Clinical trials: In-Vitro Fertilization
Infertility, Recurrent Implantation Failure
Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)
Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established.
- Trial name
- NCT01278706
- Testing
- endometrial biopsy/ies
- Where
- 2 sites in Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
IVF, Luteal Phase Defect
Luteal Phase Support In IVF Women Using GnRH Agonist
Lately, the role of GnRH agonist as luteal phase support has been recommended by various studies though the mechanism is still debatable.
- Trial name
- NCT04174378
- Testing
- Decapeptyl 0.2mg
- Where
- Malaysia
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Syndrome, Russell Silver
Silver Russell Syndrome, Parental Fertility and Assisted Reproductive Technology
Silver Russell Syndrome (SRS) is a rare imprinting disorder (about 1/16000). Parental imprinting is an epigenetic regulation phenomenon leading to the monoallelic expression of some genes.
- Trial name
- SRS-AMP (NCT06878716)
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitamin D Insufficiency, In Vitro Fertilization and Embryo Transfer
An Investigation of the Effect of Vitamin D Level During Frozen Embryo Transfer (FET) in IVF and Pregnancy Outcomes
Vitamin D is best known for keeping our bones healthy, but growing research suggests it may also play a role in fertility. Many In vitro fertilization (IVF) clinics now routinely check vitamin D levels and prescribe supplements…
- Trial name
- VitD in FET (NCT07681115)
- Testing
- No Intervention: Observational Cohort
- Where
- United Arab Emirates
- Volunteers
- 126 people
- Sponsor
- Fakih IVF Fertility Center
Infertility
The Impact of Lifestyle Behavior on in Vitro Fertilization (IVF) Outcome
The purpose of this study is to prospectively examine the impact of various lifestyle habits in both men and women on the outcome of in vitro fertilization.
- Trial name
- NCT01404858
- Testing
- There is no intervention; this is a survey only study
- Where
- United States
- Volunteers
- 12,800 people, healthy volunteers welcome
- Sponsor
- Boston IVF
Infertility
Supplementation With Human Chorionic Gonadotropin (hCG) During Controlled Ovarian Stimulation With Recombinant Follicle-stimulating Hormone (FSH) for In Vitro Fertilisation
The purpose of this trial is to study whether addition of different doses of human chorionic gonadotropins during controlled ovarian stimulation for patients undergoing IVF will improve the number of top-quality embryos.
- Trial name
- NCT00844311
- Testing
- rFSH, human chorionic gonadotropin
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
In Vitro Fertilization
Acupuncture and Chinese Herbal Medicine to Improve Live Birth Rate of in Vitro Fertilization (IVFAct)
The most successful treatment for infertility is in vitro fertilization (IVF), but less than 10% of infertile couples undergo IVF because of the high cost and relatively low success rate.
- Trial name
- IVFAct (NCT04407871)
- Testing
- Acupuncture and Chinese Herbal Medicine
- Where
- 12 sites in China
- Volunteers
- 2,728 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Male Infertility, Sperm DNA Fragmentation
Microfluidics Versus Density Gradient Centrifugation for Sperm Preparation in IVF
This randomized controlled trial aimed to compare the effectiveness of microfluidic sperm sorting and density gradient centrifugation (DGC) in reducing sperm DNA fragmentation index (DFI) and improving clinical outcomes in IVF.
- Conditions
- Male Infertility, Sperm DNA Fragmentation, In Vitro Fertilization (IVF)
- Trial name
- MCvsDGC (NCT07004309)
- Testing
- Microfluidic sperm sorting, Density Gradient Centrifugation
- Where
- Vietnam
- Volunteers
- 119 people
- Sponsor
- Hanoi Medical University
Infertility
Endometrial Curettage Before Embryo Transfer
Studies have shown that endometrial sampling in the month prior to embryo transfer may increase pregnancy rates. We wish to test this hypothesis by performing a hysteroscopy and curettage in the month proceeding embryo transfer…
- Trial name
- NCT00367367
- Testing
- Hysteroscopy and Curettage
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Infertility (IVF Patients), Male Fertility
Functional Development and Clinical Validation of a Diagnostic Tool Based on Artificial Intelligence for the Assessment of Sperm Quality and the Selection of the Optimal In Vitro Fertilisation (IVF) Treatment
Infertility is a growing global health problem affecting millions of couples worldwide, with male infertility accounting for approximately half of all cases.
- Conditions
- Infertility (IVF Patients), Male Fertility, Sperm Selection
- Trial name
- NCT07185984
- Testing
- Sperm sellection, DIAGNOSIS TOOL
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
In Vitro Fertilization, Subfertility
Hyaluronan-enriched Embryo Transfer Medium for Frozen-thawed Embryo Transfer
This is a randomized-controlled trial evaluating the effect of the use of hyaluronan (HA)-enriched embryo transfer medium on the live birth rate in women undergoing frozen-thawed embryo transfer.
- Trial name
- NCT02725827
- Testing
- EmbryoGlue (Vitrolife), Control medium
- Where
- 2 sites in Hong Kong
- Volunteers
- 550 people
- Sponsor
- The University of Hong Kong
Ovulation Induction, Infertility
An Open Label, Canadian Phase IIIb Study With Ovidrel in Ovulation Induction (OI) and Assisted Reproductive Technique (ART)
With the development of the recombinant gonadotrophins, the use of human source proteins for the production of hormones has become unnecessary.
- Trial name
- NCT01152866
- Testing
- Choriogonadotropin alpha (r-hCG)
- Volunteers
- 3 people
- Sponsor
- EMD Serono
Infertility
The Effectiveness of Endometrial Injury in IVF
Many studies have demonstrated that endometrial scratch significantly increase pregnancy rate in patients undergoing in vitro fertilization and embryo transfer.
- Trial name
- NCT02409745
- Testing
- endometrial scratch
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Fertilization in Vitro
Plasticizers and in Vitro Fertilization Outcomes
To investigate the effect of Plasticizer metabolites concentration on the in vitro fertilization outcomes
- Trial name
- NCT03733912
- Testing
- Phthalate metabolites measurement
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility, Aneuploidy
Single Embryo TrAnsfeR of Euploid Embryo
The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a…
- Trial name
- STAR (NCT02268786)
- Testing
- Preimplantation Genetic Screening by NGS
- Where
- 38 sites in United States, Australia and 2 more
- Volunteers
- 661 people
- Sponsor
- Illumina, Inc.
Infertility
A Study to Assess if Scratching the Lining of the Womb Prior to IVF Treatment Increases the Chances of Pregnancy
This study aims to see if taking a small sample from the lining of the womb (the 'scratch') before starting in vitro fertilization (IVF) treatment can influence the chance of getting pregnant and having a healthy, term baby.
- Trial name
- NCT01882842
- Testing
- Endometrial biopsy, Transvaginal ultrasound
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Nottingham University Hospitals NHS Trust
In Vitro Fertilization, Infertility
Sibling Oocyte Study of Medium for In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) With no Human Serum Albumine
The purpose of this study is to determine if a new medium with no human serum albumine added is as good as the media conventionally used for IVF/ICSI.
- Trial name
- NCT00541892
- Testing
- Medium with no human serum albumine added, Conventional medium
- Where
- Norway
- Sponsor
- Sykehuset Telemark
Other Complications Associated With Artificial Fertilization
Efficacy of Luteinizing Hormone (LH) Activity in Low Responder Patients With Transdermal Testosterone
The investigators have previously demonstrated the utility of transdermal testosterone in in vitro fertilization (IVF) low responder patients.
- Trial name
- NCT01291212
- Testing
- Testosterone and FSHr-LHr, testosterone and FSHr alone
- Where
- Spain
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Infertility
Transabdominal US-guided (UGET) vs. Modified Transvaginal US-guided (mTVET) Embryo Transfer in Human IVF
One thousand, six hundred forty-eight IVF patients undergoing ET with fresh embryos, randomized to receive mTVET (n=828) or UGET (n=820).
- Trial name
- NCT02526472
- Testing
- ET under transabdominal US guidance (UGET), ET after transvaginal US uterine measurement (mTVET)
- Where
- Italy
- Volunteers
- 1,648 people
- Sponsor
- University of Turin, Italy
Infertility
Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles
This is a randomized, double-blind, single center clinical trial study to compare oocyte competence and risk of ovarian hyperstimulation syndrome (OHSS) after receiving the standard dose of human chorionic gonadotropin (hCG)…
- Trial name
- NCT02310919
- Testing
- Low dose hCG plus FSH co-trigger, Standard dose of hCG
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco