Clinical trials: In-Hospital Cardiac Arrest
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Arrest
Relevance of Reversible Causes During OHCA (Rebecca Study)
Management of the reversible causes in cardiac arrest is fundamental for successful treatment of out-of-hospital cardiac arrests.
- Trial name
- REBECCA (NCT05784480)
- Testing
- Checklist for evaluation of reversible causes
- Where
- 2 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Cardiac Arrest
CT Perfusion (CTP) for Assessment of Poor Neurological Outcome in Comatose Cardiac Arrest Patients
ABSTRACT Brief Overview: Neurological assessment of comatose cardiac arrest patients (CCAP) is challenging because most of these patients are treated with sedatives and therapeutic hypothermia that prevent complete…
- Trial name
- CANCCAP (NCT04323020)
- Testing
- CT Perfusion
- Where
- Canada
- Volunteers
- 91 people
- Sponsor
- University of Manitoba
Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR)
The AIR-CPR Study: AI-Guided Chest Compressions
The AIR-CPR project aims to improve survival rates for patients with Out-of-Hospital Cardiac Arrest (OHCA) by utilizing Artificial Intelligence (AI) to optimize chest compression locations.
- Conditions
- Out-of-hospital Cardiac Arrest (OHCA), Cardiopulmonary Resuscitation (CPR), Aortic Valve Compression, Precision Resuscitation
- Trial name
- AIR-CPR (NCT07431710)
- Testing
- Device: AI-Enhanced Arterial Waveform Monitor (AIR-CPR App), AI-Guided Chest Compression Repositioning, Transesophageal Echocardiography (TEE)
- Where
- Taiwan
- Volunteers
- 255 people
- Sponsor
- Far Eastern Memorial Hospital
Out-Of-Hospital Cardiac Arrest
A Randomised Trial of Expedited Transfer to a Cardiac Arrest Centre for Non-ST Elevation Out-of-hospital Cardiac Arrest
The aim of ARREST is to determine the best post-resuscitation care pathway for out of hospital cardiac arrest patients without ST-segment elevation.
- Trial name
- ARREST (NCT03872960)
- Testing
- Transfer to cardiac arrest centre
- Where
- 22 sites in United Kingdom
- Volunteers
- 862 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Out-Of-Hospital Cardiac Arrest
AMSA and Amiodarone Study in Cardiac Arrest
Investigators' aim is to assess whether the administration of amiodarone during resuscitation could cause a reduction of the values of the amplitude spectral area (AMSA).
- Trial name
- MOSAIC (NCT04997980)
- Testing
- Amiodarone Injection
- Where
- 4 sites in Italy, Norway and 1 more
- Volunteers
- 629 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
In-hospital Cardiac Arrest
Evaluation of Effectiveness of Blue Code Team After In-hospital Cardiopulmonary Arrest
This study aimed to retrospectively examine patients evaluated by the Code Blue team on a Code Blue call in our hospital between 2016-2017.
- Trial name
- Codeblue (NCT03378518)
- Where
- Turkey (Türkiye)
- Volunteers
- 264 people
- Sponsor
- Aydin Adnan Menderes University
Heart Arrest
BC ECPR Trial for Out-of-Hospital Cardiac Arrest
The addition of an Extracorporeal-Cardiopulmonary Resuscitation (ECPR) service to a region may improve the survival of young patients with sudden unexpected cardiac arrest.The primary aim of this study is to determine the benefit…
- Trial name
- NCT02832752
- Testing
- ECPR Protocol
- Where
- 3 sites in Canada
- Volunteers
- 308 people
- Sponsor
- University of British Columbia
Out-Of-Hospital Cardiac Arrest
CPR Quality and Use of Feedback for OHCA
The purpose of this study is to investigate the quality of cardio-pulmonary resuscitation(CPR) delivered by EMS professionals and whether this quality can be improved by implementing real-time feedback during the event and an…
- Trial name
- NCT04152252
- Testing
- Real time feedback, Post-event debriefing
- Where
- Denmark
- Volunteers
- 2,989 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Cardiac Arrest, Perioperative Complication
The Factors Associated 30-day Mortality After Perioperative Cardiac Arrest in Adults Undergoing Non-cardiac Surgery.
Perioperative cardiac arrest (PCA) in patients undergoing noncardiac surgery is a rare but potentially catastrophic event associated with high mortality.
- Trial name
- NCT06712134
- Volunteers
- 105 people
- Sponsor
- Siriraj Hospital
Morality, Hypothermic Circulatory Arrest Time
A Comparative Study of Different Hypothermic Circulatory Arrest Strategies on Aortic Surgery.
By comparing the clinical outcome of patients underwent different hypothermic circulatory arrest (mild hypothermic versus moderate hypothermic) during aortic arch surgery, this study aims to determine the optimal hypothermic…
- Conditions
- Morality, Hypothermic Circulatory Arrest Time, Aortic-cross Clamping Time, Cardiopulmonary Bypass Time
- Trial name
- NCT03454633
- Testing
- the temperature of hypothermic circulatory arrest
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xiaoping Fan. MD
Out-of-Hospital Cardiac Arrest
Korean Cardiac Arrest Research Consortium
This study will evaluated the epidemiology and the outcomes of patients suffering out-of-hospital cardiac arrest with presumed cardiac etiology in Korea.
- Trial name
- NCT03222999
- Testing
- No intervention planned
- Where
- South Korea
- Volunteers
- 30,000 people
- Sponsor
- Korean Cardiac Arrest Research Consortium
Cardiac Arrest
The Manikin Study of Chest Compression With One Accelerometer Feedback Device
Chest compression (CC) feedback devices are used to perform CC measurements effectively and accurately on patients in hospital beds.
- Trial name
- NCT02073539
- Testing
- Stryker ST104-747, Shinchang SB-34p
- Where
- South Korea
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Hanyang University Seoul Hospital
Out-Of-Hospital Cardiac Arrest
Phase 1 Clinical Trial of Sodium Nitrite for Out of Hospital Cardiac Arrest
The purpose of this study is to determine the optimal dose of sodium nitrate administered during resuscitation to achieve a plasma level of 10 μM by hospital arrival.
- Trial name
- NCT02987088
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Cardiac Arrest
Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully…
- Trial name
- THAPCA-IH (NCT00880087)
- Testing
- Therapeutic Hypothermia, Therapeutic Normothermia
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 329 people
- Sponsor
- University of Michigan
Out-of-hospital Cardiac Arrest
Rapid Infusion of Cold Normal Saline During CPR for Patients With Out-of-hospital Cardiac Arrest
That paramedic core cooling during CPR using a rapid infusion of ice-cold (4 degrees C) large-volume (30mL/kg) normal saline improves outcome at hospital discharge compared with standard care in patients with out-of-hospital…
- Trial name
- RINSE (NCT01173393)
- Testing
- PARAMEDIC COOLING
- Where
- Australia
- Volunteers
- 1,220 people
- Sponsor
- Ambulance Victoria
Out-of-Hospital Cardiac Arrest
Early-onset Pneumonia After Out-of-hospital Cardiac Arrest
Early-onset pneumonia after out-of-hospital cardiac arrest is frequent. An association between early-onset pneumonia and an increase in morbidity has been reported in this population.
- Trial name
- PP-ACR (NCT03355885)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Brest
Out-Of-Hospital Cardiac Arrest
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest
The TAME Cardiac Arrest trial will study the ability of higher arterial carbon dioxide (PaCO2) levels to reduce brain damage, comparing giving patients 'normal' to 'slightly higher than normal' blood PaCO2 levels and assessing…
- Trial name
- TAME (NCT03114033)
- Testing
- Targeted therapeutic mild hypercapnia, Targeted normocapnia (Standard care)
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 1,700 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Sudden Cardiac Death, Acute Myocardial Infarction
Thrombus and Inflammation Study in Sudden Cardiac DEath
Sudden death is a natural death occurring within one hour after the onset of symptoms. It remains a major public health problem and accounts for 5 to 10 % of the annual total mortality ie about 300.000 in the United States.
- Trial name
- TIDE (NCT00748111)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Arrest, Arrhythmias, Cardiac
Cardiac Arrest Post-Discharge ECG Monitoring
The primary aim is to conduct a prospective observational cohort study to analyze the incidence of serious arrhythmic events that occur within 14 days after hospital discharge in patients who had been hospitalized for cardiac…
- Conditions
- Heart Arrest, Arrhythmias, Cardiac, Electrocardiography
- Trial name
- CArPEM (NCT05337371)
- Testing
- ECG patch (Philips ePatch® 2.0)
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Cardiac Arrest
Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia
The primary objective of the trial is to determine if survival to hospital discharge is improved with early therapeutic administration of a new Captisol-Enabled formulation of IV amiodarone (Nexterone-PM101) compared to placebo.
- Trial name
- ALPS (NCT01401647)
- Testing
- amiodarone, Lidocaine, Normal saline
- Where
- 9 sites in United States, Canada
- Volunteers
- 3,024 people
- Sponsor
- University of Washington