Clinical trials: In-Hospital Cardiac Arrest
Education, Medical, Undergraduate, Out-of-Hospital Cardiac Arrest
Serious Game Versus Online Course to Pre-train Medical Students on the Management of an Adult Cardiac Arrest.
The objective of this study is to compare two forms of pre-training (an online narrative presentation and a serious game) to prepare 2nd year medical students for a hands-on training with physical simulators about out-of-hospital…
- Conditions
- Education, Medical, Undergraduate, Out-of-Hospital Cardiac Arrest, Simulation Training
- Trial name
- NCT02758119
- Testing
- Serious Game, Online course
- Where
- France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ilumens
Cardiac Arrest, Metabolic Acidosis
Bicarbonate in Patients With Out-of-hospital Cardiac Arrest
A pilot study to evaluate the effect of sodium bicarbonate administration on cardiopulmonary resuscitation results and outcomes in cardiac arrest patient with severe metabolic acidosis.
- Trial name
- NCT02303548
- Testing
- Sodium bicarbonate, Normal saline
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Out-Of-Hospital Cardiac Arrest, Healthy
Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants
This study is to determine the safety and tolerability of regular insulin (Humulin R) when given intranasally (as drops in nostrils).
- Trial name
- NCT05062785
- Testing
- Intranasal insulin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Robert Silbergleit
Out-of-Hospital Cardiac Arrest
A Pilot Study of Intra-arrest Therapeutic Hypothermia in Patients Suffering Non-Traumatic Out of Hospital Cardiac Arrest
The objective of this study will be to assess the frequency of return of spontaneous circulation (ROSC), survival to admission, survival to discharge from the hospital, and neurologic function at time of discharge from the…
- Trial name
- NCT01413399
- Testing
- 4 degree chilled saline
- Where
- United States
- Volunteers
- 542 people
- Sponsor
- Wake Forest University Health Sciences
Cardiac Arrest
Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Acute myocardial infarction complicated with cardiogenic shock trigger IL-6, the strong inflammatory response, result in multiple organ failure, even death.
- Trial name
- NCT02633358
- Testing
- Therapeutic hypothermia group
- Where
- Taiwan
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Cardiac Arrest
Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Cardiac arrest is a sudden, unexpected loss of heart function. Therapeutic hypothermia, in which the body's temperature is lowered and maintained several degrees below normal for a period of time, has been used to successfully…
- Trial name
- THAPCA-IH (NCT00880087)
- Testing
- Therapeutic Hypothermia, Therapeutic Normothermia
- Where
- 33 sites in United States, Canada and 1 more
- Volunteers
- 329 people
- Sponsor
- University of Michigan
Cardiac Arrest
Pre-ROSC Intra-Nasal Cooling Effectiveness
The purpose of the study was to demonstrate the safety and feasibility of early intranasal cooling prior to return of spontaneous circulation (ROSC) in the emergency medical services (EMS) environment.
- Trial name
- PRINCE (NCT00808236)
- Testing
- RhinoChill, Control
- Where
- 15 sites in Belgium, Czechia and 3 more
- Volunteers
- 200 people
- Sponsor
- BeneChill, Inc
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
Cardiac Arrest
Code Blue Outcomes & Process Improvement Through Leadership Optimization Using Teleintensivists-Simulation
This multicenter randomized trial will employ in-situ cardiac arrest simulations ("mock codes") to test whether using telemedicine technology to add an intensive care physician as the "copilot" for cardiac arrest resuscitation…
- Trial name
- COPILOT-Sim (NCT03000829)
- Testing
- Tele-intensivist consultation, Simulated "observation" by ICU physician
- Where
- 7 sites in United States
- Volunteers
- 1,001 people
- Sponsor
- Intermountain Health Care, Inc.
Cardiac Arrest Due to Underlying Cardiac Condition, Ventricular Fibrillation
ACCESS to the Cardiac Cath Lab in Patients Without STEMI Resuscitated From Out-of-hospital VT/VF Cardiac Arrest
To determine if survival to hospital discharge with good neurological outcome for adults ages 18-75 who are resuscitated from out-of-hospital VT/VF cardiac arrest without clinical signs of a heart attack do better by going…
- Conditions
- Cardiac Arrest Due to Underlying Cardiac Condition, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- NCT03119571
- Testing
- Initial CCL admission, Initial ICU admission
- Where
- 23 sites in United States, Canada
- Volunteers
- 65 people
- Sponsor
- University of Minnesota
Cardiac Arrest
Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia
The primary objective of the trial is to determine if survival to hospital discharge is improved with early therapeutic administration of a new Captisol-Enabled formulation of IV amiodarone (Nexterone-PM101) compared to placebo.
- Trial name
- ALPS (NCT01401647)
- Testing
- amiodarone, Lidocaine, Normal saline
- Where
- 9 sites in United States, Canada
- Volunteers
- 3,024 people
- Sponsor
- University of Washington
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
Advanced Reperfusion Strategies for Refractory Cardiac Arrest
This is a Phase II, single center (Under the Center for Resuscitation Medicine at the University of Minnesota Medical School), partially blinded, prospective, intention to treat, safety and efficacy clinical trial, randomizing…
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia
- Trial name
- ARREST (NCT03880565)
- Testing
- Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Heart Arrest
Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest
This is an investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of vasopressin and methylprednisolone during adult in-hospital cardiac arrest.
- Trial name
- VAM-IHCA (NCT03640949)
- Testing
- Vasopressin, Arginine, Methylprednisolone, NaCl
- Where
- 10 sites in Denmark
- Volunteers
- 501 people
- Sponsor
- Lars Wiuff Andersen
Out-of-hospital Cardiac Arrest
Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest
The overall goal of this study is to determine whether initiating hypothermia in cardiac arrest patients as soon as possible in the field results in a greater proportion of patients who survive to hospital discharge compared to…
- Trial name
- NCT00391469
- Testing
- Rapid infusion of 2 liters of 4oC normal saline, Rapid infusion of cold normal saline
- Where
- United States
- Volunteers
- 1,359 people
- Sponsor
- University of Washington
Cardiac Arrest, Sudden Death
A Comparative Study Between a Pre-hospital and an In-hospital Circulatory Support Strategy (ECMO) in Refractory Cardiac Arrest (APACAR2)
Cardiac arrest (CA) affects approximately 40,000 people in France. It is still a major cause of death in a young population. Management of CA is defined by international recommendations, detailed by learned societies in each…
- Trial name
- APACAR2 (NCT02527031)
- Testing
- ECMO Insertion on pre hospital setting, In Hospital ECMO
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-of-Hospital Cardiac Arrest
Implementation of Gold Standard EMS CPR Programs for 2% Improvement in Survival Rates of Out-of-Hospital Cardiac Arrest in a Metropolitan City
This study aims to improve the survival rate of out-of-hospital cardiac arrest patients by 2% through a bundle of three intervention measures including: 1) dispatcher-assisted CPR, 2) multi-tiered response team CPR, and 3)…
- Trial name
- 2% Project (NCT02540629)
- Testing
- Bundled EMS CPR approach including dispatcher-assisted CPR, 3-person team CPR, and feedback CPR monitoring device
- Where
- South Korea
- Volunteers
- 12,670 people
- Sponsor
- Seoul National University Hospital
Hypoxemia, Arrhythmias
Differences in Morbidity Between a Necessity Endotracheal Suctioning Protocol Versus a Routine Endotracheal Suctioning
Morbidity frequency associated to a endotracheal suctioning is different between a necessity endotracheal suctioning protocol versus a routine endotracheal protocol.
- Conditions
- Hypoxemia, Arrhythmias, Cardiac Arrest, Ventilator Associated Pneumonia
- Trial name
- NCT01069185
- Testing
- Necessity endotracheal suctioning, Routine endotracheal suctioning
- Where
- Colombia
- Volunteers
- 92 people
- Sponsor
- Hospital Pablo Tobón Uribe
In-Hospital Cardiac Arrest
Hospital Wearable Defibrillator Inpatient Study
This study will obtain device-human interaction evaluations for the HWD1000 within the controlled environment of the hospital as well as establish that the safety profile is similar to outpatient wearable…
- Trial name
- HWD (NCT02122549)
- Testing
- HWD1000
- Where
- 8 sites in United States
- Volunteers
- 59 people
- Sponsor
- Zoll Medical Corporation
Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
To establish whether a pre-hospital advanced physician/ paramedic cardiac arrest team that is ECMO capable can establish ECMO flow within 30 minutes of collapse.
- Conditions
- Death, Sudden, Cardiac, Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation, Cardiopulmonary Arrest With Successful Resuscitation
- Trial name
- SUB30 (NCT03700125)
- Testing
- ECMO resuscitation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- Barts & The London NHS Trust