Clinical trials: Inappropriate Prescribing
Patient Safety, Inappropriate Prescribing
A Randomised Pilot Study of the REVISiT Intervention
In 2012, the General Medical Council (GMC) funded PRACtICe (PRevalence And Causes of prescrIbing errors in general practiCe) study, reported that 1 in 20 prescriptions in general practice were found to have a prescribing or…
- Conditions
- Patient Safety, Inappropriate Prescribing, Medication Errors
- Trial name
- NCT04586595
- Testing
- REVISiT intervention
- Where
- 4 sites in United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dementia, Med: Dementia
Can Value Champions Reduce Inappropriate Prescribing for People With Dementia?
The primary objective is to assess the effectiveness of training a clinician to be a 'value champion' within clinical settings to decrease the use of three classes of potentially inappropriate prescription medications (PIMs)…
- Trial name
- NCT05359679
- Testing
- Value Champion Training Program, No Intervention
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Kaiser Permanente
Inappropriate Prescribing, Implementation Science
Reduction of Low-value Prescribing Through Audit and Feedback
The objective is to estimate the effect attributable to a primary care pharmacist-led audit and feedback (AF) strategy compared to the currently used AF strategy as a management tool to evaluate healthcare performance focusing on…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- AFFAP (NCT07336550)
- Testing
- Usual AF, Facilitated AF
- Where
- Spain
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Inappropriate Prescribing, Implementation Science
De-implementation of Low-value Pharmacological Prescriptions
The De-imFAR study is a two phase study that aims to carry out and test a structured, evidence-based and theory informed process involving the main stakeholders (managers, professionals, patients and researches) for the design…
- Conditions
- Inappropriate Prescribing, Implementation Science, Behavioral Sciences
- Trial name
- De-imFAR (NCT04022850)
- Testing
- A non-reflective decision assistance strategy, A both reflective and non-reflective decision information strategy, A reflective decision structure strategy
- Where
- Spain
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Kidney Failure, Chronic
Deprescribing for Older Dialysis Patients
Aim 1 of the study is to identify the elements of a deprescribing intervention that address contextual factors specific to dialysis.
- Trial name
- NCT03631290
- Testing
- Deprescribing Intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Overactive Bladder Syndrome
Effectiveness of a Structured Intervention to Optimize the Use of Mirabegron
This study was a multicentre, quasi-experimental design, controlled, before-and-after trial to estimate the effectiveness related to the review of mirabegron use and, if appropriate, its discontinuation.
- Trial name
- NCT03536494
- Testing
- Review the use of mirabegron and its discontinuation
- Volunteers
- 1,932 people
- Sponsor
- Catalan Institute of Health
Inappropriate Dose of Drug Administered, Health Behavior
A Trial to De-prescribe Inappropriate Medications in the Community Dwelling Elderly
The objective of this trial is to test the beneficial effect of a pharmacist-initiated knowledge transfer intervention to both patients and prescribers on the discontinuation of inappropriate prescriptions, compared to usual…
- Trial name
- D-PRESCRIBE (NCT02053194)
- Testing
- Pharmacist-led educational intervention
- Volunteers
- 600 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Antibiotic Prescribing by GPs for URTI
Developing and Evaluating Interventions to Reduce Inappropriate Prescribing of Antibiotics in Primary Care
1. Do paper-based and web-based intervention modelling experiments (the methodology we are developing) identify the same predictors of GP behaviour regarding prescribing of antibiotics for upper respiratory tract infections? 2.
- Trial name
- WIME (NCT01206738)
- Testing
- Persuasive communication, Action plan, General intervention
- Where
- United Kingdom
- Volunteers
- 270 people
- Sponsor
- University of Dundee
Prevention, Benzodiazepine Dependence
Electronic Deprescribing Tool for the Prevention of PIP
This study is a cluster randomized control trial aimed to measure the effectiveness of an educational knowledge transfer intervention to prescribers on the discontinuation of two targeted classes: Benzodiazepines…
- Trial name
- NCT03192514
- Testing
- Electronic Deprescribing tool
- Where
- Portugal
- Volunteers
- 280 people
- Sponsor
- University of Beira Interior
Inappropriate Prescribing
The Study in Outpatient Medicine Using Nudges to Improve Sleep
The goal of this clinical trial is to learn if electronic health record (EHR) nudges (changes to the EHR that do not restrict freedom of choice or alter incentives) can reduce Z-drug prescribing in primary care clinics for…
- Trial name
- SOMNUS (NCT06640023)
- Testing
- Z-drug Default Quantity, Redirection + Accountable Justification
- Where
- United States
- Volunteers
- 444 people
- Sponsor
- University of Southern California
Acute Sinusitis, Streptococcal Pharyngitis
Antimicrobial Stewardship for Primary Care Pediatricians
The purpose of the study is to determine if physician education coupled with audit and feedback of antibiotic prescribing can improve antibiotic prescribing by primary care clinicians.
- Conditions
- Acute Sinusitis, Streptococcal Pharyngitis, Pneumonia, Viral Infection
- Trial name
- PARTI (NCT01806103)
- Testing
- Antimicrobial Stewardship Bundle
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Children's Hospital of Philadelphia
Respiratory Tract Infections
TRACE E-learning Implementation in Belgium
Antibiotic resistance is a worldwide health care problem. Increasing use of antibiotics is associated with an increase in the prevalence of bacteria resistant to the antibiotic used.
- Trial name
- NCT03265028
- Testing
- TRACE e-learning
- Where
- 11 sites in Belgium
- Volunteers
- 15,802 people
- Sponsor
- Universiteit Antwerpen
Dementia, Inappropriate Prescribing
An Intervention to Reduce Inappropriate Medications in Long-term Care Residents With Severe Dementia
An education intervention to promote medication reviews and interdisciplinary discussions within long-term care facilities with the aim of improving medication regimen among residents with severe dementia
- Trial name
- OptimaMed (NCT03539276)
- Testing
- Knowledge exchange
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- CHU de Quebec-Universite Laval
Inappropriate Prescribing
Effectiveness of a Community Intervention in the Chronic Use of Benzodiazepines: (BENZOSTOPJUNTOS)
This study aimed to assess the effectiveness of a comprehensive, multicomponent intervention utilizing education and support for Benzodiazepines withdrawal compared to standard care.
- Trial name
- BENZOSTOP (NCT06209827)
- Testing
- Intervention for reducing benzodiazepines long-term use.
- Where
- Spain
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- Andalusian Health Service
Inappropriate Prescribing, Antibiotic Stewardship
Antibiotic Stewardship in Small Hospitals
Core elements of effective antibiotic stewardship programs (ASPs) have been identified and evidence-based guidelines have been developed for implementation.
- Conditions
- Inappropriate Prescribing, Antibiotic Stewardship, Anti-Bacterial Agents
- Trial name
- SCORE (NCT03245879)
- Testing
- Program 1, Program 2, Program 3
- Volunteers
- 30,000 people
- Sponsor
- Intermountain Health Care, Inc.
Potentially Inappropriate Prescribing (PIP)
Potentially Inappropriate Prescribing (PIP) in Long-Term Care (LTC) Patients
The study objectives are: to validate the subsets of Screening Tool of Older People's Prescriptions (STOPP) and Screening Tool to Alert Right Treatment (START), or STOPP/START criteria, and Beers criteria applicable to HAD by…
- Trial name
- PIP in LTC (NCT02523482)
- Where
- 6 sites in Canada
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Bruyère Health Research Institute.
Respiratory Tract Infections
Non-Inferiority of Peer Comparison Interventions
The objective of this study is to test the hypothesis that the Peer Comparison intervention in the Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (BEARI) trial (Meeker et al.
- Trial name
- NCT05575115
- Testing
- Peer Comparison
- Volunteers
- 201 people
- Sponsor
- University of Southern California
Medical Overuse, Inappropriate Prescribing
Engaging Patients to Promote Deprescribing
One mechanism to reduce potentially inappropriate medications is through deprescribing, a deimplementation-based approach to thoughtfully discontinue a medication a patient is currently prescribed.
- Conditions
- Medical Overuse, Inappropriate Prescribing, Deprescriptions
- Trial name
- NCT04294901
- Testing
- Direct to patient medication brochure
- Where
- 4 sites in United States
- Volunteers
- 5,946 people
- Sponsor
- VA Office of Research and Development
Opioid Prescribing
Postoperative Nudges to Reduce Opioid Prescribing
This study tests the effectiveness of two email-based behavioral nudges, one based on peer behavior and one based on best practice guidelines, in reducing excessive opioid prescriptions after surgery.
- Trial name
- POST-OP (NCT05070338)
- Testing
- Guideline-Based (Injunctive Norm) Nudges, Peer-Based (Social Norm) Nudges
- Where
- United States
- Volunteers
- 640 people
- Sponsor
- RAND
Lumbosacral Muscle Strain
Evaluating Effectiveness of Educational Intervention to Help Physicians Address Inappropriate Patient Requests for Direct-to-Consumer Advertised Prescription Medications
The purpose of this study is to determine whether physicians can be educated to better handle inappropriate requests from patients for direct-to-consumer advertised prescription medications.
- Trial name
- NCT00915291
- Testing
- Web-based educational modules
- Where
- 4 sites in United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- American Medical Association