
- Lebanon
- Volunteers
- 277 people
- Sponsor
- American University of Beirut Medical Center
Female Infertility
A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)
The purpose of this randomized, two-arm and open label study is to demonstrate that the treatment of a daily dose of 3x10mg dydrogesterone orally is as effective and safe as the daily dose Crinone 8% intravaginal progesterone gel…
- Trial name
- LOTUS II (NCT02491437)
- Testing
- Dydrogesterone 30 mg, intravaginal progesterone gel 90 mg
- Where
- 40 sites in Australia, Belgium and 8 more
- Volunteers
- 1,034 people
- Sponsor
- Abbott
Infertility
The Effect of Interactive Music Therapy Applied for Women During the Perioperative Period for IVF on Their Stress Levels
The purpose of this study is to investigate the effect of music therapy on stress levels in female patients applying for in vitro fertilization.
- Trial name
- IVF (NCT06117202)
- Testing
- music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 240 people
- Sponsor
- Uludag University
Oocyte Retrieval, Adverse Events
The Use of Virtual Reality Technology During Oocyte Retrieval for in Vitro Fertilization
Ultrasound-guided oocyte retrieval (OR) is a short, but oftentimes painful procedure, during which the follicles are punctured trans-vaginally to obtain oocytes for in vitro fertilization (IVF).
- Conditions
- Oocyte Retrieval, Adverse Events, Procedural Anxiety, Pain Intensity
- Trial name
- NCT06733701
- Testing
- VR-based intervention (VRReliever Software V0.3.4 fromXRHealth), VR headset without any scenery
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Infertility, IVF
Quality of Human Embryos in IVF, Culturing in Differentiated Oxygen
The goal of this clinical trial is to evaluate the importance of differential O2 tension to the developing embryos. As a secondary aim, we investigate the levels of reactive oxygen species (ROS) in spent media from the developing…
- Conditions
- Infertility, IVF, Embryo
- Trial name
- NCT05737381
- Testing
- Differential oxygen tension
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Infertility, Polycystic Ovary Syndrome
GnRH Antagonist Versus GnRH Agonist in Polycystic Ovary Syndrome During in Vitro Fertilization - Embryo Transfer
GnRH (Gonadotropin-releasing hormone) antagonists in IVF (in vitro fertilization) has been accomplished by several randomized controlled trials compared with conventional GnRH agonist long protocol in polycystic ovary syndrome…
- Trial name
- NCT01402336
- Testing
- GnRH antagonist (Cetrorelix), Conventional GnRH agonist (Triptorelin)
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Infertility, Female
Laparoscopy in Failed IVF
Current in-vitro fertilization (IVF) consumers are enjoying better success rates than early seekers, but only about a quarter of IVF cycles result in a live birth and many patients remain infertile after multiple IVF attempts.
- Trial name
- NCT06165484
- Testing
- laparoscopy and hysteroscopy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infertility
KIDScore D3 Clinical Study
The aim of this study is to demonstrate that the KIDScore D3 may be used to identify those embryos on Day 3 that are most likely to form blastocysts.
- Trial name
- NCT03740828
- Testing
- KIDScore D3
- Where
- 6 sites in United States
- Volunteers
- 81 people
- Sponsor
- Vitrolife
Polycystic Ovarian Syndrome
Letrozole Combined With Gonadotropins (Gn) for Ovarian Stimulation Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) in Patients With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether letrozole combined with gonadotropins are effective in the ovarian hyperstimulating for IVF/ICSI in patients with PCOS.
- Trial name
- NCT00894608
- Testing
- letrozole + gonadotropins, GnRHa + gonadotropins
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yunyang Medical College
Female Infertility
Multiple Dose FSH-GEX(TM) in Healthy Volunteers
The aim of the current study is the pharmacokinetic and pharmacodynamic characterization of a multiple dose administration of FSH-GEX™ in healthy pituitary-suppressed female volunteers, in comparison with two marketed comparator…
- Trial name
- NCT01477073
- Testing
- FSH-GEX™, recombinant FSH, urinary FSH
- Where
- Netherlands
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Glycotope GmbH