Clinical trials: In Vitro Fertilization
Ovarian Aging, In Vitro Fertilisation (IVF) Treatment
Follicular Fluid microRNAs in Ovarian Aging and Reproduction
The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes.
- Conditions
- Ovarian Aging, In Vitro Fertilisation (IVF) Treatment, InVitro Fertilization, In Vitro Fertilization Outcome
- Trial name
- NCT07214246
- Testing
- No Interventions
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Central Florida
In Vitro Fertilization (IVF), Medically Assisted Procreation (MAP)
Microbiological Description of Sperm and Follicular Fluid Samples. Impact on IVF/ICSI Success Rates
The goal of this observational study is to quantify and identify bacteria that may be present in semen and follicular fluid samples on the day of the IVF-ICSI attempt.
- Trial name
- SPERMIBIOTE (NCT07187414)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
In Vitro Fertilization, ICSI Intracytoplasmic Spermatozoid Injection
Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI Cycles
The development of stimulation protocols for in vitro fertilisation (IVF) has led to a paradox. It has now been established that obtaining a large number of oocytes is a key to success, but that it is also a risk factor for…
- Trial name
- SOLOAGO (NCT06150703)
- Testing
- Ovulation induction with hCG + Luteal phase support with vaginal progesterone, Ovulation triggering by Triptorelin + Luteal phase support by Nafarelin
- Where
- France
- Volunteers
- 652 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adenomyosis, in Vitro Fertilization
Cohort Profile：The Shandong Adenomyosis Cohort of Population Undergoing Reproductive Technology (SAart)
Previous studies have shown that compared with infertile women without adenomyosis, the clinical pregnancy rate, live birth rate and continuous pregnancy rate of women with adenomyosis significantly reduce, and the abortion rate…
- Trial name
- NCT06604091
- Testing
- Treatment protocol
- Where
- China
- Volunteers
- 2,241 people
- Sponsor
- The Second Hospital of Shandong University
In Vitro Fertilization
Effect of Super-GDF9 on CAPA-IVM of COCs From Small Antral Follicles
CAPA-IVM (In Vitro Maturation) technology is an assisted reproductive method offering significant benefits in terms of safety and treatment costs, particularly for high-risk patients.
- Trial name
- sGDF-9 (NCT06766604)
- Testing
- Super-GDF9 supplementation during CAPA-IVM, Conventional CAPA-IVM
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Mỹ Đức Hospital
Infertility, Poor Ovarian Reserve
Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
- Conditions
- Infertility, Poor Ovarian Reserve, Embryo Growth Disorder, in Vitro Fertilization
- Trial name
- NCT07020546
- Testing
- Ovarian Platelet-rich plasma (PRP) injections
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
In Vitro Fertilization
CAPA-IVM Culture With Low Oxygen Tension
Capacitation in-vitro maturation (CAPA-IVM) has recently been advanced in culturing oocytes from the germinal vesicle (GV) stage following mild or no controlled ovarian stimulation.
- Trial name
- NCT06367985
- Testing
- Air Oxygen Concentration CAPA-IVM culture, Low Oxygen Concentration CAPA-IVM culture
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- Mỹ Đức Hospital
Male Infertility, Sperm DNA Fragmentation
Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF
This randomized controlled trial aimed to compare the effectiveness of microfluidic sperm sorting and density gradient centrifugation (DGC) in reducing sperm DNA fragmentation index (DFI) and improving clinical outcomes in IVF.
- Conditions
- Male Infertility, Sperm DNA Fragmentation, In Vitro Fertilization (IVF)
- Trial name
- MCvsDGC (NCT07004309)
- Testing
- Microfluidic sperm sorting, Density Gradient Centrifugation
- Where
- Vietnam
- Volunteers
- 119 people
- Sponsor
- Hanoi Medical University
In Vitro Fertilization, Estradiol
Impact of Supraphysiological Estradiol on ECG in IVF Patients
This prospective observational study aimed to evaluate the effects of supraphysiological estradiol (E2) levels, induced by gonadotropin therapy during IVF, on cardiac electrophysiological parameters.
- Conditions
- In Vitro Fertilization, Estradiol, Cardiac Electrophysiology, Electrocardiography (ECG)
- Trial name
- NCT07007416
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Konya City Hospital
Salidroside, Randomized Controlled Trial
Effect of Salidroside on Pregnancy Outcomes in High Childbearing Age Patients in Viro Fertilization
With the decreasing of birth rate and population in our country, population problem has become a long-term and strategic problem.
- Conditions
- Salidroside, Randomized Controlled Trial, In Vitro Fertilization, Assisted Reproductive Technology
- Trial name
- NCT06990685
- Testing
- Salidroside
- Where
- China
- Volunteers
- 370 people
- Sponsor
- The Second Hospital of Shandong University
Frozen Embryo Transfer (FET), Assisted Reproductive Techniques
Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology
The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments.
- Conditions
- Frozen Embryo Transfer (FET), Assisted Reproductive Techniques, In Vitro Fertilization (IVF), Cryopreservation of Embryos
- Trial name
- DW-FET-RCT (NCT06741748)
- Testing
- Direct Warming Method, Conventional Multi-step Thawing Method
- Where
- 3 sites in Hong Kong, United Kingdom
- Volunteers
- 578 people
- Sponsor
- Chinese University of Hong Kong
Ongoing Pregnancy, In-vitro Fertilization
Evaluation of the Effect of Dietary PI and TAC on the Outcome of Pregnancy in In Vitro Fertilization Treatment
The aim of this study is to determine the relationship between dietary total antioxidant capacity, phytochemical index, inflammatory index, dietary polyphenol intake and ongoing pregnancy outcome in couples receiving IVF…
- Trial name
- NCT05882422
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Hacettepe University
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Single Embryo Transfer, Fertilization in Vitro
Advantages of Early Intrauterine Transfer of "Blank" Culture Medium Prior to 1st or 2nd Transfer of Thawed Embryo(s).
Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure.
- Trial name
- TRABLAN (NCT06177613)
- Testing
- Blank culture transfer
- Where
- 7 sites in France, Reunion
- Volunteers
- 1,154 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
In Vitro Fertilization (IVF)
Assessment of Some Metabolic and Hematological Markers in Women Exposed to in Vitro Fertilization
Assisted reproductive technologies (ART) represent commonly utilized management strategies for infertility with multifactorial causes (including genetically predisposed diseases).
- Trial name
- NCT06812663
- Volunteers
- 115 people
- Sponsor
- Assiut University
Spermatozoa, Abnormal, in Vitro Fertilization
The Influence of Sperm Morphology and Functional Indices on Blastocyst Development in Assisted Reproduction
Samples from male partners of 120 infertile couples undergoing IVF were analyzed. Sperm morphology was assessed using the SpermBlue staining method, while TZI, MAI, and SDI were calculated.
- Conditions
- Spermatozoa, Abnormal, in Vitro Fertilization, Blastocyst, Aneuploidy
- Trial name
- NCT06801652
- Testing
- Sperm morphology indexes
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Calla IVF Center
Polycystic Ovary Syndrome, in Vitro Fertilization
Vitamin D and Pregnancy Outcome in PCOS Patients
This multicenter double-blinded placebo-controlled randomised trial aims to evaluate the effectiveness of vitamin D supplementation prior to IVF on the live birth rate in women with PCOS.
- Trial name
- NCT04082650
- Testing
- vitamin D
- Where
- 2 sites in China
- Volunteers
- 876 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Ovulation, Ovulation Inhibition
Can Ibuprofen Delay Ovulation in Natural Cycle-IVF?
During natural cycle in vitro fertilisation, no gonadotropin stimulation is used to stimulate oocyte production. Ovulation is induced with HCG (human chorionic gonadotropin) and the follicle is retrieved 36 hours later.
- Conditions
- Ovulation, Ovulation Inhibition, Ovulation Inhibition/Drug Effects, Pregnancy
- Trial name
- Ibudelay (NCT02571543)
- Testing
- Ibuprofen
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
In Vitro Fertilization, Infertility Assisted Reproductive Technology
Assessment of Reproductive Outcomes in Non-Male Factor Infertility Patients: Conventional in Vitro Fertilisation Versus Intracytoplasmic Sperm Injection
The aim of this clinical trial is to evaluate the efficiency of two fertilization techniques used in Assisted Reproduction: conventional In Vitro fertilization (cIVF) and Intracytoplasmic Sperm Injection (ICSI), in terms of…
- Trial name
- NCT06670586
- Testing
- conventional in vitro fertilization, intracytoplasmic sperm injection (ICSI)
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Maria Dolores Cuquerella Fernandez-Vazquez