Clinical trials: In-vitro Fertilization
Androgen Receptor Gene Overexpression, Normal Responders
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
AR is a steroid hormone receptor that regulates various genes' expression and affects cellular proliferation and differentiation.
- Conditions
- Androgen Receptor Gene Overexpression, Normal Responders, Poor Ovarian Response, Bologna Criteria
- Trial name
- NCT03433768
- Testing
- Real time PCR
- Volunteers
- 67 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility
FSH in GnRH-AntagoniST Controlled Ovarian Hyperstimulation Cycles (FAST)
The purpose of the non-inferiority study is to evaluate the clinical efficacy and the safety of two different subcutaneous FSH preparations (Fostimon versus Gonal-F) for controlled ovarian hyperstimulation in a GnRH-antagonist…
- Trial name
- FAST (NCT01969201)
- Testing
- Urofollitrophin, Follitrophin alpha
- Where
- 16 sites in Belgium, Italy and 4 more
- Volunteers
- 710 people
- Sponsor
- IBSA Institut Biochimique SA
in Vitro Fertilization
Improvement of in Vitro Fertilization Implantation by Soluble CD146 Dose in Embryonic Culture Environment
The study of implantation potential of the embryo stay a priority in In Vitro Fertilization (IVF). Indeed, the selection of embryos to transfer is actually based in routine check on morphologic criteria, approved by literature…
- Trial name
- AMIFIV (NCT03785119)
- Where
- France
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
IVF
Comparative Study Between Fresh and Frozen Embryo Transfer in PCOS Patients Undergoing IVF Treatment
The objective of our study is to compare in vitro fertilization (IVF) outcomes between fresh embryo transfer (ET) and frozen-thawed ET in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT05167838
- Testing
- fresh embryo transfer, Frozen embryo transfer
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Cairo University
In Vitro Fertilization, Estradiol
Impact of Supraphysiological Estradiol on ECG in IVF Patients
This prospective observational study aimed to evaluate the effects of supraphysiological estradiol (E2) levels, induced by gonadotropin therapy during IVF, on cardiac electrophysiological parameters.
- Conditions
- In Vitro Fertilization, Estradiol, Cardiac Electrophysiology, Electrocardiography (ECG)
- Trial name
- NCT07007416
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Konya City Hospital
Pregnancy Related
Endometrial Leucocytes Around the Time of Embryo Implantation in Women Undergoing in IVF-ET
Uterine natural killer (uNK) cells have been implicated to play a role in female reproductive performance. Serval studies showed an increased uNK cell density in the endometrium of women with reproductive failure.
- Trial name
- NCT04079959
- Testing
- endometrial biopsy
- Where
- Hong Kong
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong
Infertility Assisted Reproductive Technology
The Feasibility of taVNS on Pregnancy Outcomes of Infertility Patients Undergoing IVF
To assess the feasibility of taVNS on pregnancy outcomes of infertility subjects undergoing IVF, the primary aim of this trial will focus on encompassing recruitment, compliance, and preliminary engagement outcomes.
- Trial name
- NCT06742788
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Infertility
Comparison of Alternative Embryo Culture Systems
This study will compare two alternative embryo culture systems. Embryos from each patient will be randomly assigned to one of two systems. One group will be cultured conventionally in oil-covered droplets in dishes.
- Trial name
- NCT02028897
- Testing
- Conventional embryo culture, Enclosed embryo culture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Clinical Pregnancy Rate, Ovulation Induction
Follicular Long GnRH Agonist Versus Antagonist Protocol in PCOS Women Undergoing in Vitro Fertilization
Pituitary down regulation is widely used during in vitro fertilization (IVF) procedures. It can suppress the spontaneous luteinizing hormone (LH) surge, and can also make follicles growth evenly.
- Conditions
- Clinical Pregnancy Rate, Ovulation Induction, IVF
- Trial name
- NCT02496754
- Testing
- GnRH-a, GnRH-anta
- Where
- China
- Volunteers
- 1,266 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Female Infertility Due to Nonimplantation of Ovum, Complications Associated With Artificial Fertilization
Comparing Ovarian Stimulation for Assisted Reproduction With Two Different Forms of Pituitary Suppression
The purpose of this study is to assess the non-inferiority of a multidose GnRH antagonist (cetrorelix) regimen to a GnRH agonist (triptorelin) long protocol in young infertile women undergoing ovarian stimulation with Pergoveris…
- Trial name
- Pergoveris (NCT01565265)
- Testing
- Pergoveris in long protocol with GnRH agonist, Pergoveris in GnRH antagonist protocol
- Where
- Switzerland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infertility
Antagonist Protocol in IVF
The antagonist protocol in a novel method of stimulation in the in vitro fertilization (IVF) patients. It has been tried in poor responders, polycystic ovary (PCO) patients and normal females undergoing IVF.
- Trial name
- NCT02335736
- Testing
- Gonadotropins releasing hormone antagonist
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Anxiety, Pregnancy Outcomes
Effect of Breathing Exercises on Embryo Transfer Outcomes
Breathing exercises are being used in many different clinical issues in the area of medicine. Also in gynecological practice, especially during labor, breathing exercises are encouraged by health professionals to aid the…
- Trial name
- BreathIVF (NCT07109544)
- Testing
- Breathing Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eurofertil IVF Health Center
Subfertility
Transdermal Testosterone Pretreatment in Poor Responders Undergoing IVF
Ιt has been suggested that the accumulation of androgens in the micro milieu of the primate ovary, plays a critical role in early follicular development and granulosa cell proliferation.
- Trial name
- NCT01961336
- Testing
- Testosterone
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Luteal Phase Progesterone Levels
The Effect of Luteal Blood Progesterone Levels on Ongoing Pregnancy Rates
Progesterone (P4) is essential for the secretory development of endometrium and the maintenance of early pregnancy. In the luteal phase following controlled ovarian stimulation in in vitro fertilization (IVF) treatment, P4…
- Trial name
- NCT04128436
- Testing
- Taking blood samples for analyzing progesterone levels
- Where
- 3 sites in Brazil, Denmark and 1 more
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Infertility
Navigating Health Insurance Selection for IVF Benefits
The purpose of this study is to evaluate the effectiveness of an educational intervention on health insurance literacy and utilization of in vitro fertilization (IVF) insurance benefits.
- Trial name
- NCT05663645
- Testing
- Health insurance educational guide
- Where
- United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Pregnant Women
Early Progesterone Cessation After in Vitro Fertilization
There seems to be a general consensus on the supplementation of progesterone (P4) for luteal phase support (LPS) to all women after in vitro fertilization (IVF) treatment.
- Trial name
- NCT01177904
- Testing
- Cease progsterone at 5, control group: progesterone 8
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- IVI Madrid
Polycystic Ovary Syndrome, Obesity
The Effect of a Liraglutide on IVF in Obese PCOS
The aim of this study was to evaluate the impact of low dose liraglutide in combination with metformin compared to metformin alone on IVF pregnancy rate (PR) and cumulatively PR (IVF and spontaneous) in infertile obese women with…
- Conditions
- Polycystic Ovary Syndrome, Obesity, Infertility, Female
- Trial name
- NCT03353948
- Testing
- MET, COMBI
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Vitamin D Insufficiency, In Vitro Fertilization and Embryo Transfer
An Investigation of the Effect of Vitamin D Level During Frozen Embryo Transfer (FET) in IVF and Pregnancy Outcomes
Vitamin D is best known for keeping our bones healthy, but growing research suggests it may also play a role in fertility. Many In vitro fertilization (IVF) clinics now routinely check vitamin D levels and prescribe supplements…
- Trial name
- VitD in FET (NCT07681115)
- Testing
- No Intervention: Observational Cohort
- Where
- United Arab Emirates
- Volunteers
- 126 people
- Sponsor
- Fakih IVF Fertility Center
Intrauterine Abnormalities in Infertility
SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle
BACKGROUND: Despite the numerous advances in the field of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI), there still exists a maximum implantation rate per embryo transferred of about 30%.
- Trial name
- inSIGHT (NCT01242852)
- Testing
- Office hysteroscopy (in combination with a 'Saline Infusion Sonography'(SIS))
- Where
- Netherlands
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Sterility, Placenta; Implantation
A Lifestyle Intervention to Improve in Vitro Fertilization Results
Embryo adhesion and placentation depend on tissue plasminogen activator (tPA)-mediated activation of brain-derived neurotrophic factor, vascular endothelial growth factor and other growth factors, formation of hemidesmosomes, and…
- Conditions
- Sterility, Placenta; Implantation, Risk Reduction Behavior, Lifestyle
- Trial name
- W+D (NCT02648555)
- Testing
- Daily walking, Dietary recommendations
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hospital dos Servidores do Estado do Rio de Janeiro