Clinical trials: In-Vitro Fertilization
Infertility, Assisted Reproductive Technology
Does the Embryo Transfer Technique Affect the Success of in Vitro Fertilization?
Prospective, open, randomized, parallel, two-arm trial to compare the clinical pregnancy rate between most commonly used two embryo transfer techniques: trial followed by transfer technique and afterloading technique
- Conditions
- Infertility, Assisted Reproductive Technology, IVF
- Trial name
- NCT03756857
- Testing
- Afterload Transfer, Trial followed by transfer
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Acibadem Kadiköy Hospital
in Vitro Fertilization
The Role of DNA Damage of Granulosa Cell on Oocyte Quality and in Vitro Fertilization Outcome
Deoxyribonucleic acid (DNA) damage of granulosa cells obtained during oocyte retrieval will be evaluated by comet assay in unexplained infertile patients undergoing in vitro fertilization (IVF) treatment.
- Trial name
- NCT03345030
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Polycystic Ovary Syndrome
Metformin Treatment Before in Vitro Fertilization (IVF) in Women With Ultrasound Evidence of Polycystic Ovaries
The aim of study was to investigate whether pre-treatment with metformin before and during IVF increases the live birth rate compared to placebo in women with sonographic evidence of polycystic ovaries (PCO), but without any…
- Trial name
- NCT01046032
- Testing
- Metformin
- Where
- 3 sites in United Kingdom
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Metabolic Syndrome
In Vitro Fertilization Outcomes in Metabolic Syndrome
The purpose of this study is to examine the effect of metabolic syndrome in over-weight women on IVF treatment outcomes.
- Trial name
- NCT01958424
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Male Infertility
Proposed Research Protocol For Male Infertility
The purpose of this experiment is to test the feasibility of a minimally interventionist protocol for young couples with male factor infertility, which addresses the cause of infertility for these couples which is the inability…
- Trial name
- NCT01255397
- Testing
- Male Infertility Protocol
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Infertile Women Undergoing IVF or ICSI
Postbiotic Intervention on Vaginal Microbiota
This study investigates the effects of postbiotic intervention on vaginal microbiota in infertile patients. Using a pre-post test design, we will enroll 15 women aged 30-45 years with at least two IVF failures.
- Trial name
- NCT07278024
- Testing
- postbiotics
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility
The Impact of an Online Stress Management Program on In Vitro Fertilization (IVF) Outcome
The goal of this study is to determine the impact of an online stress management program, which combines stress reduction and prevention strategies with personal care products/rituals which have relaxation properties, on…
- Trial name
- NCT01156324
- Testing
- Online Stress Management Group (Upliv), Control
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston IVF
Infertility, Female, Depression
Educational and Supportive Care to Depressed Infertile Females
Infertility affects married adults, and In Vitro Fertilization (IVF) is an Assisted Reproductive Technology (ART) that can be treated. Women undergoing IVF are more likely to experience depression.
- Conditions
- Infertility, Female, Depression, IVF
- Trial name
- NCT06022640
- Testing
- Educational and supportive care
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- Al-Rasheed University College
In Vitro Fertilization
The Influence of Dopamine Agonist Cabergoline on Oocyte Maturation
The dopamine agonist cabergoline inhibits phosphorylation of the vascular endothelial growth factor receptor-2(VEGFR-2), which prevent vascular endothelial growth factor (VEGF) overexpression and reduce the severity of Ovarian…
- Trial name
- NCT01065376
- Testing
- the timing cabergoline administration
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Pregnancy, Neonates
Monitor the Incidence of Congenital Malformations in Infants of Women Who Have Been Treated With Ganirelix (Orgalutran®)(Study 38644)(P05966)(COMPLETED)
The primary purpose of this study is to collect data on the incidence of congenital malformations in infants of women with an ongoing pregnancy after controlled ovarian stimulation with recombinant follicle stimulating hormone…
- Trial name
- NCT00724789
- Testing
- ganirelix, GnRH agonist
- Volunteers
- 2,066 people
- Sponsor
- Organon and Co
WHITE NOISE, INVITRO FERTILIZATION, PAIN, ANXIETY, COMFORT
White Noise and In-vitro Fertilizasyon
In vitro fertilization is the placement of embryos into the uterus with a catheter under ultrasound guidance after the fertilization of sperm and oocytes in a laboratory tube.
- Trial name
- NCT06996340
- Testing
- White noise group, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Yasemin Sökmen
Infertility, Female, First Trimester Spontaneous Abortion
Determination of Circulating Placental Biomarkers Levels to Predict the Pregnancy Outcome of First Trimester After IVF.
This study will assess the predictive potential of circulating placental biomarkers for spontaneous miscarriage within the following month in an IVF setting.
- Trial name
- NCT04387994
- Testing
- Blood samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Infertility
Eeva 12-well Dish Study
The purpose of this study is to demonstrate that the Eeva™ System is compatible with the Eeva 12-well Dish.
- Trial name
- NDS (NCT01635036)
- Testing
- In-vitro fertilization using Eeva
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Progyny, Inc.
Primary or Secondary Infertility
Impact of Local Biopsy to the Endometrium Prior to Controlled Ovarian Stimulation on Clinical Pregnancy
In vitro fertilization (IVF) is the only available solution for many couples with various forms of infertility. The embryo implantation step in the IVF procedure is a complex multistage process and represents the majority of the…
- Trial name
- NIDABRECHE (NCT01064193)
- Testing
- biopsy, IVF
- Where
- 3 sites in France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Bordeaux
Human Sperm Survival Assay, Embryotoxicity
The Human Sperm Survival Assay (HSSA) as an Internal Quality Control for the IVF Consumables (REPROTOX 2)
The main embryotoxicity quality controls are the mouse embryo test (MEA = Mouse Embryo Assay) and the human sperm survival test (HSSA = Human Sperm Survival Assay).
- Conditions
- Human Sperm Survival Assay, Embryotoxicity, in Vitro Fertilization
- Trial name
- REPROTOX 2 (NCT05100784)
- Testing
- HSSA test
- Where
- France
- Volunteers
- 826 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Obesity, Infertility, Female
Improved Fertility After Exercise in Overweight/Obese Women
Overweight/obesity is associated with sub-fertility. The investigators will assess if regular exercise training prior to assisted fertilization will improve pregnancy rate in overweight/obese women referred to assisted…
- Trial name
- FertilEX (NCT01933633)
- Testing
- Exercise
- Where
- 2 sites in Norway
- Volunteers
- 18 people
- Sponsor
- Norwegian University of Science and Technology
IVF, Stress
Interest of Virtual Reality in the Management of Anxiety and Pain During Embryo Transfer (ET)
This study compares the use of virtual Reality versus the usual service protocol for the management of anxiety and pain related to In-Vitro fertilization (IVF) procedure
- Conditions
- IVF, Stress, Anxiety
- Trial name
- VR-INVENT (NCT05925400)
- Testing
- Virtual Reality during Embryo Transfer
- Where
- France
- Volunteers
- 12 people
- Sponsor
- CMC Ambroise Paré
Infertility, Subfertility
The Accuracy of Endometrial Ultrasound to Predict Implantation
To measure the accuracy of different ultrasound endometrial patterns to predict successful embryo implantation during assisted conception; in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03860636
- Testing
- Endometrial Pattern on Ultrasound at ET, Endometrial Pattern on Ultrasound at HCG, Endometrial Pattern on Ultrasound at TVOR
- Where
- United Kingdom
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Infertility
Predictive Value of AMH in IVF; a Prospective RCT
The primary aim of this trial is to compare two groups of women undergoing IVF (IVF=in vitro fertilisation ) treatment, to investigate if assessment of AMH (AMH=Anti-Müllerian hormone ), in addition to assessment of maternal age…
- Trial name
- AMH (NCT02013973)
- Testing
- AMH-analysis
- Where
- Sweden
- Volunteers
- 308 people
- Sponsor
- Ann Thurin Kjellberg
Infertility
Using Embryo Organoids to Discover Human-specific Mechanisms of Preimplantation Embryo Development and Early Pregnancy
EMBRYOx study aims to establish and validate the use of trophoblast organoids (embryoids) from trophoblast placental stem cells as a 3D research model in understanding further preimplantation embryo development in vitro.
- Trial name
- EMBRYOx (NCT05231551)
- Testing
- Placental tissues
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier