Clinical trials: In-Vitro Fertilization
Infertility, In Vitro Fertilization
Video-Supported Medication Education for Women Undergoing In Vitro Fertilization (IVF): Quality of Life and Psychosocial Effects
Reproductive health problems, particularly infertility, affect 48 million couples globally, ranking as the fifth most serious global obstacle for women.
- Conditions
- Infertility, In Vitro Fertilization, Psychosocial Support Systems, Quality of Life
- Trial name
- NCT06515275
- Testing
- Education via video (QR code links)
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Infertility, in Vitro Fertilization (IVF)
Use of Artificial Intelligence for Clinical Assessment of Assisted Reproductive Techniques and IVF Outcomes
The use of machine learning techniques using an artificial intelligence tool is proposed to analyze clinical data to predict best possible IVF/ART outcomes.
- Conditions
- Infertility, in Vitro Fertilization (IVF), ART
- Trial name
- AI in ART (NCT04255615)
- Testing
- AI to analyze 3 D ultrasound
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
In Vitro Fertilization (IVF), Embryo Transfer
Dual Trigger With HCG and GnRH Agonist on Thawed Modified Natural Cycle Embryo Transfer
Impact of dual trigger using recombinant human chorionic gonadotropin (HCG) and gonadotropin-releasing hormone (GnRH) agonist on thawed modified natural cycle outcomes: an open-label multi-center randomized controlled trial.
- Trial name
- NCT07269392
- Testing
- GnRH agonist
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Infertility, Poor Ovarian Reserve
Ovarian PRP Injections for Improved Embryo Quality Using Embryo Quality Score
Patients will have ovarian PRP treatments and embryo development will be observed using time-lapse imaging and AI software.
- Conditions
- Infertility, Poor Ovarian Reserve, Embryo Growth Disorder, in Vitro Fertilization
- Trial name
- NCT07020546
- Testing
- Ovarian Platelet-rich plasma (PRP) injections
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Generation Next Fertility
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Ovulation, Ovulation Inhibition
Can Ibuprofen Delay Ovulation in Natural Cycle-IVF?
During natural cycle in vitro fertilisation, no gonadotropin stimulation is used to stimulate oocyte production. Ovulation is induced with HCG (human chorionic gonadotropin) and the follicle is retrieved 36 hours later.
- Conditions
- Ovulation, Ovulation Inhibition, Ovulation Inhibition/Drug Effects, Pregnancy
- Trial name
- Ibudelay (NCT02571543)
- Testing
- Ibuprofen
- Where
- Switzerland
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stimulation in the Ovary, Embryo
Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A.
The PPOS protocol (Progestin-primed Ovarian Stimulation) involves avoiding ovulation during ovarian stimulation with progesterone.
- Conditions
- Stimulation in the Ovary, Embryo, Oocyte, Oocyte Retrieval
- Trial name
- PPDUO (NCT06637189)
- Testing
- Ganirelix, Medroxyprogesterone Acetate 10 MG
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ginefiv
Cognitive Behavioral Therapy, Hormone Disturbance
Effectiveness of CBT in Improving Psycho-Neuro-Endocrine Factors in Women Following In Vitro Fertilization Program
The goal of this clinical trial is to learn if Cognitive Behavioral Therapy (CBT) can improve psychological, neurological, and hormonal aspects in women undergoing In Vitro Fertilization (IVF).
- Conditions
- Cognitive Behavioral Therapy, Hormone Disturbance, In Vitro Fertilization
- Trial name
- NCT06521957
- Testing
- Cognitive Behavioral Therapy
- Where
- Indonesia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Metformin, Prediabetes
Effect of Metformin on Healthy Live Birth in Women With Prediabetes
To evaluate the efficacy and safety of metformin pretreatment on reproductive outcomes in infertile women with prediabetes.
- Conditions
- Metformin, Prediabetes, In-Vitro Fertilization
- Trial name
- MELT-PreDM (NCT06064669)
- Testing
- Metformin pretreatment before ovarian stimulation, Metformin pretreatment before endometrial preparation for frozen embryo transfer
- Where
- China
- Volunteers
- 988 people, healthy volunteers welcome
- Sponsor
- Shandong University
Fertilization in Vitro
Ejaculation Abstinence Time and Assisted Reproductive Technology Outcomes
The goal of this clinical trial is to learn if reducing the ejaculation abstinence time can improve the outcome of assisted reproductive technology.
- Trial name
- NCT06410417
- Testing
- Shorten abstinence time
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Embryo Transfer, Fertilization in Vitro
Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer?
The goal of this clinical trial is to test whether sexual intercourse the night after embryo transfer affects thawed embryo implantation rates.
- Conditions
- Embryo Transfer, Fertilization in Vitro, Coitus
- Trial name
- NCT06134609
- Testing
- Sexual intercourse
- Where
- Israel
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility, In Vitro Fertilization
Virtual Reality for Acute Pain and Anxiety During Egg Retrieval for in Vitro Fertility Treatment
This study is a comparison between the current standard practice of performing a transvaginal oocyte retrieval (TVOR) with paracervical block (PCB) and a relatively recently developed technology of virtual reality that is added…
- Conditions
- Infertility, In Vitro Fertilization, IVF, ART
- Trial name
- NCT05438238
- Testing
- Oncomfort
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Fertilization in Vitro, Infertility
The Impact of the Timing of Trigger on IVF Success
The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.
- Conditions
- Fertilization in Vitro, Infertility, Embryonic Development
- Trial name
- NCT02990949
- Testing
- Timing of trigger
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Colorado Center for Reproductive Medicine
Progesterone, Luteal Phase Support
Patient's Preferences About Subcutaneous or Vaginal Progesterone Administration for Luteal Phase Support
Luteal phase support in "in vitro fertilization" (IVF) cycles has been shown to improve pregnancy rates and became a standard of treatment, and progesterone is the first choice considering its safety profile and effectiveness.
- Conditions
- Progesterone, Luteal Phase Support, In Vitro Fertilization
- Trial name
- PROPER-1 (NCT03734770)
- Testing
- Subcutaneous Progesterone, Vaginal progesterone
- Where
- Italy
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
In Vitro Fertilization, Assisted Reproductive Techniques
Optimizing IVF Treatment - the Impact of Time-lapse Culture and Preimplantation Factor (PIF) on Embryo Development.
The aims of this study are to evaluate: 1. the possible effect of time-lapse culture from day zero (day of oocyte retrieval) on fertilisation rates and embryo quality in standard IVF. 2.
- Trial name
- NCT02222831
- Testing
- Day 0 denudation and time lapse culture on IVF-oocytes.
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Regionshospitalet Viborg, Skive
in Vitro Fertilization, Poor Responder
Dopamine D-2 Antagonist Use in Poor Responders in IVF: a Randomized Controlled Trial
Metoclopramide is a dopamine D2 receptor antagonist with antiemetic and gastrokinetic properties which has been approved for use in pregnant women.
- Trial name
- NCT02262923
- Testing
- metoclopramide
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Fertilization in Vitro
Poor Ovarian Responders Undergoing IVF Using Luteal Ovarian Stimulation Versus Follicular Ovarian Stimulation
The investigators attempted to compare the clinical outcomes and cumulus genes expression in poor ovarian responders undergoing luteal ovarian stimulation or follicular ovarian stimulation in in vitro fertilization cycles.
- Trial name
- NCT03238833
- Testing
- luteal ovarian stimulation, follicular ovarian stimulation
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.
In Vitro Fertilization, Frozen Embryo Transfer
Comparison of Thawing Embryos in Advance and on the Day of Transfer on Pregnancy Outcomes in FET Cycle
Respectively for patients with repeated transplant failure and routine patients, Thawing frozen embryos in advance (18h) to extend the duration of embryonic development or thawing embryos on the day of transfer in the frozen…
- Trial name
- NCT04455191
- Testing
- Thawing Embryos in Advance, Thawing Embryos on the Day of Transfer
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jinan Central Hospital
Fertilization in Vitro
The Comparison of Granulosa Cell Apoptosis Rates With or Without Luteinizing Hormone Administration in Poor Responders.
In Zeynep Kamil Women and Children's Education and Research Hospital which is a tertiary referral hospital, the investigators perform microdose flare-up gonadotropin-releasing hormone (GNRH) analogue or GNRH antagonist protocol…
- Trial name
- NCT03527823
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Sebnem Alanya Tosun
in Vitro Fertilization
Embryo Transfer With Self-spent Culture Medium
Embryo Transfer With Self-spent Culture Medium or new Culture Medium in Vitro Fertilization - Embryo Transfer Process, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the…
- Trial name
- NCT03728140
- Testing
- Self-spent Culture Medium
- Where
- China
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Bin Wu